Anatomical Region-Specific Transcriptomic Signatures and the Role of Epithelial Cells in Pterygium Inflammation: A Multi-Omics Analysis.

Purpose: This study aims to understand the differences in cellular and molecular patterns between the Main and Accessory (Acc) regions of pterygium tissue, with a focus on inflammation and mitochondrial energy metabolism.

Methods: We collected bulk RNA sequencing (RNA-seq) data from six pterygium patients and single-cell RNA-seq data from two pterygium patients. Subsequently, we investigated pathway enrichment, pathway correlation, differential gene expression, protein-protein interactions, and cell-cell communication in pterygium.

Ethnic-Specific and UV-Independent Mutational Signatures of Basal Cell Carcinoma in Koreans.

Basal cell carcinoma (BCC), the most common skin cancer, is primarily driven by Hedgehog (Hh) and TP53 pathway alterations. Although additional pathways were implicated, the mutational landscape in Asian populations, particularly Koreans, remains underexplored. We performed whole-exome sequencing of BCC tumor tissues from Korean patients and analyzed mutations in 11 established BCC driver genes (, , , , , , , , and ).

Metformin in Colorectal Cancer: Epidemiological Evidence, Predictive Biomarkers, and Implications for Prevention and Treatment.

Interest in metformin as a potential anticancer agent for colorectal cancer (CRC) has increased. However, compelling epidemiological links and strong preclinical evidence suggest that metformin has variable efficacy in patients with CRC. This variability highlights the need to identify the patients who are most likely to benefit from effective stratification.