Effects of fermented ramie feed on the growth performance, serum biochemistry, metabolic capacity, antioxidant capacity, and intestinal health of ducks.

This study investigated the effects of fermented ramie feed (FRF) on the growth performance, serum biochemistry, metabolic capacity, antioxidant capacity, and intestinal health of ducks. A total of 480 female ducks (age: 28 days) were randomly divided into five treatments (six replicates per group; 16 ducks per replicate). The control group received a basal diet and the treatment groups received the basal diet supplemented with by 3%, 6%, 9% or 12% FRF.

Dietary DL-methionine supplementation improves growth performance of Linwu ducks by regulating redox state and intestinal mucosal morphology.

This study was designed to investigate the effects of dietary supplementation with different levels of DL-methionine (DL-Met) on growth performance, intestinal mucosal morphology and antioxidant capacity of Linwu ducks. The experiment was conducted to classify 330 healthy 49 days of age female Linwu ducks into 5 treatment groups with 6 replicates per treatment and fed diets with DL-Met levels of 2.5 g/kg, 3.

Comprehensive Insights into APOBEC Mutations in Thyroid Cancer: Prognostic and Therapeutic Discoveries.

Background: The APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) family plays a vital mutagenic role in diverse human malignancies. Nevertheless, the biological characteristics of APOBEC family members and their clinical significance in cancer have not been comprehensively explored. Our primary objective was to characterize the distribution and clinical relevance of APOBEC family members and their mutations across multiple cancer types, with a particular focus on thyroid carcinoma (THCA).

Aqueous Gallium-Doped Copper Indium Selenide Quantum Dots for Non-Invasive Severity Grading of Traumatic Brain Injury.

Traumatic brain injury (TBI) represents a substantial global health challenge, yet current diagnostic tools, such as CT and MRI, despite providing anatomical detail, have limitations in assessing injury severity, monitoring progression, and guiding personalized treatments. Herein, an aqueous phase-synthesized gallium-doped copper indium selenide quantum dot (QD) probe designed for grading TBI severity is introduced. The doping of gallium ions into the semiconductor core largely restrained the nonradiative recombination rate, thereby significantly enhancing the near-infrared emission of the QDs.

Juanbi Qianggu Formula inhibits fibroblast-like synovicytes activation via repressing LncRNA ITSN1-2 to promote RIP2 K48 ubiquitination.

Background: Long non-coding RNA ITSN1-2(lncRNA ITSN1-2) promotes fibroblast-like synovicytes (FLS) proliferation and suppress apoptosis through activation of the NOD2/RIP2 signaling pathway, thereby exacerbating synovitis in Rheumatoid arthritis (RA) pathology. Juanbi Qianggu Formula (JBQG), a clinically efficacious traditional Chinese medicine, has shown significant efficiency in inhibiting FLS activation in RA and alleviating disease progression in RA patients. However, the molecular mechanism underlying JBQG's anti-arthritic effects remains incompletely understood, particularly regarding its potential to modulate lncRNA ITSN1-2-mediated NOD2/RIP2 signaling in FLS activation.

Deep Reinforcement Learning for CT-Based Non-Invasive Prediction of SOX9 Expression in Hepatocellular Carcinoma.

The transcription factor SOX9 plays a critical role in various diseases, including hepatocellular carcinoma (HCC), and has been implicated in resistance to sorafenib treatment. Accurate assessment of SOX9 expression is important for guiding personalized therapy in HCC patients; however, a reliable non-invasive method for evaluating SOX9 status remains lacking. This study aims to develop a deep learning (DL) model capable of preoperatively and non-invasively predicting SOX9 expression from CT images in HCC patients.

A hydrogel crosslinked with mixed-valence copper nanoclusters for diabetic wound healing.

Chronic diabetic wounds affect a significant number of individuals and present considerable challenges in clinical treatment. Ideal diabetic wound dressings should possess antibacterial properties, the ability to regulate redox balance, and the capacity to promote tissue regeneration. Herein, we developed an injectable mixed-valence copper nanocluster-crosslinked hydrogel (HS-Cu) through reductive metal-ligand coordination assembly of Cu and thiourea-grafted hyaluronic acid (HA-NCSN) to achieve the above-mentioned requirements in one-step.

IFNγ preconditioning improves neuroprotection of MSC-derived vesicles on injured retinal ganglion cells by suppressing microglia activation via miRNA-dependent ribosome activity.

Microglial activation plays a pivotal role in the pathogenesis of retinal ganglion cell (RGC) degeneration resulting from optic nerve crush (ONC). Small extracellular vesicles (sEVs) secreted by mesenchymal stem cells (MSCs) have the potential to prevent retinal degeneration by modulating microglial activation. In this study, we elucidated the specific effects of sEVs derived from IFN-γ-primed MSCs on the phenotypic transition of microglia and the associated pathways in ONC mice.

Heterogeneous bioinformatic data encryption on portable devices.

With the popularity of mobile health monitoring and genome sequencing techniques, the scale of biomedical and genomic data grow rapidly, with their privacy receiving more and more concerns. Encryption technique plays an important role in many aspects of security guarantee for these data. For mobile devices, encryption is even more important yet more challenging, as these devices are usually used in environments that may not be well protected and have rather limited computing resources.

The Percentage of Neutrophils is Independently Associated with Blood-Brain Barrier(BBB) Disruption in Myelin Oligodendrocyte Glycoprotein Antibody Associated Disease (MOGAD).

Purpose: This study aims to investigate the risk factors associated with blood-brain barrier(BBB) disruption in patients with myelin oligodendrocyte glycoprotein antibody associated disease(MOGAD).

Patients And Methods: We collected clinical data from 95 patients diagnosed with MOGAD at the Department of Neurology, the First Affiliated Hospital of Zhengzhou University from October 2018 to May 2024. Patients were classified into normal or damaged BBB groups based on cerebrospinal fluid (CSF) albumin/serum albumin (QAlb).

Differences in microbial communities and phosphorus cycles between rural and urban lakes: Based on glyphosate and AMPA effects.

The widespread availability of glyphosate in shallow lakes is of significant concern. Glyphosate is an organophosphorus pesticide that can affect the phosphorus cycle and microbial communities in lakes. However, the effects of glyphosate on lakes in different geographical locations remain unclear.

Cuproptosis nanoprodrug-initiated self-promoted cascade reactions for postoperative tumor therapy.

Cancer metastasis and recurrence remain a regular cause of postoperative death in patients, implying that extra consolidation treatment strategies are needed. Here, a cuproptosis nanoprodrug, termed as Lipo@CP@DQ NPs, is developed to initiate self-promoted cascade reactions to achieve the combinational effect of cuproptosis, in situ chemotherapy, and oxidative stress amplification for effectively suppressing tumor recurrence and metastasis after postoperative treatment. Lipo@CP@DQ NPs are fabricated by loading copper peroxides (CuO, CP) and hydrogen peroxide (HO)-repsonsive prodrug DQ into liposomal nanoparticles.

School mental health prevention and intervention strategies in China: a scoping review.

Student mental health issues remain a significant global concern, imposing considerable health, social, and economic burdens. China has also published numerous national policies prioritizing this area. To further investigate the current prevention and intervention programs, we conducted a scoping review, searching six databases (three in English and three in Chinese) up to May 2024.

The association between family resilience and mental health: A three-level meta-analysis.

Family resilience refers to a family's ability to successfully cope with adversity from a system dynamics perspective, and is considered an effective resource for promoting individual mental health. However, there is a lack of meta-analyses examining the relationship between family resilience and mental health outcomes, nor the impact of different cultural context factors. The current study conducted a three-level meta-analysis of 48 studies published before January 25, 2022, from 5 scientific databases.

Learn2Talk: 3D Talking Face Learns From 2D Talking Face.

The speech-driven facial animation technology is generally categorized into two main types: 3D and 2D talking face. Both of these have garnered considerable research attention in recent years. However, to our knowledge, the research into 3D talking face has not progressed as deeply as that of 2D talking face, particularly in terms of lip-sync and perceptual mouth movements.

Relationship between Perceived Family Resilience, Emotional Flexibility, and Anxiety Symptoms: a Parent-Adolescent Dyadic Perspective.

Family resilience is crucial for individual's psychological health. Previous studies explored the protective factors of anxiety at the individual level, with less attention paid to the impact of family interaction from a dyadic perspective. This study utilized the Actor-Partner Interdependence Mediation Model to investigate the relationship between family resilience, emotional flexibility, and anxiety symptoms.

C-N cleavage of secondary amide to access primary amide by a Co(II)/Oxone oxidation system.

Cleavage of the C-N bond of a secondary amide could provide alternative access to primary amides; however, this strategy remains challenging due to oxidation resistance of the amide. Herein, we employed the cobalt(II)/Oxone catalytic system, one of the advanced oxidation processes (AOPs), to make it available to break the strong C-N bond of various secondary (sulfon)amides, especially those bearing electron-poor or -substituted -arenes, to desirable primary (sulfon)amides. Control experiments showed that it was probably not the generally-considered persulfate anion radical in the cobalt/peroxymonosulfate (Co/PMS) system but the proposed high-valent cobalt-oxo intermediate that should be the major active species for the initial N-H oxidation of -aryl amides.

Practical and regioselective halonitrooxylation of olefins to access β-halonitrates.

Organic nitrates, as effective donors of the signaling molecule nitric oxide, are widely applied in the pharmaceutical industry. However, practical and efficient methods for accessing organic nitrates are still scarce, and achieving high regiocontrol in unactivated alkene difunctionalization remains challenging. Here we present a simple and practical method for highly regioselective halonitrooxylation of unactivated alkenes.

Focal liver lesion diagnosis with deep learning and multistage CT imaging.

Diagnosing liver lesions is crucial for treatment choices and patient outcomes. This study develops an automatic diagnosis system for liver lesions using multiphase enhanced computed tomography (CT). A total of 4039 patients from six data centers are enrolled to develop Liver Lesion Network (LiLNet).

How do glyphosate and AMPA alter the microbial community structure and phosphorus cycle in rice-crayfish systems?

Glyphosate, a commonly used organophosphorus herbicide in rice-crayfish cropping regions, may alter regional phosphorus cycle processes while affecting the structure of microbial communities. However, the effects of glyphosate residues on rice-crayfish systems remain unclear. In this study, we assessed the spatial and temporal distribution characteristics of glyphosate and its primary degradation products, as well as the impact mechanisms of glyphosate on microbial communities and the phosphorus cycle in rice-crayfish systems such as paddy fields, breeding ditches and recharge rivers.

Adapting pest management strategies to changing climates for the redlegged earth mite, Halotydeus destructor.

As climate change continues to modify temperature and rainfall patterns, risks from pests and diseases may vary as shifting temperature and moisture conditions affect the life history, activity, and distribution of invertebrates and diseases. The potential consequences of changing climate on pest management strategies must be understood for control measures to adapt to new environmental conditions. The redlegged earth mite (RLEM; Halotydeus destructor [Tucker]) is a major economic pest that attacks pastures and grain crops across southern Australia and is typically controlled by pesticides.