To explore the prognostic efficacy and mechanism of ABCC5 clinical scoring model in hepatocellular carcinoma.

Objective: The study found that ATP-binding cassette subfamily C member 5 (ABCC5) is highly expressed in hepatocellular carcinoma (HCC). It aims to explore ABCC5 role and prognostic value in HCC and uses the DrugBank database to identify potential therapeutic drugs targeting ABCC5, assessing its potential as a biomarker and treatment target for HCC.

Methods: RNA-seq and clinical data from TCGA-LIHC and GSE76427 were analyzed to identify ABCC5-associated differentially expressed genes and miRNAs.

Structural characterization and therapeutic potential of exopolysaccharide EPS-W-1 from Lactiplantibacillus plantarum strain ZL1 isolated from kimchi against DSS-induced colitis.

Ulcerative colitis (UC) is associated with intestinal barrier dysfunction, gut microbiome (GM) dysbiosis, inflammation, and immune dysregulation. Lactic acid bacteria-derived exopolysaccharides (LAB-EPS) have biotherapeutic potential to stimulate immune responses and influence the GM. Therefore, this work aimed to extract the bioactive EPS (EPS-W-1) from Lactiplantibacillus plantarum ZL1, isolated from Korean kimchi, and then characterize the chemical structure of EPS-W-1 using HPLC, GC-MS, and NMR.

MIM waveguide structure consisting of a baffle and a ring cavity embedded in a square metal layer.

This paper presents a design for a tunable plasmon refractive index nanosensor based on Fano resonance. The proposed structure comprises a metal-insulator-metal waveguide featuring a silver baffle and a ring cavity embedded in a square (RCSQ). This innovative structural configuration effectively excites dual Fano resonances by leveraging the unique properties of its constituent elements and geometry.

Co-Infection by Porphyromonas gingivalis and Fusobacterium nucleatum Increases PD-L1 Expression in Esophageal Cancer Tissues.

Currently, the impact of the microbiome on the progression and recurrence of esophageal cancer remains unclear. Microbes have been demonstrated to increase programmed death-ligand 1 (PD-L1) expression in certain epithelial tumors, thereby facilitating immune escape. Therefore, we hypothesized that the microbiome in esophageal tissues might be involved in the progression and recurrence of esophageal squamous cell carcinoma (ESCC) through PD-L1 upregulation.

Asymmetric synthesis of β-amino acid derivatives by stereocontrolled C(sp)-C(sp) cross-electrophile coupling via radical 1,2-nitrogen migration.

Optically pure non-natural β-amino acids are noteworthy molecular motifs of numerous pharmaceutically important molecules. Skeletal editing of abundant α-amino acid scaffolds via tandem radical 1,2-N-shift/cross-coupling represents a powerful tool to straightforward assemble new β-amino acid molecules; however, this strategy presents substantial challenges owing to difficulties in reactivity and regio-/enantiocontrol. Herein, we report a cross-electrophile C(sp)-C(sp) coupling of β-bromo α-amino acid esters with aryl bromides via a π-system-independent 1,2-N-shift, which allows access to α-arylated β-amino acid motifs with high efficiency and regioselectivity.

Burden of hypertensive heart disease among women of childbearing age in global, regional, and national regions from 1990 to 2021 and projection until 2040.

Background: The present research focuses on elucidating the global burden of hypertensive heart disease (HHD) among women of childbearing age (WCBA). By utilizing all available data and adopting the methodology employed in the Global Burden of Disease (GBD) study, this study aims to comprehensively analyze the epidemiological characteristics of this highly prevalent disorder.

Methods: In this research, we retrieved three key indicators-prevalence, incidence, and DALYs-related to HHD in WCBA from the GBD database for the period 1990 to 2021.

A country-wide survey into the composition and transformation of short-chain organic acids in anaerobic sludge digesters at wastewater treatment plants in Denmark.

Short chain organic acids (SCOAs) containing 1-6 carbons are important intermediates in anaerobic digestion (AD) of sewage sludge, and transformation of SCOAs is often the rate-limiting step. Comprehensive information about SCOAs in full-scale anaerobic digesters is thus crucial to better monitor and regulate the AD process. However, large-scale investigations and comparisons are still scare for industrial digesters, especially when considering the diverse operating conditions and AD techniques applied in the plants.

Observation of the efficacy and safety of concurrent intensity-modulated radiation with 5-fluorouracil and oxaliplatin for locally advanced nasopharyngeal carcinoma.

Purpose: The purpose of this study was to investigate the clinical efficacy and safety of concurrent intensity-modulated radiotherapy in combination with 5-fluorouracil and oxaliplatin for patients diagnosed with locally advanced nasopharyngeal carcinoma.

Material And Methods: A total 66 patients with a newly diagnosed and previously treated locally advanced nasopharyngeal carcinoma were enrolled in this study. The patients were divided into two groups: the control group receiving intensity-modulated radiotherapy with 5-fluorouracil and cisplatin (n=33) and the observation group receiving intensity-modulated radiotherapy with 5-fluorouracil and oxaliplatin (n=33).

Antifouling peptides engineered with amino-terminal copper-nickel-binding motifs for low-fouling and antibacterial electrochemical detection of HER2 in complex biofluids.

Conventional electrochemical biosensors used for biomarker detection in complex biofluids often suffer from reduced sensitivity and accuracy due to nonspecific molecular adsorption and bacterial interference. To overcome these limitations, it is essential to design biosensors that combine antifouling and antibacterial functionalities. Herein, a multifunctional branched peptide (MBP) was designed and used to construct electrochemical biosensor for human epidermal growth factor receptor 2 (HER2) detection in complex biofluids.

Anticancer and chemo-sensitizing effects of annonacin via p53-mediated DNA damage in ovarian cancer.

Ovarian cancer (OC) is a highly lethal malignancy in women, often diagnosed at advanced stages. Carboplatin is the primary chemotherapy drug used clinically; however, most patients experience relapse and develop drug resistance after initial treatment, underscoring the urgent need for novel therapeutic strategies. This study investigated the anti-cancer activity and chemo-sensitizing effects of annonacin, an active compound in the fruit extract of Asimina triloba, as well as its underlying mechanisms in OC.

Sliding ferroelectricity of multilayer h-BN.

The emergence of two-dimensional ferroelectrics has spurred significant interest for beyond-Moore electronics. Recent breakthroughs have demonstrated the robust out-of-plane ferroelectricity in specifically engineered hexagonal boron nitride (h-BN) configurations interlayer sliding mechanisms. We systematically investigate stacking-dependent ferroelectric ordering in multilayer h-BN using first principles calculation methods and the modern theory of polarization.

[Elucidating the Spatial Differentiation of Soil Organic Matter and Influencing Factors within the Yihe River Basin].

Accurate prediction of the spatial distribution of soil organic matter （SOM） is crucial for improving the productivity of arable land， developing modern precision agriculture， regulating soil carbon balance， and protecting the ecological environment. Previous research has analyzed the horizontal spatial distribution characteristics and influencing factors of SOM in different regions. Still， few studies have examined the spatial distribution of SOM and its drivers from a vertical perspective.

Long-Term or Recurrent Antibiotic Use in Early Life and the Risk of Type 2 Diabetes: A Population-Based Prospective Cohort and a Case-Control Study.

Background: Antibiotics in childhood are commonly used and have been linked to gut microbiome dysbiosis and metabolic disorders. However, direct evidence regarding the association between long-term or recurrent antibiotic use (LRAU) during early life and diabetes was scarce. We performed this study to investigate this association in two population-based studies.

Corrosion Protection of Rare Earth for Kilowatt-Level Alkaline Seawater Electrolyzer.

The competitive adsorption of Cl caused by anode OH consumption under high current density is an important factor restricting the development of an alkaline seawater electrolyzer (ASWE). Here, we propose a strategy for rare earth corrosion protection which utilizes oxygen friendly rare earths that do not participate in the reaction to adsorb OH and maintain the surface environment for stable anodic catalysis in an ASWE. Differential electrochemical mass spectrometry (DEMS) and electrochemical quartz crystal microbalance (EQCM) were used to identify the causes of chlorine corrosion on the high current anode plate of traditional Ni mesh.

Advanced Development of High-Entropy Alloys in Catalytic Applications.

Conventional alloys have long been limited by their simple compositions, which make it difficult to meet the requirements of modern catalysis applications. In contrast, high-entropy alloys (HEAs), characterized by multi-principal elements in near-equimolar ratios, have become a transformative paradigm in materials science since their inception in 2004. The unique core effects of HEAs, including the high-entropy effect, severe-lattice distortion effect, sluggish-diffusion effect, and cocktail effect, endow them with superior catalytic properties of activity, selectivity, and durability.

Relationship between BMI and chemotherapy-induced peripheral neuropathy in cancer patients: a dose-response meta-analysis.

Objective: This meta-analysis aimed to evaluate the dose-response relationship between body mass index (BMI) and the risk of chemotherapy-induced peripheral neuropathy (CIPN) in cancer patients.

Methods: We conducted a dose-response meta-analysis of 10 studies involving 6,841 cancer patients. Studies reporting BMI and CIPN outcomes were selected.

Research and Application of Composite Functional Dust Suppressant for the Slope Road of a Metal Mine.

In addressing the inadequacies of bonded dust suppressants employed in mining road applications, a novel approach is proposed for the research and development of a multifunctional road surface dust suppressant. A moisturizing functional component was added to enhance the fluidity and penetration capabilities of the dust suppressant; it can improve the coupling efficiency between the dust suppressant and the dust particles and then enhance the strength and thickness of the cemented layer of the dust suppressant. Fenugreek gum is selected as the bonding functional component due to its abundance in hydrophilic groups, facilitating enhanced coupling compatibility among the functional components and improving the coupling strength and crush-resistant performance of the dust suppressant cemented layer.

Long-Term Resorption Rates of Conchal and Rib Cartilage Grafts in Nasal Tip Plasty in Asian Patients: A Retrospective Study.

Background: Autologous cartilage has been extensively employed in nasal tip plasty procedures. Nevertheless, long-term resorption rates of autologous cartilage grafts, particularly on the nasal tip, remain uncertain to surgeons worldwide. Thus, the present study aims to assess the resorption rate of conchal cartilage and rib cartilage.

Metabolomics and network pharmacology approach to identify potential bioactive compounds from Trichoderma sp. against oral squamous cell carcinoma.

This study aimed to profile metabolites from five Trichoderma strains and assess their cytotoxic and pharmacological activities, particularly targeting oral squamous cell carcinoma (OSCC). UHPLC-TOF-MS analysis revealed the presence of 25 compounds, including heptelidic acid, viridiol isomers, and sorbicillinol from the different Trichoderma extracts. Pharmacokinetic analysis showed moderate permeability and low interaction with P-glycoprotein, suggesting good drug absorption with minimal interference in cellular uptake.

Usenamine A: a potential therapeutic agent for rheumatoid arthritis and ankylosing spondylitis through its anti-inflammatory activity.

Background: Usenamine A (UA) is a natural compound isolated from the lichen , and its therapeutic effects on rheumatic diseases are not well understood. This study aimed to evaluate the potential anti-inflammatory effects of UA and its therapeutic effects on rheumatoid arthritis (RA) and ankylosing spondylitis (AS).

Materials And Methods: Molecular docking was performed between the 3D structure of UA and the TNF-TNFR2 complex.

Proteolysis-regulated excited state electron transfer of AgS/In(OH)@BSA nanocomposites for fluorescence-photoelectrochemistry dual-mode biosensing of heparin.

Sharing the same photoexcitation process, fluorescence (FL) and photoelectrochemistry (PEC) accomplish optical-optical and optical-electrochemical switches respectively, and are both widely used in diverse fields. However, since FL and PEC are mutually exclusive in principle, it is difficult to obtain intense FL and PEC responses in a system, limiting FL-PEC dual-mode applications. In this study, AgS quantum dots (QDs) and In(OH) nanoblocks (NBs) are simultaneously synthesized by BSA-templated bio-mineralization, and the excited state electrons of AgS/In(OH)@BSA nanocomposites (NCs) are further regulated by a proteolysis process.

Experimental Investigation of the Combustion Characteristics and Thermal Hazards of Methylsilyl-Modified Silica Aerogels.

The thermal safety of hydrophobic silica aerogels (SAs) is essential to thermal insulation applications. Herein, trimethylchlorosilane (TMCS), dimethyldichlorosilane (DMDCS), and methyltrichlorosilane (MTCS) were employed as surface modifiers to prepare three different methylsilyl-modified SAs (i.e.

Recent advancements in antibiotics removal by bio-electrochemical systems (BESs): From mechanisms to application of emerging combined systems.

Recent advancements in bio-electrochemical systems (BESs) for antibiotic removal are receiving great attentions due to the electro-active bacteria on the electrode that could elevate the removal efficiency. Enhanced detoxification performance of BESs compared to the traditional biological processes indicates the great potential serving as a sustainable alternative or a pre-/post-processing unit to improve the performance of biological processes. However, the successfully application of BESs to antibiotic-polluted water remediation requires a deeper discussion on their operational performance and emerging coupled systems.