Value of intravoxel incoherent motion and diffusion kurtosis imaging to differentiate hepatocellular carcinoma and intrahepatic cholangiocarcinoma.

Background: The differential diagnosis between hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) is crucial. The individual differences of patients increase the complexity of diagnosis. Currently, imaging diagnosis mainly relies on conventional computed tomography and magnetic resonance imaging (MRI), but few studies have investigated MRI functional imaging.

Application of AI-assisted compressed sensing in high resolution Gd-EOB-DTPA-enhanced MRI during hepatobiliary phase at 5.0 T.

Background: Liver tumor lesions are usually evaluated through magnetic resonance imaging (MRI), and currently the magnetic resonance field strengths are mainly 1.5 T and 3.0 T.

Optimization strategy for fat-suppressed T2-weighted images in liver imaging: The combined application of AI-assisted compressed sensing and respiratory triggering.

Purpose: This study aimed to optimize the imaging time and image quality of T2WI-FS through the integration of Artificial Intelligence-Assisted Compressed Sensing (ACS) and respiratory triggering (RT).

Materials And Methods: A prospective cohort study was conducted on one hundred thirty-four patients (99 males, 35 females; average age: 57.93 ± 9.

Assessment of biventricular cardiac function using free-breathing artificial intelligence cine with motion correction: Comparison with standard multiple breath-holding cine.

Purpose: To assess the image quality and biventricular function utilizing a free-breathing artificial intelligence cine method with motion correction (FB AI MOCO).

Methods: A total of 72 participants (mean age 38.3 ± 15.

Causticizition of electrolytic aluminum slag for selective lithium recovery and fluorine fixation.

Electrolytic aluminum slag (EAS) is a secondary resource containing lithium and hazardous waste with high soluble fluorine content. In this paper, a Ca(OH) causticizing strategy is proposed for selective lithium recovery and fluorine leakage elimination from EAS. The impurities in EAS are causticized by Ca(OH) and transformed into CaF, CaAlSiO and CaAl(OH), causing the impurities in EAS to precipitate and separate from the Li dissolved in the solution.

Lnc-DARVR/miR-365-1-5p/LAMB1 axis regulates rotavirus replication via the complement C3 pathway.

Unlabelled: Antiviral effectors and cytokines are critical components of host innate immunity. However, the regulatory mechanisms governing the roles of these molecules in host-virus interactions are still unclear. Although long non-coding RNAs (lncRNAs) have been recognized as key players in various biological processes, their involvement in the complement system of host antiviral defenses remains to be explored.

3D time-of-flight magnetic resonance angiography of lenticulostriate artery imaging at 5.0 Tesla: a hierarchic analysis method and clinical applications.

Background: Lenticulostriate artery (LSA) arteriosclerosis is a key pathological basis for cerebrovascular diseases including stroke and cerebral small vessel disease. However, the comprehensive visualization and the meticulous quantitative analysis of the entire spectrum of LSA branches remain an ongoing clinical challenge. This study aimed to explore the efficacy of LSA branch detection using ultra-high field clinical 5.

Histogram analysis of continuous-time random walk and restrictive spectrum imaging for identifying hepatocellular carcinoma and intrahepatic cholangiocarcinoma.

Background: To compare the ability and potential additional value of various diffusion models, including continuous-time random walk (CTRW), restrictive spectrum imaging (RSI), and diffusion-weighted imaging (DWI), as well as their associated histograms, in distinguishing the pathological subtypes of liver cancer.

Methods: 40 patients with liver cancer were included in this study. Histogram metrics were derived from CTRW (D, α, β), RSI (f, f, f), and DWI (ADC) parameters across the entire tumor volume.

Lifespan trajectories of fornix volume and tractography: a 5.0 T MRI study.

The fornix, playing a critical role in memory formation and maintenance, is recognized as an ultra-early biomarker for dementia. However, its trajectory during healthy aging remains incompletely understood. This study employed an ultra-high-field 5.

Multimodal associations between posterior hippocampus glutamate metabolism, visual cortex connectivity, and intrusive trauma reexperiencing symptoms.

Objective: Hippocampal dysfunction is implicated in posttraumatic stress disorder (PTSD), particularly intrusive reexperiencing symptoms, and may be mediated by glutamatergic excitotoxicity. Markers of glutamate dysfunction (higher glutamate to N-acetyl aspartate levels; Glu/NAA) in the hippocampus (HPC) have been linked to reexperiencing symptoms. However, the HPC demonstrates heterogeneity along its anterior-posterior axis, with different functional connectivity patterns and PTSD symptom associations, motivating investigations into glutamate metabolism in anterior and posterior HPC subregions (a/pHPC).

Lifespan trajectories of the morphology and tractography of the corpus callosum: A 5.0 T MRI study.

The corpus callosum (CC) is the largest white matter fiber bundle connecting the two hemispheres, facilitating interhemispheric integration and hemispheric specialization. Neuroimaging studies have identified the CC as a marker for aging and various neuropsychiatric disorders. However, studies focusing on high-resolution imaging and detailed lifespan characterizations of CC morphology and connectivity are still limited, highlighting the need for further investigation.

Comparison of single shot and multishot diffusion-weighted imaging in 5-T magnetic resonance imaging for brain disease diagnosis.

Background: Diffusion-weighted imaging (DWI) with single-shot echo-planar imaging (ssEPI) is a valuable tool for detecting acute brain lesions but does suffer from image distortions. Multishot echo-planar imaging (msEPI) is a technique for reducing such distortions. This study aimed to compare the image quality and diagnostic efficacy of ssEPI- and msEPI-DWI at 5.

Endovascular treatment of ruptured basilar artery trunk aneurysms: complications and long-term outcomes.

Object: Treatment of ruptured basilar artery trunk (BAT) aneurysms is challenging, and is associated with high complication and mortality rates. Herein, we analyzed the complications, long-term outcomes, and outcome predictors of endovascular treatment for ruptured BAT aneurysms.

Methods: Between January 2011 and July 2023, 36 patients with 36 ruptured BAT aneurysms underwent endovascular treatment at our institution.

Application of 5T glutamate chemical exchange saturation transfer imaging in brain tumors: preliminary results.

Purpose: Glutamate chemical exchange saturation transfer (GluCEST) is a non-invasive CEST imaging technique for detecting glutamate levels in tissues. We aimed to investigate the reproducibility of the 5T GluCEST technique in healthy volunteers and preliminarily explore its potential clinical application in patients with brain tumors.

Methods: Ten volunteers (4 males, mean age 29 years) underwent three 5T GluCEST imaging scans.

Probiotics combined with atorvastatin administration in the treatment of hyperlipidemia: A randomized, double-blind, placebo-controlled clinical trial.

Background: Hyperlipidemia is a common feature of chronic diseases. The aim of this work was designed to assess the role of probiotics (Lactobacillus casei Zhang, Bifidobactetium animalis subsp. lactis V9, and Lactobacillus plantarum P-8) in the treatment of hyperlipidemia.

ML241 Antagonizes ERK 1/2 Activation and Inhibits Rotavirus Proliferation.

Rotavirus (RV) is the main pathogen that causes severe diarrhea in infants and children under 5 years of age. No specific antiviral therapies or licensed anti-rotavirus drugs are available. It is crucial to develop effective and low-toxicity anti-rotavirus small-molecule drugs that act on novel host targets.

The feasibility of half-dose contrast-enhanced scanning of brain tumours at 5.0 T: a preliminary study.

Purpose: This study investigated and compared the effects of Gd enhancement on brain tumours with a half-dose of contrast medium at 5.0 T and with a full dose at 3.0 T.

Quantifying H&E staining results, grading and predicting IDH mutation status of gliomas using hybrid multi-dimensional MRI.

Objective: To assess the performance of hybrid multi-dimensional magnetic resonance imaging (HM-MRI) in quantifying hematoxylin and eosin (H&E) staining results, grading and predicting isocitrate dehydrogenase (IDH) mutation status of gliomas.

Materials And Methods: Included were 71 glioma patients (mean age, 50.17 ± 13.

Improved Detection of Target Metabolites in Brain Tumors with Intermediate TE, High SNR, and High Bandwidth Spin-Echo Sequence at 5T.

Background And Purpose: Due to high chemical shift displacement, challenges emerge at ultra-high fields when measuring metabolites using H-MRS. Our goal was to investigate how well the high SNR and high bandwidth spin-echo (HISE) technique perform at 5T for detecting target metabolites in brain tumors.

Materials And Methods: Twenty-six subjects suspected of having brain tumors were enrolled.

Study on the electrodeposition of uranium in chloride molten salt.

This study focuses on the recovery of UO from oxide spent fuel using electrodeposition. UO was used as the initial material and dissolved in NaCl-2CsCl using NHCl at high temperatures by means of chlorination reaction. The electrolysis process was conducted using a three-electrode system to investigate the effects of cathode material and diameter, electrolysis temperature, electrolysis time, electrolysis voltage, and uranium concentration in the molten salt on the electrolysis reaction.

Safety, Immunogenicity, and Mechanism of a Rotavirus mRNA-LNP Vaccine in Mice.

Rotaviruses (RVs) are a major cause of diarrhea in young children worldwide. The currently available and licensed vaccines contain live attenuated RVs. Optimization of live attenuated RV vaccines or developing non-replicating RV (e.

Disturbed meningeal lymphatic function associated with malignancy and progression in patients with intracranial malignant tumors.

Background: Meningeal lymphatic vessels (mLVs) have proven to bear a relationship with tumor immunity and therapeutic efficacy of intracranial malignant tumors in pre-clinical animal studies. We aimed to explore the association between mLV function and intracranial malignant tumors in clinical participants.

Methods: The participants were allocated to a control group or a group of patients with intracranial tumors.

Oleanolic acid, a small-molecule natural product, inhibits ECM degeneration in osteoarthritis by regulating the Hippo/YAP and Wnt/β-catenin pathways.

Over the past few decades, osteoarthritis (OA) has been a major health problem worldwide. It is urgent to develop new, effective, and safe drugs to treat OA. There are many pentacyclic triterpenoids in nature that are safe and have health benefits.

Mesenchymal stromal cell biotherapy for Parkinson's disease premotor symptoms.

Parkinson's disease (PD) is a neurodegenerative disorder with motor deficits due to nigrostriatal dopamine depletion and with the non-motor/premotor symptoms (NMS) such as anxiety, cognitive dysfunction, depression, hyposmia, and sleep disorders. NMS is presented in at least one-fifth of the patients with PD. With the histological information being investigated, stem cells are shown to provide neurotrophic supports and cellular replacement in the damaging brain areas under PD conditions.