Multifunctional applications of hydrogel materials in myocardial infarction treatment: from tissue repair to microenvironment regulation.

Myocardial infarction (MI) is one of the leading causes of heart failure and death worldwide. While conventional treatments have limitations in promoting myocardial repair and regeneration, hydrogel, as a multifunctional biomaterial, shows great potential in MI treatment due to its unique physicochemical properties and biocompatibility. This paper reviews the multifunctional applications of hydrogels in MI therapeutics, including drug delivery (miRNAs, exosomes, ), electrical conduction, immunomodulation, detection, tissue engineering, and microfluidic functions.

Serum Pepsinogen as a Biomarker of Gastrointestinal Stromal Tumors (GIST) in Stomach.

Background: Gastric GISTs (GG) are significant mesenchymal tumors. No biomarker has been identified for GG detection. We first observed mucosal atrophy surrounding GG tumors, leading to the hypothesis that localized atrophy may alter serum pepsinogen (PG) levels.

FAM49B mediates tumor progression and poor prognosis of gastric cancer through activating PI3K/AKT pathway.

Gastric cancer is a common malignancy worldwide. It has been shown that the actin cytoskeleton modulator family with sequence similarity 49 member B (FAM49B) is involved in the initiation and spread of malignancies. However, the role of FAM49B is still unknown in gastric cancer.

A Resource for Exploring Regional Diversity in the Male Rat Brain Synaptic Proteome.

The functional complexity of the mammalian brain is rooted in the diverse protein composition of synapses across distinct regions. To address the need for a detailed molecular understanding of this regional diversity, we generated the first comprehensive proteomic map of synaptosomes from six key rat brain regions: anterior cortex, posterior cortex, hippocampus, striatum, olfactory bulb, and cerebellum. Using high-resolution quantitative proteome and the Percoll density gradient ultracentrifugation, we identified 3,440 proteins and yielded high synaptic enrichment (60.

Stress hyperglycemia ratio and incident hypertension in chinese middle-aged and older adults: mediating roles of lipids in a prospective cohort.

Background: Although dysglycemia and dyslipidemia contribute to hypertension, the role of stress hyperglycemia ratio (SHR), a dynamic glycemic marker, and its interaction with lipids remain unclear. Currently, the independent and synergistic effects of these factors on hypertension in older adults have not been fully elucidated in a large cohort. This study investigated the SHR-lipid interplay and quantified the mediating pathways, addressing a critical gap in understanding the metabolic drivers of hypertension.

Causal Relationship Between Matrix Metalloproteinase and Cervical Lesions: A Two-Sample Mendelian Randomization Analysis.

Purpose: This study aimed to investigate the causal relationship between matrix metalloproteinases (MMPs) and cervical lesions, as their correlation remains unclear despite reports of their involvement in the pathogenesis of these lesions.

Patients And Methods: A two-sample Mendelian randomization (MR) analysis was performed using genome-wide association studies (GWAS) summary data to assess the causal associations of MMPs (MMP-1, 2, 3, 7, 9, 10, 12, 14, 16, and 17) with cervical lesions. The primary analysis utilized the inverse-variance weighted (IVW) method, supplemented by weighted median, mode, and MR-Egger regression.

Nomogram-based risk stratification to analyze the value of receiving postoperative adjuvant therapy after neoadjuvant immunochemotherapy for patients with locally advanced esophageal squamous carcinoma.

Purpose: To develop a prognosis nomogram for locally advanced esophageal squamous cell carcinoma (LA-ESCC) patients after neoadjuvant immunochemotherapy (NICT) and assess postoperative adjuvant therapy (PAT) value through survival risk stratification.

Methods: We retrospectively analyzed 297 LA-ESCC patients (2019-2023) receiving NICT with or without PAT, randomly divided into the training and validation cohorts. Independent prognostic factors were determined by Least Absolute Shrinkage and Selection Operator (Lasso) regression and multivariate Cox analysis.

Diagnostic value of serum TSI levels in Graves' disease and direct comparison of diagnostic performance with TRAb: A systematic review and meta-analysis.

This study aimed to systematically assess the diagnostic value of thyroid-stimulating immunoglobulin on the Siemens Immulite platform (the TSI assay) and to conduct a direct comparison with thyrotropin receptor antibodies on the Roche cobas platform (the TRAb assay) for the diagnosis of Graves' disease (GD). We performed systematic literature searches across multiple databases. Following strict screening, we identified 20 eligible clinical studies that evaluated the diagnostic value of the TSI assay, either alone or in comparison with the TRAb assay.

Case Report: A Chinese family with MYH9-RD caused by p.E1841K mutation exhibiting widespread may-hegglin inclusions.

Introduction: MYH9-related disease (MYH9-RD) is a rare autosomal dominant genetic syndrome characterized by congenital thrombocytopenia, with a risk of developing progressive nephropathy, sensorineural deafness, and presenile cataract. Due to its presentation of isolated thrombocytopenia, it is frequently misdiagnosed as immune thrombocytopenic purpura (ITP).

Methods: A 10-year-old girl with an initial diagnosis of ITP was evaluated, based on isolated thrombocytopenia and intermittent epistaxis.

Aberrant highly prokineticin 2 and its association with inflammatory indexes and functional recovery in acute ischemic stroke patients.

Background: Prokineticin 2 is associated with the macrophages-mediated biological process, neuronal death, oxidative stress, and inflammatory processes, while its clinical value in patients with acute ischemic stroke (AIS) has not been explored. This study aimed to evaluate the level of prokineticin 2 and its association with inflammatory indexes and functional recovery in AIS patients.

Methods: Serum samples in 210 AIS patients at admission and in 30 healthy subjects at enrollment were collected.

Clinical Characteristics of Auditory Mismatch Negativity in Patients with Chronic Disorders of Consciousness Following Intracerebral Haemorrhage: A Prognostic Prediction Study.

Objective: To examine the clinical features of auditory mismatch negativity (MMN) and its potential utility in prognostic prediction in patients with chronic disorders of consciousness (DOC) following intracerebral haemorrhage (ICH).

Methods: Between September 2023 and July 2024, 24 patients with chronic DOC following ICH were recruited. The Coma Recovery Scale-Revised (CRS-R) was used to assess the patients' level of consciousness, dividing them into vegetative state, minimally conscious state and escaped minimally conscious state groups.

Efficacy and safety of bevacizumab biosimilar SIBP04 compared with bevacizumab (Avastin®) as first-line treatment for locally advanced or metastatic non-squamous non-small-cell lung cancer: A randomized, double-blind, phase 3 trial.

Background: SIBP04 is a biosimilar of bevacizumab (Avastin®, Roche, Basel, Switzerland). This study evaluated the equivalence of SIBP04 to Avastin® as first-line treatment for locally advanced or metastatic non-squamous non-small-cell lung cancer (nsqNSCLC).

Methods: In this randomized, double-blind, multi-center, phase 3 trial, we recruited patients with locally advanced or metastatic nsqNSCLC from 58 hospitals at China.

Neonicotinoid pesticides: residue detection and dietary risk assessment in commercially available plant-based agricultural products in North China.

Neonicotinoid pesticides were detected, and dietary risk assessment was performed in commercially available vegetables and fruits in North China from 2021 to 2024. A modified QuEChERs (quick, easy, cheap, effective, rugged, and safe) pretreatment method combined with UPLC-MS/MS (ultra-high-performance liquid chromatography triple quadrupole mass spectrometry) was applied to the detection. The validation and evaluation of the method were performed in terms of matrix effect, recovery (75.

m6A Methylation-Induced Autophagy Impairment by TFEB Regulation in SOD1-G93A ALS Cell Model.

We investigate the role of m6A RNA methylation in regulating transcription factor EB (TFEB) and its contribution to mitochondrial autophagy (mitophagy) dysfunction in amyotrophic lateral sclerosis (ALS). ALS cell models were used to analyse mitophagy markers and TFEB expression under METTL3 and TFEB modulation, using RT-qPCR, Western blot, MeRIP, RIP, and immunofluorescence. Elevated m6A methylation and reduced TFEB expression were observed in hSOD1-G93A models.

Predictive model for CRT risk in cancer patients with central venous access devices: a systematic review and meta-analysis.

Introduction: With the high incidence of central venous access device catheter-related thrombosis (CRT) in patients with cancer, its early onset, and the characteristics of clinically insignificant symptoms, risk assessment is essential for the targeted application of thromboprophylaxis. The aim of this paper was to review the risk prediction models developed for central venous access device CRT in patients with cancer and to evaluate their performance.

Methods: PubMed, Embase, Web of Science, Cochrane Library, CNKI, SinoMed, Wanfang Data, and VIP databases were searched, and the search timeframes ranged from the establishment of the database to May 22, 2024.

Hospital type and clinical outcomes in peritoneal dialysis: Findings from the PDTAP study.

BackgroundThere are inequalities in resource allocation and services across peritoneal dialysis (PD) centers in China. This study aimed to explore the association between hospital type (university-affiliated vs. non-university-affiliated hospitals) and clinical outcomes in PD patients.

Inhibition of EZH2 by SHR2554 modifies subset ratios and suppresses polyfunctional responses of peripheral blood T cells from hematopoietic stem cell donors.

T cells play pivotal roles in orchestrating immune responses after allogeneic hematopoietic stem cell transplantation. Donor T cells facilitate the reconstitution of the recipient's immune system and Enhancer of Zeste Homolog 2 (EZH2) is crucial for T-cell differentiation and plasticity. Inhibitors of EZH2 may protect patients undergoing allogeneic stem cell transplantation from developing graft-versus-host disease without compromising the beneficial graft-versus-leukemia effect.

Unraveling the role of HIF2α in melanoma progression and epithelial-mesenchymal transition.

Melanoma is a highly heterogeneous and aggressive malignancy. Hypoxia within the tumor microenvironment is closely associated with tumor progression. However, the role of hypoxia-inducible factor 2α (HIF2α), a key transcription factor, in melanoma remains poorly understood.

Fisetin Ameliorates Vascular Calcification by Regulating HNRNPA1-Mediated Ferroptosis.

Background: Fisetin has shown anti-inflammation, antioxidation, and antitumor effects, which could repress ferroptosis-related oxidative stress to attenuate the atherosclerotic progression. The current study aimed to further investigate the effect of fisetin on vascular calcification and its interaction with ferroptosis during the process.

Methods: Aortic smooth muscle cell (ASMC) was induced by high phosphate (HP) to mimic vascular calcification cellular model.

An evidence map of clinical practice guideline recommendations and quality of non-pharmaceutical interventions for post-stroke emotional disorders.

Background: Clinical practice guidelines (CPGs) have an indispensable role in guiding the selection of various non-pharmaceutical interventions (NPIs) for post-stroke emotional disorders (PSED). However, little is known about their quality and recommendations. This study aims to critically appraise the quality of existing NPIs for PSED CPGs and extract relevant recommendations, present the research distribution of various NPIs in an evidence map, and assist clinicians in making decisions.

Cancer disrupts sex hormone-inflammation relationships: Analysis of ALI in males from NHANES 2007-2018.

Background: To investigate the correlation between sex hormone levels and Advanced Lung Cancer Inflammation Index (ALI) in male cancer populations, and compare with non-cancer male populations, in order to elucidate the potential regulatory role of sex hormones in cancer-related inflammation.

Methods: We analyzed data from NHANES 2007-2018, including 11,280 males (1,135 cancer patients, 10,145 non-cancer controls). Serum testosterone and estradiol were measured using ID-LC-MS/MS.

Association of air pollutants exposure and increased risk of peritoneal dialysis-related peritonitis: An observational study from PDTAP cohort.

IntroductionAlthough the impact of air pollutants on infectious diseases is well-known, there is limited evidence regarding its effects on peritoneal dialysis (PD) patients. This study aimed to investigate the association between air pollutants and PD-related peritonitis.MethodsThis is an observational study affiliated to the PD Telemedicine-assisted Platform Cohort Study (PDTAP study), which is a national-level cohort study in China.

Diagnostic methods for pancreatic cancer and their clinical applications (Review).

Pancreatic cancer (PC) is often considered one of the most aggressive and deadly types of cancer, distinguished by its swift advancement and unfavorable prognosis. This reality highlights the vital necessity for early detection to improve patient survival rates. In recent years, notable advancements in medical technology have catalyzed the development of various diagnostic approaches, including imaging modalities, tumor markers, tissue biopsy, liquid biopsy, volatile organic compounds and nanomaterials.

Proteomics profiling reveals the potential targets of Apatinib inhibiting the proliferation of glioma U251 cell.

Glioblastoma multiforme (GBM) is an intracranial malignant tumor that seriously threatens human life. Recently, studies have reported that solid glioma can be effectively treated with Apatinib by inhibiting vascular endothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase from affecting the formation of new blood vessels. However, whether Apatinib can inhibit the proliferation of glioma cells by affecting potential targets beyond angiogenesis in glioma remains unclear.