Contribution of Respiratory Syncytial Virus to Burden of Lower Respiratory Tract Infections: A Global Analysis of 204 Countries and Territories, 1990-2021.

Respiratory syncytial virus (RSV) is a major cause of morbidity and mortality from lower respiratory infections (LRIs) worldwide. This study analyzes trends in age-standardized death rates (ASDRs) and disability-adjusted life years (DALYs) due to RSV-induced LRIs from 1990 to 2019, using data from the Global Burden of Disease Study 2021 (GBD 2021). The findings show a gradual decline in deaths, ASDR, and DALYs throughout this period.

Meta-transcriptomics characterization of individual reveals a wide spectrum of viral and bacterial pathogens in Inner Mongolia of China.

Mongolian marmot is a reservoir for various zoonotic pathogens, including , , and hantaviruses. However, our understanding of the marmot's pathogen profile remains incomplete. Here, we used an unbiased metatranscriptomic approach to comprehensively characterize the virome and bacterial microbiome of 106 Mongolian marmot sampled from Chen Barag Banner, Inner Mongolian, China.

Contrasting tracheal, bronchus, and lung cancer burdens and care quality: a comparative analysis of China and global trends.

Background: This study aims to explore the temporal trends of tracheal, bronchus, and lung cancer burden in Fujian Province, China, and globally. Additionally, it evaluates changes in attributable risk factors and the quality of care.

Methods: Based on data from the Fujian Provincial Center for Disease Control and Prevention and the Global Burden of Disease (GBD), the age-standardized rates (ASRs) of incidence, death, and disability-adjusted life years (DALY) were collected and analyzed.

High-fat and low-fiber diet elevates the gut resistome: a comparative metagenomic study.

Antimicrobial resistance (AMR) is a global health challenge. The gut microbiome, a major reservoir for AMR, is influenced by dietary habits. However, the specific impact of dietary patterns on gut resistome remains poorly understood.

Spatiotemporal Distribution of Hand, Foot, and Mouth Disease and the Influence of Air Pollutants and Socioeconomic Factors on Incidence in Fujian, China.

Background: Hand, foot, and mouth disease (HFMD) typically exhibits spatiotemporal clustering. This study aimed to analyze the spatiotemporal heterogeneity of HFMD in Fujian Province, China, and to identify the associations of air pollutants and socioeconomic factors with the incidence.

Methods: Daily reported HFMD case data, daily air pollutant data, and socioeconomic data in Fujian Province from 2014 to 2023 were collected for analysis.

The association between poor dental health and gastric cancer risk: a nationwide cohort and sibling-controlled study.

Background: Poor dental health has been linked to an increased risk of gastric cancer (GC), but previous studies were limited by their retrospective design and relatively small sample size.

Methods: We followed a nationwide cohort of 5,888,034 Swedish adults over the age of 19 who visited a dentist between 2009 and 2016. Additionally, a nested case-control study was conducted by comparing incident GC cases to their siblings.

Safety and immunogenicity of thiomersal-free recombinant hepatitis E vaccine: A randomized, double-blind, active-controlled study.

Introduction: The first recombinant hepatitis E vaccine (Escherichia Coli), Hecolin® (Xiamen Innovax, China), was approved for people aged ≥16 years. Innovax has developed a thiomersal-free formulation process change according to the requirement of 2020 Chinese Pharmacopoeia. This study aimed to evaluate the safety and immunogenicity of the thiomersal-free hepatitis E vaccine compared with the licensed hepatitis E vaccine in people aged ≥16 years.

Healthy lifestyles and the incidence risk and time of carotid plaque: a nationwide cohort study.

Background: The association between lifestyles and carotid plaque showed heterogeneity in results across studies, which may be limited by sample size or population characteristics. In addition, there is a lack of evidence on how long healthy lifestyles delay plaque development and on the metabolic factors which are likely to mediate these associations. This study aims to investigate the impact of multiple healthy lifestyles on the risk and time of carotid plaque incidence in the early stages of atherosclerotic cardiovascular disease (CVD), and to identify the metabolic factors mediating this association.

Effective features of e-cigarette prevention videos: A qualitative study with primary school students.

Introduction: While video-based prevention campaigns show promise in addressing the rising e-cigarette use among youth, little is known about what makes such videos effective from children's perspectives, particularly in China's cultural context. This study aimed to investigate which video content elements could be effective in preventing e-cigarette use among children, providing evidence-based guidance for developing e-cigarette prevention materials and information design targeting children.

Methods: Using purposive sampling, we conducted four gender-stratified focus groups with 35 primary school students (aged 12-13 years) in Beijing and Yunnan.

Pneumonia caused by : A case report.

As well known, the species of Bordetella, such as and are prevalent respiratory tract pathogens. , another species of Bordetella genus, could cause meningitis, bacteremia, lung disease, endocarditis, chronic cholangitis and soft tissue abscess. In this study, we reported a new case of infection in Asia with the clinical presentation and laboratory diagnosis.

[Spousal correlations of blood lipid based on a family design].

Objective: To explore the spousal correlations of total cholesterol (TC), total triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C), and to investigate the reasons behind these spousal correlations.

Methods: Participants and data were from the baseline survey of family-based cohort studies in Fangshan, Beijing and Tulou, Fujian. The origin of spousal correlations were explored from perspectives of convergence, assortative mating, social homogamy.

Modulating lipid metabolism for enhancement of coenzyme Q production in Rhodobacter sphaeroides.

Coenzyme Q10 (CoQ), a lipid-soluble isoprenylated benzoquinone essential for electron transfer, is synthesized in the inner mitochondrial membrane of eukaryotes and plasma membrane of prokaryotes like Rhodobacter sphaeroides. Despite its natural production capacity, industrial-scale CoQ synthesis remains limited by ineffective metabolic regulation and scarce genetic tools in R. sphaeroides.

A Multi-Regional Epidemiological Evaluation on Post-vaccination Serological Testing in Prevention of Vertical Transmission of Hepatitis B Virus - 10 Counties, 5 Provinces, China, 2019-2024.

What Is Already Known About This Topic?: Post-vaccination serologic testing (PVST) of infants born to hepatitis B virus (HBV) infected mothers is important for evaluating effectiveness of strategies for preventing mother-to-child transmission (MTCT) of HBV.

What Is Added By This Report?: PVST was conducted in 43.7% of 7,425 infants born to HBV-infected mothers and showed that 0.

Rapid penetrating inactivation and disinfection through ice layers by light-condensed deep ultraviolet LED irradiation.

The longer survival of virus and bacteria under low temperature greatly accelerates the infection risk and duration. How to effectively and rapidly inactivate them beneath ice layer in cold chain logistics has been an important issue never being well studied. Here, we demonstrate a novel light condenser design of high power UVC-LED device for rapid penetrating inactivation through ice layers.

Associations of exposure to arsenic species and endogenous sex hormones with oral cancer: a hospital-based study in Southeastern China.

The effects of arsenic species and endogenous sex hormones on oral cancer risk, particularly their molecular interactions, have been infrequently reported. This study aimed to assess the individual and combined effects of arsenic species and endogenous sex hormones on oral cancer risk and elucidate the association between hormones, arsenic species, and arsenic metabolism. A case-control study (comprising 144 cases and 144 controls) was conducted from January 2020 to January 2024 in Southeastern China.

Machine learning-based exploration of the associations between multiple minerals' intake and thyroid dysfunction: data from the National Health and Nutrition Examination Survey.

Objectives: The associations between various minerals' intake and thyroid dysfunction (TD), including hyperthyroidism and hypothyroidism, are still inconclusive, which may be attributed to the potential synergistic effects among various minerals.

Methods: The data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2001-2002 and 2007-2012 databases. Dietary interviews were conducted to collect the consumption of multiple minerals.

Analyzing the causal relationship between gut microbiotas, blood metabolites, and COVID-19 susceptibility: A Mendelian randomization study.

Gut microbiota and blood metabolites play crucial roles in the progression and outcomes of COVID-19, but the causal relationships and mechanisms remain unclear. Our aim is to use two-sample Mendelian randomization (MR) to explore the causal relationships between gut microbiota, COVID-19 susceptibility, and potential mediating blood metabolites. We utilized summary statistics from the largest genome-wide association studies (GWAS) to date on gut microbiota (n = 18,340), blood metabolites (n = 115,078), and COVID-19 susceptibility (cases n = 60,176 and controls n = 1310,725 from the COVID-19 Host Genetics Initiative meta-analysis).

Prediction of neoadjuvant chemotherapy efficacy and prognostic biomarker analysis in patients with triple-negative breast cancer.

Background: Neoadjuvant chemotherapy has become a common and effective treatment modality for triple-negative breast cancer (TNBC). The primary goal is to reduce the size of the primary tumor, enabling breast-conserving surgery, axillary preservation, and a transition to operability, thereby providing patients with more therapeutic options. Although neoadjuvant chemotherapy (NAC) has demonstrated favorable outcomes in clinical practice, predicting its efficacy and prognostic value in TNBC remains a key challenge in current clinical research.

Nomogram prediction of the lymph-vascular space invasion in cervical cancer: comparison of 2009 and 2018 staging systems.

Background: Lymph-vascular space invasion (LVSI) is a crucial prognostic factor in cervical cancer (CC), and its assessment is essential for developing personalized treatment strategies.

Objective: The primary objective of this study was to focused on constructing LVSI predictive model based on clinical indicators and evaluating its predictive performance across different FIGO staging cohorts.

Study Design: We included 691 patients, with 348 patients having 2009 FIGO stage IB1-IIA2 CC assigned to Cohort 1, and 343 patients with 2018 FIGO stage IB1-IIIC1r CC assigned to Cohort 2.

, a novel aminoglycoside acetyltransferase gene identified from an animal isolate DW0551.

Background: Bacterial resistance to aminoglycoside antimicrobials is becoming increasingly severe due to their use as commonly prescribed antibiotics. The discovery of new molecular mechanisms of aminoglycoside resistance is critical for the effective treatment of bacterial infections.

Methods: Bacteria in goose feces were isolated by plate streaking.

Head-to-head immunogenicity comparison of one-dose Cecolin and Gardasil in Chinese girls aged 9-14 years: A randomized and open-label clinical trial.

Background: The World Health Organization (WHO) urges global administration of at least one dose of the HPV vaccine, particularly for girls aged 9-14, to work towards the elimination of cervical cancer. However, data on the efficacy of a single dose of Cecolin®, a bivalent HPV vaccine, remain quite limited. Therefore, it is crucial to design studies investigating the protective effects of a single dose of Cecolin® in Chinese girls.

Epidemiological characteristics and spatiotemporal distribution of hepatitis C in southeast coastal areas of China from 2015 to 2022.

Objective: The purpose of this study was to analyze the epidemiological characteristics and spatial-temporal distribution characteristics of hepatitis C in Fujian Province, China, from 2015 to 2022, and to provide reference for the risk identification, early warning and prevention and control measures of hepatitis C in Fujian Province.

Methods: The incidence data of hepatitis C in Fujian Province from 2015 to 2022 were collected from the China Information System for Disease Control and Prevention. Descriptive epidemiology method and JRP 4.

The Global and Regional Burden of Gallbladder and Biliary Tract Cancer and Attributable Risk Factors: Trends and Predictions.

Background: Gallbladder and biliary tract cancer (GBTC) is a serious disease burden. A comprehensive assessment of the disease burden is essential for improving prevention and treatment strategies.

Methods: The estimated annual percentage change, Joinpoint regression analysis and age-period-cohort model (APCM) were used to comprehensively evaluate the current status and trend of GBTC burden from 1990 to 2021 from the Global Burden of Disease Study.

Global burden of prostate cancer: age-period-cohort analysis from 1990 to 2021 and projections until 2040.

Background: Prostate cancer (PCa) is the second most common cancer among men worldwide. This study uses data from the 2021 Global Burden of Disease (GBD) study to estimate the global burden of prostate cancer from 1990 to 2021.

Methods: We analyzed the incidence, mortality, and disability-adjusted life years (DALYs) of prostate cancer globally from 1990 to 2021.

FEN1-assisted LAMP for specific and multiplex detection of pathogens associated with community-acquired pneumonia.

Lower respiratory tract infections (LRITs), including community-acquired pneumonia (CAP), are the fifth leading cause of death worldwide over the last ten years, posing a serious threat to global healthcare. Conventional laboratory assays for detecting pathogens are hindered by complicated procedures, a long turnaround time and a lack of multiplex detection capabilities. In this study, a flap-endonuclease 1 (FEN1)-assisted loop-mediated isothermal amplification (LAMP) method was designed, and an assay based on this method was developed to identify three leading pathogens for CAP, namely, , and .