Association between residential greenness and allergic diseases among adolescents in South Korea: A nationwide representative study.

Background: Residential greenness is an important environmental factor potentially influencing the development of allergic diseases in adolescents; however, its impact remains understudied in South Korea. This study aimed to examine the association between residential greenness and allergic disease prevalence using nationally representative data.

Method: We analyzed data from 1,130,598 adolescents (7-12th grade) participating in the Korean Youth Risk Behavior Web-based Survey (2007-2024).

Impact of the WellCheck smartphone app linked to electronic health records on clinical outcomes in patients with type 2 diabetes: Study protocol for primary care-based, prospective, multicenter, cluster-randomized, pragmatic clinical trials.

ClinicalTrials.gov NCT06419816. Registered on 14 May 2024.

Effects of photobiomodulation on multiple health outcomes: an umbrella review of randomized clinical trials.

Background: Photobiomodulation (PBM) is a non-invasive therapy increasingly used for pain, inflammation, and tissue repair, yet a comprehensive synthesis of its effectiveness across multiple health outcomes remains lacking. Herein, we aimed to systematically assess the clinical effects and strength of evidence for PBM across a wide range of health outcomes using data from existing meta-analyses of randomized controlled trials (RCTs).

Methods: We conducted an umbrella review of meta-analyses of RCTs, searching five databases up to December 8, 2023.

Correlation of Income Instability With 12 Non-Communicable Disease Risks in Korea: A Prospective Cohort Study.

Background: Due to the lack of comprehensive longitudinal studies examining the impact of long-term volatility on health issues, existing research primarily focused on income levels rather than fluctuation. Thus, we aimed to investigate the relationship between income instability and a range of physical health conditions using an extensive longitudinal dataset.

Methods: This study utilized data from the Korean Genome and Epidemiology Study (KoGES) Ansan-Anseong cohort (2001-2022), which includes valuable confounding factors such as demographic, socioeconomic, lifestyle, and clinical factors.

Global, Regional, and National Burden of Pharyngeal Cancer and Projections to 2050 in 185 Countries: A Population-Based Systematic Analysis of GLOBOCAN 2022.

Background: Pharyngeal cancer has resulted in 3.23 million disability-adjusted life years as of 2019. Based on anatomical site, pharyngeal cancers are categorized into oropharyngeal cancers (OPCs), nasopharyngeal cancers (NPCs), and hypopharyngeal cancers (HPCs).

Global cancer mortality among children, adolescents, and young adults from 77 countries, 1990-2021: a global time-series analysis and modelling study.

Background: The patterns of cancer burden in children, adolescents and young adults are distinct from those in the general adult population, underscoring the importance of developing targeted research and interventions. Thus, we analyzed global, regional, and national cancer mortality trends via the World Health Organization (WHO) Mortality Database among children aged 0-14 years and adolescents and young adults aged 15-34 across 77 WHO Member States.

Methods: Age-standardized country-specific cancer mortality rates (deaths per 100,000) and years of life lost between 1990 and 2021 were estimated via a locally weighted scatterplot smooth curve.

Dual Roles of HbA1c Variability and Body Composition for Cardiovascular Risk: A Cohort Study of 8224 Adults With Type 2 Diabetes Mellitus.

Background: Glycaemic variability and body composition are emerging predictors of cardiovascular disease (CVD) in patients with Type 2 diabetes mellitus (T2DM); however, their combined impact remains unclear. We investigated the association among HbA1c variability, body composition parameters and cardiovascular outcomes in adults with T2DM.

Methods: This retrospective cohort study analysed electronic health records from a university hospital (2011-2020), including 8224 adults (mean age 58.

Gender differences in the association between community care and quality of life among older adults in China.

As population aging accelerates in China, community care services have become increasingly important for supporting the well-being of older adults. However, research examining gender-specific associations between community care services and quality of life (QoL) remains limited. This study aimed to investigate the gender-specific associations between the perceived availability of community care services and QoL among older adults, using data from the eighth wave (2017-2018) of the China Longitudinal Healthy Longevity Survey (CLHLS).

A Multimodal Predictive Model for Chronic Kidney Disease and Its Association With Vascular Complications in Patients With Type 2 Diabetes: Model Development and Validation Study in South Korea and the U.K.

Objective: To develop a multimodal model to predict chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T2DM), given the limited research on this integrative approach.

Research Design And Methods: We obtained multimodal data sets from Kyung Hee University Medical Center (n = 7,028; discovery cohort) for training and internal validation and UK Biobank (n = 1,544; validation cohort) for external validation. CKD was defined based on ICD-9 and ICD-10 codes and/or estimated glomerular filtration rate (eGFR) ≤60 mL/min/1.

Trends in Diet Quality by the Diagnosis of Chronic Diseases in Korea, 2013-2021: A Nationwide Representative Study.

Background: In the context of increased health risks for individuals with underlying conditions due to the coronavirus disease 2019 (COVID-19) pandemic, this study investigated whether dietary improvements differ based on the diagnosis of chronic diseases.

Methods: This study used data from the Korea National Health and Nutrition Examination Survey from 2013 to 2021, including 45,391 individuals aged 19 years and older. Diet quality was assessed by the Korean Healthy Eating Index (KHEI) scores.

Disproportionality analysis of serotonin syndrome associated with selective serotonin reuptake inhibitors: a pharmacovigilance analysis.

Purpose: The incidence and risk of serotonin syndrome associated with selective serotonin reuptake inhibitors (SSRIs) have increased. However, large-scale studies investigating this relationship remain limited. Therefore, this study aims to evaluate the signal detection between six SSRIs and serotonin syndrome, rank their relative risks, and propose practical preventive strategies.

Global, Regional, and National Trends in Maternal Mortality Ratio Across 37 High Income Countries From 1990 to 2021, With Projections up to 2050: A Comprehensive Analysis From the WHO Mortality Database.

Background: Understanding the global trends and future projections of maternal mortality ratio (MMR) is crucial as it can provide insights into improving policies and healthcare systems aimed at enhancing the quality of obstetric care and reducing preventable deaths. Given recent reports of increasing MMR trends in some high-income countries (HICs), we aimed to analyze the global trends of MMR from 1990 to 2021 and project future trends until 2050 across 37 countries.

Methods: Age-standardized country-specific MMR for 37 countries from 1990 to 2021 were assessed through a locally weighted scatter plot smoother (LOESS) curve, with weighting based on individual country populations, utilizing the World Health Organization Mortality Database.

National trends in dyslipidemia prevalence, awareness, treatment, and control in South Korea from 2005 to 2022.

Dyslipidemia has steadily increased in South Korea over the past two decades, emerging as a major public health concern and key risk factor for cardiovascular disease. Thus, our study aimed to investigate long-term trends in the prevalence, awareness, treatment, and control of dyslipidemia in South Korea, including the COVID-19 pandemic. This study utilized data from nationally representative cross-sectional surveys conducted as part of the Korea National Health and Nutrition Examination Survey from 2005 to 2022, analyzing long-term trends of dyslipidemia among 98,396 individuals aged over 30.

Global burden of antidepressant-associated seizures from 1967 to 2023: A comparative analysis of the international pharmacovigilance database.

Background: Although antidepressants have been implicated in seizure risk, comprehensive safety data examining this risk across different antidepressants remains limited.

Methods: Data from Vigibase, an international pharmacovigilance database, encompassing 131,255,418 reports from 1967 to 2023, was analyzed. Reporting odds ratio (ROR) and information component (IC) were calculates to identify disproportionate associations between 17 antidepressants and seizures.

Trends in adolescent violence victimization pre-, intra-, and post-COVID-19 pandemic in South Korea, 2012-2023: a nationwide cross-sectional study.

Background: Adolescent violence victimization is a major public health concern, but research has been limited by short durations and small samples, restricting long-term understanding. This study examined its trends and vulnerabilities in South Korea, focusing on the impact of COVID-19 pandemic.

Methods: Data were collected from 740,687 nationally representative samples (7-12th grade adolescents) through the Korean Youth Risk Behavior Web-based Survey from 2012 to 2023.

Nationwide Trends in Screen Time and Associated Risk Factors by Family Structures Among Adolescents, 2008-2022: Nationwide Cross-Sectional Study.

Background: Although understanding long-term trends in adolescent screen time and the influence of family structure is essential, there is a lack of research addressing these issues comprehensively.

Objective: This study aimed to conduct comprehensive investigations into adolescent screen time before and during the COVID-19 pandemic, with a particular focus on family structures.

Methods: This study used nationwide, large-scale data from the Korea Youth Risk Behavior Web-Based Survey from South Korea.

Machine Learning-Based Prediction of Substance Use in Adolescents in Three Independent Worldwide Cohorts: Algorithm Development and Validation Study.

Background: To address gaps in global understanding of cultural and social variations, this study used a high-performance machine learning (ML) model to predict adolescent substance use across three national datasets.

Objective: This study aims to develop a generalizable predictive model for adolescent substance use using multinational datasets and ML.

Methods: The study used the Korea Youth Risk Behavior Web-Based Survey (KYRBS) from South Korea (n=1,098,641) to train ML models.

Association Between Social Engagement Frequency and the Risk of Depression in South Korea, the United States, and the United Kingdom: Multinational Evidence From Longitudinal Studies of Aging.

Background: Although a greater social engagement is often associated with a reduced risk of depression, longitudinal studies that account for diverse social structures and cultural contexts among middle-aged or older are limited.

Methods: This study utilized cohort data from the Korean Longitudinal Study of Aging (n = 11,174; 2006-2020) in South Korea (KR), the Health and Retirement Study (n = 42,405; 2004-2019) in the United States, and the English Longitudinal Study of Aging (n = 28,624; 2002-2019) in the United Kingdom, including a total of 29,378 individuals from the population aged ≥45 years. Social engagement frequency was categorized into infrequent, intermediate, and frequent, with changes classified as unchanged, increased, or decreased.

National Trends in Asthma Prevalence among Adolescents in South Korea, 2007-2023: A National Representative Serial Study.

Introduction: Although previous studies have analyzed trends in asthma prevalence among adolescents before and during the COVID-19 pandemic, research specifically investigating asthma prevalence after the pandemic is lacking. Therefore, this study aims to analyze the long-term trends and the impact of the COVID-19 pandemic on the prevalence of asthma among Korean adolescents.

Methods: Data were collected from a nationwide representative study (Korean Youth Risk Behavior Web-based Survey), conducted among adolescents aged 12-18 years from 2007 to 2023.

Dose-response association between physical activity and diagnosed hypertension in 2.4 million Korean population: Korea Community Health Survey 2009-2022.

Background: Hypertension, a significant risk factor for global public health, is well-known to be preventable and manageable through physical activity (PA). However, many studies suggest that excessive PA may not provide additional benefits. Thus, we aimed to conduct a quantitative analysis of the relationship between hypertension and PA levels.

Development and Validation of a Machine Learning Algorithm for Predicting Diabetes Retinopathy in Patients With Type 2 Diabetes: Algorithm Development Study.

Background: Diabetic retinopathy (DR) is the leading cause of preventable blindness worldwide. Machine learning (ML) systems can enhance DR in community-based screening. However, predictive power models for usability and performance are still being determined.

Temporal trends and patterns in mortality from falls across 59 high-income and upper-middle-income countries, 1990-2021, with projections up to 2040: a global time-series analysis and modelling study.

Background: Deaths related to falls are a substantial public health problem worldwide, and insight into trends and differences in global fall-related deaths can be valuable for identifying prevention strategies and developing effective policies. Thus, we aimed to estimate global fall-related mortality rate trends and forecast future fall-related deaths.

Methods: In this global time-series analysis and modelling study, we investigated temporal trends in fall-related mortality rates from 1990 to 2021 using the WHO Mortality Database, following the GATHER guidelines, and forecasted trends until 2040 across 59 high-income and upper-middle-income countries.

An anonymized, de-identified registry study protocol to determine the effectiveness and safety of weight loss with enavogliflozin in patients with type 2 diabetes mellitus.

Sodium-glucose co-transporter 2 inhibitors, such as enavogliflozin, offer promising metabolic benefits for patients with type 2 diabetes (T2D), including glycemic control and improved cardiac function. Despite the clinical evidence, real-world evidence is needed to validate their safety and effectiveness. This study aims to evaluate the effects of weight loss and safety of enavogliflozin administration in patients with T2D in a real-world clinical setting over 24 weeks.