[Observation on time-effect for the stimulating at Zusanli (ST 36) with minimally invasive embedding with PGLA in the healthy person].

Objective: To explore the objectivity and time-effect of stimulating effect at acupoint with PGLA in the healthy person, and to provide a basis for the rational interval of minimally invasive embedding of PGLA.

Methods: Before embedding, 8 h, 3rd, 7th, 10th, 14th day after embedding, medical imaging magnetic resonance imaging (MRI) scanning technique was used to collect local T2WI pressure-lowering and T2-Mapping 8 echoes sequence image of left Zusanli (ST 36) in 8 cases of healthy person. The T2-Mapping 8 echoes sequence image was generated by the relevant software to the T2-Mapping image and the local T2 value was measured.

The effects of running exercise on oligodendrocytes in the hippocampus of rats with depression induced by chronic unpredictable stress.

Running exercise has been shown to be associated with decreased symptoms of depression. However, the mechanisms underlying these antidepressant effects of running exercise remain relatively unclear. In the current study, we investigated the relationship between depressive symptoms in chronic unpredictable stress (CUS) model rats treated with running exercise and changes in oligodendrocytes in the hippocampus.

Nuclear Receptor Coactivator 2 Promotes Human Breast Cancer Cell Growth by Positively Regulating the MAPK/ERK Pathway.

As a member of the p160 steroid receptor coactivator (SRC) family, nuclear receptor coactivator 2 (NCOA2) is known to play essential roles in many physiological and pathological processes, including development, endocrine regulation, and tumorigenesis. However, the biological function of NCOA2 in breast cancer is not fully understood. We found that the copy number of the gene was frequently amplified in four breast cancers datasets, varying from 6 to 10%, and the mRNA levels of were also upregulated in 11% of the sequenced cases/patients (TCGA provisional dataset).

Reduced nitrogen supply enhances the cellular antioxidant potential of phenolic extracts through alteration of the phenolic composition in lettuce (Lactuca sativa L.).

Background: Nitrogen availability is an important environmental factor that determines the production of phenolic compounds in vegetables, but the relationship between low nitrogen-induced alterations of phenolic compounds in vegetable crops and the cellular antioxidant activities of these compounds remains unclear. This study investigated the effect of reduced nitrogen supply (0.05 mmol L nitrate) on phenolic metabolism in lettuce and the protective role of phenolic extracts against H O -induced oxidative stress in Caco-2 cells by determining cell damage, reactive oxygen species (ROS) content and antioxidant enzyme activities.

Ultrastructural organization of NompC in the mechanoreceptive organelle of campaniform mechanoreceptors.

Mechanoreceptive organelles (MOs) are specialized subcellular entities in mechanoreceptors that transform extracellular mechanical stimuli into intracellular signals. Their ultrastructures are key to understanding the molecular nature and mechanics of mechanotransduction. Campaniform sensilla detect cuticular strain caused by muscular activities or external stimuli in Each campaniform sensillum has an MO located at the distal tip of its dendrite.

Surface-Acoustic-Wave-Based Lab-on-Chip for Rapid Transport of Cryoprotectants across Cell Membrane for Cryopreservation with Significantly Improved Cell Viability.

Cryopreservation is essential to effectively extend the shelf life of delicate biomaterials while maintaining proper levels of cell functions. Cryopreservation requires a cryoprotective agent (CPA) to suppress intracellular ice formation during freezing, but it must be removed prior to clinical use due to its toxicity. Conventional multistep CPA loading and unloading approaches are time consuming, often creating osmotic shocks and causing mechanical injuries for biological samples.

Surgical Tumor-Derived Personalized Photothermal Vaccine Formulation for Cancer Immunotherapy.

Personalized cancer vaccines show great potential in cancer immunotherapy by inducing an effective and durable antitumor response. However, the limitation of neoantigen identification, low immunogenicity, and weak immune response hamper the development of personalized cancer vaccines. The surgically removed tumor contains tumor antigens specific to the patient, which provides a promising source for personalized cancer vaccines.

Arp2/3-branched actin regulates microtubule acetylation levels and affects mitochondrial distribution.

Actin and microtubule cytoskeletons regulate cell morphology, participate in organelle trafficking and function in response to diverse environmental cues. Precise spatial-temporal coordination between these two cytoskeletons is essential for cells to live and move. Here, we report a novel crosstalk between actin and microtubules, in which the branched actin maintains microtubule organization, dynamics and stability by affecting tubulin acetylation levels.

CoS nanowires@NiCo LDH nanosheets arrays on nickel foams towards efficient overall water splitting.

Water electrolysis is considered to be an effective way to fabricate hydrogen, and it is desirable to find the highly efficient, inexpensive and good durability bifunctional electrocatalysts for overall water splitting. In this paper, we synthesis a unique structured catalyst that was composed by CoS nanowires and nickel cobalt layered double hydroxide (NiCo-LDH) nanosheets. The ultrathin nanosheets decorated on the CoS nanoarrays offer large specific surface area, numerous active edge sites and excellent electrical conductivity for fast electron transfer.

High-Safety Nonaqueous Electrolytes and Interphases for Sodium-Ion Batteries.

Rapidly developed Na-ion batteries are highly attractive for grid energy storage. Nevertheless, the safety issues of Na-ion batteries are still a bottleneck for large-scale applications. Similar to Li-ion batteries (LIBs), the safety of Na-ion batteries is considered to be tightly associated with the electrolyte and electrode/electrolyte interphase.

Reduction of the Lorenz Number in Copper at Room Temperature due to Strong Inelastic Electron Scattering Brought about by High-Density Dislocations.

In this work, heat and charge transport were measured in a series of deformed bulk Cu samples where dislocation density was tuned but dislocation character generally remained unchanged. We observed a notable violation of the Wiedemann-Franz law at room temperature for such a conventional metal. We show that high-density dislocations introduce strong inelastic electron scattering, which relax heat and charge currents to different extents.

Multishelled FeCo@FeCoP@C Hollow Spheres as Highly Efficient Hydrogen Evolution Catalysts.

Active nonprecious metal-based hydrogen evolution reaction (HER) electrocatalysts are critical for the clean and sustainable generation of hydrogen. Here, we synthesized multishelled FeCo@FeCoP@C hollow spheres by the carbonization and phosphorization of the FeCo-MIL-88 metal-organic framework. Owing to both composition (FeCo mixed phosphide) and morphology (multishelled morphology) effects, the as-obtained FeCo@FeCoP@C exhibits excellent HER performance with a low overpotential of 65 mV to achieve an HER current density of 10 mA cm and high stability in acidic solution.

Using Octuplet Siamese Network For Osteoporosis Analysis On Dental Panoramic Radiographs.

Dental Panoramic radiography (DPR) image provides a potentially inexpensive source to evaluate bone density change through visual clue analysis on trabecular bone structure. However, dense overlapping of bone structures in DPR image and scarcity of labeled samples make learning of accurate mapping from DPR patches to osteoporosis condition challenging. In this paper, we propose a deep Octuplet Siamese Network (OSN) to learn and fuse discriminative features for osteoporosis condition prediction using multiple DRP patches.

Changes in white matter and the effects of fluoxetine on such changes in the CUS rat model of depression.

Objective: To explore the pathogenesis of depression and the possible mechanism of the effects of selective serotonin reuptake inhibitors (SSRIs) on the myelinated fibers and myelin sheaths in the white matter during the antidepressant action of fluoxetine.

Methods: In this study, Sprague Dawley (SD) rats were divided into a Control group, a group treated with CUS and no drugs (CUS/Standard group) and a group treated with CUS and fluoxetine (CUS/FLX group). The CUS/FLX group was treated with fluoxetine at dose of 5 mg/kg for 21 days.

17-allylamino-17-demethoxygeldanamycin impeded chemotherapy through antioxidant activation via reducing reactive oxygen species-induced cell death.

Hyperthermia enhances the anticancer effects of thymidylate synthase (TYMS) inhibitors (raltitrexed, RTX) and improves the precise biochemical mechanisms partially through enhancement of intracellular drug absorption. Recent research focuses on the potential anticancer drug target Heat Shock Protein 90 (HSP90), which could increase the sensitivity of cancer cells to TYMS inhibitors; however, with different HSP90 inhibitors, several research studies finally showed a poor efficacy in preclinical or clinical research. Here, we showed that 17-allylamino-17-demethoxygeldanamycin (17-AAG, HSP90 inhibitor) affects the efficacy of chemotherapy through antioxidant activation-induced resistance.

Effects of early intravenous low-dose of metoprolol on cardiac sympathetic activities and electrophysiological properties in myocardial infarction heart.

This study observed the effects of early intravenous low-doses of metoprolol on cardiac sympathetic activities and electrophysiological properties in myocardial infarction (MI) dogs. Thirty two mongrel dogs with the first diagonal branch of the left anterior descending coronary artery ligated were randomly divided into three groups: The low-dose group was given metoprolol 0.6 mg/kg immediately by intravenous injection (n=12); the target-dose group was given metoprolol 1.

Tumor-associated macrophages promote lung metastasis and induce epithelial-mesenchymal transition in osteosarcoma by activating the COX-2/STAT3 axis.

Osteosarcoma (OS) is a common, malignant musculoskeletal tumor in young people. Neoadjuvant chemotherapy has improved the survival of osteosarcoma patients but with limited benefit due to metastasis. Tumor-associated macrophages (TAMs) are involved in various mechanisms of tumor biology, which include oncogenesis, drug resistance, and tumor immune escape, as well as tumor metastasis.

Automatic Rectification of the Hybrid Stereo Vision System.

By combining the advantages of 360-degree field of view cameras and the high resolution of conventional cameras, the hybrid stereo vision system could be widely used in surveillance. As the relative position of the two cameras is not constant over time, its automatic rectification is highly desirable when adopting a hybrid stereo vision system for practical use. In this work, we provide a method for rectifying the dynamic hybrid stereo vision system automatically.

"Non-Naked" Gold with Glucose Oxidase-Like Activity: A Nanozyme for Tandem Catalysis.

It has been widely reported that "naked" gold nanoparticles (Au NPs) without protectors have glucose oxidase (GOx)-like activity, and the use of protectors can inhibit the GOx-like activity. Here, "non-naked" Au NPs with GOx-like activity are synthesized by using protein as protector. Although "naked" Au NPs have peroxidase-like activity and GOx-like activity, the optimal pH ranges of the both activities are obviously different.

Sex difference of mutation clonality in diffuse glioma evolution.

Background: Sex differences in glioma incidence and outcome have been previously reported but remain poorly understood. Many sex differences that affect the cancer risk were thought to be associated with cancer evolution.

Methods: In this study, we used an integrated framework to infer the timing and clonal status of mutations in ~600 diffuse gliomas from The Cancer Genome Atlas (TCGA) including glioblastomas (GBMs) and low-grade gliomas (LGGs), and investigated the sex difference of mutation clonality.

Ternary confined-functional sulfur composite with a host-sulfur-container architecture for lithium/sulfur batteries.

In this work, a ternary confined-functional sulfur composite with a Host-Sulfur-Container structure is designed and synthesized for high performance lithium sulfur batteries. The host in this unique architecture is porous carbon, which contains interconnected macropore tunnels and meso/micropores on the macropore tunnel walls. These hierarchical pores exhibit a synergistic effect to adsorb sulfur in their spaces and provide more nucleation sites to direct the uniform coating of sulfur.

Novel antibodies against GPIbα inhibit pulmonary metastasis by affecting vWF-GPIbα interaction.

Background: Platelet glycoprotein Ibα (GPIbα) extracellular domain, which is part of the receptor complex GPIb-IX-V, plays an important role in tumor metastasis. However, the mechanism through which GPIbα participates in the metastatic process remains unclear. In addition, potential bleeding complication remains an obstacle for the clinical use of anti-platelet agents in cancer therapy.

Short-Term Nitrate Limitation Prior to Harvest Improves Phenolic Compound Accumulation in Hydroponic-Cultivated Lettuce ( Lactuca sativa L.) without Reducing Shoot Fresh Weight.

Long-term exposure to a low nitrogen supply could effectively improve phenolic content in vegetables, but it also greatly decreases the yield. Therefore, it is necessary to develop cost-effective strategies of nitrogen management to overcome these obstacles. Here, we find that decreasing the nitrogen (NO) supply from 8.