Molecular mechanism of resveratrol in suppressing lung adenocarcinoma based on network pharmacology and molecular docking.

Resveratrol is a natural polyphenol known for its antioxidant and anti-inflammatory effects, but its role in lung adenocarcinoma (LUAD) remains unclear. Our study integrated network pharmacology, molecular docking, and bioinformatics to investigate the molecular mechanisms by which resveratrol suppresses LUAD through the identification of key targets and pathways. We identified 100 resveratrol-related targets and 50,000 LUAD-related genes from databases, finding 98 overlapping targets.

Sepsis following hysteroscopic removal of retained products of conception: A case report and literature review.

Rationale: Sepsis following hysteroscopy is an rare complication, with current evidence suggesting that routine prophylactic antibiotic administration may not be warranted. However, this does not imply that we should disregard vigilance regarding the potential occurrence of severe infections post-hysteroscopy.

Patient Concerns: A 27-year-old female underwent hysteroscopic resection of retained products of conception after incomplete medical abortion.

Quality characteristics and digestive behavior of seed oils from two Huajiao (Zanthoxylum bungeanum and Zanthoxylum schinifolium).

Huajiao seeds represent an underutilized high-quality woody oilseed resource rich in unsaturated fatty acids and diverse nutritional factors. This study investigated the quality characteristics and digestive behavior of two Huajiao seed oils (Zanthoxylum bungeanum seed oil (ZBSO) and Zanthoxylum schinifolium seed oil (ZSSO)). The results demonstrated that both oils were rich in unsaturated fatty acids, with ZBSO containing 76.

Mechanisms of patulin biodegradation by Wickerhamomyces anomalus XL1 in apple juice.

Patulin (PAT), a mycotoxin primarily produced by Penicillium species, presents a serious food safety challenge due to its widespread occurrence and harmful health effects. Among current detoxification approaches, yeast-based degradation is particularly promising, offering high efficiency, environmental sustainability, and preservation of food quality-key attributes for industrial application. However, the enzymatic pathways involved and the potential for concurrent quality enhancement remain poorly understood.

Superiority of ultrasound-extracted Flammulina velutipes polysaccharides over hot water-extracted ones in mitigating colonic cell pyroptosis: Discoveries into modulation of NLRP3 pathway.

Flammulina velutipes is a major edible fungus with abundant yield and mature industrial production technology. Its main functional component, Flammulina velutipes polysaccharide, has huge development and utilization value. In light of the current uncertainty regarding the mechanisms by which Flammulina velutipes polysaccharides prevent colonic cell pyroptosis, the mechanisms of ultrasound-extracted Flammulina velutipes polysaccharide (FVPU2) in inhibiting colonic cell pyroptosis in mice were investigated, and compared with Flammulina velutipes polysaccharide extracted via hot water extraction (FVPH2).

Biopreservation technology of sourdough co-fermented with Fructilactobacillus sanfranciscensis and Propionibacterium freudenreichii: Effects and mechanisms for enhancing bread quality and extending shelf life.

This study presents a biopreservation method using sourdough co-fermented with Fructilactobacillus sanfranciscensis and Propionibacterium freudenreichii, optimizing conditions to 220 hydration and 24 h fermentation. The composite sourdough bread quality was evaluated through physicochemical, storage, sensory, and microbial tests, with mechanisms analyzed based on microstructure, rheology, and dough structure. Results showed that: first, the composite sourdough enhanced bread physicochemical properties, increasing volume, height-to-diameter ratio, elasticity, and resilience, while reducing baking loss, hardness, chewiness, and adhesiveness.

Dissecting the microbial, physicochemical, and flavor dynamics of core and peel layers in Houhuo Daqu: Insights into quality regulation.

Houhuo Daqu (HHD) exhibits significant heterogeneity between its core and peel layers, yet their differences remain underexplored. This study integrates metagenomic sequencing and electronic sensory technologies to compare the physicochemical properties, microbial communities, and flavor profiles of HHD's core and peel. Results reveal distinct microbial communities and diversity between the layers.

Effects of ultrasonication on the emulsification behavior and nutritional properties of myofibrillar protein-tussah pupa (Antheraea pernyi) protein complexes: A multiscale investigation.

Tussah pupa protein (TPP), rich in diverse bioactive components and demonstrating extensive physiological activities, has attracted attention in food processing. However, its limited emulsion stability restricts application potential, requiring improvement of techno-functional properties. The effects of myofibrillar protein (MP) compounding coupled with ultrasonic treatment on the emulsifying properties and nutritional value of TPP were systematically investigated from a multi-scale perspective in this study.

Efficacy of Ginkgo biloba extract in controlling patulin production by Penicillium expansum in sweet cherries.

Fungal toxin contamination presents significant hazards to agroecosystems and food safety. Penicillium expansum (P. expansum) emerges as a primary threat, damaging sweet cherries through spoilage and generating the hazardous mycotoxin patulin (PAT).

In vitro bioaccessibility of carotenoids in satsuma mandarin juice: Effects of high hydrostatic pressure and it-mediated matrix changes.

In this study, the effects of high hydrostatic pressure (HHP)-mediated alterations in matrix composition on the bioaccessibility of carotenoids in satsuma mandarin juice were assessed. Results showed that the total carotenoid content increased significantly under HHP treatment (300-600 MPa), and the total carotenoids bioaccessibility was optimal at 600 MPa/1 min. The bioaccessibility of carotenoids in satsuma mandarin juice was positively correlated with the contents of titratable acids, total phenols and total sugars, all of which increased significantly after HHP.

The structural characterization, functional properties and interface performance of sesame proteins from different cultivars.

Sesame protein of different cultivars exhibits varying functional characteristics, making it challenging to achieve standardization in industrial applications. Therefore, we aimed to identify more suitable sesame protein for industrial processing. This study characterized the composition, structure, interfacial properties, and functional traits of sesame protein of nine cultivars.

MOF-engineered activated carbon adsorbent enabling semi-selective ethyl carbamate removal in fermented foods.

Fermented foods are valued for their diverse flavor and health benefits, but the formation of ethyl carbamate (EC), a potential carcinogen, during production and storage poses challenges. Current EC reduction methods often compromise flavor and bioactive components. This study exemplifies a novel adsorbent combining activated carbon with metal-organic framework (MOF) chemistry for semi-selective EC removal.

Enhanced freeze-drying efficiency in restructured peach: Multiscale insights into heat and mass transfer mechanisms from experiments and computational simulations.

While restructuring agricultural products enhances heat and mass transfer during freeze-drying, the underlying mechanisms remain poorly understood. This study employed a multiscale approach, combining freezing dynamics, sublimation drying kinetics, X-ray tomography, gas permeability assessments, thermodynamic parameters analysis, and mathematical modeling to systematically investigate the differences in transfer properties between natural and restructured peaches across the freezing and sublimation drying processes. Key results demonstrated that restructuring decreased the freezing time by 21.

Protective effect of osmanthus water extract on liver dysfunction caused by DBP based on organoids and organ chips technologies.

This study aimed to investigate the protective mechanism of Osmanthus fragrans water extract (OSF) against liver injury induced by dibutyl phthalate (DBP). We utilized liver organoids and liver organ chip technology to replicate the liver microenvironment in vivo. Metabolomic analysis revealed that DBP induced oxidative stress and lipid metabolism disorders; however, following intervention with OSF, the associated abnormal metabolites were significantly reduced.

Exploring the potential of egg yolk spheres to stabilize foams by pH shift: Structural, interfacial, and capillary foam effects.

The poor foaming of egg yolks has long plagued the food industry. In this study, four egg yolk spheres (EYS) were prepared via acid- and alkaline pH-shift methods, and the main factors affecting the variation in their foaming capacity were determined. The tertiary structure of EYS under hydrogen bonding and electrostatic interactions unfolded in acidic shifts, exposing many functional groups, and refolded in basic shifts and exposed hydrophobic side chains.

Iodine Enabled Mild 1,3-Hydroxyiodation of Arylcyclopropanes.

1,3-difunctionalized skeletons are important feedstocks and frequently appear in pharmaceuticals. However, effective and straightforward approaches to these scaffolds remain challenging. Herein, we reported a mild and efficient strategy for 1,3-hydroxyiodation, employing molecular iodine as both the promoter and iodinating agent.

Plasticity Mechanisms in Nanostructured Cubic Boron Nitride: Internal Defects and Amorphous Layers.

Nanostructured cubic boron nitride (NS-cBN) has attracted significant attention due to its high hardness and excellent thermal stability, yet a systematic strategy to balance strength and toughness through atomically structural design remains elusive. Here, we integrate plasticity theory with large-scale atomistic simulations to elucidate the size-dependent roles of internal defects, i.e.

LncRNA TP53TG1 promotes the growth and osteo/dentinogenic differentiation of dental pulp stem cells by activating the Smad3 and JNK1/2 pathway.

TP53TG1 is a long non-coding RNA related to the TP53 gene, which plays an important role in various biological processes such as tumorigenesis, cell cycle regulation, and DNA damage repair. In recent years, researchers have begun to explore the role of TP53TG1 in dental pulp biology, especially its potential impact on pulpitis and other pulp-related diseases. However, the role of TP53TG1 in human dental pulp stem cells (hDPSCs) remains unclear.

Association between vitamin K intake and periodontitis in American elderly population: a cross-sectional analysis of NHANES data.

Background: An increasing amount of data has been acquired on the close relationship between Vitamin K intake and the progression of periodontitis. The purpose of this study was to estimate whether Vitamin K intake is associated with periodontitis among older adults in America using information from the National Health and Nutrition Examination Survey (NHANES) database.

Methods: A cross-sectional analysis of data on periodontal indices and vitamin K intake among American adults aged 60 years and older in the 2009-2014 NHANES database was extracted.

Understanding efficiency losses from radiative and nonradiative recombination in CuZnSn(S,Se) solar cells.

The photovoltaic performance of CuZnSn(S,Se) is limited by open-circuit voltage losses (ΔV) in the radiative (ΔV) and non-radiative (ΔV) limits, due to sub-bandgap absorption and deep defects, respectively. Recently, several devices with power conversion efficiencies approaching 15% have been reported, prompting renewed interest in the possibility that the key performance-limiting factors have been addressed. In this work, we analyze the sources of ΔV in these devices and offer directions for future research.

[SMARCA4-deficient uterine sarcoma: a clinicopathological analysis of five cases].

To investigate the clinicopathological features of SMARCA4-deficient uterine sarcoma. Five cases of SMARCA4-deficient uterine sarcoma at the Department of Pathology, the First Affiliated Hospital of Nanjing Medical University from 2018 to 2024 were collected. The morphological and immunohistochemical features were observed and analyzed.

[Clinicopathological features of lymphoepithelioma-like carcinoma with abnormal expression of follicular dendritic cell markers: report of four cases].

To explore the clinical features, histopathological morphology, and differential diagnosis of lymphoepithelioma-like carcinoma with abnormal expression of follicular dendritic cell markers. From 2020 to 2021, 4 cases of lymphoepithelioma-like carcinoma with abnormal expression of follicular dendritic cell markers diagnosed in Fujian Cancer Hospital (2 cases) and the Second Affiliated Hospital of Fujian Medical University (2 cases) were collected. Different ancillary procedures such as HE, special stains, immunohistochemistry, and in situ hybridization techniques were used to assess the histopathological features and immunophenotypes.

Artificial intelligence in wearable biosensing: Enhancing data analysis and decision-making.

The convergence of artificial intelligence (AI) and wearable biosensors is revolutionizing personalized healthcare, enabling continuous monitoring, early detection of health issues, which enhances the efficiency of data processing and real-time decision-making. Multimodal Large Language Models (MLLMs) play a pivotal role in this ecosystem by offering advanced capabilities in analyzing complex health data, understanding nuanced health contexts, and generating tailored health recommendations instantaneously. This study provides insights into how machine learning, deep learning algorithms, and MLLM can work together to facilitate the analysis of physiologic data for real-time monitoring and early warning systems as well as complex decision support mechanisms.

Functionalized Dynamic Membrane for Wastewater Treatment.

Traditional dynamic membranes (DMs) are plagued by membrane fouling and low performance during long-term operation. In recent years, researchers have developed various functionalized dynamic membranes (FDMs) derived from DMs, employing different functional materials to provide an economically viable and promising solution for wastewater treatment. Nevertheless, there remains a gap in the comprehensive understanding of FDMs and the challenges encountered in their application.