Recent progress in gemcitabine-loaded nanoparticles for pancreatic cancer therapy: a review.

The treatment of pancreatic cancer remains a formidable challenge. Despite recent advances in diagnostic techniques and therapeutic approaches, the overall five-year survival rate for patients with pancreatic cancer remains below 9%, reflecting a dismal prognosis. Currently, surgical resection is the only potentially curative option; however, only about 10% of patients are eligible for surgery at the time of diagnosis.

Lactate-Activated GPR132-Src Signal Induces Macrophage Senescence and Aggravates Atherosclerosis Under Diabetes.

Diabetes is widely acknowledged as a significant risk factor for atherosclerosis, facilitating plaque formation through various mechanisms. Although both conditions are linked to the aging process, the relationship among cellular senescence, diabetes, and atherosclerosis remains inadequately understood. This study presents evidence that elevated glucose levels expedite the progression of atherosclerosis by promoting macrophage senescence.

A small molecule esculetin accelerates postprandial lipid clearance involving activation of C/EBPβ and CD36-mediated phagocytosis by adipose tissue macrophages.

: Adipose tissue buffers dietary lipids to maintain postprandial lipid homeostasis. Adipose tissue macrophages (ATMs) mediate the phagocytosis of postprandial lipids from the exogenous diet, generating high-density lipoprotein (HDL) particles that facilitate lipid circulation and excretion. However, the underlying mechanisms remain poorly understood.

CD163 macrophages attenuate pressure overload-induced left ventricular systolic dysfunction and cardiac mitochondrial dysfunction via interleukin-10.

Macrophage depletion exacerbates pressure overload-induced heart failure, but therapeutic translation is hindered by macrophage subset heterogeneity. The functional role of CD163 macrophages in heart failure remains unclear. Transverse aortic constriction (TAC) was employed to induce pressure overload.

Variational quantum metrology with the Loschmidt echo.

By leveraging quantum effects, such as superposition and entanglement, quantum metrology promises higher precision than classical strategies. It is, however, a challenging task to achieve the higher precision on practical systems. This is mainly due to difficulties in engineering nonclassical states and performing nontrivial measurements on the system, especially when the number of particles is large.

Advances in self-assembled nanotechnology in tumor therapy.

The emergence of nanotechnology has opened up a new way for tumor therapy. Among them, self-assembled nanotechnology has received extensive attention in medicine due to its simple preparation process, high drug-loading capacity, low toxicity, and low cost. This review mainly summarizes the preparation methods of self-assembled nano-delivery systems, as well as the self-assembled mechanism of carrier-free nanomedicine, polymer-carried nanomedicine, polypeptide, and metal drugs, and their applications in tumor therapy.

CD163 protein inhibits lipopolysaccharide-induced macrophage transformation from M2 to M1 involved in disruption of the TWEAK-Fn14 interaction.

Macrophages play a crucial role in regulating inflammation and innate immune responses, and their polarization into distinct phenotypes, such as M1 and M2, is involved in various diseases. However, the specific role of CD163, a scavenger receptor expressed by macrophages, in the transformation of M2 to M1 macrophages remains unclear. Here, dexamethasone-induced M2 macrophages were treated with lipopolysaccharide (LPS) to induce the transformation of M2 to M1 macrophages.

A ubiquitination-mediated degradation system to target 14-3-3-binding phosphoproteins.

The phosphorylation of 14-3-3 binding motif is involved in many cellular processes. A strategy that enables targeted degradation of 14-3-3-binding phosphoproteins (14-3-3-BPPs) for studying their functions is highly desirable for basic research. Here, we report a phosphorylation-induced, ubiquitin-proteasome-system-mediated targeted protein degradation (TPD) strategy that allows specific degradation of 14-3-3-BPPs.

The proGnostic role of caRdiac rehAbilitation in patients with left ventriCular anEurysm formation after anterior myocardial infarction (the GRACE study): Study rationale and design of a prospective randomized controlled trial.

Background: Cardiac rehabilitation (CR) is an essential intervention after acute myocardial infarction (MI). However, it is still unclear whether patients with left ventricular aneurysm (LVA) formation after anterior MI would benefit from CR programs. This clinical trial is designed to assess the role of CR in patients with LVA formation after anterior MI.

WDR73 Depletion Destabilizes PIP4K2C Activity and Impairs Focal Adhesion Formation in Galloway-Mowat Syndrome.

(1) Background: Galloway-Mowat syndrome (GAMOS) is a rare genetic disease, classically characterized by a combination of various neurological symptoms and nephrotic syndrome. WDR73 is the pathogenic gene responsible for GAMOS1. However, the pathological and molecular mechanisms of GAMOS1, especially nephrotic syndrome caused by WDR73 deficiency, remain unknown.

Model Checking Fuzzy Computation Tree Logic Based on Fuzzy Decision Processes with Cost.

In order to solve the problems in fuzzy computation tree logic model checking with cost operator, we propose a fuzzy decision process computation tree logic model checking method with cost. Firstly, we introduce a fuzzy decision process model with cost, which can not only describe the uncertain choice and transition possibility of systems, but also quantitatively describe the cost of the systems. Secondly, under the model of the fuzzy decision process with cost, we give the syntax and semantics of the fuzzy computation tree logic with cost operators.

Numerical investigation of field-effect control on hybrid electrokinetics for continuous and position-tunable nanoparticle concentration in microfluidics.

We introduce herein an effective way for continuous delivery and position-switchable trapping of nanoparticles via field-effect control on hybrid electrokinetics (HEK). Flow field-effect transistor exploiting HEK delicately combines horizontal linear electroosmosis and transversal nonlinear electroosmosis of a shiftable flow stagnation line (FSL) on gate terminals under DC-biased AC forcing. The microfluidic nanoparticle concentrator proposed herein makes use of a simple device geometry, in which an individual or a series of planar metal strips serving as gate electrode (GE) are subjected to a hybrid gate voltage signal and arranged in parallel between a pair of 3D driving electrodes.

Association Between Serum Uric Acid Levels and Traditional Cardiovascular Risk Factors in Xiamen Residents of China: A Real-World Study.

Background: Serum uric acid (SUA) levels was associated with cardiovascular diseases and cardiovascular events. However, the relationship between SUA levels and traditional cardiovascular risk factors has not been well-established among Xiamen residents. Our study aimed to estimate the relationship between SUA levels and cardiovascular risk factors among Xiamen residents using real-world data.

In vitro Assessment of Cardiac Reprogramming by Measuring Cardiac Specific Calcium Flux with a GCaMP3 Reporter.

Cardiac reprogramming has become a potentially promising therapy to repair a damaged heart. By introducing multiple transcription factors, including Mef2c, Gata4, Tbx5 (MGT), fibroblasts can be reprogrammed into induced cardiomyocytes (iCMs). These iCMs, when generated in situ in an infarcted heart, integrate electrically and mechanically with the surrounding myocardium, leading to a reduction in scar size and an improvement in heart function.

Improving Cardiac Reprogramming for Heart Regeneration in Translational Medicine.

Direct reprogramming of fibroblasts into CM-like cells has emerged as an attractive strategy to generate induced CMs (iCMs) in heart regeneration. However, low conversion rate, poor purity, and the lack of precise conversion of iCMs are still present as significant challenges. In this review, we summarize the recent development in understanding the molecular mechanisms of cardiac reprogramming with various strategies to achieve more efficient iCMs.

Resonant quantum principal component analysis.

Principal component analysis (PCA) has been widely adopted to reduce the dimension of data while preserving the information. The quantum version of PCA (qPCA) can be used to analyze an unknown low-rank density matrix by rapidly revealing the principal components of it, i.e.

Effect of platelet-rich plasma on peri-implant trabecular bone volume and architecture: A preclinical micro-CT study in beagle dogs.

Objectives: To evaluate the peri-implant trabecular bone volume and architecture changes with 6-month follow-up after local application of platelet-rich plasma (PRP) and platelet-poor plasma (PPP) using high-resolution micro-CT.

Material And Methods: Seventy-two dental implants were placed into healed mandibular sites of 9 beagle dogs. Implants were randomly divided into 4 groups following a split-mouth design: control I; control II; PPP; and PRP.

Floquet-engineered quantum state transfer in spin chains.

Quantum state transfer between two distant parties is at the heart of quantum computation and quantum communication. Among the various protocols, the counterdiabatic driving (CD) method, by suppressing the unwanted transitions with an auxiliary Hamiltonian H(t), offers a fast and robust strategy to transfer quantum states. However, H(t) term often takes a complicated form in higher-dimensional systems and is difficult to realize in experiment.

Quantum Simulation of Resonant Transitions for Solving the Eigenproblem of an Effective Water Hamiltonian.

It is difficult to calculate the energy levels and eigenstates of a large physical system on a classical computer because of the exponentially growing size of the Hilbert space. In this work, we experimentally demonstrate a quantum algorithm which could solve this problem via simulated resonant transitions. Using a four-qubit quantum simulator in which two qubits are used as ancillas for control and measurement, we obtain the energy spectrum of a 2-qubit low-energy effective Hamiltonian of the water molecule.

Experimental demonstration of nonlinear quantum metrology with optimal quantum state.

Nonlinear quantum metrology may exhibit better precision scalings. For example, the uncertainty of an estimated phase may scale as Δϕ∝1/N under quadratic phase accumulation, which is 1/N times smaller than the linear counterpart, where N is probe number. Here, we experimentally demonstrate the nonlinear quantum metrology by using a spin-I (I>1/2) nuclear magnetic resonance (NMR) ensemble that can be mapped into a system of N=2I spin-1/2 particles and the quadratic interaction can be utilized for the quadratic phase accumulation.

Achieved chin position after genioplasty follows the planned horizontal change better than the planned vertical change.

Purpose: The soft-tissue pogonion closely follows changes of the bony pogonion, but it is unknown how often an augmented bony pogonion reaches the intended position. Here we assessed the agreement between planned surgical changes and achieved results in chin surgery.

Materials And Methods: Surgical treatment was planned based on clinical examination, cast model analysis, and cephalometric image analysis.