Thermal denaturation of porcine myofibrillar proteins at different heating temperatures: A focus on the surface hydrophobicity.

Changes in the hydrophobic interactions of porcine myofibrillar proteins (MPs) were investigated at various heating and internal temperatures (ITs). MP extracts were heated at 50, 60, 70, 80, or 90 °C until their ITs reached the same respective values (±2 °C) and were labeled IT50, IT60, IT70, IT80, and IT90. The intrinsic tryptophan fluorescence intensity (FI) of the MPs decreased after heating at all ITs ( < 0.

Global Prevalence of Functional Abdominal Pain Disorder among Children and Adolescents According to the Rome III and IV Criteria: A Systematic Review and Meta-Analysis.

Background/aims: Despite the global burden of functional abdominal pain disorder (FAPD) and its four subtypes (irritable bowel syndrome [IBS], functional dyspepsia [FD], abdominal migraine [AM], and functional abdominal pain not otherwise specified [FAP-NOS]), studies involving an estimation of FAPD prevalence based on the Rome III or IV criteria are limited. Therefore, we aimed to estimate the prevalence of FAPD and its four subtypes.

Methods: A comprehensive literature search was conducted in PubMed/MEDLINE, Embase, Google Scholar, and the Cochrane Library.

Characteristics of freeze-dried meat batter powder subjected to different freezing temperatures.

This study investigated the effects of the freezing temperatures (-20 °C and -70 °C) on the properties of freeze-dried (FD) meat batter. A trend toward a faster drying rate was found in the batter frozen at -20 °C (cf., -70 °C; P = 0.

Structural characterization and therapeutic potential of exopolysaccharide EPS-W-1 from Lactiplantibacillus plantarum strain ZL1 isolated from kimchi against DSS-induced colitis.

Ulcerative colitis (UC) is associated with intestinal barrier dysfunction, gut microbiome (GM) dysbiosis, inflammation, and immune dysregulation. Lactic acid bacteria-derived exopolysaccharides (LAB-EPS) have biotherapeutic potential to stimulate immune responses and influence the GM. Therefore, this work aimed to extract the bioactive EPS (EPS-W-1) from Lactiplantibacillus plantarum ZL1, isolated from Korean kimchi, and then characterize the chemical structure of EPS-W-1 using HPLC, GC-MS, and NMR.

Crystal structure of Fis1 and Bap31 provides information on protein-protein interactions at mitochondria-associated ER membranes.

In eukaryotic cells, mitochondria and the endoplasmic reticulum (ER) form close contacts at mitochondria-associated ER membranes (MAMs), which are involved in diverse cellular processes. The outer mitochondrial membrane protein Fis1, known for its role in mitochondrial fission, has been reported to interact with the ER-resident protein Bap31. Here, we present crystal structures of the cytosolic domain of human Fis1 in two distinct conformations, along with a co-crystal structure of Fis1 bound to the C-terminal region of the Bap31_vDED domain.

Top 10 drugs most frequently associated with adverse events of myocarditis and pericarditis.

Myocarditis and pericarditis are managed with various treatments, yet prior studies and case reports indicate that certain drug classes may elevate the risk for these inflammatory cardiac conditions. This research aimed to systematically identify the leading drugs most frequently associated with myocarditis and pericarditis cases. Analyses were carried out using the global database of individual case safety reports from 1968 to 2024.

Global prevalence of congenital color vision deficiency among children and adolescents, 1932-2022.

Purpose: To estimate the prevalence of congenital color vision deficiency (CVD), categorized by geographical region, ethnicity, type (deutan, protan, and tritan), and severity (anomalous trichromacy, dichromacy, and monochromacy).

Design: Systematic review and meta-analysis of the literature.

Participants: A total of 1,703,619 participants, including 31,493 patients from 56 studies across 21 countries and five continents, were included in our analysis.

Correlation of Income Instability With 12 Non-Communicable Disease Risks in Korea: A Prospective Cohort Study.

Background: Due to the lack of comprehensive longitudinal studies examining the impact of long-term volatility on health issues, existing research primarily focused on income levels rather than fluctuation. Thus, we aimed to investigate the relationship between income instability and a range of physical health conditions using an extensive longitudinal dataset.

Methods: This study utilized data from the Korean Genome and Epidemiology Study (KoGES) Ansan-Anseong cohort (2001-2022), which includes valuable confounding factors such as demographic, socioeconomic, lifestyle, and clinical factors.

Global, Regional, and National Burden of Pharyngeal Cancer and Projections to 2050 in 185 Countries: A Population-Based Systematic Analysis of GLOBOCAN 2022.

Background: Pharyngeal cancer has resulted in 3.23 million disability-adjusted life years as of 2019. Based on anatomical site, pharyngeal cancers are categorized into oropharyngeal cancers (OPCs), nasopharyngeal cancers (NPCs), and hypopharyngeal cancers (HPCs).

Global cancer mortality among children, adolescents, and young adults from 77 countries, 1990-2021: a global time-series analysis and modelling study.

Background: The patterns of cancer burden in children, adolescents and young adults are distinct from those in the general adult population, underscoring the importance of developing targeted research and interventions. Thus, we analyzed global, regional, and national cancer mortality trends via the World Health Organization (WHO) Mortality Database among children aged 0-14 years and adolescents and young adults aged 15-34 across 77 WHO Member States.

Methods: Age-standardized country-specific cancer mortality rates (deaths per 100,000) and years of life lost between 1990 and 2021 were estimated via a locally weighted scatterplot smooth curve.

Global burden of brain and central nervous system cancer in 185 countries, and projections up to 2050: a population-based systematic analysis of GLOBOCAN 2022.

Background: Brain and central nervous system (CNS) cancers are associated with high mortality and morbidity. Here, we aimed to systematically evaluate and compare brain and CNS cancer between pediatric and adult populations.

Methods: This study utilized the GLOBOCAN 2022 database to analyze incidence and mortality estimates for brain and CNS cancers across 185 countries and territories in 2022.

Changes in the Properties of Frozen Meat with Freezing and Storage Conditions and Non-Destructive Analyses for Monitoring Meat Quality.

Freezing is a valuable technique for increasing the shelf-life of meat. However, various changes occur in the physicochemical properties of frozen meat, which are affected by the frozen storage conditions, including the freezing temperature and storage duration. Conventional methods for measuring the properties of frozen-thawed meat are destructive and time-consuming.

A Multimodal Predictive Model for Chronic Kidney Disease and Its Association With Vascular Complications in Patients With Type 2 Diabetes: Model Development and Validation Study in South Korea and the U.K.

Objective: To develop a multimodal model to predict chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T2DM), given the limited research on this integrative approach.

Research Design And Methods: We obtained multimodal data sets from Kyung Hee University Medical Center (n = 7,028; discovery cohort) for training and internal validation and UK Biobank (n = 1,544; validation cohort) for external validation. CKD was defined based on ICD-9 and ICD-10 codes and/or estimated glomerular filtration rate (eGFR) ≤60 mL/min/1.

Trends in Diet Quality by the Diagnosis of Chronic Diseases in Korea, 2013-2021: A Nationwide Representative Study.

Background: In the context of increased health risks for individuals with underlying conditions due to the coronavirus disease 2019 (COVID-19) pandemic, this study investigated whether dietary improvements differ based on the diagnosis of chronic diseases.

Methods: This study used data from the Korea National Health and Nutrition Examination Survey from 2013 to 2021, including 45,391 individuals aged 19 years and older. Diet quality was assessed by the Korean Healthy Eating Index (KHEI) scores.

Burden of Cardiovascular Outcomes After SARS-CoV-2 Infection in South Korea and Japan: A Binational Population-Based Cohort Study.

Background: Despite the significant global impact of the COVID-19 pandemic, limited studies have investigated the long-term cardiovascular sequelae of SARS-CoV-2 infection, particularly among Asian populations. This large-scale, population-based binational cohort study with long-term follow-up aimed to investigate the association between SARS-CoV-2 infection and the risk of cardiovascular events.

Methods: We used binational, large-scale, and population-based cohorts, including a Korean nationwide cohort (K-CONV-N [Korea Disease Control and Prevention Agency-COVID-19-National Health Insurance Service cohort]; discovery cohort; n=18 989 129) and a Japanese nationwide cohort (Japan Medical Data Center; validation cohort; n=12 218 680).

Global, Regional, and National Trends in Maternal Mortality Ratio Across 37 High Income Countries From 1990 to 2021, With Projections up to 2050: A Comprehensive Analysis From the WHO Mortality Database.

Background: Understanding the global trends and future projections of maternal mortality ratio (MMR) is crucial as it can provide insights into improving policies and healthcare systems aimed at enhancing the quality of obstetric care and reducing preventable deaths. Given recent reports of increasing MMR trends in some high-income countries (HICs), we aimed to analyze the global trends of MMR from 1990 to 2021 and project future trends until 2050 across 37 countries.

Methods: Age-standardized country-specific MMR for 37 countries from 1990 to 2021 were assessed through a locally weighted scatter plot smoother (LOESS) curve, with weighting based on individual country populations, utilizing the World Health Organization Mortality Database.

Agar-based composite emulsion gel as a pork fat substitute in sausages: Understanding meat batter stabilization mechanisms based on fat sources.

Agar (AG), konjac glucomannan (GM), and gum arabic (GA) were used to produce a corn-oil emulsion gel, and the optimal polysaccharide ratio for a stable structure was determined via response surface methodology. The optimal AG-GM-GA emulsion gel contained 1.91 %, 2.

Global and Regional Burden of Vaccine-Associated Transverse Myelitis and Potentially Associated With Vaccines From 1967 to 2023: An Analysis of the International Pharmacovigilance Data.

Limited data on the potential safety risk of vaccine-associated transverse myelitis (TM) is available. Thus, we aimed to identify the global burden and clinical features of vaccine-associated TM to facilitate tailored monitoring of potential adverse vaccine reactions. This study used data from the World Health Organization pharmacovigilance database, which contains over 35 million reports from over 140 countries.

Impact of metabolic health and weight transition on COVID-19 risk: A population-based cohort study.

Objectives: Obesity and metabolic health are known factors influencing COVID-19 severity. However, the effect of changes in metabolic health and weight status on COVID-19 outcomes remains unclear. To investigate the association between changes in metabolic health and weight status over time and COVID-19-related risks.

The orange protein regulates the minor antenna protein CP24 via an oxidative stress-dependent structural switch.

Abiotic stress significantly affects plant photosynthetic efficiency, leading to a global reduction in agricultural yields. The Orange (Or) protein plays a crucial role in regulating carotenoid homeostasis and enhancing plant adaptation to abiotic stress. In this study, we found that the sweetpotato Or protein (IbOr) physically interacts with the minor antenna protein IbCP24 in the chloroplast and promotes its degradation.

Effectiveness of the live zoster vaccine in patients with type 2 diabetes: a nationwide emulated target trial.

Objectives: Real-world studies on its effectiveness in patients with type 2 diabetes mellitus (T2DM) remain limited. This study aimed to evaluate the effectiveness of the live zoster vaccine in patients with T2DM more than 10 years.

Methods: In this target trial emulation study, we utilized a large-scale, nationwide cohort in South Korea, consisting of individuals aged 50 years and older with T2DM from January 1, 2012 to December 31, 2021 (n = 934 945).

National trends in dyslipidemia prevalence, awareness, treatment, and control in South Korea from 2005 to 2022.

Dyslipidemia has steadily increased in South Korea over the past two decades, emerging as a major public health concern and key risk factor for cardiovascular disease. Thus, our study aimed to investigate long-term trends in the prevalence, awareness, treatment, and control of dyslipidemia in South Korea, including the COVID-19 pandemic. This study utilized data from nationally representative cross-sectional surveys conducted as part of the Korea National Health and Nutrition Examination Survey from 2005 to 2022, analyzing long-term trends of dyslipidemia among 98,396 individuals aged over 30.