Novel preoperative computed tomography (CT)-derived parameters to enhance self-expanding metallic stents (SEMS) outcomes in obstructive colorectal cancer.

Aim: This study aimed to evaluate whether preoperative computed tomography (CT)-based morphological parameters predict the clinical success of self-expanding metallic stents (SEMS) in malignant colorectal obstruction.

Materials And Methods: Sixty-six patients with acute malignant colonic obstruction who underwent SEMS placement between 2016 and 2021 were retrospectively analysed. Tumour length, wall thickness, and lumen diameter were measured on preoperative CT, and ratios with SEMS dimensions were calculated.

Associations between masseter and temporal muscle measurements and sarcopenia and nutritional status in older adults.

Purpose: The aim of this study was to investigate the relationship between temporal muscle thickness (TMT) as well as temporal (TMA) and masseter muscle (MMA) area with nutritional status and sarcopenia in older individuals.

Methods: This was a retrospective cross-sectional study. A total of 275 participants were evaluated to establish comprehensive geriatric assessment guidelines.

Investigating the role of biomarkers using liquid biopsy in the diagnosis of meningiomas.

Aim: Meningiomas are the most common type of primary brain tumor found in adults. While magnetic resonance imaging (MRI) is commonly used to diagnose meningiomas, determining the tumor grade is challenging. Tumor grading is essential for selecting the most appropriate treatment and determining the extent of surgical resection when surgery is performed.

Comparison of the efficacy of mFOLFOX-6 and mDCF regimens in the treatment of metastatic gastric cancer: a multicenter retrospective study.

Background: Metastatic gastric cancer (GC) and gastroesophageal junction (GEJ) cancer are associated with a poor prognosis. Recent advancements in treatment have incorporated trastuzumab, anti-PD-1 agents, and anti-claudin therapies alongside chemotherapy (ChT), significantly improving outcomes. Contemporary studies predominantly employ doublet ChT as the backbone for these regimens, although historically triplet ChT regimens have been favored, particularly in younger patients requiring rapid tumor shrinkage.

Synthesis, Characterization, and Comprehensive In Vitro and In Silico Evaluation of the Anti-Inflammatory Potential of Novel 1,2,3-Triazole-Arylidenehydrazide/Thiazolidinone Hybrids.

Five novel 1,2,3-triazole/arylidenehydrazide/thiazolidinone hybrid compounds (7-11) were synthesized and characterized using NMR, HRMS, IR, and HPLC purity analysis. The cytotoxicity of these compounds was evaluated on fibroblasts and THP-1 cells, showing that all compounds were nontoxic at the tested concentrations. The wound healing assay revealed that compounds 7, 9, and 10 significantly enhanced wound closure, with a 7.

Epidemiology and Outcomes of Candida-Associated Osteoarticular Infections: A Multicenter Retrospective Study from Turkey.

This multicentre retrospective study investigated the epidemiology, clinical characteristics, and fluconazole resistance rates of Candida species in osteoarticular infections across Turkey as well as the factors influencing complete recovery. Data were gathered from 73 adult patients diagnosed with proven or probable Candida-associated osteoarticular infections between 2015 and 2025 from 20 healthcare centres. The most common clinical presentation was spondylodiscitis, followed by the involvement of phalangeal bones in the hands and feet.

In silico and in vitro antibacterial evaluation of eight Anatolian Salvia species with chemical profiling by LC-HRMS.

Salvia species play a significant role in the pharmaceutical and nutraceutical industries due to their rich chemical profiles and notable biological activities. This study aimed, for the first time, to comprehensively investigate the phytochemical profile and antibacterial properties of eight selected Salvia species. Ethanol and water extracts were prepared from the dried aerial parts, and their chemical compositions were analyzed via LC-HRMS.

Assessment of oxidative stress and trace element dynamics in acute myocardial infarction and heart failure: a focus on zinc, copper, and thiol dynamics.

Background: Acute Myocardial Infarction (AMI) and Heart Failure (HF) are the leading global causes of death from Cardiovascular Diseases (CVD). This study aimed to investigate the association of serum Zinc (Zn), Copper (Cu), and thiol levels with CVD and new potential biomarkers.

Methods: The study included serum samples from 150 participants, including 50 AMI patients, 50 HF patients, and 50 healthy individuals.

Secondary Metabolite Profiling of P.H. Davis and (K. Koch) Boiss. by LC-HRMS and Evaluation of Antioxidant and Anticholinergic Activities.

In this study, phenolic compounds of methanol extracts obtained from the leaves and branches of P.H. Davis and (K.

Salvage Surgery with Iliac Wing Autograft Following Total Calcanectomy for Calcaneal Chondrosarcoma.

Primary malignancies originating in the calcaneus are rare, constituting fewer than 1% of skeletal tumors. Traditional approaches like amputation, though effective, result in significant morbidity. This study presents a case of a 32-year-old male with calcaneal chondrosarcoma, managed with total calcanectomy and subsequent limb salvage through iliac wing autograft reconstruction.

New 1,1'-hydrazine-bis(phenoxy-1,2,3-triazol-acetamide) derivatives as potent inhibitors against acetylcholinesterase, butyrylcholinesterase, and α-glucosidase.

In this study, novel 1,1'-hydrazine-bis(phenoxy-1,2,3-triazol-acetamide) derivatives 10a-n were synthesized, and because of their structural features, they were evaluated against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and α-glucosidase. AChE and BChE are two important targets in the treatment of Alzheimer's disease (AD), and α-glucosidase is a carbohydrate-hydrolyzing enzyme with therapeutic importance in diabetes. Furthermore, cell studies were performed on the title compounds against SH-SY5Y neuroblastoma cells as a cancer cell line and HEK293 cells as a normal cell line.

The Effect of Ginger and Mint on Postoperative Nausea and Vomiting in Patients Undergoing Total Thyroidectomy.

Purpose: Postoperative nausea and vomiting (PONV) is a group of symptoms that develop in patients within 24 hours after surgical intervention and are undesirable outcomes complicating patients' postoperative recovery. The purpose of this study was to establish the impact of ginger and peppermint essential oil inhalation for PONV in patients who underwent total thyroidectomy.

Design: Our study was designed as a randomized controlled experimental study.

Evaluation of the relationship between vitamin D deficiency and microalbuminuria, glycaemic control, lipid profile in patients with type 2 diabetes mellitus.

Objective: To evaluate the relationship of vitamin D deficiency with microalbuminuria, glycaemia and lipid profile in type 2 diabetes mellitus patients.

Methods: The retrospective, clinical study was conducted at Family Medicine outpatient clinics of Istanbul Bezmialem Vakıf University, Faculty of Medicine Hospital, Turkey, and comprised data between July 1 and December 31, 2019 related to adult type 2 diabetes patients. Data was classified according to vitamin D levels; <20 ng/mL in group 1, and >20 ng/mL in group 2.

CT evaluation of gastrointestinal system perforations: A retrospective comparative analysis between retroperitoneal and intraperitoneal perforation sites.

Background: Correct identification of the etiology and anatomical location of perforations is paramount for ensuring optimal therapeutic intervention and surgical planning in cases of gastrointestinal tract perforation.

Purpose: This study aimed to retrospectively evaluate the distinctive multidetector computed tomography (MDCT) findings of intraperitoneal and retro-/extraperitoneal perforation by comparing the locations of free air in the abdomen and other imaging findings.

Material And Methods: A total of 226 patients with acute abdominal pain who visited the emergency department and underwent contrast-enhanced CT between January 2016 and November 2023 were included.

Neuroprotective Effects of Phosphodiesterase Inhibitors on Sestrin-2 (SESN2) Expression and Autophagy in Alzheimer's Disease Model.

Objective: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and the accumulation of amyloid-beta (Aβ) peptides. The neuroprotective protein sestrin-2 (SESN2) has been implicated in the cellular response to oxidative stress and autophagy, processes that are disrupted in AD. This study explores the effects of phosphodiesterase inhibitors (PDEIs) roflumilast (RF), rolipram (ROL), and tadalafil (TAD) on SESN2 expression and autophagy in Aβ25-35-treated hippocampal neuron (HT-22) cell cultures.

Radiologic prevalence of otic capsule dehiscence and development of the Yenigun classification for semicircular canal dehiscence.

Objective: The superior semicircular canal dehiscence is the most well-known otic capsule dehiscence. However, several other dehiscences affect the semicircular canals, cochlea, and vestibule. Our research aimed to examine the frequency, distribution, and correlation between radiologic otic capsule dehiscence in patients exhibiting symptoms of third window syndrome.

Novel thiazolidinedione hybrids as cholinesterase inhibitors and targeting neuroblastoma: design, synthesis, in vitro and in silico biological evaluations.

In this study, a novel series of eleven 3,5-disubstituted thiazolidine-2,4-dione (TZD) derivatives were rationally designed and synthesized, incorporating tertiary amine moieties to enhance cholinesterase binding. The acetamide-linked TZD scaffold was selected for its potential dual functionality: cholinesterase inhibition and cytotoxicity against neuronal cells. All compounds were evaluated for their inhibitory activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), alongside cytotoxicity assays on SH-SY5Y cancerous neuroblastoma and HEK-293 healthy cells.

Appetite loss in older adults without undernutrition: associated factors and clinical implications.

Background: The aim of this study was to investigate the clinical implications of appetite loss in older adults with normal nutritional status, prior to the development of malnutrition.

Methods: This study included a total of 755 older outpatients with normal nutritional status as determined by the Mini Nutritional Assessment (MNA ≥ 24). Council on Nutrition Appetite Questionnaire was used to assess appetite status.

Exploring the Modulatory Effects of Vitamin B12 on Morphine-Induced Conditioned Place Preference in Rats.

Background: This study aims to investigate the effects of vitamin B12 on morphine-induced conditioned place preference (CPP), a model commonly used to assess the rewarding effects of drugs. Morphine is a potent analgesic widely used for moderate to severe pain, but it also poses a significant risk of addiction. Previous studies suggest that cyanocobalamin (vitamin B12) may enhance the analgesic effects of morphine and reduce tolerance, but its impact on morphine addiction remains unclear.

New targets and strategies in treatment of metastatic gastric cancer.

Introduction: Gastric cancer is a common type of cancer and one of the leading causes of cancer-related deaths. Unfortunately, the number of cases has been rising in recent years. Since this cancer often does not show symptoms in its early stages, most people are diagnosed when the disease is already advanced (stage 3 or 4).

Radiological and Electrodiagnostic Insights into Suprascapular Nerve Dysfunction: A Key Predictor of Poor Functional Outcomes in Shoulder Hemiarthroplasty.

Background: Suprascapular nerve (SSN) dysfunction has emerged as underexplored factor influencing functional outcomes after shoulder hemiarthroplasty (SHA) for proximal humerus fractures. Despite achieving optimal tuberosity healing and prosthesis alignment, some patients continue to experience poor functional recovery. This study investigates the role of suprascapular nerve dysfunction as a key determinant of unfavorable outcomes following SHA.

Long-Term Follow-Up of Cardiac Magnetic Resonance Imaging in Children with MIS-C Associated With COVID-19: A Prospective Study.

Background: The researchers identified cases of multisystem inflammatory syndrome in children (MIS-C), which was linked to COVID-19 starting in 2020. MIS-C is associated with significant cardiovascular morbidity in the acute phase. A small number of articles in the literature have recorded the long-term myocardial effects of MIS-C patients in children treated in pediatric intensive care units (PICUs).