Activity and access of surgical abortion in metropolitan France.

Objective: To report the territorial distribution and characteristics of healthcare centres performing surgical abortion in France, along with the accessibility of these centres.

Material And Methods: A nationwide population-based cohort study of all women hospitalized for surgical abortion was conducted from January 1 to December 31, 2022 in metropolitan France. Number, location, activity volume and use of local anaesthesia rate of surgical abortion centres were reported as distribution activity across metropolitan France.

Association between residential greenness and allergic diseases among adolescents in South Korea: A nationwide representative study.

Background: Residential greenness is an important environmental factor potentially influencing the development of allergic diseases in adolescents; however, its impact remains understudied in South Korea. This study aimed to examine the association between residential greenness and allergic disease prevalence using nationally representative data.

Method: We analyzed data from 1,130,598 adolescents (7-12th grade) participating in the Korean Youth Risk Behavior Web-based Survey (2007-2024).

Final Report on the Safety and Efficacy of Poly-L-Lactic Acid Filler (Gana V) Injection for the Correction of Nasolabial Fold: A Double-Blind, Non-Inferiority, Randomized, Split-Face Controlled Trial.

Background: We presented the interim results (6 months) of the trial on the safety and efficacy of poly-L-lactic acid filler (PLLA; Gana V) injection for the correction of nasolabial fold (NLF); however, no long-term follow-up trials through 24 months have been conducted on this topic.

Objective: We aimed to evaluate the safety and efficacy of Gana V, a new PLLA filler, over 24 months for NLF correction compared with Sculptra, a well-established PLLA filler.

Methods: This double-blind, randomized, non-inferiority, and split-face controlled trial was conducted in France.

Quantifying the impact of immortal time bias: empirical evidence from meta-analyses.

ObjectivesImmortal time bias (ITB) occurs when a period during which, by design, participants cannot experience the outcome (like death) is incorrectly included in the treatment group's follow-up, artificially making the treatment look better than it truly is. We aimed to identify a systematic sample of cases of ITB in the literature of studies using survival analysis and assess the impact of ITB on the results.DesignMeta-epidemiological study (PROSPERO[CRD42022356073]).

Global Prevalence of Functional Abdominal Pain Disorder among Children and Adolescents According to the Rome III and IV Criteria: A Systematic Review and Meta-Analysis.

Background/aims: Despite the global burden of functional abdominal pain disorder (FAPD) and its four subtypes (irritable bowel syndrome [IBS], functional dyspepsia [FD], abdominal migraine [AM], and functional abdominal pain not otherwise specified [FAP-NOS]), studies involving an estimation of FAPD prevalence based on the Rome III or IV criteria are limited. Therefore, we aimed to estimate the prevalence of FAPD and its four subtypes.

Methods: A comprehensive literature search was conducted in PubMed/MEDLINE, Embase, Google Scholar, and the Cochrane Library.

Prevalence and health outcomes of combustible cigarettes and noncombustible nicotine or tobacco products: a nationwide cross-sectional study in South Korea.

Objective: Limited evidence exists on type of tobacco use changes and differential health outcomes following the introduction of non-combustible nicotine or tobacco products (NNTPs). Therefore, this study aimed to evaluate the characteristics, trends, and health outcomes of exclusive combustible cigarette users and dual users of combustible cigarette and NNTP.

Methods: This study analyzed data from the Korea National Health and Nutrition Examination Survey from 2013 to 2021 ( = 18,763).

ACE inhibition increases Alzheimer's disease risk by promoting tau phosphorylation.

Reportedly, over 60% of individuals in the USA aged 65 or older take antihypertensive medications, making it crucial to evaluate their potential impact on dementia. Alzheimer's disease (AD), the most prevalent form of dementia, develops insidiously over decades, effectively precluding clinical trials of antihypertensive drug effects on AD risk. Through a triangulation approach integrating large-scale human genetics, population-based study, and rigorous experimental models, we identified that angiotensin-converting enzyme (ACE) inhibitors were associated with increased AD risk, with no significant associations observed for other antihypertensive classes, including angiotensin II receptor blockers and calcium channel blockers.

National trends in hypertension stratified by central adiposity using waist-to-height ratio in South Korea, 2005 to 2022.

Despite the growing prevalence of hypertension due to lifestyle changes and aging populations, with central obesity as a critical risk factor, there is limited research examining the association between central adiposity and hypertension trends. To address this gap, this study analyzed trends in hypertension prevalence among Korean adults categorized by healthy and increased central adiposity based on waist-to-height ratio (WHtR) and investigated the associated risk factors. We utilized data from 98,396 adults aged 30 years and older from the Korea National Health and Nutrition Examination Survey from 2005 to 2022 in South Korea.

Loneliness and isolation: Are they associated with the wish for an earlier end of life?

Aim: To examine the association of loneliness and social isolation with the desired age at death among middle-aged and older adults in Germany.

Methods: Data were taken from the German Aging Survey (wave 8: nationally representative sample of community-dwelling individuals aged ≥43 years; n = 3826). The mean age equaled 69.

Single-cell transcriptomic and pharmacological studies of onvansertib for small cell lung cancer treatment.

Polo-like kinase 1 (PLK1), a serine/threonine protein kinase, plays a crucial role in essential biological processes such as cell division, DNA damage response, and cell death. Since its dysregulation is highly associated with tumor development and progression, PLK1 inhibitors, including onvansertib, have been developed as promising anti-cancer therapeutics. Onvansertib is currently under Phase II investigation to evaluate its safety and efficacy in patients with relapsed small cell lung cancer (SCLC).

Impact of the WellCheck smartphone app linked to electronic health records on clinical outcomes in patients with type 2 diabetes: Study protocol for primary care-based, prospective, multicenter, cluster-randomized, pragmatic clinical trials.

ClinicalTrials.gov NCT06419816. Registered on 14 May 2024.

Effects of photobiomodulation on multiple health outcomes: an umbrella review of randomized clinical trials.

Background: Photobiomodulation (PBM) is a non-invasive therapy increasingly used for pain, inflammation, and tissue repair, yet a comprehensive synthesis of its effectiveness across multiple health outcomes remains lacking. Herein, we aimed to systematically assess the clinical effects and strength of evidence for PBM across a wide range of health outcomes using data from existing meta-analyses of randomized controlled trials (RCTs).

Methods: We conducted an umbrella review of meta-analyses of RCTs, searching five databases up to December 8, 2023.

Country-level prevalence of and factors associated with smoking cessation among adolescents across 91 countries.

Background: There is a paucity of research on patterns of attempts at smoking cessation, success, and influencing factors in adolescents. This study aims to analyze the prevalence of ex-smokers and current smokers with cessation attempts in adolescents worldwide and to identify the factors that affect cessation attempts along with outcomes.

Methods: This study utilized the Global Youth Tobacco Survey (2010-2021) to investigate tobacco use among adolescents aged 13-15 years.

Top 10 drugs most frequently associated with adverse events of myocarditis and pericarditis.

Myocarditis and pericarditis are managed with various treatments, yet prior studies and case reports indicate that certain drug classes may elevate the risk for these inflammatory cardiac conditions. This research aimed to systematically identify the leading drugs most frequently associated with myocarditis and pericarditis cases. Analyses were carried out using the global database of individual case safety reports from 1968 to 2024.

Global prevalence of congenital color vision deficiency among children and adolescents, 1932-2022.

Purpose: To estimate the prevalence of congenital color vision deficiency (CVD), categorized by geographical region, ethnicity, type (deutan, protan, and tritan), and severity (anomalous trichromacy, dichromacy, and monochromacy).

Design: Systematic review and meta-analysis of the literature.

Participants: A total of 1,703,619 participants, including 31,493 patients from 56 studies across 21 countries and five continents, were included in our analysis.

Correlation of Income Instability With 12 Non-Communicable Disease Risks in Korea: A Prospective Cohort Study.

Background: Due to the lack of comprehensive longitudinal studies examining the impact of long-term volatility on health issues, existing research primarily focused on income levels rather than fluctuation. Thus, we aimed to investigate the relationship between income instability and a range of physical health conditions using an extensive longitudinal dataset.

Methods: This study utilized data from the Korean Genome and Epidemiology Study (KoGES) Ansan-Anseong cohort (2001-2022), which includes valuable confounding factors such as demographic, socioeconomic, lifestyle, and clinical factors.

Global, Regional, and National Burden of Pharyngeal Cancer and Projections to 2050 in 185 Countries: A Population-Based Systematic Analysis of GLOBOCAN 2022.

Background: Pharyngeal cancer has resulted in 3.23 million disability-adjusted life years as of 2019. Based on anatomical site, pharyngeal cancers are categorized into oropharyngeal cancers (OPCs), nasopharyngeal cancers (NPCs), and hypopharyngeal cancers (HPCs).

Global cancer mortality among children, adolescents, and young adults from 77 countries, 1990-2021: a global time-series analysis and modelling study.

Background: The patterns of cancer burden in children, adolescents and young adults are distinct from those in the general adult population, underscoring the importance of developing targeted research and interventions. Thus, we analyzed global, regional, and national cancer mortality trends via the World Health Organization (WHO) Mortality Database among children aged 0-14 years and adolescents and young adults aged 15-34 across 77 WHO Member States.

Methods: Age-standardized country-specific cancer mortality rates (deaths per 100,000) and years of life lost between 1990 and 2021 were estimated via a locally weighted scatterplot smooth curve.

Associations between body mass index categories and geriatric assessment tests among older adults with chronic kidney disease: A prospective study.

Background: The optimal body mass index (BMI) among older adults with chronic kidney disease (CKD) in geriatric assessment tests has not been studied. This study investigates the relationship between BMI and Comprehensive Geriatric Assessment (CGA) parameters among older adults with CKD.

Methods: A total of 319 older adults with CKD were included.

Determinants of loneliness among older adults: A systematic review based on recent longitudinal studies.

Aims: To synthesize studies examining the determinants of loneliness among older adults based on recent longitudinal observational studies.

Methods: PRISMA guidelines were followed (PROSPERO ID CRD420251006752). In mid-March 2025, four established databases were searched and an additional hand search was performed.

Global Burden of Drug-Induced Anaphylaxis Associated With 33 Classes of Antibiotics (1968-2024): A Pharmacovigilance Analysis.

Background: Despite antibiotic-induced anaphylaxis being a severe allergic reaction requiring immediate care, large-scale studies examining all antibiotic subtypes remain limited. This study addresses this gap by analysing 33 antibiotic classes, along with epidemiological and regional variations.

Methods: This study utilised the world's largest pharmacovigilance database, with over 35 million individual case safety reports from 140 countries.