Beta blockers linked to reduced 1-Year mortality in critically ill congestive heart failure patients with differential benefits across subgroups.

The efficacy of beta (β) blockers in critically ill patients with congestive heart failure (CHF) remains uncertain. This study investigated the association of β blockers use with 1-year all-cause mortality in these patients. Utilizing a retrospective cohort, the Medical Information Mart in Intensive Care-Ⅳ database, we identified critically ill CHF patients between 2008 and 2022.

SIRT1 Modulates the Photodynamic Anticancer Activity of 5,10,15-Triethoxycarbonyl P(V) Corrole in Hepatocellular Carcinoma.

: Hepatocellular carcinoma (HCC) remains a global health challenge with limited therapeutic efficacy. Photodynamic therapy (PDT) using 5,10,15-triethoxycarbonyl P(V) corrole () shows promise, but its molecular mechanisms and regulatory factors, particularly the role of SIRT1, are poorly understood. : The effects of combined with red light irradiation (625 nm) on HCC cells (HepG2, PLC/PRF5, MHCC97H) were evaluated via MTT, clonogenic assays, flow cytometry (apoptosis, mitochondrial membrane potential, ROS), and Western blotting (p53, Bax, Bcl-2, cleaved caspase-3, SIRT1).

Study on the Influence Mechanism of Alkaline Earth Element Doping on the Thermoelectric Properties of ZnO.

As a promising n-type semiconductor thermoelectric material, ZnO has great potential in the high-temperature working temperature range due to its advantages of abundant sources, low cost, high thermal stability, and good chemical stability, as well as being pollution-free. Sr-doped ZnO-based thermoelectric materials were prepared using the methods of room-temperature powder synthesis and high-temperature block synthesis. The phase composition, crystal structure, and thermoelectric performances of ZnO samples with different Sr doping levels were analyzed using XRD, material simulation software and thermoelectric testing devices, and the optimal doping concentrations were obtained.

Distinct Phosphorylation Patterns of AT1R by Biased Ligands and GRK Subtypes.

G protein-coupled receptors (GPCRs) transmit through G proteins upon agonist activation, followed by phosphorylation by GPCR kinases (GRKs) to initiate β-arrestin signaling. However, the molecular mechanisms underlying GPCR signaling regulation by distinct agonists, GRK subtypes, and phosphorylation patterns remain poorly understood. The angiotensin II (AngII) type 1 receptor (AT1R), a prototypical GPCR, serves as an ideal model for studying biased ligands and signaling.

Exploring novel roles of lipid droplets and lipid metabolism in regulating inflammation and blood-brain barrier function in neurological diseases.

The blood-brain barrier (BBB) is a critical structure that maintains the brain's homeostasis by regulating the transport of molecules and protecting it from harmful substances. However, in neurological diseases such as ischemic stroke, Alzheimer's disease, Parkinson's disease, and multiple sclerosis, the integrity and function of the BBB can be significantly compromised. In these conditions, BBB disruption leads to increased permeability, which facilitates neuroinflammation, exacerbates neuronal damage, and accelerates disease progression.

Impact of different INSTIs on BMI among people living with HIV who newly started ART in Shenzhen, China: a real-world data analysis.

Background: Integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) might be associated with weight gain. The impact of different types of INSTIs has not been determined, particularly in combination with tenofovir disproxil fumarate (TDF) or tenofovir alafenamide fumarate (TAF).

Methods: We conducted a retrospective cohort study using real-world data from people living with HIV (PLWH) aged ≥18 years who newly started ART between 2019 and May 2023 in Shenzhen, China.

Cost-Effectiveness and Cost-Utility Analysis of Tongxinluo Capsules Compared With Conventional Therapy for the Treatment of Acute Myocardial Infarction.

Aim: Tongxinluo (TXL) capsule, a traditional Chinese medicine compound, has proven effective in acute myocardial infarction (AMI), but its cost-effectiveness is unclear.

Methods: This economic evaluation utilized individual data from clinical trials to compare major adverse cardiac and cerebrovascular events (MACCEs) at 30 days and quality-adjusted life years (QALYs) at 1 year between an intervention group (TXL combined with conventional therapy) and the control group (placebo plus conventional therapy), from a healthcare perspective. A lifetime cost-utility analysis (CUA) was conducted using a Markov model, and sensitivity analyses were performed to evaluate the robustness of the results.

Extending the MXenes to Menes with Emergent Quantum Phenomena.

Menes, as emerging MXenes-like materials, have garnered significant attention due to their fantastic properties and promising applications. However, Menes have rich structural spaces, and most of their intrinsic characters are still unknown, which severely limit their further exploration in certain areas. In this work, using first-principles and high-throughput calculations, we systemically explore the Menes family by varying the "M" and "" sites from the aspect of their mechanical and kinetic stability as well as electronic traits.

Application of Large Language Models in Stroke Rehabilitation Health Education: 2-Phase Study.

Background: Stroke is a leading cause of disability and death worldwide, with home-based rehabilitation playing a crucial role in improving patient prognosis and quality of life. Traditional health education often lacks precision, personalization, and accessibility. In contrast, large language models (LLMs) are gaining attention for their potential in medical health education, owing to their advanced natural language processing capabilities.

Cellular Adaptation to Mechanical Stress Emerges via Cell Shrinkage Triggered by Nonlinear Calcium Elevation.

Organisms constantly encounter unpredictable environmental perturbations, necessitating adaptation to maintain homeostasis. However, the fundamental principles by which organisms identify specific cues and transition to an adaptive state remain unclear. Here, using a mouse mechanical ventilation model and a cell stretch model, it is found that the cellular adaptation to mechanical stress can be induced by applying low amplitude stretches to cells, and demonstrate that the adaptation emerges once a defined stretch threshold is reached.

Exogenous melatonin alleviates drought stress in cotton by enhancing root cortical activity and metabolic adaptation.

Introduction: The root cortex plays a critical role in water uptake and metabolic activity, directly influencing root functionality. However, despite melatonin's known role in plant stress tolerance, its mechanisms in modulating root cortical anatomy and metabolic adaptation under drought remain unclear. This study examines the impact of exogenous melatonin on the root cortex of cotton under drought stress, focusing on its relationship with water uptake and drought resilience.

She ethnomedicine ameliorates ovarian dysfunction through enhanced cellular proliferation and anti-inflammation.

Ethnopharmacological Relevance: Polycystic ovary syndrome (PCOS) and premature ovarian failure (POF) are common causes of female infertility, both characterized by endocrine and metabolic dysregulation and anovulation. The She ethnomedicine formula, Medical Research Center Sheyao No. 1 (MRCSY1#), traditionally used for reproductive disorders, remains mechanistically underexplored.

Comparison of computed tomography and guided bronchoscopy in the diagnosis of pulmonary nodules: A systematic review and meta-analysis.

Objective: To compare the diagnostic effects of computed tomography (CT) and bronchoscopy guided biopsy on pulmonary nodules.

Methods: "Subject words + free words" were used to search four literature databases including Pubmed, Embase, Cochrane Library, and Web of Science. The subject words were CT, bronchoscope-guided biopsy, pulmonary nodules, and diagnosis.

Prevalence and associated factors of depressive symptoms among older adult diabetic patients in China: a nationally representative cross-sectional study.

Background: Diabetes and depressive symptoms exhibit a high comorbidity in the older adult population, and their combined effects significantly reduce patients' quality of life. This study aims to investigate the prevalence of depressive symptoms among older adults with diabetes in China and identify key associated factors, providing evidence-based insights for the development of targeted intervention strategies.

Methods: This study utilizes data from the 2015, 2018, and 2020 waves of the China Health and Retirement Longitudinal Study (CHARLS), including older adults aged 60 years and above who have been diagnosed with diabetes ( = 3,609).

A Chromosome End Without Terminal Telomere Repeats is Stable for Multiple Cell Divisions.

We have formed new short telomeres in using an inducible nuclease that cuts near telomere repeats in cells that lack, cannot recruit or cannot fully activate telomerase. Sequencing these new telomeres showed that cells can divide at least 4 times with ~30 bp of non-telomeric sequence at the chromosome end in cells lacking telomerase, which contrasts with current models for the roles of terminal single-stranded telomere repeats and the telomere proteins in telomere protection and replication. Cells that cannot recruit or activate telomerase had similar results, with additional rearrangements or telomere repeat addition, respectively.

Research on the Optimization of the Electrode Structure and Signal Processing Method of the Field Mill Type Electric Field Sensor.

Aiming at the issues that the field mill type electric field sensor lacks an accurate and complete mathematical model, and its signal is weak and contains a large amount of harmonic noise, on the basis of establishing the mathematical model of the sensor's induction electrode, the finite element method was adopted to analyze the influence laws of parameters such as the thickness of the shielding electrode and the distance between the induction electrode and the shielding electrode on the sensor sensitivity. On this basis, the above parameters were optimized. A signal processing circuit incorporating a pre-integral transformation circuit, a differential amplification circuit, and a bias circuit was investigated, and a completed mathematical model of the input and output of the field mill type electric field sensor was established.

Expert Consensus on Clinical Application of Implantable Biventricular Assist Devices.

While biventricular assist devices (BiVADs) remain underutilized in Western countries for biventricular heart failure (BHF), their application is expanding in China. This consensus synthesizes international guidelines, medical evidence, and Chinese clinical expertise to establish standardized protocols for BiVAD management. Key recommendations include: (1) Preoperative right heart catheterization and echocardiography for central venous pressure (CVP): pulmonary capillary wedge pressure (PCWP) ratio and pulmonary artery pulsatility index (PAPi) assessment (Class I); (2) BiVAD indication in refractory BHF or high-risk right heart failure post-left ventricular assist device (LVAD) implantation (Class IIa); (3) Right atrial implantation as the preferred surgical approach (Class IIa); (4) Warfarin-based anticoagulation (INR 2.

Critical gene network and signaling pathway analysis of the extracellular signal-regulated kinase (ERK) pathway in ischemic stroke.

Background And Objective: Ischemic stroke remains a leading cause of morbidity worldwide, demanding reliable biomarkers and mechanistic insights to inform personalized diagnostic and therapeutic strategies. We sought to integrate multiple ischemic stroke transcriptomic datasets, identify key extracellular signal-regulated kinase (ERK) pathway-related biomarkers, delineate immune-stromal heterogeneity, and develop a nomogram for clinical risk assessment.

Methods: We retrieved three public microarray datasets (GSE22255, GSE16561, GSE58294) and merged two of them (GSE22255, GSE16561) into a discovery cohort after stringent batch correction.

[The Efficacy of Combination of Avatrombopag and rhIL-11 in Adult Patients of Acute Myeloid Leukemia with Cancer Treatment-Induced Thrombocytopenia].

Objective: To investigate the safety and efficacy of avatrombopag（AVA） combined with rhIL-11 in treating thrombocytopenia induced by chemotherapy in acute myeloid leukemia.

Methods: The clinical information of 8 patients in the real world who received avatrombopag combined with rhIL-11 in cancer treatment-induced thrombocytopenia(CTIT) after AML chemotherapy were retrospectively analyzed, and at the same time, 8 patients who received rhIL-11 only in CTIT after AML chemotherapy served as the control group, A preliminary observation was to summarize and compare the therapeutic efficacy and adverse effects between the two groups.

Results: D3 and D7 platelet counts were not significantly different between the observation group and the control group after treatment.

An Updated Review of BiCuSeO-Based Thermoelectric Materials.

Since 2010, BiCuSeO has emerged as a captivating subject of investigation within the realm of thermoelectric materials. Its allure lies in a remarkable confluence of characteristics: a distinctive natural super-lattice structure, an elevated Seebeck coefficient, and a low thermal conductivity, all of which have collectively piqued the intense interest of scientists worldwide. Over the subsequent eight-year period, an extensive array of research endeavors has been meticulously carried out, delving deep into the multifaceted properties of BiCuSeO and exploring avenues for performance enhancement.

Hammerhead Ribozymes: Structural Insights, Catalytic Mechanisms, and Cutting-Edge Applications in Synthetic Biology.

Hammerhead ribozymes are a class of small RNA molecules with catalytic activity. Their compact size, high catalytic efficiency, structural simplicity, and modular design flexibility make them ideal tools for RNA manipulation and gene regulation. In recent years, these ribozymes have demonstrated tremendous application potential across diverse fields, including gene regulation, disease therapy, and biosensing, significantly advancing related research.

High frequency capillary wave-enabled ultra-small droplets for inhaled drug delivery.

Benefiting from localization, targeting and rapid response, inhaled drug delivery has become an indispensable method for treating lung diseases. However, the efficacy of drug delivery is often compromised by the physical characteristics of the aerosol produced by current nebulization methods, , large droplet size distributions, which are deposited in the upper airways. In this study, a portable, low-energy, and low-cost approach to nebulize drugs with appropriate size distribution is introduced using capillary wave breakup induced by gigahertz (GHz) acoustic waves.

SGLT-2 Inhibitors: A Deeper Dive into Their Renal Protective Properties beyond Glycemic Control and Proteinuria Reduction.

Background: Chronic kidney disease (CKD) is highly prevalent and associated with an increasing burden on patients and the healthcare system. Its complex causes and diverse manifestations pose considerable challenges in slowing disease progression. Over the last few decades, pharmacotherapeutic strategies have primarily focused on reducing albuminuria, managing complications, and alleviating symptoms.

A Chromosome End Without Terminal Telomere Repeats is Stable for Multiple Cell Divisions.

We have formed new short telomeres in using an inducible nuclease that cuts near telomere repeats in cells that lack, cannot recruit or cannot fully activate telomerase. Sequencing these new telomeres showed that cells can divide at least 4 times with ~30 bp of non-telomeric sequence at the chromosome end in cells lacking telomerase, which contrasts with current models for the roles of terminal single-stranded telomere repeats and the telomere proteins in telomere protection and replication. Cells that cannot recruit or activate telomerase had similar results, with additional terminal truncations or telomere repeat addition.