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Article Abstract
The functional complexity of the mammalian brain is rooted in the diverse protein composition of synapses across distinct regions. To address the need for a detailed molecular understanding of this regional diversity, we generated the first comprehensive proteomic map of synaptosomes from six key rat brain regions: anterior cortex, posterior cortex, hippocampus, striatum, olfactory bulb, and cerebellum. Using high-resolution quantitative proteome and the Percoll density gradient ultracentrifugation, we identified 3,440 proteins and yielded high synaptic enrichment (60.11% synapse-unique proteins). In-depth functional analysis using the SynGO database revealed region-specific enrichments in the cellular components and biological processes. This study provides a valuable resource and foundational insights into the molecular architecture underlying regional synaptic diversity, paving the way for future investigations into brain function and neurological disorders.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12391371 | PMC |
| http://dx.doi.org/10.1038/s41597-025-05873-1 | DOI Listing |
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