Impact of crisis intervention on mental health in the context of specific civilian emergencies.

Background: The implementation of crisis response strategies, such as natural hazards, pandemics, and conflicts, is necessary during times of emergency. Despite the importance of these interventions, mental health outcomes in emergency situations remain poorly understood. There is a lack of research on the comparative effectiveness of different interventions.

Impact of combined ginsenoside-MC1 and irisin on mitochondrial apoptosis in diabetic rats with hepatic reperfusion injury: Role of AMPK/JNK signalling.

Hepatic ischaemia-reperfusion (IR) injury is a serious clinical issue, especially in patients with type 2 diabetes mellitus (T2DM). As mitochondria play a critical role in the regulation of IR-induced liver damage, mitochondria-targeted treatment is of the utmost significance for improving outcomes. The present study explored the mitoprotective role of combined ginsenoside-MC1 (GMC1) and irisin administration in diabetic rats with hepatic IR injury.

Experimental study on axial compression performance of I-shaped aluminum concrete columns embedded in CFRP-PVC square tubes.

To investigate the axial compressive behavior of CFRP-PVC square tube-embedded aluminum concrete columns, five specimens and one control specimen without I-shaped aluminum were tested under uniaxial compression, with the number of CFRP layers and spacing as variable parameters. The failure modes, load-displacement responses, and mechanical properties such as peak load, ductility, stiffness, and energy dissipation were systematically analyzed. Results showed that the incorporation of I-shaped aluminum improved the peak load and ductility by an average of 48.

In vitro characterization of Trichophyton rubrum biofilm by combined anti-biofilm enzymes.

Trichophyton rubrum, a dermatophyte, demonstrates a notable ability to form mature biofilms on skin and associated surfaces, strengthening its resistance to antifungal agents. This characteristic poses intricate challenges in dermatological research and therapeutic strategies, underscoring the need for innovative approaches to effectively manage fungal infections. This work assessed the impact of the anti-biofilm enzymes, i.

Integrating population-level and cell-based signatures for drug repositioning.

Motivation: Drug repositioning presents a streamlined and cost-efficient way to expand the range of therapeutic possibilities. Drugs with human genetic evidence are more likely to advance successfully through clinical trials towards FDA approval. Single gene-based drug repositioning methods have been implemented, but approaches leveraging a broad spectrum of molecular signatures remain underexplored.

Slotting blasting model experiment and PCA-PNN evaluation model of influencing factors of slitting effect.

Numerous parameters influence the slotting performance of slotted cartridge, to facilitate rapid, efficient, and accurate predictions of the slitting performance, statistical analysis of PMMA blasting experiments with six different slitted cartridge parameters yielded 12 evaluation indicators. Subsequently, a principal component analysis (PCA) method was introduced to reduce the dimensionality of the data associated with these indicators, and three new comprehensive indicators were extracted for a comprehensive assessment of the slotting performance. The PCA scores ranked the influence of the six slotted cartridge parameters on slotting performance as follows: decoupling coefficient, slotting width, slotting angle, slotting tube thickness, slotting tube material, and charge amount.

Moral Judgment Under Induced Anxiety: Threat-of-Shock Reduces Sensitivity to Immoral Acts and Alters Neural Processing.

This study investigates how anxiety influences moral judgment processes using event-related potential (ERP) techniques. Participants were instructed to rate their feelings towards other's moral and immoral acts while neural responses were recorded under safe and threat-of-shock (TOS) conditions. Participants reported significantly higher anxiety levels in the TOS context, accompanied by increased non-specific skin conductance responses (NSSCR), indicating heightened autonomic nervous system activity.

Self-activating air filtration device for aerosol control during luminal instruments drying in the sterile processing department.

Background: Luminal instruments are characterized by their slender internal lumens, which make them particularly challenging to clean and dry. A common drying method used by Sterile Processing Department (SPD) technicians involves blowing high-pressure air into one end of the lumen to expel moisture. However, this process generates a significant amount of aerosols that may contain bacteria, viruses, and other microorganisms.

Atom-precise coinage metal nanoclusters for near-infrared emission: excited-state dynamics and mechanisms.

Understanding the excited-state dynamics of atomically precise coinage metal nanoclusters (CMNCs) is pivotal for elucidating their photoluminescence (PL) mechanisms and rationally tuning emission properties-particularly in the near-infrared (NIR) region, where CMNC-based nanomaterials have tremendous potential for biomedical and optoelectronic applications. This review presents a systematic and comprehensive account of recent advances in investigating the excited-state dynamics and PL mechanisms of NIR-emitting CMNCs with atomic precision, leveraging the synergistic integration of time-resolved spectroscopy and time-dependent density functional theory (TD-DFT) calculations. Distinct from previous reviews that offer a broad survey of CMNC properties, the present review focuses specifically on intrinsic factors, highlighting molecular vibrational features and electronic structure modulation as key determinants of NIR emission.

Characterization of strontium-rich groundwater in a typical alpine basin on Tibetan Plateau: Implications for sustainable exploitation and development.

This study focuses on mineral groundwater in alpine regions and its sustainable exploitation. The Tongde basin on Tibetan Plateau was investigated to reveal the hydrochemistry and formation of mineral groundwater in alpine basins and its sustainable development under anthropogenic disturbances. The results show that groundwater there is characterized by enriched strontium, with concentrations in the range of 0.

Optimization design of interior space based on the two-stage deep learning network and Single sample-driven method.

This study addresses the limitations of traditional interior space design, particularly the timeliness and uniqueness of solutions, by proposing an optimized design framework that integrates a two-stage deep learning network with a single-sample-driven mechanism. In the first stage, the framework employs a Transformer network to extract multi-dimensional features (such as spatial layout, color distribution, furniture style, etc.) from input space images, generating an initial feature vector.

YOLOv11-WBD: A wavelet-bidirectional network with dilated perception for robust metal surface defect detection.

In the field of quality control, metal surface defect detection is an important yet challenging task. Although YOLO models perform well in most object detection scenarios, metal surface images under operational conditions often exhibit coexisting high-frequency noise components and spectral aliasing background textures, and defect targets typically exhibit characteristics such as small scale, weak contrast, and multi-class coexistence, posing challenges for automatic defect detection systems. To address this, we introduce concepts including wavelet decomposition, cross-attention, and U-shaped dilated convolution into the YOLO framework, proposing the YOLOv11-WBD model to enhance feature representation capability and semantic mining effectiveness.

Global, regional, and national burdens of five main digestive system cancers in adolescents and young adults from 1990 to 2021 based on the Global Burden of Disease Study 2021: A cross-sectional study.

Objective: To evaluate the burden and trends of digestive system cancers in adolescents and young adults (AYAs) globally between 1990 and 2021.

Methods: Data were extracted from the Global Burden of Diseases, Injuries, and Risk Factors Study (1990-2021). We analyzed global, regional, and national disease burdens by calculating the age-standardized incidence (ASIR), mortality (ASMR), and disability-adjusted life years (DALYs) for AYAs.

Prevalence and patterns of multimorbidity among adults in rural Shanxi Province, China: A post-hoc exploratory subgroup analysis of a cross-sectional study.

Background: In China, the prevalence of chronic diseases is increasing, especially in rural areas, affecting younger populations and associating with multimorbidity. However, in resources-limited rural areas, there is a lack of primary data to the prevalence and patterns of multimorbidity in young populations. This study aims to analysis the differences in multimorbidity prevalence and patterns across different age groups and genders among adults in rural Shanxi Province.

HLX and SLC25A20: Immunologic regulators bridging ankylosing spondylitis and uveitis via multi-omics integration and machine learning.

Background: Ankylosing spondylitis (AS), a chronic inflammatory disorder affecting axial joints, is frequently complicated by uveitis. However, the molecular mechanisms linking AS to secondary uveitis remain poorly understood.

Methods: We integrated transcriptomic datasets from AS (GSE73754) and uveitis (GSE194060) cohorts to identify shared molecular pathways.

Relationship between the blood urea nitrogen to serum albumin ratio and in-hospital mortality in patients with type 2 diabetes mellitus complicated with ischemic stroke.

Background: Type 2 diabetes mellitus (T2DM) complicated with ischemic stroke is a major challenge to global public health and is related to poor prognosis. However, the role of blood urea nitrogen(BUN)to serum albumin ratio (BAR) in predicting in-hospital mortality of T2DM patients with ischemic stroke has not been fully explored. This study was carried out to investigate the relationship between BAR level and in-hospital mortality of T2DM patients with ischemic stroke.

Nano-Chinese herbal medicines and their delivery strategies for central nervous system disease therapy.

Central nervous system (CNS) diseases, including neurodegenerative diseases, stroke, brain tumors, and others, result in poor quality of life and can cause substantial disability. Not all CNS diseases are amenable to surgical approaches, so drug development is important for disease treatment. Unfortunately, there are few drugs currently available for CNS diseases.

Global disease burden of inflammatory bowel disease in women and women of childbearing age from 1990 to 2021 and its prediction to 2040.

Objective: The incidence of inflammatory bowel disease (IBD) peaks between the ages of 15 and 40. This age range coincides with women of childbearing age (WCBA), who face unique challenges like adverse pregnancy outcomes and heightened anxiety. Despite the rising global prevalence of IBD, particularly among younger populations, the burden of IBD among women, especially WCBA, remains underexplored.

CK2 derived from brain microvascular endothelial cells induces astrocyte inflammatory response in Escherichia coli-induced meningitis.

Neuroinflammation within the central nervous system (CNS) is recognized as a critical pathological process in meningitic Escherichia coli (E. coli) infection, leading to severe neurodegenerative disorders and long-term sequelae. Astrocyte reactivity plays a pivotal role in driving the neuroinflammatory cascade in response to pathological stimuli from peripheral sources or other cellular components of the CNS.

InterVelo: A Mutually Enhancing Model for Estimating Pseudotime and RNA Velocity in Multi-Omic Single-Cell Data.

Motivation: RNA velocity has become a powerful tool for uncovering transcriptional dynamics in snapshot single-cell data. However, current RNA velocity approaches often assume constant transcriptional rates and treat genes independently with gene-specific times, which may introduce biases and deviate from biological realities. Here, we present InterVelo, a novel deep learning framework that simultaneously learns cellular pseudotime and RNA velocity.

Two-dimensional 1T-phase MnIrO for high-performance acidic oxygen evolution reaction.

Proton exchange membrane water electrolysis (PEMWE) is regarded as the most promising technique for the sustainable production of green hydrogen due to its multiple advantages such as high working current density and high hydrogen purity. However, the anodic oxygen evolution reaction (OER) has a significant impact on the overall efficiency of the electrolytic water reaction due to its sluggish kinetics, which has prompted the search for catalysts possessing both high activity and durability. Iridium oxide exhibits excellent stability under acidic conditions but has poor catalytic activity, leading to its inability to meet the strict requirements of large-scale industrial applications.

Radiotherapy-Related Bladder Fistula: A Hidden Cause of Recurrent Abdominal Symptoms.

BACKGROUND Non-traumatic bladder rupture, a rare yet potentially life-threatening condition, can stem from diverse factors such as malignancies, bladder inflammation, or bladder diverticulum rupture. Pelvic radiotherapy, in extremely rare instances, can lead to radiation cystitis and subsequent bladder fistula formation. Patients with such conditions often present with abdominal pain, hematuria, oliguria, and urinary ascites.

Expression and Genetic Polymorphisms of CXCR5 Are Associated with Postoperative Incisional Pain in Patients Undergoing Laparoscopic Cholecystectomy.

This study aimed to identify the biomarkers that was associated with the postoperative incisional pain in patients with acute cholecystitis undergoing laparoscopic cholecystectomy surgery (ACC-LC). Sixty ACC-LC patients were enrolled and divided into mild pain (MP) and moderate-to-severe pain (MSP) groups based on their visual analog scale (VAS) scores 24 hours postoperatively. RNA sequencing was used to screen the potential pain associated markers, and ELISA were used to analyze the expression of one identified marker, CXCR5 in peripheral blood mononuclear cells (PBMCs).