UFMylation Modulates OFIP Stability and Centrosomal Localization.

Background: OFIP, also known as KIAA0753, is a centrosomal and pericentriolar satellite protein implicated in ciliogenesis, centriolar duplication, and microtubule stability. In humans, genetic mutations affecting OFIP have been implicated in the pathogenesis of Oral-Facial-Digital (OFD) Syndrome and Joubert Syndrome. Ubiquitin-fold Modifier 1 (UFM1), the most recently identified ubiquitin-like protein, is covalently transferred to its substrates, in a process known as UFMylation.

Improving the Electrochemical Properties of SiO Anode for High-Performance Lithium-Ion Batteries by Magnesiothermic Reduction and Prelithiation.

For lithium-ion batteries, silicon monoxide is a potential anode material, but its application is limited by its relatively large irreversible capacity loss, which leads to its low initial Coulombic efficiency (ICE). In this study, we conduct a two-step reaction for the formation of silicon oxide-based materials, including a magnesiothermic reduction of SiO with Mg, followed by the solid-state lithiation of silicon oxide with LiCO. Our results demonstrate that Mg can reduce SiO to Si and form MgSiO, while LiCO reacts with SiO to form LiSiO.

The negative association between the docosapentaenoic acid intake and the incidence of AMD based on NHANES 2005-2008.

Introduction: Age-related macular degeneration (AMD) is an ophthalmic disease that causes visual impairment and is one of the leading causes of blindness in the elderly. Fatty acids are essential nutrients required by the body and play a cornerstone role in the life activities of the body. Many studies have reported that fatty acids are involved in the development of AMD.

Dynein Light Intermediate Chains Exhibit Different Arginine Methylation Patterns.

Background: The motor protein dynein is integral to retrograde transport along microtubules and interacts with numerous cargoes through the recruitment of cargo-specific adaptor proteins. This interaction is mediated by dynein light intermediate chain subunits LIC1 (DYNC1LI1) and LIC2 (DYNC1LI2), which govern the adaptor binding and are present in distinct dynein complexes with overlapping and unique functions.

Methods: Using bioinformatics, we analyzed the C-terminal domains (CTDs) of LIC1 and LIC2, revealing similar structural features but diverse post-translational modifications (PTMs).

Hospital volume-mortality association after esophagectomy for cancer: a systematic review and meta-analysis.

Background: Postoperative mortality plays an important role in evaluating the surgical safety of esophagectomy. Although postoperative mortality after esophagectomy is partly influenced by the yearly hospital surgical case volume (hospital volume), this association remains unclear.

Methods: Studies assessing the association between hospital volume and postoperative mortality in patients who underwent esophagectomy for esophageal cancer were searched for eligibility.

Composition and constraints of lithium isotopes in cryoconite from various remote glacier areas of the Tibetan Plateau.

Lithium isotope is one of the most promising indicators for the study of continental silicate weathering, and lithium concentrations and its isotopic compositions in earth surface can provide a better understanding of the geochemical behavior and isotopic fractionation during weathering and erosion. This work focused on the composition and distribution of Li isotope in cryoconite deposited on various glacier areas in a large range of the Tibetan Plateau and surroundings, as well as its implications for cryoconite dust provenances. Results showed that δLi in cryoconite varied within the same order of magnitude (-2.

Quantifying uranium radio-isotope ratios in riverine suspended particulate matter: Insights into natural and anthropogenic influences in the glacial-fed river system of the NE Tibetan Plateau.

The analysis of uranium isotope ratio U/U in environmental media serves as a reliable method to distinguish between natural and anthropogenic sources of uranium, playing a crucial role in assessing the extent of contamination with anthropogenic uranium and disturbances in its biogeochemical cycle. In this study, we focus on the northeastern Tibetan Plateau to examine the atomic ratio of U and U in riverine suspended particulate matter (SPM) across eight glacial watersheds. Results reveal that the U/U atomic ratio in the suspended load ranges from 0.

Impact of government subsidies on innovation of Chinese biopharmaceutical firms: Based on kink threshold model.

Do government subsidies achieve the goals of stimulating firm innovation and macro-regulation? Existing studies have not reached a consistent conclusion. We will study the incentive effect of government subsidies on innovation of biopharmaceutical firms, analyze the optimal interval of government subsidies, and improve the efficiency of government subsidies. Thus, based on kink threshold model using data from Chinese biopharmaceutical listed companies from 2013-2019, this study analyzes the impact of government subsidies on innovation inputs and outputs.

Life expectancy and healthy life expectancy of patients with advanced schistosomiasis in Hunan Province, China.

Background: Few studies have investigated the change in life expectancy (LE) and the healthy lifespan among patients with advanced schistosomiasis. This study was to evaluate the LE and healthy life expectancy (HLE) for patients and assess the mechanism responsible for the LE inequality.

Methods: We utilized data from a dynamic advanced schistosomiasis cohort (10,362 patients) for the period from January 2008 to December 2019 in Hunan Province, China, to calculate the LEs of patients, and made a comparison with that of general population (19,642 schistosomiasis-free individuals) in the schistosomiasis endemic areas.

Insight into atmospheric deposition and spatial distribution of bioavailable iron in the glaciers of northeastern Tibetan Plateau.

Iron (Fe) is an essential micronutrient in glacial ecosystems and modulates global biogeochemical cycles. To find out the deposition concentration, multiple origins and release form of iron in various glacier areas of central Asia, this study investigated the total Fe (TFe) and dissolved-Fe (dFe, diameter < 0.45 or <0.

A method of detecting apple leaf diseases based on improved convolutional neural network.

Apple tree diseases have perplexed orchard farmers for several years. At present, numerous studies have investigated deep learning for fruit and vegetable crop disease detection. Because of the complexity and variety of apple leaf veins and the difficulty in judging similar diseases, a new target detection model of apple leaf diseases DF-Tiny-YOLO, based on deep learning, is proposed to realize faster and more effective automatic detection of apple leaf diseases.

Early rehabilitation nursing in ICU promotes rehabilitation of patients with respiratory failure treated with invasive mechanical ventilation.

Objective: This paper aimed at exploring the application value of early rehabilitation nursing (ERN) in intensive care unit (ICU) for nursing patients with respiratory failure (RF) treated with invasive mechanical ventilation (IMV).

Methods: Admitted to the ICU of our hospital from January 2019 to June 2020, 172 RF patients that was treated with IMV were selected as the research objects. Those in the general group (n=80) received routine nursing in ICU, whereas those in the recovery group (n=92) received ERN on the basis of the general group.

Cluster nursing can reduce postoperative delirium and improve the negative emotions and quality of life of elderly ICU patients.

Objective: To explore the application effect of cluster nursing in post-surgery elderly patients in intensive care units (ICU).

Methods: From March 2019 to August 2020, a total of 167 elderly patients admitted to the ICU in Changzhou No. 2 People's Hospital, the Affiliated Hospital of Nanjing Medical University were recruited as the study cohort.

Mutation of the BAG-1 domain decreases its protective effect against hypoxia/reoxygenation by regulating HSP70 and the PI3K/AKT signalling pathway in SY-SH5Y cells.

BCL-2-associated athanogene-1 (BAG-1) is a multifunctional protein that was first identified as a binding partner of BCL-2. Our previous results indicated that BAG-1 large (BAG-1L) overexpression significantly increases cell viability and decreases apoptosis by upregulating HSP70 and p-AKT in response to hypoxia/reoxygenation in SY-SH5Y cells. However, the functional domain of BAG-1L that exerts these protective effects against hypoxic damage has not been identified.

[Preliminary study on the effect of lipopolysaccharide challenge on the genes expression of inflammatory factors in A549 cells].

Objective: To explore the effects of lipopolysaccharide (LPS) on the expression of inflammatory genes in A549 cells line under different concentrations and different action time, this study laid the foundation for further establishment of acute respiratory distress syndrome (ARDS) cell model in the optimal concentration-time way.

Methods: A549 cells line was incubated routinely in 5% CO incubator at 37 centigrade with high glucose DMEM medium which included 10% fetal calf serum. Cells in logarithmic phase was cultured for passage, the cells was count to adjust cell density to (5-7)×10 and tile evenly in six-hole plate.

Accuracy Evaluation of Five Blood Glucose Monitoring Systems in Patients from Different Departments.

Background: Self-monitoring of blood glucose (SMBG) systems are expected to be accurate and provide reliable results. The international standard ISO (International Organization for Standardization) 15197:2013 is widely accepted for the accuracy evaluation for SMBG systems. Accuracy evaluation was performed for 5 different SMBG systems in patients from multi-departments at the hospital.

A prospective longitudinal evaluation of cognition and depression in postoperative patients with high-grade glioma following radiotherapy and chemotherapy.

Aim Of Study: The survival rate in high-grade glioma (HGG) patients receiving a combined regimen of radiotherapy (RT) and temozolomide after tumor resection was increased. However, cognitive deficits and depression after the treatments challenge the treatments. The aim of this study was to evaluate the cognition and depression in postoperative patients with HGG following RT and chemotherapy.

Association between Nine Types of TCM Constitution and Five Chronic Diseases: A Correspondence Analysis Based on a Sample of 2,660 Participants.

Objective: The purpose of this study was to explore the association of nine types of Traditional Chinese Medicine (TCM) constitution with the five chronic diseases: hypertension, hyperlipidemia, diabetes mellitus, heart disease, and obesity.

Methods: Chi-squared test was performed to investigate the distribution characteristics of TCM constitutions in the participants with the five chronic diseases in questionnaire. Correspondence analysis was used to explore the correlation between them.

Association between Body Mass Index and Health-Related Quality of Life: The "Obesity Paradox" in 21,218 Adults of the Chinese General Population.

Background: There was no consistent recognition of the association between high or low body mass index (BMI) and health related quality of life (HRQL). The aim of this research was to study the association between BMI and HRQL in Chinese adults, and to further explore the stability of that association in the subgroup analysis stratified by status of chronic conditions.

Methods: A total of 21,218 adults aged 18 and older were classified as underweight, normal weight, overweight, class I obese, and class II obese based on their BMI.

Case-control study on the associations between lifestyle-behavioral risk factors and phlegm-wetness constitution.

Objective: To explore the relationships between different lifestyle-behavioral factors and phlegm-wetness type of Traditional Chinese Medicine constitution, so as to provide health management strategies for phlegm-wetness constitution.

Methods: A case-control study was conducted with the cases selected from the database of Chinese constitution survey in 9 provinces or municipalities of China. 1380 cases met the diagnostic criteria of phlegm-wetness type were taken as the case group, and 1380 cases were randomly selected from gentleness type as the control group.

[Correspondence analysis of chinese medical constitution features in different ages population].

Objective: To explore the distribution features of Chinese medical constitutions in different ages population, thus providing scientific evidence of constitution process theory.

Methods: Recruited were 21 948 cases from a survey of Chinese medical constitutions and health conditions in 9 provinces or municipalities across China (including Jiangsu, Anhui, Gansu, Qinghai, Fujian, Beijing, Jilin, Jiangxi, and Henan) from Dec 2005 to Jan 2007. The body constitution type of individual was diagnosed using discriminant analysis on the basis of Chinese medical constitution questionnaire.

Correlation between tobacco and alcohol use and Traditional Chinese Medicine constitutions: an analysis based on a sample from general population of China.

Objective: To investigate the relationship between smoking and drinking and constitution types from Traditional Chinese Medicine (TCM) theory.

Methods: The Constitution in Chinese Medicine Questionnaire (CCMQ) was used. A sample of 8448 subjects from nine provinces and municipalities was chosen from the database of the TCM constitution and health status survey.

Responsiveness of three subjective report of outcome measures for chronic heart failure.

Objective: To compare the responsiveness of a newly designed symptom scale, the Chinese Medical Symptom Rating Scale for Heart Failure (CMSRS-HF), with the Chinese version of Minnesota Living with Heart Failure Questionnaire (MLHFQ) and the Medical Outcomes Study Short-form 36 (SF-36), and provide basis for the selection of subjective outcome measures for clinical evaluation of treatment of chronic heart failure by integrated traditional Chinese and Western medicine.

Methods: One hundred and fifty-six patients with chronic heart failure were recruited from three clinical centers and were treated with Chinese herbal medicine based on syndrome classification. The patients were classified with standard of New York Heart Association and evaluated with CMSRS-HF, MLHFQ and SF-36.

Development of a nanoparticle-based influenza vaccine using the PRINT technology.

Unlabelled: Historically it is known that presentation of vaccine antigens in particulate form, for a wide range of pathogens, has clear advantages over the presentation of soluble antigen alone [J.C. Aguilar, E.

Second virial coefficient determination of a therapeutic peptide by self-interaction chromatography.

Self-interaction of macromolecules has been shown to play an important role in a number of physical processes, including crystallization, solubility, viscosity, and aggregation. Peptide self-interaction is not as well studied as for larger proteins, but should play an equally important role. The osmotic second virial coefficient, B, can be used to quantify peptide and protein self-interaction.