Long-Term Follow-Up of Cardiac Magnetic Resonance Imaging in Children with MIS-C Associated With COVID-19: A Prospective Study.

Background: The researchers identified cases of multisystem inflammatory syndrome in children (MIS-C), which was linked to COVID-19 starting in 2020. MIS-C is associated with significant cardiovascular morbidity in the acute phase. A small number of articles in the literature have recorded the long-term myocardial effects of MIS-C patients in children treated in pediatric intensive care units (PICUs).

Antiviral activities of phenylalanine derivatives carrying carboxylic acid bioisosteres against chikungunya and parainfluenza virus type 3.

Pathogenic RNA viruses from various virus families represent substantial public health hazards. Specific antiviral drugs effective against most RNA virus infections have not yet been developed. In this study, it was aimed to investigate the broad-spectrum antiviral activities of phenylalanine derivatives designed by replacing the carboxylic acid moiety with various bioisosteres such as nitrile, hydroxamidine and 5-oxo/thioxo-1,2,4-oxadiazole.

A Critical Appraisal of Off-Label Use and Repurposing of Statins for Non-Cardiovascular Indications: A Systematic Mini-Update and Regulatory Analysis.

Statins exhibit pleiotropic anti-inflammatory, antioxidant, and immunomodulatory effects, suggesting their potential in non-cardiovascular conditions. However, evidence supporting their repurposing remains limited, and off-label prescribing policies vary globally. To systematically review evidence on statin repurposing in oncology and infectious diseases, and to assess Hungarian regulatory practices regarding off-label statin use.

Effects of periodontal disease prediction system on oral hygiene motivation in patients with periodontitis: a prospective randomized controlled clinical study.

Aim: The aim of this study is to enhance and maintain individual patients' oral hygiene motivation using a computer-based visualization program entitled as Periodontal Disease Prediction (PDP).

Materials And Methods: Patients were randomly assigned to three groups: (a) conventional method group (CM, n = 40), (b) Three-dimensional animation (3DA, n = 40), and (c) PDP interaction (n = 40). A total of 120 patients (60 females, 60 males; aged 30-60 years) diagnosed with Stage III Grade B periodontitis and poor oral hygiene (OHI-S > 3) were included.

Balance and biomechanics: exploring lower extremity biomechanics in Parkinson's disease.

Background: Postural instability (PI) is a symptom seen in 16% of Parkinson Disease (PD) patients and has limited response to dopaminergic therapy. Understanding the factors contributing to PI, such as biomechanical changes, is important for the development of non-pharmacological treatment.

Aims: To investigate the relationship between lower extremity biomechanics and balance parameters in PD patients.

Annexin A1 levels in polycystic ovary syndrome: impact of professional mechanical plaque removal.

Objective: This study aimed to investigate the local inflammatory profile in women with polycystic ovary syndrome (PCOS) by assessing interleukin (IL)-6, IL-10, and annexin A1 (ANXA1) levels in saliva and gingival crevicular fluid (GCF), and to compare the clinical and biochemical responses to proffessional mechanical plaque removal (PMPR) between women with PCOS and systemically healthy individuals.

Methods: Eighty women were allocated into four groups: (1) PCOS-healthy periodontium (PCOSH), (2) PCOS-gingivitis (PCOSG), (3) systemically healthy-gingivitis (SG), (4) systemically and periodontally healthy (SH). Clinical periodontal parameters and saliva/GCF samples were collected at baseline and 6 weeks after PMPR.

Percutaneous, transpapillary, and transmural drainage in acute cholecystitis: a comparative analysis of techniques, stent selection, and clinical.

Acute cholecystitis is a common inflammatory condition of the gallbladder, primarily caused by gallstone obstruction, leading to increased intraluminal pressure, ischemia, and infection. While laparoscopic cholecystectomy remains the standard treatment, gallbladder drainage techniques have emerged as effective alternatives for high-risk surgical patients. This review explores the indications, techniques, and comparative outcomes of various gallbladder drainage methods, including percutaneous transhepatic gallbladder drainage (PTGBD), endoscopic transpapillary gallbladder drainage (ETGBD), and endoscopic ultrasound-guided gallbladder drainage (EUS-GBD).

A rare case of cutaneous vascular phenomena and fulminant cardiac involvement in paediatric multisystem inflammatory syndrome in children following asymptomatic COVID-19 exposure in a 7-year-old child.

Multisystem inflammatory syndrome in children is a systemic disorder that involves incessant fever, extreme inflammation, and organ dysfunction, which is at first associated with exposure to COVID-19. This case, however, presents a unique twist. A 7-year-old paediatric patient, initially presenting with fever and rash, exhibited a polymorphous rash varying from macular to maculopapular, with a cutis marmorata-like appearance, particularly on the extremities.

Description of Multicopy Recombinant Hepatitis B Surface Antigen: From Expression to Immune Analysis.

Hepatitis B virus (HBV) remains a significant global health challenge. Although antiviral treatments have improved, vaccines containing the Hepatitis B surface antigen (HBsAg) are still the most effective prevention method. Since 1998, HBV vaccines have been part of Turkiye's mandatory childhood vaccination program, with all vaccines currently imported.

Comparative analysis of melatonin's protective role against flattening filter and flattening filter-free X-ray induced nephropathy: focus on apoptosis and SIRT1 modulation.

Background: Radiation-induced nephropathy is a major concern, particularly for patients undergoing radiotherapy. This study investigates melatonin's (MEL) protective effects against kidney damage induced by Flattening Filter (low dose rate-LDR) and Flattening Filter Free (high dose rate-HDR) X-ray by focusing on apoptosis and SIRT1 modulation in rats.

Methods: Forty rats were divided into five groups (n = 8): Group 1 (control), Group 2 (FF-LDR, 400MU/min), Group 3 (MEL + FF-LDR), Group 4 (FFF-HDR, 1400MU/min), and Group 5 (MEL + FFF-HDR).

Identification and evaluation of drug-related problems in community pharmacy in Turkey: a descriptive prevalence study.

Background: Community pharmacies (CPs) are key healthcare providers, playing a significant role in optimizing drug therapy and preventing drug-related problems (DRPs). This study aims to assess the prevalence, characteristics, and related factors of DRPs in Turkish patients in the community pharmacy setting.

Methods: A cross-sectional, prospective study was conducted between December 2023 and December 2024 in a community pharmacy.

Genotype-Phenotype Correlation in Lipoid Proteinosis: 15 Cases from Turkiye.

Introduction: Lipoid proteinosis (LP), a rare autosomal recessive disorder typified by generalized thickening of the skin, mucosa, and certain viscera, is associated with pathogenic variants. Skin lesions like beaded eyelid papules, acneiform scars, wavy, yellow papules and nodules typically appear in early childhood. Some patients may exhibit neurological abnormalities like temporal lobe or hippocampi-amygdala complex calcification, epilepsy, and neuropsychiatric abnormalities.

Synthesis, human carbonic anhydrase I and II inhibition, and in silico studies of 2-ethoxy-6-formylphenyl [1,1'-biphenyl]-4-sulfonate derived thiosemicarbazones.

This study describes the synthesis and biological evaluation of 2-ethoxy-6-formylphenyl [1,1'-biphenyl]-4-sulfonate-based thiosemicarbazones 5(a-s) as potential inhibitors of human carbonic anhydrase isoforms hCA I and hCA II. Among the synthesized compounds, 5 k exhibited potent inhibition, with IC values of 89.25 nM and 54.

The effect of a 12-week physiotherapy program on lower extremity function and gait in children with isolated gastrocnemius tightness.

Background: Isolated gastrocnemius tightness (IGT) limits ankle dorsiflexion with the knee extended. This study evaluated a 12-week physiotherapy program's effects on lower extremity function and gait in children with IGT.

Materials And Methods: A single-group pre-post interventional design was used, including 30 children aged 6-12 years with bilateral IGT.

Associations between body mass index categories and geriatric assessment tests among older adults with chronic kidney disease: A prospective study.

Background: The optimal body mass index (BMI) among older adults with chronic kidney disease (CKD) in geriatric assessment tests has not been studied. This study investigates the relationship between BMI and Comprehensive Geriatric Assessment (CGA) parameters among older adults with CKD.

Methods: A total of 319 older adults with CKD were included.

The role of complement C3 deposition in ANCA-associated glomerulonephritis: a registry-based study of clinical, histopathological, and prognostic insights.

Background: ANCA-associated glomerulonephritis (ANCA-GN) is a leading cause of pauci-immune crescentic GN. Recent evidence indicates that complement activation, marked by C3 deposition in glomeruli, may contribute to more severe renal injury and influence renal outcomes. We aim to evaluate the clinical, histopathological, and prognostic implications of C3 deposition in ANCA-GN.

The Impact of Ketogenic Diet Consumption on the Sporadic Alzheimer's Model Through MT1/MT2 Regulation.

Melatonin and its receptors play a primary role in regulating circadian rhythms, which are frequently disrupted in patients with Alzheimer's disease (AD). Furthermore, there is increasing evidence that the use of a ketogenic diet (KD) delays the onset of AD. Therefore, we aimed to investigate whether KD has an ameliorative effect on AD through the regulation of melatonin receptors.

Management of critically located brain metastases in patients with precluded survival using customised double-dose prescription-based, adaptive accelerated staged radiosurgery: a long-term retrospective analysis.

Background: Patients with brain metastases face a poor prognosis when deemed not to be suitable for onco-surgical intervention. This feasibility study analyses the outcome of adaptive radiosurgery applied in customised settings to a group of patients with brain metastases, where no other form of treatment was deemed safe and/or feasible.

Methods: 29 patients with 35 brain metastases deemed not to be candidates for surgery, radiotherapy or systemic treatment were treated with MRI-guided adaptive Gamma Knife radiosurgery in 3 separate sessions with a 72-hour interval.

Two-Staged Three-Layered Cranial Reconstruction: Galeocapsular Flaps Through Tissue Expansion and Slit-Designed CAD/CAM Titanium Implants.

The formation of extradural dead space in cranial reconstruction increases the risk of seroma, hematoma, and abscess formation, necessitating complex procedures such as free flap reconstruction. This study presents a novel approach combining a customized CAD/CAM-designed titanium implant with strategically placed slots and tissue expansion to generate galeocapsular flaps, ensuring both vascularized implant coverage and improved aesthetic outcomes. A 10-year-old male patient with a large cranial defect underwent a 2-stage procedure.

Epidemiological and clinical analysis, and outcomes of tuberculosis co-infection among people living with HIV in Türkiye (2014-2024) ClinSurv HIV cohort: A large case series.

Background: Tuberculosis (TB) is one of the most common opportunistic infections in people living with HIV (PLHIV). Mycobacterium tuberculosis may cause more TB in all stages of HIV infection than in the general population, with the incidence of TB and the spread of pulmonary TB to other organs increasing as the CD4 count decreases.

Objective: In this HIV cohort study, we aimed to evaluate the clinical features, diagnosis, and prognosis of TB among PLHIV in Türkiye.

The effect of video-assisted teaching on nursing students'practice skills and anxiety levels in Range of Motion (ROM) exercises: a randomized controlled study.

Background: Video-assisted teaching is becoming increasingly important in nursing education.

Aim: This randomized controlled study was conducted to determine the effect of video-assisted instruction on nursing students' Range of Motion (ROM) practice skills and anxiety levels.

Methods: The study sample consisted of 72 first-year nursing students enrolled in the Fundamentals of Nursing course at a university in Istanbul, Turkey.

The Relationship Between Spiritual Well-Being and Treatment Compliance in Adult Patients with Type 2 Diabetes in Northwestern Türkiye.

This study aimed to examine the relationship between treatment compliance and spiritual well-being in adult patients with type 2 diabetes. The sample included 165 patients diagnosed with type 2 diabetes who attended the endocrinology outpatient clinic of a public hospital in Istanbul, Türkiye, between November 2023 and May 2024. Data were collected using the Patient Information Form, the Type 2 Diabetes Mellitus Treatment Patient Compliance Scale, and the Spiritual Well-Being Scale.

Machine learning based CAGIB score predicts in-hospital mortality of cirrhotic patients with acute gastrointestinal bleeding.

Acute gastrointestinal bleeding (AGIB) is a potentially lethal complication in cirrhosis. In this prospective international multi-center study, the performance of CAGIB score for predicting the risk of in-hospital death in 2467 cirrhotic patients with AGIB was validated. Machine learning (ML) models were established based on CAGIB components, and their area under curves (AUCs) were calculated and compared.