Innovative Development of Low Carbon Cementitious Materials Based on Magnesium Smelting Slag by the Response Surface Method: Chemical Activation, Hydration Characteristics and Application.

The swift expansion of the worldwide magnesium industry has resulted in substantial accumulation of magnesium slag (MS) as a byproduct of the magnesium metal smelting process, presenting a growing environmental hazard. To effectively address the issue of MS resource usage, the synergistic activation impact among MS, fly ash (FA), and desulfurized gypsum (DG) was examined utilizing response surface methodology (RSM). This study calculated the appropriate ratio of cementitious materials and investigated the hydration characteristics of magnesium-slag-based low-carbon cementitious materials (MSLCM).

Photochemical Production of Singlet Oxygen in Adirondack Long-Term Monitoring Lakes of Varying Browning Status.

Widespread browning of surface waters in boreal and temperate regions of the Northern Hemisphere has been documented through long-term monitoring of color or dissolved organic matter (DOM) over recent decades. While the ecological implications of browning have received considerable attention, its impacts on the photochemical production of reactive intermediates from DOM remain understudied despite their importance for biogeochemical processes and contaminant fate in sunlit surface waters. To address this gap, we investigated singlet oxygen (O) production in 37 lakes within the Adirondack Long-Term Monitoring (ALTM) program.

Early response and long-term prognosis of paediatric ITP: Exploration of future management strategies.

Immune thrombocytopenia (ITP) is the most common immunological haemorrhagic disease in childhood. Our retrospective study analysed hospitalized paediatric ITP patients to identify determinants of early treatment response and long-term clinical outcomes. The study found that younger children had a higher 7-day complete response (CR) rate and were more likely to achieve CR in the early stages (p = 0.

Entrustable professional activities for pediatric and subspecialties residency training in China.

Background And Objectives: Outcome-based medical education is the latest focus in the past decade, and Entrustable Professional Activities(EPAs) have emerged as efficient vehicles to assess physicians. However, few studies have discussed the use of EPAs for residency training in pediatric medicine and its subspecialties. We conducted a pilot study to examine the feasibility of EPAs as a component of the clinical program of assessment in pediatric standardized residency training.

Association between physical activity and sedentary behavior with cardiometabolic multimorbidity in the elderly hypertensive population: an observational and Mendelian randomization study.

Background: The causal relationships between physical activity (PA), sedentary behavior (SB), and the risk of cardiometabolic disease (CMD) in hypertensive populations remain unclear. We conducted a Mendelian randomization (MR) analysis to investigate these associations.

Methods: We conducted an observational analysis using a sample of 18,963 hypertensive population.

Core collection construction and genetic diversity analysis of tea plant (Camellia sinensis [L:] O. Kuntze) accessions in Huangshan city using SSR markers.

Assessing genetic diversity and building a core collection is essential to advancing tea plant breeding. In this study, ten SSR markers exhibiting robust amplification and polymorphism were employed to genotype 292 tea accessions sourced from various regions in Huangshan city. The results revealed significant genetic variation, encompassing 180 alleles.

Using roof borehole electrical resistivity tomography to monitor roof water infiltration in a mine work face.

Roof water inrush in coal mining is a significant type of water-related disaster that usually results from the interconnection of water-bearing geological formations formed by cracks during and after work face mining. Therefore, monitoring roof water infiltration is of paramount importance in preventing or mitigating water inrush in the mine work face. This study employed the roof borehole electrical resistivity tomography method to conduct physical experiments for monitoring water seepage in roof cracks generated during coal model mining.

, a novel cell wall-associated receptor kinase gene from , promotes growth but reduces cold tolerance in .

Cold significantly impacts the growth and development of tea plants, thereby affecting their economic value. Receptor-like kinases (RLKs) are thought to play a pivotal role in signaling the plant's response to cold and regulating cold tolerance. Among the RLK subfamilies, wall-associated receptor-like kinases (WAKs) have been investigated across various plant species and have been shown to regulate cell growth and stress responses.

Complement C3 deposition restricts the proliferation of internalized by promoting autophagy.

Complement C3 (C3) is usually deposited spontaneously on the surfaces of invading bacteria prior to internalization, but the impact of C3 coating on cellular responses is largely unknown. () is a facultative intracellular pathogen that subverts autophagy and replicates in both phagocytic and nonphagocytic cells. In the present study, we deposited C3 components on the surface of by complement opsonization before cell infection and confirmed that C3-coatings remained on the surface of the bacteria after they have invaded the cells, suggesting cannot escape or degrade C3 labeling.

Composition, distribution, and risk assessment of heavy metals in large-scale river water on the Tibetan Plateau.

Heavy metals present in aquatic ecosystems constitute a significant threat to both the environment and human health. In this study, we analyzed various heavy metals (As, Cr, Co, Ni, Cu, Mo, Cd, Pb and Sb) using extensive surface water samples collected from the Tibetan Plateau in 2021 and 2023. Results showed that downstream water samples exhibited higher content (mean 12.

Composition and constraints of lithium isotopes in cryoconite from various remote glacier areas of the Tibetan Plateau.

Lithium isotope is one of the most promising indicators for the study of continental silicate weathering, and lithium concentrations and its isotopic compositions in earth surface can provide a better understanding of the geochemical behavior and isotopic fractionation during weathering and erosion. This work focused on the composition and distribution of Li isotope in cryoconite deposited on various glacier areas in a large range of the Tibetan Plateau and surroundings, as well as its implications for cryoconite dust provenances. Results showed that δLi in cryoconite varied within the same order of magnitude (-2.

Quantifying uranium radio-isotope ratios in riverine suspended particulate matter: Insights into natural and anthropogenic influences in the glacial-fed river system of the NE Tibetan Plateau.

The analysis of uranium isotope ratio U/U in environmental media serves as a reliable method to distinguish between natural and anthropogenic sources of uranium, playing a crucial role in assessing the extent of contamination with anthropogenic uranium and disturbances in its biogeochemical cycle. In this study, we focus on the northeastern Tibetan Plateau to examine the atomic ratio of U and U in riverine suspended particulate matter (SPM) across eight glacial watersheds. Results reveal that the U/U atomic ratio in the suspended load ranges from 0.

Comparison on distribution and sources of typical major and toxic trace elements in various glacial watersheds of the northeast Tibetan Plateau.

Toxic and major elements, such as As and Fe, in watersheds can significantly impact the surrounding water environment and ecosystem. Thus, in this study, we conducted an investigation into the origins and spatial distribution of typical toxic trace elements (As and Mn) and crustal major elements (Al, Fe, and Ti) in suspended particulate matter (SPM) across various glacial watersheds located at different elevations in the northeastern Tibetan Plateau (NETP) from June to July in 2017. The results revealed that the mean value of each element followed the order of abundance in the samples, with Al having the highest mean value at 21307 µg/L, followed by Fe at 13366 µg/L, Ti at 1520 µg/L, Mn at 245 µg/L, and As at 66.

Insights on the distribution and environmental implications of the radio-isotope U in surface soils and glaciers of the Tibetan Plateau.

Atom ratio between U and U is often used as an indicator of U contamination as the isotopic signature of products generated by the nuclear and military industry significantly vary from the natural isotopic ratio of U. In this study, surface soils and glaciers samples were collected in the Tibetan Plateau (TP) and its surrounding areas and analyzed for U isotopic composition. Results show that the U/U atom ratios in the surface soils of the TP ranges from 0.

Controllable Droplet Sliding on a Smart Shape-Memory Slippery Surface.

Recently, slippery surfaces with controllable droplet sliding have aroused much attention in both fundamental research and realistic applications. However, for almost all existing surfaces, constant stimuli such as heat, light, magnetic field, etc., are indispensable.

Identification of icaritin derivative IC2 as an SCD-1 inhibitor with anti-breast cancer properties through induction of cell apoptosis.

Background: Breast cancer is the most common malignancy affecting women, yet effective targets and related candidate compounds for breast cancer treatment are still lacking. The lipogenic enzyme, stearoyl-CoA desaturase-1 (SCD1), has been considered a potential target for breast cancer treatment. Icaritin (ICT), a prenylflavonoid derivative from the Traditional Chinese Medicine Epimedii Herba, has been reported to exert anticancer effects in various types of cancer.

Synthesis and biological evaluation of new series of quinazoline derivatives as EGFR/HER2 dual-target inhibitors.

It is generally believed that EGFR/HER2 dual-target inhibitors may overcome the resistance of EGFR TKIs caused by HER2 overexpression. The structure-based synthesis and biological evaluation of quinazoline derivatives as EGFR/HER2 dual-target inhibitors has been studied in this paper. II-1, II-2, III-3, III-4 displayed comparable inhibitory potency against EGFR and HER2 and II-1 showed remarkable antiproliferative activities against NCI-H358/PC-9/Calu-3/NCI-H1781 (EGFR IC = 0.

Mechanistic study on photochemical generation of I/I radicals in coastal atmospheric aqueous aerosol.

The reactive iodine species may exhibit significant impacts on many global atmospheric issues and the I/I radicals play key roles for inducing the formation of these reactive iodine species. However, the current understanding on the formation of I/I radicals in atmospheric aqueous aerosol is still quite limited. The results reported herein suggest that I/I can be produced simultaneously in aqueous aerosol by several sunlight-driven photochemical pathways including direct photo-dissociation of soluble organic iodine (SOI) at rates of 0.

Uranium isotopes of aeolian dust deposited in northern Tibetan Plateau glaciers: Implications for tracing aeolian dust provenance.

Asian dust comprises a large portion of the northern hemisphere atmospheric dust load, thereby exerting substantial influence on the Earth's climate, global biogeochemistry and hydrological cycle through accelerated snow and ice melt. Dust deposited on alpine glaciers encodes information on broad scale atmospheric-environmental processes. The (U/U) values of dust fine particulates can reflect the comminuting time and intermediate processes; thus, it provides a new method for the provenance of aeolian dust in the glacial snowpack/cryoconite.

Synthesis and biological evaluation of novel 5,6-dihydrobenzo[h]quinazoline derivatives as FLT3 inhibitors.

Fms-like tyrosine kinase 3 (FLT3) is widely expressed and often mutated in acute myeloid leukemia (AML), which makes it an important target for the treatment of AML. The structure-based synthesis and biological evaluation of 5,6-dihydrobenzo[h]quinazoline derivatives as FLT3 inhibitors have been studied in this paper. III-1a, III-1c, III-2a, III-2c, and III-4a displayed comparable inhibitory potency against FLT3-ITD and showed remarkable antiproliferative activities against MV4-11.

Photo-generated hydroxyl radicals contribute to the formation of halogen radicals leading to ozone depletion on and within polar stratospheric clouds surface.

Polar stratospheric clouds (PSCs), of which the surface is a dynamic liquid water layer and might consist of aqueous HNO and HO, is a well-known key meteorological condition contributing to the ozone hole in the polar stratosphere. PSCs has been considered to provide abundant surface for the heterogeneous reactions causing the formation of the Cl and HOCl, which are further photolyzed into Cl and ClO radicals leading to the ozone destruction. Here we demonstrated that the sunlight drives the massive and stable production of OH radicals in aqueous HNO and its main photo-induced byproduct HNO.

Synthesis and biological evaluation of diaryl urea derivatives as FLT3 inhibitors.

As a class III receptor tyrosine kinase (RTK), FMS-like tyrosine kinase 3 (FLT3) is always overexpressed in many cases of acute leukemia. This paper studies the structure-based synthesis and biological evaluation of diaryl urea derivatives as FLT3 inhibitors. Encouragingly, compounds 15b, 16b, 24a, and 24c showed excellent biological activities in a low nanomolar range.