Prevalence and health outcomes of combustible cigarettes and noncombustible nicotine or tobacco products: a nationwide cross-sectional study in South Korea.

Objective: Limited evidence exists on type of tobacco use changes and differential health outcomes following the introduction of non-combustible nicotine or tobacco products (NNTPs). Therefore, this study aimed to evaluate the characteristics, trends, and health outcomes of exclusive combustible cigarette users and dual users of combustible cigarette and NNTP.

Methods: This study analyzed data from the Korea National Health and Nutrition Examination Survey from 2013 to 2021 ( = 18,763).

Anatomical Region-Specific Transcriptomic Signatures and the Role of Epithelial Cells in Pterygium Inflammation: A Multi-Omics Analysis.

Purpose: This study aims to understand the differences in cellular and molecular patterns between the Main and Accessory (Acc) regions of pterygium tissue, with a focus on inflammation and mitochondrial energy metabolism.

Methods: We collected bulk RNA sequencing (RNA-seq) data from six pterygium patients and single-cell RNA-seq data from two pterygium patients. Subsequently, we investigated pathway enrichment, pathway correlation, differential gene expression, protein-protein interactions, and cell-cell communication in pterygium.

Country-level prevalence of and factors associated with smoking cessation among adolescents across 91 countries.

Background: There is a paucity of research on patterns of attempts at smoking cessation, success, and influencing factors in adolescents. This study aims to analyze the prevalence of ex-smokers and current smokers with cessation attempts in adolescents worldwide and to identify the factors that affect cessation attempts along with outcomes.

Methods: This study utilized the Global Youth Tobacco Survey (2010-2021) to investigate tobacco use among adolescents aged 13-15 years.

Global prevalence of congenital color vision deficiency among children and adolescents, 1932-2022.

Purpose: To estimate the prevalence of congenital color vision deficiency (CVD), categorized by geographical region, ethnicity, type (deutan, protan, and tritan), and severity (anomalous trichromacy, dichromacy, and monochromacy).

Design: Systematic review and meta-analysis of the literature.

Participants: A total of 1,703,619 participants, including 31,493 patients from 56 studies across 21 countries and five continents, were included in our analysis.

Correlation of Income Instability With 12 Non-Communicable Disease Risks in Korea: A Prospective Cohort Study.

Background: Due to the lack of comprehensive longitudinal studies examining the impact of long-term volatility on health issues, existing research primarily focused on income levels rather than fluctuation. Thus, we aimed to investigate the relationship between income instability and a range of physical health conditions using an extensive longitudinal dataset.

Methods: This study utilized data from the Korean Genome and Epidemiology Study (KoGES) Ansan-Anseong cohort (2001-2022), which includes valuable confounding factors such as demographic, socioeconomic, lifestyle, and clinical factors.

Adverse event reports of seizure for insomnia medication from 1967 to 2023.

Insomnia may negatively impact seizure control; however, the corresponding evidence remains limited. This study analyzed the seizure risk associated with various insomnia medications using a comprehensive pharmacovigilance database and identified safe options for patients at high risk of seizures. VigiBase, a database of adverse drug reaction reports from over 140 countries, comprises 35 million reports published from 1967 to 2023.

Biomarkers for Alzheimer's disease across diverse biological domains: an umbrella review and evidence map.

Background: This study aimed to systematically assess the quality, biases, and credibility of associations between potential Alzheimer's disease (AD) biomarkers through an umbrella review of existing meta-analyses.

Methods: We systematically searched PubMed/MEDLINE, Embase, CINAHL, and Google Scholar up to December 18, 2024, for meta-analyses of observational studies examining biomarkers for AD. Two reviewers independently screened studies and extracted data.

In Vitro Anthelmintic Effect of Selected Agents Against Microcotyle sebastis and Microcotyle caudata, the Gill Monogenean Parasites of Rockfish, Sebastes spp.

The in vitro efficacy of various anthelminthic agents was investigated against adults and eggs of the Microcotyle sebastis and M. caudata. Praziquantel (PZQ), ivermectin (IVM), trichlorfon (TCF), fenbendazole (FNBZ), febantel (FBT), flubendazole (FLBZ), thiabendazole (TBZ), formalin, hydrogen peroxide and sodium hypochlorite (NaOCl) were selected as test agents.

Global burden of vaccine-associated Raynaud's phenomenon, 1968-2024: A comprehensive analysis of the pharmacovigilance database.

Purpose: Reports of Raynaud's phenomenon following vaccination have been steadily increasing; however, research on vaccine-associated Raynaud's phenomenon remains limited. This study aims to provide a comprehensive analysis of the association between Raynaud's phenomenon and various vaccines.

Method: This study used data from international pharmacovigilance, which contains over 35 million adverse event cases from more than 140 countries.

Global and Regional Burden of Vaccine-Associated Transverse Myelitis and Potentially Associated With Vaccines From 1967 to 2023: An Analysis of the International Pharmacovigilance Data.

Limited data on the potential safety risk of vaccine-associated transverse myelitis (TM) is available. Thus, we aimed to identify the global burden and clinical features of vaccine-associated TM to facilitate tailored monitoring of potential adverse vaccine reactions. This study used data from the World Health Organization pharmacovigilance database, which contains over 35 million reports from over 140 countries.

Effectiveness of the live zoster vaccine in patients with type 2 diabetes: a nationwide emulated target trial.

Objectives: Real-world studies on its effectiveness in patients with type 2 diabetes mellitus (T2DM) remain limited. This study aimed to evaluate the effectiveness of the live zoster vaccine in patients with T2DM more than 10 years.

Methods: In this target trial emulation study, we utilized a large-scale, nationwide cohort in South Korea, consisting of individuals aged 50 years and older with T2DM from January 1, 2012 to December 31, 2021 (n = 934 945).

Global burden of antidepressant-associated seizures from 1967 to 2023: A comparative analysis of the international pharmacovigilance database.

Background: Although antidepressants have been implicated in seizure risk, comprehensive safety data examining this risk across different antidepressants remains limited.

Methods: Data from Vigibase, an international pharmacovigilance database, encompassing 131,255,418 reports from 1967 to 2023, was analyzed. Reporting odds ratio (ROR) and information component (IC) were calculates to identify disproportionate associations between 17 antidepressants and seizures.

Adverse drug reaction patterns of GLP-1 receptor agonists approved for obesity treatment: Disproportionality analysis from global pharmacovigilance database.

Aims: This study aims to compare adverse drug reaction patterns of liraglutide, semaglutide and tirzepatide-glucagon-like peptide-1 receptor agonists (GLP-1 RAs) approved for anti-obesity medications-to evaluate their real-world safety.

Materials And Methods: This disproportionality analysis utilized a case-control design with VigiBase. The study focused on reports of adverse events associated with liraglutide, semaglutide and tirzepatide, selected based on warnings in the US Food and Drug Administration approval labels for each drug.

Disproportionality analysis from World Health Organization data on migraine-specific medications and cerebrovascular diseases.

Background: Migraine is a major cause of population ill health, with an estimated global prevalence of approximately 14-15%. However, given the limited research on the associations between specific migraine medications and adverse cerebrovascular events, this study aimed to investigate these relationships and their impact on cerebrovascular risk.

Methods: This study utilized data from the global pharmacovigilance database, which covers 170 countries from 1968 to 2024.

Long-term trends in the prevalence of cardiovascular-kidney-metabolic syndrome in South Korea, 2011-2021: a representative longitudinal serial study.

Background: The American Heart Association recently introduced a new framework, known as cardiovascular-kidney-metabolic (CKM) syndrome, aimed at the early prevention of cardiovascular disease. However, this syndrome has not been studied extensively outside of the United States. Thus, this study aimed to examine the long-term trends in CKM syndrome and its associated demographic features in South Korea.

Long-term trends and patterns in ultra-processed food consumption among Korean adults from 1998 to 2022.

Ultra-processed foods are linked to adverse health outcomes, making it crucial to monitor consumption trends. Despite rising consumption due to Westernized diets in Asia, long-term studies targeting Asian adults are lacking. Thus, we analyzed ultra-processed food consumption trends among Korean adults from 1998 to 2022.

Use of Biologics to Treat Asthma during Pregnancy and Adverse Events in Pregnant Women and Newborns: A Global Pharmacovigilance Analysis.

Introduction: Despite the increasing evidence supporting the use of biologics for treating severe asthma, there is a lack of evidence regarding their use in pregnant women. This study aims to evaluate the safety of biologics for pregnant women, utilizing global pharmacovigilance database.

Methods: Reports documented between 1980 and 2023 were extracted from the VigiBase that mentioned pregnancy- or fetus-related reactions with drugs indicated for asthma, including reslizumab, omalizumab, mepolizumab, dupilumab, benralizumab, and other non-biologics.

Association between behavioral and sociodemographic factors and high subjective health among adolescents: a nationwide representative study in South Korea.

The need to understand subjective health has increased during the COVID-19 pandemic, given its substantial impact on lifestyle habits and perceptions. Thus, this study aimed to investigate the trends and association of subjective health with demographic and behavioral factors, primarily focusing on the change when the COVID-19 pandemic emerged. This study used data from the Korea Youth Risk Behavior Web-based Survey, comprising 1,190,468 adolescents aged 12-18 years (female, 48.

Antipsychotic use during pregnancy and outcomes in pregnant individuals and newborns.

Background: Despite the increasing use of antipsychotics during pregnancy, comprehensive evaluations of their individual safety profiles using global data remain limited. This study aimed to assess the safety of various antipsychotics during pregnancy by comparing them to quetiapine, which has a relatively large body of safety data.

Method: Utilizing the World Health Organization pharmacovigilance database (1968-2023; n = 131,255,418 reports), we identified 11,406 reports of antipsychotic exposure during pregnancy.

Worldwide burden of antidiabetic drug-induced sarcopenia: An international pharmacovigilance study.

Background: Sarcopenia is a condition that poses a significant risk in the older population, with diabetes identified as a risk factor. Recent evidence suggests that GLP-1 RA, commonly used as antidiabetic treatments, may potentially induce sarcopenia. This study aimed to investigate the association between sarcopenia and various antidiabetic drugs, including GLP-1 RAs.

National trends in type 2 diabetes mellitus stratified by central adiposity using waist-to-height ratio in South Korea, 2005-2022.

Studies investigating the association between type 2 diabetes mellitus and central adiposity are lacking. Therefore, this study aimed to investigate trends in type 2 diabetes mellitus stratified by central adiposity using waist-to-height ratio (WHtR). Trends in type 2 diabetes mellitus were examined by central adiposity, using WHtR, with data from the Korea National Health and Nutrition Examination Survey (2005-2022).

Global burden of ADHD medication-associated cardiovascular disease, 1967-2023: A comparative analysis using the WHO pharmacovigilance database.

Background: Despite the widespread use of attention-deficit hyperactivity disorder (ADHD) medications and their known sympathomimetic effects on the cardiovascular system, cardiovascular risk assessment of these medications using comprehensive global data is limited. This study investigated the association between individual ADHD medications and cardiovascular disease (CVD) using global pharmacovigilance data.

Methods: Reports from the World Health Organization international pharmacovigilance database were utilized (1967-2023; total reports, n=131,255,418).