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Background: Correct identification of the etiology and anatomical location of perforations is paramount for ensuring optimal therapeutic intervention and surgical planning in cases of gastrointestinal tract perforation.
Purpose: This study aimed to retrospectively evaluate the distinctive multidetector computed tomography (MDCT) findings of intraperitoneal and retro-/extraperitoneal perforation by comparing the locations of free air in the abdomen and other imaging findings.
Material And Methods: A total of 226 patients with acute abdominal pain who visited the emergency department and underwent contrast-enhanced CT between January 2016 and November 2023 were included. The study consisted of 146 male and 80 female patients with a median age of 53.5 years. Surgical findings determined the site of perforation in all cases. Two radiologists evaluated the CT images in a consensus blind to operative findings, assessing the presence of specific air distributions and strong predictors of gastrointestinal tract perforation.
Results: The study included 192 intraperitoneal and 34 retro-/extraperitoneal perforation cases. Subphrenic free air and periportal free air were statistically significant in differentiating intraperitoneal gastrointestinal tract perforation among specific air distributions. Conversely, the presence of free air in the minor pelvis, right lower quadrant, left lower quadrant, and retroperitoneum was significant in differentiating retro-/extraperitoneal gastrointestinal tract perforation. Among strong imaging predictors, only ascites was statistically significant in differentiating intraperitoneal from retro-/extraperitoneal perforations.
Conclusion: Findings from MDCT may serve as predictive indicators for the precise localization of gastrointestinal tract perforations, which is crucial for appropriate management and surgical planning.
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http://dx.doi.org/10.1007/s00117-025-01500-7 | DOI Listing |
Biomater Sci
September 2025
College of Marine Life Science, Ocean University of China, Qingdao, 266003, PR China.
Polyphenols, rich in phenolic structures, are widely found in plants and known for disturbing the cellular oxidative stress and regulating the signal pathways of tumor proliferation and metastasis, making them valuable in cancer therapy. Polyphenols display high adherence due to the presence of phenolic hydroxyl groups, which enables the formation of covalent and non-covalent interactions with different materials. However, nonspecific adhesion of polyphenols carries significant risks in applications as polyphenols might adhere to proteins and polysaccharides in the bloodstream or gastrointestinal tract, leading to thrombosis and lithiasis.
View Article and Find Full Text PDFTurk J Pharm Sci
September 2025
Drugs Testing Laboratory, Department of Drugs Control, Bangalore, India.
Objectives: The study aimed to combine instant-release and mini-tablet methodologies to develop novel orally disintegrating mini-tablets (ODMTs) for a frequently pescribed antibiotic, cefixime trihydrate (CT), in paediatric patients.
Materials And Methods: CT-loaded microcapsules were prepared using Eudragit EPO and Hydroxy Propyl Methyl Cellulose E50 by spray drying technique. The optimized microcapsules were mixed with co-processed ready-to-use tableting excipients, Ludiflash and Pearlitol 200SD, in different proportions and then compressed into ODMTs and evaluated.
Adv Healthc Mater
September 2025
Smart Polymeric Biomaterials Research Group, Campus Group T, KU Leuven, Andreas Vesaliusstraat 13, Leuven, 3000, Belgium.
The lower gastrointestinal (GI) tract is affected by a range of diseases, including colorectal cancer and inflammatory bowel disease, among others. Effective treatment of these conditions requires drug delivery systems (DDSs) capable of precise targeting. While pH- and enzyme-sensitive DDSs are the most used, they often suffer from premature drug release and target specificity, limiting their efficacy.
View Article and Find Full Text PDFNutr J
September 2025
Department of Geriatric, The First Hospital of China Medical University, No. 155 Nanjing North Street, Heping Ward, Shenyang, 110001, China.
Objective: This study analyzed data from the US population to examine how oral microbiome diversity and diet quality individually and synergistically affect frailty.
Methods: This study included 6,283 participants aged 20 years or older from the 2009-2010 and 2011-2012 NHANES cycles. A frailty index (FI) consisting of 36 items was developed, with items related to nutritional status excluded.
Curr Microbiol
September 2025
Department of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
This review article describes recent research advances in the relationship between spinal cord injury (SCI) and the gut microbiota and each other's inflammatory response. SCI is a serious neurological disease that directly damages physiological function. Recent studies have shown that SCI significantly affected the composition and function of the gut microbiota, and even caused intestinal inflammation.
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