Correction: Liquid-liquid phase separation drives immune signaling transduction in cancer: a bibliometric and visualized study from 1992 to 2024.

[This corrects the article DOI: 10.3389/fonc.2025.

ACSL4 Drives C5a/C5aR1-Calcium-Induced Fibroblast-to-Myofibroblast Transition in a Bleomycin-Induced Mouse Model of Pulmonary Fibrosis.

Idiopathic pulmonary fibrosis (IPF) is characterized by excessive extracellular matrix (ECM) deposition driven by aberrant fibroblast-to-myofibroblast transition (FMT). However, the upstream regulators and downstream effectors of this process remain incompletely understood. Here, we identify acyl-CoA synthetase long-chain family member 4 (ACSL4), a lipid metabolic enzyme, as a critical mediator linking complement component 5a (C5a)/C5a receptor 1 (C5aR1) signaling to FMT via calcium signaling.

Clinical features and prognosis of carcinoma ex pleomorphic adenoma of the lacrimal gland: a comprehensive case series and literature review.

Aim: To examine carcinoma ex pleomorphic adenoma (CXPA) and its development to provide information for its clinical assessment and prognosis.

Methods: The clinical data of 26 patients with pathologically diagnosed CXPA were included for analysis. The patients' medical histories and data (.

Growth and development characteristics of fruit and vegetative bud outgrowth of Prunus sibirica L. in relation to physiological fruit drop.

Background: Prunus sibirica L. is one of the most pivotal eco-economic tree species in China's arid and semi-arid areas. The phenomenon of physiological fruit drop in P.

Global trends of big data analytics in health research: a bibliometric study.

Background: The field of "Big Health," which encompasses the integration of big data in healthcare, has seen rapid development in recent years. As big data technologies continue to transform healthcare, understanding emerging trends and key advancements within the field is essential.

Methods: We retrieved and filtered articles and reviews related to big data analytics in health research from the Web of Science Core Collection, including SCI Expanded and SSCI, covering the period from 2009 to 2024.

Orbital myoepithelial carcinoma: implications for diagnosis and treatment strategies.

Background: Given the rarity orbital myoepithelial carcinoma (OMC) and the paucity of current evidence characterizing its clinical profile, this study aims to summarize the clinical features and prognostic outcomes of OMC.

Methods: This retrospective cohort study analyzed a consecutive series of 12 patients with histopathologically confirmed OMC managed at Beijing Tongren Hospital, Capital Medical University (January 1, 2000-December 31, 2024), with evaluation of demographic data, clinical features, imaging findings, histopathological features, treatment modalities, prognostic outcomes, and follow-up records, using progression-free survival and overall survival as primary outcome measures alongside clinical presentation and imaging study assessments.

Results: Twelve patients (58.

Development and evaluation of a quality-of-life questionnaire for patients with orbital malignant tumours.

Background: Orbital malignant tumours seriously affect the quality of life of patients; however, there is currently no quality-of-life questionnaire for patients with orbital malignant tumours.

Objective: To develop and evaluate a quality-of-life questionnaire for patients with orbital malignant tumours.

Methods: A pool of items was generated through a literature search, expert meeting and patient interview.

Targeting Glutamine Metabolism Transporter SLC25A22 Enhances CD8+ T-Cell Function and Anti-PD-1 Therapy Efficacy in Cervical Squamous Cell Carcinoma: Integrated Metabolomics, Transcriptomics and T-Cell-Incorporated Tumor Organoid Studies.

Cervical squamous cell carcinoma(CSCC) represents formidable challenge in clinical oncology, exacerbated by poor prognosis and resistance to current treatments, including anti-PD-1 therapy, highlighting the urgent need for alternative therapeuties. Metabolic characteristics have emerged as potential drivers of treatment resistance and immune evasion. Herein, 1) based on metabolomic and transcriptomic analyses of 44 CSCC and 18 normal tissues, glutamine-enriched and immunosuppressive microenvironment is identified in CSCC.

A trans-long-chain prenyl diphosphate synthase promotes ubiquinone 10 biosynthesis in grape.

Prenyl diphosphate synthase (PDS) plays indispensable roles in terpene biosynthesis. However, there is an ongoing debate regarding whether grape (Vitis vinifera) geranyl diphosphate synthase (VvGDS, VIT_15s0024g00850) can generate geranyl diphosphate (GPP), the precursor of monoterpene biosynthesis. Here, we demonstrated that VvGDS localizes in mitochondria and is an authentic trans-long-chain PDS (thus, VvGDS was renamed VvPDS), which is essential for ubiquinone (UQ) biosynthesis.

Therapeutic roles of natural and engineered mesenchymal stem cells and extracellular vesicles in atopic dermatitis.

Atopic dermatitis (AD) is a chronic and inflammatory disease characterized by skin barrier destruction, sustained inflammation, and immune imbalance. Increasing evidence has suggested mesenchymal stem cells (MSCs) exhibit great potentials in treating AD due to the strong anti-inflammatory, immunomodulatory, and regenerative repair properties. As a cell-free nanocarrier, MSC-derived extracellular vesicles (MSC-EVs) play critical roles in mediating intercellular communications.

Targeting CD39 boosts PD-1 blockade antitumor therapeutic efficacy via strengthening CD8 + TILs function and recruiting B cells in cervical cancer.

Although the programmed cell death protein 1 (PD-1) blockade has been authorized for the treatment of recurrent and metastatic cervical cancer (CC) patients, a significant proportion of CC patients show low objective response rates (ORR) to immune checkpoint blockades (ICBs). Therefore, identifying novel combination treatment strategies to enhance ICBs therapeutic efficacy for CC patients is urgently needed. Here, we discovered that CD39 was highly expressed in exhausted CD8 + T cells from 10 CC patients in our center via single-cell RNA sequencing (scRNA-seq).

The relevance of B7-H3 and tumor-associated macrophages in the tumor immune microenvironment of solid tumors: recent advances.

B7 homolog 3 (B7-H3) is a member of the B7 ligand family. It is highly expressed in various human cancers, especially mesenchymal malignancies. B7-H3 regulates cancer progression through multiple signaling pathways such as JAK2/STAT3, NF-κB, PI3K/AKT, and ERK.

TIGIT deficiency promotes autoreactive CD4 T-cell responses through a metabolic‒epigenetic mechanism in autoimmune myositis.

Polymyositis (PM) is a systemic autoimmune disease characterized by muscular inflammatory infiltrates and degeneration. T-cell immunoreceptor with Ig and ITIM domains (TIGIT) contributes to immune tolerance by inhibiting T cell-mediated autoimmunity. Here, we show that a reduced expression of TIGIT in CD4 T cells from patients with PM promotes these cells' differentiation into Th1 and Th17 cells, which could be rescued by TIGIT overexpression.

The extrahepatic markers in postmenopausal women with metabolic dysfunction-associated steatotic liver disease: A systematic review.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent, multifactorial systemic metabolic disorder, now recognized as the most common chronic liver disease globally. Female susceptibility to MASLD varies across menstrual states, influenced by genetic factors, age, menopausal status, and physical activity. Postmenopausal women, experiencing a significant reduction in estrogen, are particularly vulnerable to metabolic imbalances, increasing their risk of MASLD, disease progression, liver fibrosis, insulin resistance, and adverse cardiovascular events compared to premenopausal women and age-matched men.

Visual analysis of research status and development trends in the field of postgraduate nursing education.

Aim: The purpose of this study was to systematically analyze the research status and development trends in the field of postgraduate education in nursing through visual analysis.

Methods: We conducted a comprehensive online search of English literature via citation index extensions in the Web of Science Core Collection Database. Chinese literature was searched online via the CNKI, Wanfang, VIP and China Medical Biobank Databases.

Stepwise Self-Assembly of Multisegment Mesoporous Silica Nanobamboos for Enhanced Thermal Insulation.

Imitating the multinodal structures of plants and arthropods, precisely engineered multisegment nanostructures demonstrate enhanced synergistic properties and exceptional functionalities that surpass those of individual components. Utilizing micelle assemblies for constructing segments allows for precise structural control but requires management of interactions and assembly from molecular to mesoscopic levels, posing a significant challenge. In this paper, we present a stepwise self-assembly strategy to fabricate multisegment mesoporous silica (mSiO) nanobamboos.

Temperature thresholds induce abrupt shifts in biodiversity and ecosystem services in montane ecosystems worldwide.

Montane ecosystems are crucial for maintaining global biodiversity and function that sustain life on our planet. Yet, these ecosystems are highly vulnerable to changing temperatures and may undergo critical transitions under ongoing climate change. What we do not know is to what extent montane biodiversity and ecosystem services will respond to local temperature variations in a gradual versus abrupt manner across global environments.

Development and characterization of a novel immortalized human vaginal fibroblast cell line for advanced applications in reproductive health.

Background: Reproductive health issues related to the vagina, face significant challenges due to the lack of standardized research models. Vaginal fibroblasts, which constitute approximately 55% of the vaginal wall's cellular composition, are crucial for tissue repair, remodelling, and reproductive health. These fibroblasts have broad applications in regenerative medicine and gynaecological treatments.

Clinical study of 37 cases of orbital melanoma.

Background: To analyze the clinical features and prognosis of orbital melanoma.

Design: Retrospective observational case series.

Methods: A retrospective analysis of the electronic medical records, histopathology, imaging examinations, and follow-up information of 37 patients with orbital melanoma.

Liquid-liquid phase separation drives immune signaling transduction in cancer: a bibliometric and visualized study from 1992 to 2024.

Background: Liquid-liquid phase separation (LLPS) is a novel concept that could explain how living cells precisely modulate internal spatial and temporal functions. However, a comprehensive bibliometric analysis on LLPS and immune signaling processes in cancer is still scarce. This study aims to perform a bibliometric assessment of research to explore the landscape of LLPS research in immune signaling pathways for cancer.

Chitooligosaccharide enhances plant resistance to P. nicotianae via sugar homeostasis and microorganism assembly.

Phytophthora nicotianae is a highly destructive soil-borne plant pathogen that leads to significant economic losses in agriculture. Chitooligosaccharides (COS) are popular biostimulant which can promote plant growth and responses to biotic and abiotic stresses. However, the role of COS in resisting the black-shank disease (BSD, caused by P.

Orbital natural killer/T-cell lymphoma: a comprehensive case series and literature review.

Purpose: To evaluate the clinical features, pathological findings, treatment, and prognosis of patients with orbital natural killer/T-cell lymphoma (NKTCL).

Methods: This retrospective study collected clinical data from 11 patients diagnosed with orbital NKTCL by pathological examination at Beijing Tongren Hospital, Capital Medical University, between November 2005 and March 2024. The patients were followed up to assess their prognosis.

A 10-meter resolution dataset of abandoned and reclaimed cropland from 2016 to 2023 in Inner Mongolia, China.

Amid growing global food security concerns and frequent armed conflicts, real-time monitoring of abandoned cropland is essential for strategic planning and crisis management. This study develops a method to map abandoned cropland accurately, crucial for maintaining the food supply chain and ecological balance. Utilizing Sentinel-1/2 satellite data, we employed multi-feature stacking and machine learning to create the ARCC10-IM (Abandoned and Reclaimed Cropland Classification at 10-meter resolution in Inner Mongolia) dataset, which tracks annual cropland activity.