Mitochondrial Transfer Between Cancer and T Cells: Implications for Immune Evasion.

Intercellular mitochondrial transfer in the tumor microenvironment (TME) is a paradigm-shifting process that redefines cancer-T cell crosstalk. This review explores its dual nature as both a tumor immune evasion strategy and a promising therapeutic avenue. Crucially, oxidative stress acts as a key regulator, inducing tunneling nanotube (TNT) formation to facilitate this organelle exchange.

Anatomical Region-Specific Transcriptomic Signatures and the Role of Epithelial Cells in Pterygium Inflammation: A Multi-Omics Analysis.

Purpose: This study aims to understand the differences in cellular and molecular patterns between the Main and Accessory (Acc) regions of pterygium tissue, with a focus on inflammation and mitochondrial energy metabolism.

Methods: We collected bulk RNA sequencing (RNA-seq) data from six pterygium patients and single-cell RNA-seq data from two pterygium patients. Subsequently, we investigated pathway enrichment, pathway correlation, differential gene expression, protein-protein interactions, and cell-cell communication in pterygium.

Hyperspectral and Color Imaging of Solvent Vapor Sorption Into Porous Silicon.

A porous silicon thin film photonic crystal (rugate) sample with both a radial gradient in the rugate reflectance band wavelength and two spatially separated pore-wall surface chemistries (methylated and oxidized) was monitored by hyperspectral and color imaging while it was dosed with vapors of acetone, ethanol, heptane, 2-propanol, and toluene at concentrations ranging from 100 to 3,000 mg m. The shift in the wavelength of the rugate reflectance band maximum at each position along a transect across the two surface chemistries, as derived from the hyperspectral imaging, could discriminate between the different solvents and concentrations of solvents, while the change in hue derived from the color camera data along an analogous transect did not provide discrimination. The discrimination between solvents was mainly due to the two different surface chemistries, and the gradient associated with the change in the rugate reflectance band wavelength did not affect the selectivity significantly.