Global burden of anxiety, depression, self-harm (1990-2021) and the impact of COVID-19 pandemic.

Background: Major depressive disorder (MDD), anxiety disorders, and self-harm are substantial contributors to the global disease burden, exacerbated by the COVID-19 pandemic.

Methods: We used Global Burden of Diseases Study (GBD) 2021 to estimate global, regional, and national prevalence, mortality, and disability-adjusted life years (DALYs) for MDD, anxiety disorders, and self-harm from 1990 to 2021. Annual percentage changes were calculated for pre-pandemic (1990-2019) and pandemic (2019-2021) periods.

Activity and access of surgical abortion in metropolitan France.

Objective: To report the territorial distribution and characteristics of healthcare centres performing surgical abortion in France, along with the accessibility of these centres.

Material And Methods: A nationwide population-based cohort study of all women hospitalized for surgical abortion was conducted from January 1 to December 31, 2022 in metropolitan France. Number, location, activity volume and use of local anaesthesia rate of surgical abortion centres were reported as distribution activity across metropolitan France.

Assessment of the care experience during medical transition for transgender and gender diverse people in France: results from the PREMIUM study.

Background: Improving access to medical transition for transgender and gender diverse (TGD) individuals is a priority, which requires data on the experience of medical transition during and after the process. However, no Patient-Reported Experience Measurement (PREM) questionnaire has been developed specifically for this population until now in the French context. The primary objective was to provide preliminary evidence of the psychometric properties regarding validity and reliability of the PREMIUM questionnaires among TGD individuals undergoing medical transition.

Global prevalence of congenital color vision deficiency among children and adolescents, 1932-2022.

Purpose: To estimate the prevalence of congenital color vision deficiency (CVD), categorized by geographical region, ethnicity, type (deutan, protan, and tritan), and severity (anomalous trichromacy, dichromacy, and monochromacy).

Design: Systematic review and meta-analysis of the literature.

Participants: A total of 1,703,619 participants, including 31,493 patients from 56 studies across 21 countries and five continents, were included in our analysis.

Global, Regional, and National Burden of Pharyngeal Cancer and Projections to 2050 in 185 Countries: A Population-Based Systematic Analysis of GLOBOCAN 2022.

Background: Pharyngeal cancer has resulted in 3.23 million disability-adjusted life years as of 2019. Based on anatomical site, pharyngeal cancers are categorized into oropharyngeal cancers (OPCs), nasopharyngeal cancers (NPCs), and hypopharyngeal cancers (HPCs).

Global cancer mortality among children, adolescents, and young adults from 77 countries, 1990-2021: a global time-series analysis and modelling study.

Background: The patterns of cancer burden in children, adolescents and young adults are distinct from those in the general adult population, underscoring the importance of developing targeted research and interventions. Thus, we analyzed global, regional, and national cancer mortality trends via the World Health Organization (WHO) Mortality Database among children aged 0-14 years and adolescents and young adults aged 15-34 across 77 WHO Member States.

Methods: Age-standardized country-specific cancer mortality rates (deaths per 100,000) and years of life lost between 1990 and 2021 were estimated via a locally weighted scatterplot smooth curve.

Associations between body mass index categories and geriatric assessment tests among older adults with chronic kidney disease: A prospective study.

Background: The optimal body mass index (BMI) among older adults with chronic kidney disease (CKD) in geriatric assessment tests has not been studied. This study investigates the relationship between BMI and Comprehensive Geriatric Assessment (CGA) parameters among older adults with CKD.

Methods: A total of 319 older adults with CKD were included.

Hypothalamic imaging in Alzheimer's disease and Lewy body dementia: A systematic review and meta-analysis.

Symptoms related to sleep, weight, and endocrine dysfunction are common in Alzheimer's disease (AD) and Lewy body dementia (LBD). The cause of these symptoms is not known, but they may be related to hypothalamic neurodegeneration. We performed a systematic search of MEDLINE and EMBASE for studies using MRI or PET imaging to examine the hypothalamus in AD or LBD.

Adverse event reports of seizure for insomnia medication from 1967 to 2023.

Insomnia may negatively impact seizure control; however, the corresponding evidence remains limited. This study analyzed the seizure risk associated with various insomnia medications using a comprehensive pharmacovigilance database and identified safe options for patients at high risk of seizures. VigiBase, a database of adverse drug reaction reports from over 140 countries, comprises 35 million reports published from 1967 to 2023.

Biomarkers for Alzheimer's disease across diverse biological domains: an umbrella review and evidence map.

Background: This study aimed to systematically assess the quality, biases, and credibility of associations between potential Alzheimer's disease (AD) biomarkers through an umbrella review of existing meta-analyses.

Methods: We systematically searched PubMed/MEDLINE, Embase, CINAHL, and Google Scholar up to December 18, 2024, for meta-analyses of observational studies examining biomarkers for AD. Two reviewers independently screened studies and extracted data.

Biostimulants in Aesthetic Medicine: A Systematic Review and Meta-analysis of Efficacy, Safety, and Patient Satisfaction.

Biostimulants, including calcium hydroxyapatite (CaHA), poly-L-lactic acid (PLLA), and polycaprolactone (PCL), have become popular in aesthetic medicine as they lead to long-term tissue rejuvenation. However, their efficacy (e.g.

Is adjuvant chemotherapy beneficial in NSCLC patients over 75? Insights from a retrospective analysis.

Background: Lung cancer remains the leading cause of cancer-related mortality worldwide. In resected stage II-III Non-Small Cell Lung Cancer (NSCLC), adjuvant chemotherapy (ACT) improves survival, but its benefit in elderly patients remains unclear due to the lack of dedicated studies. We conducted a retrospective study to assess benefit and predictive factors of ACT in NSCLC patients over 75-years-old.

Understanding the relationship of sleep-related problems with positive affect and negative affect in young people: Insights from the EHDLA study.

Background: The prevalence of sleep-related problems in adolescents has been recognized as a public health issue. Research on how specific sleep-related problems may be related to mood and affect variations in this age group is scarce. Therefore, the current study aims to explore the relationships between sleep-related problems and positive and negative affect in a sample of Spanish adolescents.

Use of Z-codes related to social determinants of health among adult inpatients in France: a nationwide study from 2014 to 2022.

Background: Health is shaped by a complex network of socio-economic, environmental and behavioral factors, known as social determinants of health (SDOH). SDOH can be optionally documented using Z codes from the International Classification of Diseases, Tenth Revision (ICD-10) in the French national hospital database. This study aimed to (a) describe the use of SDOH codes among adult inpatients in France in 2022, and temporal trends from 2014 to 2022; and (b) identify the characteristics of hospital stays associated with the presence of SDOH codes.

Strategic pathways to International Classification of Diseases, 11th Revision, adoption in France and the United States.

The International Classification of Diseases, 11th Revision (ICD-11), developed by the World Health Organization, represents a transformative update to global health data classification systems. Building on the foundation of ICD-10, it introduces innovative features such as multilingual coding, advanced interoperability, postcoordination, and improved specificity, enabling better alignment with modern healthcare and digital information systems. This commentary explores the adoption pathways for ICD-11 in France and the United States, 2 countries with complex healthcare infrastructures and distinct implementation strategies.

Trends in Diet Quality by the Diagnosis of Chronic Diseases in Korea, 2013-2021: A Nationwide Representative Study.

Background: In the context of increased health risks for individuals with underlying conditions due to the coronavirus disease 2019 (COVID-19) pandemic, this study investigated whether dietary improvements differ based on the diagnosis of chronic diseases.

Methods: This study used data from the Korea National Health and Nutrition Examination Survey from 2013 to 2021, including 45,391 individuals aged 19 years and older. Diet quality was assessed by the Korean Healthy Eating Index (KHEI) scores.

TREATMENT OF HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS IN THE INTENSIVE CARE UNIT: TOO LATE AFTER RESORTING TO INVASIVE ORGAN SUPPORTS?

Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome that can lead to early death from multiple organ failure. In secondary HLH, etiological treatment is an emergency, but sometimes impossible until complementary results (microbiology, histology) are available. A "bridge to etiological treatment" with anti-inflammatory drugs (anti-JAK, anti-cytokines or etoposide) is then essential.

Exercise training and inflammatory adipokines in patients with type 2 diabetes: a systematic review, meta-analysis, and meta-regression.

Background: Improvements in adipocytes levels can reduce the risk of diabetes and cardiovascular disease, indicating adipocytes to be a hopeful remedial target in type 2 diabetes mellitus (T2DM) and other related diseases. However, there is no consensus on the role of various exercise training on adipokines in T2DM and the results are contradictory. Therefore, this systematic review, meta-analysis, and meta-regression investigated the effects of different types of exercise training on some inflammatory adipokines concentrations in T2DM.

Network-based alterations in task-induced functional connectivity in bipolar disorder: An functional near-infrared spectroscopy study.

Background: Functional near-infrared spectroscopy (fNIRS) is increasingly used to examine cognitive abilities and support the diagnosis of bipolar disorder (BD). Despite its growing application, research on functional connectivity in BD remains limited, and task-induced functional connectivity remains under-investigated. This study aims to differentiate patients with BD from healthy controls (HCs) based on fNIRS-derived functional connectivity.

Global burden of vaccine-associated Raynaud's phenomenon, 1968-2024: A comprehensive analysis of the pharmacovigilance database.

Purpose: Reports of Raynaud's phenomenon following vaccination have been steadily increasing; however, research on vaccine-associated Raynaud's phenomenon remains limited. This study aims to provide a comprehensive analysis of the association between Raynaud's phenomenon and various vaccines.

Method: This study used data from international pharmacovigilance, which contains over 35 million adverse event cases from more than 140 countries.

Long-Term Sequelae of COVID-19: A Systematic Review and Meta-Analysis of Symptoms 3 Years Post-SARS-CoV-2 Infection.

The symptoms of long COVID are well-documented. However, the long-term effects beyond 2 years remain poorly understood due to a lack of data. This systematic review and meta-analysis examined the prevalence of persistent symptoms in COVID-19 survivors 3 years following initial SARS-CoV-2 infection.

Artificial Intelligence improves follow-up appointment uptake for diabetic retinal assessment: a systematic review and meta-analysis.

Background/objectives: Artificial intelligence (AI) assessment of diabetic retinopathy (DR) instead of scarce trained specialists could potentially increases the efficiency and accessibility of screening programs. This systematic review aims to systematically examine the uptake of follow-up appointments with initial computer-based AI and human graders of DR.

Methods: We conducted a systematic review and meta-analysis by screening articles in any languages in PubMed, MEDLINE (Ovid), EMBASE, Web of Science, Cochrane CENTRAL and CDSR published from database inception up to 20 August 2024.