Antifouling peptides engineered with amino-terminal copper-nickel-binding motifs for low-fouling and antibacterial electrochemical detection of HER2 in complex biofluids.

Conventional electrochemical biosensors used for biomarker detection in complex biofluids often suffer from reduced sensitivity and accuracy due to nonspecific molecular adsorption and bacterial interference. To overcome these limitations, it is essential to design biosensors that combine antifouling and antibacterial functionalities. Herein, a multifunctional branched peptide (MBP) was designed and used to construct electrochemical biosensor for human epidermal growth factor receptor 2 (HER2) detection in complex biofluids.

Quantitative contrast enhancement volume on immediate post-thrombectomy CT predicts symptomatic intracranial hemorrhage and functional outcomes in acute large vessel occlusion stroke.

Objectives: Symptomatic intracranial hemorrhage (sICH) following endovascular thrombectomy (EVT) for acute ischemic stroke due to anterior circulation large vessel occlusion (AIS-LVO) significantly impacts clinical outcomes. Contrast enhancement (CE) on immediate post-EVT non-contrast CT (NCCT) may reflect blood-brain barrier disruption, but its volumetric correlation with sICH and functional independence remains underexplored.

Methods: We performed a retrospective screening on consecutive AIS-LVO patients who had CE on NCCT immediately within 2 h after EVT.

The effect of cerebral collateral recycle on outcomes for patients with large ischemic infarct undergoing endovascular treatment.

Background And Objectives: Although several large clinical trials have shown that endovascular treatment (EVT) is beneficial for patients with large core infarction, their outcomes were still much worse than those with mild infarction. Therefore, given the cerebral collateral recycle (CCR) as an effective prognostic marker, this study explored the relationship between CCR and clinical outcomes in patients with large ischemic infarct.

Methods: We conducted a retrospective multicenter cohort study of patients with acute ischemic stroke due to large vessel occlusion (AIS-LVO).

Association Between Premorbid Frailty Status and Functional Independence in Acute Ischemic Stroke Patients Following Endovascular Treatment in the Late Window.

Purpose: Although the predictive role of cerebral tissue impairment has been extensively investigated in acute ischemic stroke (AIS) patients undergoing endovascular treatment (EVT) in the late window, the impact of peripheral organs on clinical outcomes in these patients remains largely unknown. Therefore, we aimed to explore whether frailty, a reflection of the patient's physical status based on peripheral organ health at admission, could be associated with outcomes among AIS patients treated by EVT in the late window of 6-24 hours from stroke onset.

Patients And Methods: This was a post-hoc analysis of our RESCUE-BT trial, with findings validated in an external cohort.

The OsZHD1 and OsZHD2, Two Zinc Finger Homeobox Transcription Factor, Redundantly Control Grain Size by Influencing Cell Proliferation in Rice.

Grain size is vital determinant for grain yield and quality, which specified by its three-dimensional structure of seeds (length, width and thickness). The ZINC FINGER-HOMEODOMAIN (ZHD) proteins play critical roles in plant growth and development. However, the information regarding the function in reproductive development of ZHD proteins is scarce.

Favorable Cerebral Collateral Cascades Improve Futile Recanalization by Reducing Ischemic Core Volume in Acute Ischemic Stroke Patients Undergoing Endovascular Treatment.

Although endovascular treatment (EVT) was the first-line therapeutic strategy for acute ischemic stroke (AIS), half of the patients could not achieve functional independence. Previous studies suggested arterial collateral was an important predictor of this phenomenon. However, cerebral collateral circulation was regulated by arteries, venous, and microcirculation, and its role remained unclear.

Intra-Arterial Tenecteplase Following Endovascular Reperfusion for Large Vessel Occlusion Acute Ischemic Stroke: The POST-TNK Randomized Clinical Trial.

Importance: The impact of adjunctive intra-arterial tenecteplase administration following near-complete to complete reperfusion by endovascular thrombectomy (EVT) for acute ischemic stroke is unknown.

Objective: To assess the efficacy and adverse events of adjunctive intra-arterial tenecteplase in patients with large vessel occlusion stroke who had achieved near-complete to complete reperfusion (defined as a score on the expanded Thrombolysis in Cerebral Infarction [eTICI] scale of 2c to 3) after EVT.

Design, Setting, And Participants: Investigator-initiated, randomized, open-label, blinded outcome assessment trial implemented at 34 hospitals in China among 540 patients with stroke due to proximal intracranial large vessel occlusion within 24 hours of the time they were last known to be well, with an eTICI score of 2c to 3 after EVT, and without prior intravenous thrombolysis.

Predicting Futile Recanalization by Cerebral Collateral Recycle Status in Patients with Endovascular Stroke Treatment: The CHANOA Score.

Rationale And Objectives: The correlation between collateral circulation and futile recanalization (FR) is still controversial, and few studies have explored the influence of comprehensive cerebral collateral circulation on FR after endovascular stroke treatment. Therefore, based on cerebral collateral recycle (CCR) status, we aimed to establish an effective scoring system to identify the probability of FR.

Methods: This was a multicenter retrospective cohort study.

Multi-relational graph contrastive learning with learnable graph augmentation.

Multi-relational graph learning aims to embed entities and relations in knowledge graphs into low-dimensional representations, which has been successfully applied to various multi-relationship prediction tasks, such as information retrieval, question answering, and etc. Recently, contrastive learning has shown remarkable performance in multi-relational graph learning by data augmentation mechanisms to deal with highly sparse data. In this paper, we present a Multi-Relational Graph Contrastive Learning architecture (MRGCL) for multi-relational graph learning.

iTRAQ-based protein profiling and functional identification of four genes involved in rice basal resistance against Magnaporthe oryzae in two contrasting rice genotypes.

Rice blast, caused by Magnaporthe oryzae, is one of the most destructive rice diseases. Developing blast-resistant rice cultivars represents the most economical and environmentally friend strategy for managing the disease. In our previous study, an isobaric tags for relative and absolute quantitation (iTRAQ)-based comparative protein quantification was carried out to investigate the resistance gene Piz-t gene-mediated resistance response to infection in two contrasting rice genotypes of the Piz-t transgenic Nipponbare line (NPB-Piz-t) and its wild-type Nipponbare (NPB).

The Association of the Spatial Location of Contrast Extravasation with Symptomatic Intracranial Hemorrhage after Endovascular Therapy in Acute Ischemic Stroke Patients.

Background: Contrast extravasation (CE) on brain non-contrast computed tomography (NCCT) after endovascular therapy (EVT) is commonly present in patients with acute ischemic stroke (AIS). Substantial uncertainties remain about the relationship between the spatial location of CE and symptomatic intracranial hemorrhage (sICH). Therefore, this study aimed to evaluate this association.

Characterization of serum polyunsaturated fatty acid profile in patients with inflammatory bowel disease.

Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the digestive tract. The aetiology and pathogenesis of IBD are complex, which may lead to metabolic disorders. As a kind of metabolite, polyunsaturated fatty acid (PUFA) is closely related to IBD.

Increasing diversity and biotic homogenization of lake plankton during recovery from acidification.

Determining biodiversity responses to environmental change, such as acidification, is critical for ecosystem projections under future global change scenarios. Here, we analyzed three plankton communities of phytoplankton, crustaceans and rotifers in 28 lakes in the Adirondack Park, USA, during 1994-2012, and examined the spatiotemporal trends in their alpha and beta diversity during recovery from acidification. For all plankton assemblages, Shannon diversity increased towards recent years and high lake pH, and there was an increasing community dissimilarity with pH changes.

Interlayer Link Prediction in Multiplex Social Networks Based on Multiple Types of Consistency Between Embedding Vectors.

Online users are typically active on multiple social media networks (SMNs), which constitute a multiplex social network. With improvements in cybersecurity awareness, users increasingly choose different usernames and provide different profiles on different SMNs. Thus, it is becoming increasingly challenging to determine whether given accounts on different SMNs belong to the same user; this can be expressed as an interlayer link prediction problem in a multiplex network.

Rapid removal of Cr(III) from high-salinity wastewater by cellulose-g-poly-(acrylamide-co-sulfonic acid) polymeric bio-adsorbent.

A cellulose-g-poly-(acrylamide-co-sulfonic acid) polymeric bio-adsorbent (CASA) was prepared by grafting copolymerization, and used to adsorb Cr(III) from leather wastewater. The SEM, XRD, FTIR, and XPS results showed that CASA contains many spherical particles and functional groups such as NH, CO, and HSO. The adsorption experiments revealed that CASA presented excellent adsorption performance for Cr(III) (274.

Exploring the construction and infiltration strategies of social bots in sina microblog.

Nowadays, millions of people use Online Social Networks (OSNs) like Twitter, Facebook and Sina Microblog, to express opinions on current events. The widespread use of these OSNs has also led to the emergence of social bots. What is more, the existence of social bots is so powerful that some of them can turn into influential users.

Diagnostic and Clinical Significance of Serum Levels of D-Lactate and Diamine Oxidase in Patients with Crohn's Disease.

Background: Crohn's disease (CD) is a chronic intestinal inflammatory disease. An ideal laboratory marker that can predict the prognosis in terms of relapse of the disease is clinically desirable.

Methods: A total of 59 CD patients were enrolled in this study.