One-Dimensional Conductive Metal-Organic Frameworks Enable Real-Time Chemiresistive Detection of Thermal Runaway Gases.

The rapid growth of the electric vehicle industry has raised concerns about battery thermal runaway, which poses serious safety risks. Real-time detection of characteristic gases is crucial for early warning, but there is a lack of highly sensitive and selective gas-sensing materials, especially for carbon monoxide (CO) detection at room temperature in oxygen-free environments. Here, a novel one-dimensional (1D) conductive metal-organic framework (MOF) is synthesized as a highly sensitive and selective room-temperature CO gas-sensing material for battery thermal runaway detection.

Hspb1 inhibits microglial ferroptosis and pro-inflammatory activation to alleviate cerebral ischemia/reperfusion injury in mice.

Heat shock protein beta-1 may be involved in regulating ferroptosis in cells. The expression of heat shock protein beta-1 is upregulated after stroke; however, the underlying mechanism of action of heat shock protein beta-1 in cerebral ischemia/reperfusion injury remains unclear. Here, using both in vivo and in vitro models of ischemic injury-middle cerebral artery occlusion/reperfusion in C57BL/6J mice and oxygen-glucose deprivation/reoxygenation in BV-2 microglial cells-we observed that heat shock protein beta-1 overexpression significantly reduced infarct volume, mitigated neuronal loss, and improved neurological outcomes.

Intracranial Hemorrhage in Patients With Stroke After Endovascular Treatment With or Without IV Alteplase: An Individual Participant Data Meta-Analysis.

Importance: For patients with acute ischemic stroke due to anterior circulation large vessel occlusion and presenting directly to endovascular treatment (EVT)-capable centers, intravenous thrombolysis (IVT) before EVT raises concerns about intracranial hemorrhage (ICH), but details are not well understood.

Objective: To determine the frequency and subtypes of ICH in patients treated with IVT plus EVT vs EVT alone and to determine the association between various ICH subtypes and patient functional outcomes.

Data Sources: PubMed and MEDLINE were searched from database inception through March 9, 2023.

Antihypertensive Drugs after Thrombectomy in Acute Ischemic Stroke with Poor Collateral Are Associated with Unfavorable Outcome.

Introduction: The impact of antihypertensive drugs on functional outcome in patients with acute ischemic stroke (AIS) after endovascular thrombectomy (EVT) remains controversial and may vary with collateral status (CS). We aimed to investigate the joint effect of CS and antihypertensive drugs on functional outcome in patients with AIS.

Methods: We retrospectively analyzed anterior circulation large-vessel occlusion AIS patients who underwent EVT in our hospital between January 2018 and December 2022.

Reinforcement learning-based event-driven optimal prevention control strategy for citrus huanglongbing model.

Citrus Huanglongbing (HLB) is an infectious disease transmitted by Asian citrus psyllids (ACP), which leads to serious economic losses in the citrus industry. Therefore, it is crucial to investigate the prevention and control strategy of citrus HLB. In this paper, the dynamics of HLB propagation between citrus trees and ACP is considered.

Ultralow energy adaptive neuromorphic computing using reconfigurable zinc phosphorus trisulfide memristors.

Reconfigurable devices enable adaptive neuromorphic computing by dynamically allocating circuit resources. However, integrating diverse functionalities with ultralow energy consumption in a single device remains challenging. Here, we demonstrate reconfigurable zinc phosphorus trisulfide (ZnPS) memristors that exhibit both volatile and non-volatile switching with superior performance metrics, including a low switching voltage (~0.

Systolic blood pressure within 24 hours after successful reperfusion correlates with outcomes in acute ischemic stroke: a secondary analysis of the EHCHANTED2/MT Trial.

Background: The optimal threshold or range for systolic blood pressure (SBP) control in patients with successful reperfusion after endovascular thrombectomy for acute ischemic stroke (AIS) remains undefined. This study investigated whether SBP within the first 24 hours after successful reperfusion correlates with functional outcomes in AIS.

Methods: In this secondary analysis of the ENCHANTED2/MT trial, patients were categorized into two groups (120-140 mm Hg and 140-180 mm Hg, respectively) based on achieved SBP within 24 hours after randomization.

Facilitating angioplasty and stenting with dual-lumen balloon microcatheter for intracranial atherosclerotic stenosis-related large vessel occlusion: A comparative study.

Background And Purpose: Intracranial large vessel occlusion due to atherosclerotic stenosis (ICAS) complicates acute ischemic stroke (AIS) management, with challenges such as reocclusion, thrombus migration. This study provides a preliminary evaluation of a novel technique-Facilitating Angioplasty and Stenting with a Dual-Lumen Balloon Microcatheter-for ICAS-related large vessel occlusions, using data from a single-center registry and comparing them to a reference cohort from a multicenter trial.

Methods: This retrospective study utilized data from two sources: the OCEAN-AIS-EVT REGISTRY for the FAST ICAS group and the DIRECT-MT trial for the traditional treatment group.

Safety and efficacy of cerebral robot assisted angiography: randomized comparison of robotic versus manual procedures.

Background: While robotic assisted technology has advanced in cardiovascular interventions, neurovascular applications still lack a robotic system. To assess the safety and efficacy of novel robotic systems designed for cerebral angiography, we conducted a multicenter, randomized controlled non-inferiority trial.

Methods: 130 patients were recruited who received cerebral angiography in four centers.

Design and Experimental Demonstration of an Integrated Sensing and Communication System for Vital Sign Detection.

The identification of vital signs is becoming increasingly important in various applications, including healthcare monitoring, security, smart homes, and locating entrapped persons after disastrous events, most of which are achieved using continuous-wave radars and ultra-wideband systems. Operating frequency and transmission power are important factors to consider when conducting earthquake search and rescue (SAR) operations in urban regions. Poor communication infrastructure can also impede SAR operations.

Advances on Emerging Integrated Photocapacitors: Strategies, Design, and Challenges.

The energy crisis necessitates the development and utilization of renewable energy sources. Integrated photocapacitors have gained attention due to their integrated design for energy conversion and storage, offering a novel solution for efficient solar energy utilization. This review outlines the relevant mechanisms of integrated photocapacitors and presents a new theoretical model based on the current state of research.

Modified microcatheter first-pass effect: Enhancing diagnostic accuracy and treatment strategies for ICAS in acute ischemic stroke.

Objectives: To evaluate the effectiveness of the modified microcatheter first-pass effect in guiding treatment decisions for ICAS-related occlusions during endovascular therapy (EVT) for AIS.

Methods: This study analyzed data from 31 AIS patients with a positive modified microcatheter first-pass effect from the OCEAN-AIS-EVT REGISTRY collected between July 2023 and January 2024. We evaluated diagnostic accuracy, procedural efficiency, recanalization rates, and safety.

Interaction of brain imaging features and effects of intensive blood pressure lowering after endovascular treatment for acute ischaemic stroke: the pre-specified secondary analyses of ENCHANTED2/MT trial.

Background: The second Enhanced Control of Hypertension and Thrombectomy Stroke Study (ENCHANTED2/MT) was terminated early when the intensive blood pressure lowering to a systolic level of 120 mm Hg or lower, compared to 140-180 mm Hg, was harmful in patients who received successful endovascular therapy for acute ischaemic stroke due to large-vessel occlusion. We aimed to determine the interaction of key brain imaging features and the effect of treatment on clinical outcomes.

Methods: ENCHANTED2/MT was a prospective, randomised, open-label, blinded-endpoint, controlled trial that aimed to assess the effectiveness of different intensities of blood pressure control on the functional independence in patients who had received successful endovascular therapy for acute ischaemic stroke from large-vessel occlusion at 44 hospitals in China between July 20, 2020 and March 7, 2022.

diagnosis based on SERS-LFIA: research hotspots, increase sensitivities, combined detection, multimodal detection and related patents.

In recent years, the SERS-LFIA platform has gained significant traction in diagnostics. However, a comprehensive review of its advancements and applications is still lacking. This review first employing a bibliometric approach to analyze research trends.

Explainable Machine Learning Model for Predicting Persistent Sepsis-Associated Acute Kidney Injury: Development and Validation Study.

Background: Persistent sepsis-associated acute kidney injury (SA-AKI) shows poor clinical outcomes and remains a therapeutic challenge for clinicians. Early identification and prediction of persistent SA-AKI are crucial.

Objective: The aim of this study was to develop and validate an interpretable machine learning (ML) model that predicts persistent SA-AKI and to compare its diagnostic performance with that of C-C motif chemokine ligand 14 (CCL14) in a prospective cohort.

Collaborative light-off and light-on bacterial luciferase biosensors: Innovative approach for rapid contaminant detection.

Bioluminescence-based light-off and light-on biosensors are widely used in environmental monitoring due to their rapid, cost-effective, real-time, and easy operation. However, stability and sensitivity issues in detecting real samples remain challenging. This study introduces a novel approach utilizing combined light-off and light-on biosensors for rapid and sensitive contaminants detection within 45 min in real samples.

Elemene as a binding stabilizer of microRNA-145-5p suppresses the growth of non-small cell lung cancer.

Elemene is widely recognized as an effective anti-cancer compound and is routinely administered in Chinese clinical settings for the management of several solid tumors, including non-small cell lung cancer (NSCLC). However, its detailed molecular mechanism has not been adequately demonstrated. In this research, it was demonstrated that elemene effectively curtailed NSCLC growth in the patient-derived xenograft (PDX) model.

Asymptomatic Hemorrhagic Events and Functional Outcomes in Acute Stroke: A Secondary Analysis of the DIRECT-MI Randomized Clinical Trial.

Importance: Asymptomatic hemorrhagic infarction (HI) and subarachnoid hemorrhage (SAH) after endovascular treatment (EVT) for acute ischemic stroke are commonly considered low risk, but their long-term impact on functional outcomes is unclear.

Objective: To determine whether asymptomatic HI and SAH are associated with worse 90-day functional recovery in patients with acute ischemic stroke treated with EVT.

Design, Setting, And Participants: This is a secondary analysis of the DIRECT-MT randomized clinical trial, which compared intravenous thrombolysis prior to EVT with EVT alone.

Water-Enhanced Multicolor Electrochromism in Nickel-Catecholate MOFs.

Metal-organic frameworks (MOFs) represent a novel electrochromic material system but are limited in tunable color versatility, rapid switching speed, and long-term cycling stability. A new multicolor electrochromic behavior is reported, with transitions from green to blue to purple, in conducting nickel-catecholate (Ni-CAT-1) MOFs. The system significantly improves cycling stability to 2000 cycles and reduces switching time to 3.

Anomalous component-dependent lattice thermal conductivity in MoWTaTiZr refractory high-entropy alloys.

Refractory high-entropy alloys (RHEAs) have been of great interest due to their excellent mechanical properties at elevated temperatures. However, there are few studies on their thermodynamic properties. Here, we investigate lattice thermal conductivity of MoWTaTiZr RHEAs using the equilibrium molecular dynamics (EMD) method.

Algae Biomass Hydrogels for Enhanced Removal of Heavy Metal Ions.

Heavy metal ion pollution in aquatic environments is a critical global issue, damaging ecosystems and threatening human health via bioaccumulation in the food chain. Despite promising progress with biosorbents, the development of environmentally friendly and stable heavy metal adsorbents requires further exploration. In this study, we present an algae-loaded alginate hydrogel as a composite adsorbent for heavy metals.

Intravenous thrombolysis before endovascular treatment versus endovascular treatment alone for patients with large vessel occlusion and carotid tandem lesions: individual participant data meta-analysis of six randomised trials.

Background: For patients with large vessel occlusion and carotid tandem lesions, the best treatment approach is not clear. Intravenous thrombolysis in addition to endovascular treatment might increase the risk of intracranial haemorrhage and decrease effectiveness in this cohort, particularly for patients receiving acute carotid stenting. In an individual participant data meta-analysis of six randomised controlled trials (RCTs), no clear benefit was seen of intravenous thrombolysis in patients with large-vessel occlusion stroke who were eligible for direct endovascular treatment.

Tuning Ru-O Coordination for Switching Redox Centers in Acidic Oxygen Evolution Electrocatalysis.

Avoiding lattice oxygen involvement (oxygen redox) while promoting the coupling of adjacent adsorbed oxygen (metal redox) during the acidic oxygen evolution reaction (OER) is essential for gaining high activity and robust stability in RuO-based catalysts but remains elusive. Here, we present a precise strategy to selectively activate the metal redox process while suppressing the undesired oxygen redox pathway by fine-tuning the Ru-O coordination number in amorphous RuO. The optimized catalyst exhibits outstanding acidic OER performance, achieving a low overpotential of 215 mV at 10 mA cm and maintaining stability for 300 h with a negligible degradation rate of 100 µV h.

Establishment of a R-Sphere labelled immunoassay platform and its rapid combined quantitative detection of ketamine and morphine in serum.

Background And Aims: Ketamine and morphine are among the most commonly abused drugs. Ketamine is classified as a new psychoactive substance, while morphine represents the opioid class. These two substances may exhibit synergistic or antagonistic effects in their pharmacological actions, and their combined abuse could lead to more severe health risks, such as respiratory depression.

In Situ High Selectivity Contact-Electroreduction of CO to Methanol Using an Imine-Mediated Metal-Free Vitrimer Catalyst.

Metal catalysts for the CO reduction reaction (CORR) face challenges such as high cost, limited durability, and environmental impact. Although various structurally diverse and functional metal-free catalysts have been developed, they often suffer from slow kinetics, low selectivity, and nonrecyclability, significantly limiting their practical applications. In this study, we introduce a recyclable nonmetallic polymer material (vitrimer) as a catalyst for a new platform in contact-electrocatalysis.