Corneal endothelial and ocular biometric parameters in children with history of retinopathy of prematurity and treated with laser or intravitreal injections.

Objective: To investigate corneal endothelial and ocular biometric parameters in children with retinopathy of prematurity (ROP) treated with intravitreal injection (IVI) of anti-vascular endothelial growth factor (VEGF) or laser photocoagulation.

Design: A retrospective cohort study.

Participants: Seventy-four children with a history of ROP who visited a tertiary hospital between 2016 and 2021; 13 children were treated with laser and 61 with IVI.

Identification, characterization and expression analysis of the CDPK family in kelp Saccharina japonica.

Background: Calcium-dependent protein kinases (CDPKs) are crucial sensors and serine/threonine protein kinases in plants, involved in growth, development, and stress responses. However, research on CDPKs in a distinct eukaryotic lineage, such as brown algae, is scarce. Given its independent taxonomic position, brown algae CDPKs might exhibit unique structural and functional characteristics in ecological adaptation.

A PEDF-Derived Short Peptide Prevents Sodium Iodate-Induced Retinal Degeneration in Rats by Activating the SLC7A11/GSH/GPX4 Pathway in the RPE Cells.

Retinal pigment epithelial (RPE) cell damage caused by oxidative stress is a key factor in the pathogenesis of dry age-related macular degeneration (AMD). 6dS peptide is derived from the neuroprotective motif of pigment epithelium-derived factor (PEDF) and has antioxidant effects. This study used the sodium iodate (SI, a chemical oxidant)-induced animal dry AMD model to investigate the 6dS-mediated antioxidant mechanism.

Association of mold exposure and solid household fuel use with depression and anxiety among older adults in China.

Background: Exposure to mold and solid cooking fuels represents a significant environmental health concern, contributing substantially to indoor air pollution among elderly populations. However, the association between mold exposure, household fuel use, and mental health remains poorly understood. Here we examine individual and joint associations of these exposures on depression, anxiety, and their co-occurrence in older adults.

Engineered red blood cell extracellular vesicles for delivery of Dox and siIDO1 enhance targeted chemo-immunotherapy of acute myeloid leukemia.

Background: As a malignancy of hematopoietic origin, the standard-of-care cytoreductive chemotherapy can not provide satisfactory treatment effect for patients with acute myeloid leukemia (AML). Immunotherapy has received increasing attention in leukemia treatment. However, the immunosuppressive microenvironment and low cancer immunogenicity of AML blasts create major obstacles to effectively inducing immune responses.

Prediction model for growth trends of subpleural subsolid nodules using CT radiomics and radiological features.

Subpleural subsolid nodules (SSNs) pose challenges in early malignant transformation risk stratification, leading to over-surveillance or delayed treatment. To develop a radiological-radiomics combined model for predicting growth of subpleural SSNs and optimizing individualized follow-up strategies. This retrospective study included 494 subpleural SSNs (training set: 345; test set: 149) with ≥ 3 years follow-up CT.

Magnesium promoting OVX rats' rotator cuff tear repair with relieving stem cell senescence effect.

The rotator cuff tear (RCT) repairing of tendon-to-bone junction (enthese) after surgery in osteoporotic patients is mainly hindered by poor bone formation at the damaged humeral tuberosity region. We found that long-term oral supplementation of Magnesium ions (Mg) can significantly promote humeral tuberosity bone formation and enthese regeneration after RCT surgery in ovariectomized (OVX) rats, attributing to the promotive effect of Mg on the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and its inhibition of new bone mineralization. Meanwhile, the in vitro replicative senescent markers of BMSCs are significantly relieved by Mg.

Molecular Mechanism of Aflatoxin B Synthesis Related AfVerB Regulating the Development, AFB Biosyntheis and Virulence of Mainly Through Its CYP Domain.

and its secondary metabolites aflatoxins pose a significant threat to the health of humans, animals, and plants. Therefore, there is an urgent need to control contamination. AfverB plays a key role in the aflatoxin gene cluster; however, its function and mechanism in fungal development and virulence remain poorly understood.

Core collection construction and genetic diversity analysis of tea plant (Camellia sinensis [L:] O. Kuntze) accessions in Huangshan city using SSR markers.

Assessing genetic diversity and building a core collection is essential to advancing tea plant breeding. In this study, ten SSR markers exhibiting robust amplification and polymorphism were employed to genotype 292 tea accessions sourced from various regions in Huangshan city. The results revealed significant genetic variation, encompassing 180 alleles.

Infection toxicity assessment of tumor necrosis factor α inhibitors in the treatment of IBD: a real-world study based on the US food and drug administration adverse events reporting system (FAERS).

Background: Tumor necrosis factor α (TNF-α) inhibitors are widely used to treat inflammatory bowel disease (IBD), but systematic risk assessment of infectious toxicity is still lacking.

Research Design And Methods: We used disproportional analysis to calculate infection-related risk signals for four TNF-α inhibitors and compared them with infection-related signals for seven other therapies.

Results: There were 55,379 reports of infection-related adverse events (AEs) with TNF-α inhibitors as a 'primary suspect (PS)' therapy.

Diverse Bone Matrix and Mineral Alterations in Osteoporosis with Different Causes: A Solid-State NMR Study.

Osteoporosis (OP), which is a common skeletal disease with different causes, is prevalent in the aging population. Postmenopause women generally suffer from OP with bone loss due to estrogen deficiency. Diabetes is also associated with OP by complex metabolic mechanisms.

Exploring the potential mechanisms of sorafenib resistance in hepatocellular carcinoma cell lines based on RNA sequencing.

Background: Exploring the mechanisms underlying sorafenib resistance that arises in hepatocellular carcinoma (HCC) may provide new treatment perspectives.

Methods: Drug-resistant and drug-sensitive HCC cell lines were constructed from existing HepG2 and Huh7 cell lines, and gene expression profiles were determined. Genes differentially expressed between the resistant and sensitive lines were identified and organized into modules based on weighted gene co-expression network analysis.

BoundaryScreen: Summoning the Home Screen in VR via Walking Outward.

A safety boundary wall in VR is a virtual barrier that defines a safe area, allowing users to navigate and interact without safety concerns. However, existing implementations neglect to utilize the safety boundary wall's large surface for displaying interactive information. In this work, we propose the BoundaryScreen technique based on the "walking outward" metaphor to add interactivity to the safety boundary wall.

Surface moieties drive the superior protection of curcumin-derived carbon quantum dots against retinal ischemia-reperfusion injury.

Despite the recognized neuroprotective benefits of curcumin, its clinical utility is constrained by poor bioavailability and high cytotoxicity at effective doses. This study evaluates the therapeutic potential of curcumin-derived carbon quantum dots (Cur-CQDs) for retinal protection against ischemia-reperfusion (IR) injury in rats. Cur-CQDs were synthesized mild pyrolysis at varying temperatures and assessed for efficacy in rat retinal ganglion cells and a model of retinal IR injury.

Two new cyclopentanoid monoterpenes from the fruits of .

Two new cyclopentanoid monoterpenes, catalpovatins A-B (-), together with nine known compounds (-), were isolated from the fruits of G. Don. The structures of these compounds were elucidated based on their spectroscopic data.

Association between inflammatory score, healthy lifestyle, and cardiovascular disease: a national cohort study.

Background: The inflammation score is currently regarded as a reliable composite index for comprehensive assessment of inflammatory status. However, the relationship between inflammation score and cardiovascular disease (CVD) is unclear. Thus, we aimed to explore the association of inflammatory score with CVD, as well as to evaluate whether adhering to a healthy lifestyle could alleviate this association.

Silencing hepatic PCSK9 via novel chimeric AAV8 mitigates the progression of atherosclerosis by inhibiting inflammation in ApoE mice.

Adeno-associated virus (AAV) is the most widely utilized vector for gene therapy. Proprotein convertase subtilisin/kexin type 9 (PCSK9), predominantly expressed in the liver, plays a crucial role in lipid regulation and atherosclerosis progression. Here, we developed a novel chimeric AAV8.

Cyclin-dependent kinase 4/6 inhibitor-associated pulmonary toxicity: a disproportionality analysis from 2015 to 2023 based on the FAERS database.

Objectives: This study aimed to describe the pulmonary toxicity of cyclin-dependent kinase 4/6 inhibitors (CDK 4/6 inhibitors) (palbociclib, ribociclib, and abemaciclib) in patients being treated for breast cancer using the Food and Drug Administration Adverse Event Reporting System (FAERS) database.

Research Design And Methods: Disproportionality analysis was performed to assess pulmonary toxicity associated with CDK 4/6 inhibitors. Clinical characteristics, onset time, sensitivity analysis, subgroup analyses, drug combinations, comorbidities, and co-reported events were performed.

Post-Marketing Pharmacovigilance of Canakinumab from the FDA Adverse Event Reporting System (FAERS).

Canakinumab, a humanized anti-IL-1β monoclonal antibody, is known for its ability to suppress IL-1β-mediated inflammation. However, continuous monitoring of its safety remains essential. Thus, we comprehensively evaluated the safety signals of canakinumab by data mining from FAERS.

Engineered cell membrane vesicles loaded with lysosomophilic drug for acute myeloid leukemia therapy via organ-cell-organelle cascade-targeting.

Acute myeloid leukemia (AML) presents significant treatment challenges due to the severe toxicities and limited efficacy of conventional therapies, highlighting the urgency for innovative approaches. Organelle-targeting therapies offer a promising avenue to enhance therapeutic outcomes while minimizing adverse effects. Herein, inspired that primary AML cells are enriched with lysosomes and sensitive to lysosomophilic drugs (e.

IL-6R Inhibitors and Gastrointestinal Perforations: A Pharmacovigilance Study and a Predicting Nomogram.

IL-6R inhibitors are widely used in many inflammation-related diseases, especially so during the COVID-19 pandemic. However, their relationship with gastrointestinal perforations (GIPs) has been reported more and more. We comprehensively analyzed IL-6R inhibitors in association with GIPs from the United States FDA Adverse Event Reporting System (FAERS).

Measurements of Objective Cyclotorsion in a Population of Healthy Children.

This study aimed to compare ocular torsion measurements to investigate normative objective cyclotorsion values in a population of healthy, full-term and preterm children. The participants enrolled in this study had an age range of 3-12 years and were divided into two groups, full-term (gestational age (GA) > 37 weeks) and preterm without retinopathy of prematurity (ROP) (GA ≤ 37 weeks). The disc-center-fovea angle (DFA) was used to evaluate ocular torsion using two different imaging modalities: optical coherence tomography (OCT) with a 55-degree field of view (FV) and conventional fundus photography (CFP) with a 45-degree FV.

, a novel cell wall-associated receptor kinase gene from , promotes growth but reduces cold tolerance in .

Cold significantly impacts the growth and development of tea plants, thereby affecting their economic value. Receptor-like kinases (RLKs) are thought to play a pivotal role in signaling the plant's response to cold and regulating cold tolerance. Among the RLK subfamilies, wall-associated receptor-like kinases (WAKs) have been investigated across various plant species and have been shown to regulate cell growth and stress responses.

DeCGR: an interactive toolkit for deciphering complex genomic rearrangements from Hi-C data.

Background: Complex genomic rearrangements (CGRs) drive the restructuring of chromatin architecture, resulting in significant interactions among rearranged fragments, visible as anomalous interaction blocks in chromatin contact maps generated by chromosome conformation capture technologies such as Hi-C. These blocks not only offer the orientation and genome coordinates of rearranged fragments but also filter out false positive CGRs, thereby facilitating CGR assembly. Despite this, there is a lack of interactive graphical software tailored for this purpose.

Dietary patterns and risk of multiple cancers: umbrella review of meta-analyses of prospective cohort studies.

Background: Numerous prospective cohort studies have investigated the influence of dietary patterns on the risks of various cancers, although the findings differed.

Objectives: To evaluate the associations of dietary patterns with risks of various cancers and assess the strength and validity of the evidence.

Methods: Relevant articles were retrieved from the PubMed, EMBASE, Web of Science, and Cochrane library databases from inception to February 22, 2024.