Association of Omeprazole-Related Myopathy With Drug-Drug and Drug-Gene Interactions Involving CYP2C19 and CYP3A4: A Nested Case-Control Study.

Background: Omeprazole, a widely used proton pump inhibitor, has been associated with rare but serious adverse events such as myopathy. Previous research suggests that concurrent use of omeprazole with fluconazole, a potent cytochrome P450 (CYP) 2C19/3A4 inhibitor, may increase the risk of myopathy. However, the contribution of genetic polymorphisms in CYP enzymes remains unclear.

Morphology of Taylor Cone in Stable Regime: Experimental and Numerical Insights.

In the stable cone-jet regime, liquid usually presents the shape of a cone extended by a jet at its apex, with jet breakup yielding fine drops. The dynamics of the Taylor cone critically affect the stability of the jet and further determine the jet and/or drop size. In the present work, the morphology of the Taylor cone, cone length, and cone angle were studied through experimental and numerical means, where the operating parameters and liquid properties are considered.

O-GlcNAcylated YTHDF2 promotes bladder cancer progression by regulating the tumor suppressor gene via mA modification.

Objectives: Bladder cancer is a common malignancy with high incidence and poor prognosis. N-methyladenosine (mA) modification is widely involved in diverse physiological processes, among which the mA recognition protein YTH N-methyladenosine RNA binding protein F2 (YTHDF2) plays a crucial role in bladder cancer progression. This study aims to elucidate the molecular mechanism by which O-linked -acetylglucosamine (O-GlcNAc) modification of YTHDF2 regulates its downstream target, period circadian regulator 1 (), thereby promoting bladder cancer cell proliferation.

Study on Apoptosis of Various Tissues at Different Intervals after Death of Yangtze Sturgeon ().

The collection and preservation of postmortem genetic material from recently deceased animals of rare and endangered species represent a critical yet underexplored avenue in conservation biology. While extensive research has been conducted on the human postmortem interval (PMI), there is a notable gap in understanding the postmortem preservation of germplasm in endangered species. This study aimed to investigate the dynamics of apoptosis in various tissues of the Yangtze sturgeon at different postmortem time points, and to provide a reference for identifying the optimal time window for germplasm preservation in rare and endangered fish in the wild.

Modification of Amino-Functionalized Organic-Silica Hybrid Monoliths via a Catalyst-Free Amino-Yne Click Reaction for Capillary Liquid Chromatography.

A novel post-modification strategy was developed for rapid functionalization of monoliths through amino-yne click chemistry. This approach enabled the conjugation of activated alkynes onto amino-functionalized organic-silica hybrid monolith surfaces under mild, catalyst-free conditions. Systematic investigation of critical reaction parameters was conducted to optimize the post-modification process.