Fusion of Deep Transfer Learning and Radiomics in MRI-Based Prediction of Post-Surgical Recurrence in Soft Tissue Sarcoma.

Soft  tissue sarcomas (STS) are heterogeneous malignancies with high recurrence rates (33-39%) post-surgery, necessitating improved prognostic tools. This study proposes a fusion model integrating deep transfer learning and radiomics from MRI to predict postoperative STS recurrence. Axial T2-weighted fat-suppressed imaging (TWI) of 803 STS patients from two institutions was retrospectively collected and divided into training (n = 527), internal validation (n = 132), and external validation (n = 144) cohorts.

Epidemiological features of nontyphoidal Salmonella infections reported to foodborne disease surveillance system in china, 2013-2022.

Background: Nontyphoidal Salmonella (NTS) is the most commonly reported foodborne gastrointestinal infection and ranks among the top three causes of foodborne bacterial outbreaks in China.

Methods: This study analyzed NTS data from the Foodborne Disease Surveillance System in China from 2013 to 2022 to summarize epidemiological features and assess reporting rate changes. We employed joinpoint regression model to calculate the annual percentage change in NTS reporting rate, sex reporting rate, as well as rural-urban reporting rate.

Neuronal oscillatory imbalances in GNAO1-related disorders associated with disease severity.

Objective: This study investigates excitatory/inhibitory (E/I) imbalances in GNAO1-related disorders (GNAO1-RD), linking neuronal dysfunction to clinical severity using E/I-sensitive electroencephalography (EEG) analyses.

Methods: We conducted an observational study involving 12 children with GNAO1-RD caused by pathogenic variants and 36 age-matched, typically developing children (TDC). EEG was recorded during eyes-closed rest.

IRF8 aggravates nonalcoholic fatty liver disease via BMAL1/PPARγ axis.

Non-alcoholic fatty liver disease (NAFLD) is a hepatic metabolic syndrome arising from lipid metabolic imbalance, with its prevalence increasing globally. In this study, we observed a significant up-regulation of interferon regulatory factor 8 (IRF8) in the liver of NAFLD model mice and patients. Overexpression of IRF8 induced lipid accumulation in the mouse primary hepatocytes.

Feasibility of ADC histogram analysis for predicting of postoperative recurrence in aggressive spinal tumors.

Background: Risk stratification of spinal tumors is a major unmet clinical need for personalized therapy.

Purpose: To explore the feasibility of pretreatment whole-lesion apparent diffusion coefficient (ADC) histogram in predicting local recurrence of aggressive spinal tumors.

Methods: 119 aggressive spinal tumor patients (median age, 40; range, 13-74  years) confirmed by pathological findings with a mean follow-up of 36 months were enrolled and divided into the recurrence and non-recurrence group.

Validation Status of Electronic Sphygmomanometers in China: A National Survey.

Background: Although the information on the validation status of electronic sphygmomanometer (ES) devices in use in health care institutions and households is much more clinically relevant than that of ES models available on the market, it remains insufficient.

Methods: A national survey was conducted across all administrative regions of mainland China to assess the validation status of ESs. Fifty-eight cities were selected with stratification by municipality, provincial capital, and other cities, and health care institutions and households in each city were chosen by convenience to identify ES devices in use according to the study protocol.

Diarrheagenic Outbreak Reporting to Foodborne Disease Outbreaks Surveillance System - China, 2011-2022.

What Is Already Known About This Topic?: Foodborne diarrheagenic (DEC) outbreaks constitute a significant global public health concern, yet comprehensive data on outbreak incidence and epidemiological characteristics in China remain limited.

What Is Added By This Report?: Between 2011 and 2022, there were 413 foodborne DEC outbreaks reported to foodborne disease outbreak surveillance system, resulting in 8,127 illnesses, 2,565 hospitalizations, and one fatality. Enteroaggregative (EAEC) emerged as the predominant causative pathogen (48.

Morbidity, Mortality, and Epidemiological Features of Clinical Invasive Listeriosis Isolates from Sentinel Surveillance in Beijing, China, 2013-2022.

Listeriosis is a relatively rare but severe foodborne disease, which has significant public health concern of persons with underlying conditions and pregnant women. This study aimed to estimate the morbidity, mortality, and fatality rates of listeriosis over a 10-year period and clarify the epidemiological features of the pathogen in Beijing, China, based on voluntary reporting of sentinel surveillance. A total of 228 listeriosis cases were reported with annual morbidity rate of 1.

Current Advance, Challenges and Future Perspectives of Conduction System Pacing.

Existing techniques for pacing the right ventricle and providing cardiac resynchronization therapy through biventricular pacing are not effective in restoring damage to the conduction system. Therefore, the need for new pacing modalities and techniques with more sensible designs and algorithms is justified. Although the benefits of conduction system pacing (CSP), which mainly include His bundle pacing (HBP) and left bundle branch area pacing (LBBAP), are evident in patients who require conduction system recuperation, the critical criteria for left CSP remain unclear, and the roles of different pacing modalities of CSP for cardiac resynchronization are not definite.

Unlocking Solid-State Sodium-Metal Batteries at -15 °C by Electrolyte Optimization and Interface Regulation.

Beta-AlO-based solid-state sodium metal batteries are some of the best options for large-scale energy storage systems because of their high energy density, high-level safety, and low cost. Nevertheless, their room-/low-temperature operation remains challenging due to low ionic conductivity of Beta-AlO electrolyte and weak solid-solid contact of the Na/Beta-AlO interface. Herein, an integrated strategy was developed via electrolyte optimization and interface regulation, in which Cu as a stabilizing agent was incorporated into Beta-AlO to improve density and ionic conductivity and the InS interface layer was introduced between the Na anode and solid electrolyte to induce the in situ formation of a mixed conductive layer (Na-In alloy and NaS).

Pancreatic β cell interleukin-22 receptor subunit alpha 1 deficiency impairs β cell function in type 2 diabetes via cytochrome b5 reductase 3.

Impaired β cell function is a hallmark of type 2 diabetes (T2D), but the underlying cellular signaling machineries that regulate β cell function remain unknown. Here, we identify that the interleukin-22 receptor subunit alpha 1 (IL-22RA1), known as a co-receptor for IL-22, is downregulated in human and mouse T2D β cells. Mice with β cell Il22ra1 knockout (Il22ra1βKO) exhibit defective insulin secretion and impaired glucose tolerance after being fed a high-fat diet (HFD) or an HFD/low dose of streptozotocin (STZ).

Weakly supervised chest X-ray abnormality localization with non-linear modulation and foreground control.

Chest X-ray is widely used to diagnose lung diseases. Due to the demand for accelerating analysis and interpretation to reduce the workload of radiologists, there has been a growing interest in building automated systems of chest X-ray abnormality localization. However, fully supervised methods usually require well-trained radiologists to annotate bounding boxes manually, which is labor-intensive and time-consuming.

Exploration of protein and genetic targets causing atrioventricular block: mendelian-randomization analyses based on eQTL data and pQTL data.

Background: Atrioventricular block (AVB) is a heterogeneous group of arrhythmias. AVB can lead to sudden arrest of the heart and subsequent syncope or sudden cardiac death. Few scholars have investigated the underlying molecular mechanisms of AVB.

Development and validation of a CT-based deep learning radiomics signature to predict lymph node metastasis in oropharyngeal squamous cell carcinoma: a multicentre study.

Objectives: Lymph node metastasis (LNM) is a pivotal determinant that influences the treatment strategies and prognosis for oropharyngeal squamous cell carcinoma (OPSCC) patients. This study aims to establish and verify a deep learning (DL) radiomics model for the prediction of LNM in OPSCCs using contrast-enhanced computed tomography (CECT).

Methods: A retrospective analysis included 279 OPSCC patients from 3 institutions.

Optimizing Clinical Trial Eligibility Design Using Natural Language Processing Models and Real-World Data: Algorithm Development and Validation.

Background: Clinical trials are vital for developing new therapies but can also delay drug development. Efficient trial data management, optimized trial protocol, and accurate patient identification are critical for reducing trial timelines. Natural language processing (NLP) has the potential to achieve these objectives.

Pathogenic Surveillance of Foodborne Illness-Related Diarrhea - Beijing Municipality, China, 2013-2023.

What Is Already Known About This Topic?: Foodborne diseases present a significant public health concern, particularly in China, where they represent a significant food safety challenge. Currently, there is a need for a thorough and systematic analysis of the extended epidemiological patterns of foodborne diseases in Beijing Municipality.

What Is Added By This Report?: Monitoring results show that Norovirus and diarrheagenic (DEC) are the most commonly identified foodborne diarrheal pathogens.

Uni-directional release of ibuprofen from an asymmetric fibrous membrane enables effective peritendinous anti-adhesion.

Drug-loaded porous membranes have been deemed to be effective physicochemical barriers to separate postoperative adhesion-prone tissues in tendon healing. However, cell viability and subsequent tissue regeneration might be severely interfered with the unrestricted release and the locally excessive concentration of anti-inflammatory drugs. Herein, we report a double-layered membrane with sustained and uni-directional drug delivery features to prevent peritendinous adhesion without hampering the healing outcome.

Applying dynamic contrast-enhanced MRI tracer kinetic models to differentiate benign and malignant soft tissue tumors.

Background: To explore the potential of different quantitative dynamic contrast-enhanced (qDCE)-MRI tracer kinetic (TK) models and qDCE parameters in discriminating benign from malignant soft tissue tumors (STTs).

Methods: This research included 92 patients (41females, 51 males; age range 16-86 years, mean age 51.24 years) with STTs.

Illuminated fulvic acid stimulates denitrification and As(III) immobilization in flooded paddy soils via an enhanced biophotoelectrochemical pathway.

Fulvic acid (FA) is a representative photosensitive dissolved organic matter (DOM) compound that occurs naturally in paddy soils. In this study, the effect of a FA + nitrate treatment (0, 4 and 8 mg/L FA + 20 mmol/L nitrate) on denitrification and As(III) immobilization in flooded paddy soils was assessed under dark and intermittently illuminated conditions (12 h light+12 h dark). The FA input stimulated denitrification in illuminated soils (~100 % of nitrate removal within 6 days) compared to dark conditions (~92 % nitrate removal after 6 days).