Giant two-photon upconversion from 2D exciton in doubly-resonant plasmonic nanocavity.

Photon upconversion through high harmonic generation, multiphoton absorption, Auger recombination and phonon scattering performs a vital role in energy conversion and renormalization. Considering the reduced dielectric screening and enhanced Coulomb interactions, semiconductor monolayers provide a promising platform to explore photon upconversion at room temperature. Additionally, two-photon upconversion was recently demonstrated as an emerging technique to probe the excitonic dark states due to the extraordinary selection rule compared with conventional excitation.

Insufficient telomeric DNA damage response promotes chromosomal instability in aged oocytes.

Increased chromosomal instability impairs oocyte quality, contributing to female reproductive aging. The telomeric DNA damage response (DDR) is essential for genomic stability; however, how oocytes respond to telomeric damage remains elusive. Here, we observed that aged human germinal vesicle (GV) oocytes accumulated telomeric DNA damage.

Profiling of SFTS virus and host protein interactions by affinity purification-mass spectrometry.

Severe Fever with Thrombocytopenia Syndrome (SFTS), caused by the novel phlebovirus SFTSV (SFTS bunyavirus), was first identified in 2009 across several Chinese provinces, with a case fatality rate reaching 30 %. Given its compact genome, SFTSV critically depends on host cellular machinery for replication and pathogenesis. In this study, we employed a systematic strategy combining co-immunoprecipitation of viral-host complexes with formaldehyde crosslinking and affinity purification-mass spectrometry (AP-MS) to comprehensively map SFTSV-host interactions.

Recent Advances in the Isolation, Bioactivity, Biosynthesis, and Total Synthesis of Hamigerans.

Hamigerans, a class of diterpenoid natural products isolated from marine sponge , are characterized by distinctive 6-6-5 or 6-7-5 tricyclic skeletons. These compounds have been a focal point for synthetic chemists in recent years due to their remarkable biological activities. In this Review, we summarize the progress made in the isolation, biosynthesis, bioactivity, and total synthesis of hamigerans, with particular emphasis on synthetic studies published since 2013.

Search for an Anomalous Production of Charged-Current ν_{e} Interactions without Visible Pions across Multiple Kinematic Observables in MicroBooNE.

This Letter presents an investigation of low-energy electron-neutrino interactions in the Fermilab Booster Neutrino Beam by the MicroBooNE experiment, motivated by the excess of electron-neutrino-like events observed by the MiniBooNE experiment. This is the first measurement to use data from all five years of operation of the MicroBooNE experiment, corresponding to an exposure of 1.11×10^{21} protons on target, a 70% increase on past results.

Observation of Three Resonant Structures in the Cross Section of e^{+}e^{-}→π^{+}π^{-}h_{c}.

Using e^{+}e^{-} collision data collected with the BESIII detector operating at the Beijing electron positron collider, the cross section of e^{+}e^{-}→π^{+}π^{-}h_{c} is measured at 59 points with center-of-mass energy sqrt[s] ranging from 4.009 to 4.950 GeV with a total integrated luminosity of 22.

An Activatable and Covalent Tumor-Associated Antigen Capturer Enabling Systemic Injection for Promoted Antitumor Immunity.

Antigen-capturing nanomaterials hold great promise for cancer immunotherapy; however, the need for tumor localized administration and limited antigen-binding affinity remains the "Achilles heel" of this strategy. Herein, we present a tumor microenvironment (TME)-activatable nanoplatform, TDR848@FPB, designed for systemic administration and enhanced covalent capture of tumor-associated antigens (TAAs), enabling effective immunotherapy with minimal off-target effects and independent of localized tumor administration. This platform encapsulates a photosensitizer-conjugated, light-activated toll-like receptor (TLR) agonist, which induces immunogenic cell death and triggers a pro-inflammatory TME conducive to antigen capture upon light irradiation.

Robust Antifogging and Antifouling Coating Tailored with Zwitterionic Nanocellulose for Multi-Functional Applications.

Biofouling often occurs simultaneously with fogging, presenting significant challenges to visibility, safety, and operational efficiency. The development of biocompatible coatings that offer both antifouling performance and stability under fogging conditions is highly sought after. A method to form multifunctional coatings is presented, utilizing a zwitterionic nanocellulose composite material that demonstrates both antifogging and antifouling properties, suitable for application on various surfaces.

The Natural Product Osthole, Known for Its Insecticidal and Antimicrobial Properties, Potentially Binds to Amidase, Offering a Novel Approach for Controlling Tomatoes Gray Mold for the First Time.

Osthole exhibits strong inhibitory activity against phytopathogenic fungi; however, its antifungal mechanism remains unclear. This study assessed osthole's inhibitory effects on several phytopathogenic fungi, revealing a half-maximal effective concentration of 70.03 μg/ml against the hyphal growth of .

Flexible photonic contactless human-machine interface based on visible-blind near-infrared organic photodetectors.

Contactless human-machine interfaces (C-HMIs) are revolutionizing artificial intelligence (AI)-driven domains, yet face application limitations due to narrow sensing ranges, environmental fragility, and structural rigidity. To address these obstacles, we developed a flexible photonic C-HMI (Flex-PCI) using flexible visible-blind near-infrared organic photodetectors. In addition to its unprecedented performance across key metrics, including broad detection range (0.

Correction: Clinical efficacy of non-pharmacological treatment of functional constipation: a systematic review and network meta-analysis.

[This corrects the article DOI: 10.3389/fcimb.2025.

S-LaMoO solid solution: a sulfur cathode with a non-shaped matrix enables a better lithium-sulfur battery.

A prefabricated matrix is normally used as the cathode host for lithium-sulfur batteries to address the shuttle effect problem. Unconventionally, herein we present a non-shaped matrix for a sulfur cathode that enables a better lithium-sulfur battery. The fast oxide-ion conductor LaMoO is introduced into the sulfur cathodes for the first time.

Visible Light-Driven Membrane-Bound Compartment for Precise Regulation of Enzyme Activity.

Photo-responsive systems provide a powerful tool to reversibly regulate enzyme activity. However, inhibitor-based strategies, though widely used, are often restricted to specific enzymes. Noninhibitor strategies, such as enzyme surface modification or genetic mutation, often compromise structural integrity or residual activity.

CT-based Radiomics of Intratumoral and Peritumoral Regions to Predict the Recurrence Risk in Patients with Non-muscle-invasive Bladder Cancer within Two Years after TURBT.

Background: Predicting the recurrence risk of NMIBC after TURBT is crucial for individualized clinical treatment.

Objective: The objective of this study is to evaluate the ability of radiomic feature analysis of intratumoral and peritumoral regions based on computed tomography (CT) imaging to predict recurrence in non-muscle-invasive bladder cancer (NMIBC) patients who underwent transurethral resection of bladder tumor (TURBT).

Methods: A total of 233 patients with NMIBC who underwent TURBT were retrospectively analyzed.

The X-Age Project to construct a Chinese aging clock.

The global surge in the population of people 60 years and older, including that in China, challenges healthcare systems with rising age-related diseases. To address this demographic change, the Aging Biomarker Consortium (ABC) has launched the X-Age Project to develop a comprehensive aging evaluation system tailored to the Chinese population. Our goal is to identify robust biomarkers and construct composite aging clocks that capture biological age, defined as an individual's physiological and molecular state, across diverse Chinese cohorts.

Sweat-amplified dermal transfer and combined toxicity of per- and polyfluoroalkyl substances and organophosphate esters mixtures in children's textiles.

The widespread application of chemical additives in textiles raises concerns about dermal exposure, especially in children. We analyzed 28 per- and polyfluoroalkyl substances (PFAS) and 9 organophosphate esters (OPEs) in household textiles and children's garments. PFAS were detected in 87.

IRF7 drives resistance to oncolytic virotherapy by restricting viral replication and suppressing antitumor immunity.

Oncolytic viruses (OVs) represent a promising approach for cancer immunotherapy by inducing direct tumor lysis and stimulating antitumor immunity. However, tumor-intrinsic resistance remains a major barrier to their efficacy. In this study, we established an OV-resistant MC38 colon cancer model (MC38) and identified interferon regulatory factor 7 (IRF7), a key regulator of type I interferon signaling, as significantly upregulated in resistant cells.

Silicate Enhances the Long-Term Dechlorination Performance of Sulfidized Zero-Valent Iron: Trade-Off between Passivation and In Situ Oxidation.

Sulfidized zero-valent iron (S-ZVI) holds promise in the remediation of chlorinated hydrocarbons. However, S-ZVI is susceptible to corrosion in aquifers with elevated dissolved oxygen (DO) levels. This study demonstrates, for the first time, that a trade-off between the passivation and oxidative corrosion of aged S-ZVI can be achieved in the presence of silicate to promote its dechlorination performance on trichloroethylene.

Structure Engineering Enabled O-O Radical Coupling in Spinel Oxides for Enhanced Oxygen Evolution Reaction.

Developing cost-effective spinel oxide catalysts with both high oxygen evolution reaction (OER) activity and stability is crucial for advancing sustainable clean energy conversion. However, practical applications are often hindered by the activity limitations inherent in the adsorbate evolution mechanism (AEM) and the stability limitations associated with the lattice oxygen mechanism (LOM). Herein, we demonstrate structural changes induced by phase transformation in CoMn spinel oxides, which yield more active octahedral sites with shortened intersite distance.

Taxonomy, phylogeny, and biogeography of the Oriental subfamily Perittopinae China & Usinger, 1949 (Hemiptera: Heteroptera: Veliidae).

The collision of the Indian and Eurasian plates during the Eocene represents a major tectonic shift that significantly altered biotic dynamics and promoted species diversification across the Oriental region. To explain the diversification of taxa from the Indian subcontinent into Southeast Asia, two principal hypotheses have been proposed: the "Biotic-ferry" and "Step-stone" models. The subfamily Perittopinae, a lineage of semi-aquatic bugs comprising a single genus and 20 extant species, provides an ideal system for testing these hypotheses due to its disjunct distribution spanning the Indian subcontinent and Southeast Asia.

Investigation of the Endometrial Microbiome in Recurrent Pregnancy Loss Individuals: Microbial Imbalance and Network Fragility.

Purpose: Emerging evidence suggests that an abnormal endometrial microbiota may be a potential factor contributing to recurrent pregnancy loss (RPL). This study aimed to characterize the endometrial microbiota in patients with RPL and to explore its association with miscarriage.

Patients And Methods: Based on specific inclusion and exclusion criteria, EndoMetrial Microbiome Assay (EMMA) data from women attending clinics were collected and categorized into RPL and control groups according to their miscarriage history.

Leveraging artificial intelligence and antibiotic data to facilitate the design of novel fungicides.

Background: Rapid advances in generative artificial intelligence (AI) are accelerating the process of pesticide development. However, transfer learning-based de novo design focuses on generating molecules that are highly similar to existing inhibitors, which may limit the exploration of novel scaffolds and thereby constrain innovative breakthroughs in pesticide development.

Results: This study proposes a new strategy for fungicide design using antibiotics.

In vivo quantitative assessment of atherosclerotic plaque: A validation study on the optical coherence tomography-derived index of plaque attenuation.

Growing evidence indicates that coronary plaque instability is an independent risk factor for adverse coronary events, yet current optical coherence tomography (OCT) assessment of high-risk plaque characteristics (HRPC) relies largely on qualitative interpretation. The index of plaque attenuation (IPA) is a quantitative OCT-based metric that may provide a more objective evaluation. This retrospective observational diagnostic accuracy study assessed the performance of OCT-derived IPA for HRPC detection in patients with acute coronary syndrome or stable angina, using expert consensus qualitative OCT analysis as the reference standard.

A Diselenide-Based Triple-Responsive Nanogel for Tumor Chemo-Photoimmunotherapy.

In this study, we successfully developed a diselenide-based, triple-responsive intelligent nanogel, IR780@BEAP, for lung cancer therapy. Exploiting the elevated levels of reactive oxygen species (ROS) and glutathione (GSH) in the tumor microenvironment (TME), a ROS/GSH dual-responsive diselenide cross-linker (DSe5) was synthesized and used to cross-link betulin (BE) with polysaccharide (AP) while coloading the photosensitizer IR780. The resulting nanogel, IR780@BEAP, exhibited an appropriate particle size (137.

Enhanced Giant Ferroelectric Tunneling Electroresistance in 2D Ruddlesden-Popper Oxides.

Ferroelectric tunnel junctions (FTJs) based on ferroelectric switching and quantum tunneling effects with thickness down to a few unit cells have been explored for applications of two-dimensional (2D) electronic devices in data storage and neural networks. As a key performance indicator, the enhanced tunneling electrosistance (TER) ratio provides a broader dynamic range for precise modulation of synaptic weights, improving the stability and accuracy of neural networks. Herein, we report an observation of pronounced enhancement in the TER ratio by over 4 orders of magnitude through the fabrication of large-scale heterostructures combining bismuth ferrite with two-dimensional Ruddlesden-Popper oxide BiFeO.