Early response and long-term prognosis of paediatric ITP: Exploration of future management strategies.

Immune thrombocytopenia (ITP) is the most common immunological haemorrhagic disease in childhood. Our retrospective study analysed hospitalized paediatric ITP patients to identify determinants of early treatment response and long-term clinical outcomes. The study found that younger children had a higher 7-day complete response (CR) rate and were more likely to achieve CR in the early stages (p = 0.

Study on the law and mechanism by which oxalic acid dissolves tungstic acid.

The traditional alkali autoclaving tungsten smelting process has several disadvantages, such as high production costs, high water consumption and prominent "three wastes" problem, all of which seriously hinder the sustainable development of the tungsten smelting industry. We found that tungstic acid (HWO) can be dissolved in oxalic acid and that HWO can be easily precipitated from a solution at relatively high temperatures. Thus, traditional ammonium para-tungstate (APT) can potentially be replaced by HWO as the smelting intermediate, which is expected to overcome the problems associated with the alkali autoclaving process, and solve the problem of ammonia/ammonium pollution at the source.

Extraction of Tungsten from Tungsten Fine Mud by Caustic Soda Autoclaving.

Tungsten fine mud is a type of tailings containing minerals such as quartz and potassium feldspar as well as a small amount of tungsten. In this article, tungsten fine mud was decomposed by caustic soda autoclaving. The results showed that at a temperature of 160 °C, caustic soda concentration of 100 g/L, treatment time of 2 h, liquid/solid ratio of 2.

Unveiling the oncogenic role of LZTS1 in colorectal cancer.

Although leucine zipper tumour suppressor 1 (LZTS1) has been considered a potential tumour suppressor, accumulating evidence suggests that LZTS1 is highly expressed in many cancer types. To unravel the exact role of LZTS1 in colorectal carcinogenesis, we performed the bioinformatic analysis of LZTS1, including expression differences, correlations between expression levels and survival, methylation status of LZTS1 promoter and related cellular pathways based on TCGA dataset, GEO databases and our own CRC patient cohort. Furthermore, we confirmed the oncogenic function of LZTS1 in human mammalian cells by employing a series of assays including tissue microarray, immunoblotting, cell proliferation and migration assay.

Neoantigen identification: Technological advances and challenges.

Neoantigens have emerged as promising targets for cutting-edge immunotherapies, such as cancer vaccines and adoptive cell therapy. These neoantigens are unique to tumors and arise exclusively from somatic mutations or non-genomic aberrations in tumor proteins. They encompass a wide range of alterations, including genomic mutations, post-transcriptomic variants, and viral oncoproteins.

Efficacy and safety of thrombopoietin receptor agonists in children and adults with persistent and chronic immune thrombocytopenia: a meta-analysis.

Introduction: In this paper, we systematically review the efficacy and safety of thrombopoietin receptor agonists (TPORAs) for treatment of persistent and chronic immune thrombocytopenia (ITP) in children and adults.

Methods: We searched PubMed, MEDLINE, ScienceDirect, Scopus, EMbase and the Cochrane Library to collect randomized controlled trials (RCTs) of TPO-RAs which including avatrombopag hetrombopag eltrombopag and romiplostim treated persistent and chronic ITP from their earliest records to February 2022.

Results: We included 15 RCTs with a total of 1563 patients.

Placebo effect of rTMS on post-stroke motor rehabilitation: a meta-analysis.

Previous studies have shown that placebo repetitive transcranial magnetic stimulation (rTMS) was effective on post-stroke motor rehabilitation. However, the placebo effect has not been systematically assessed. Therefore, this meta-analysis was conducted to resolve this issue and explore potential influencing factors further.

Effect of Provisional Restorations with Ovate Pontics on Preservation of the Ridge after Tooth Extraction: Case Series.

Objective: To evaluate the effect of provisional restorations using ovate pontics on the hard and soft tissues of the alveolar ridge after tooth extraction.

Methods: Patients with intact buccal bone after extraction of a maxillary incisor underwent a series of treatments. The protocol included tooth extraction and provisional restoration using ovate pontics.

Biomechanics of Hybrid Anterior Cervical Fusion and Artificial Disc Replacement in 3-Level Constructs: An In Vitro Investigation.

Background: The ideal surgical approach for cervical disk disease remains controversial, especially for multilevel cervical disease. The purpose of this study was to investigate the biomechanics of the cervical spine after 3-level hybrid surgery compared with 3-level anterior cervical discectomy and fusion (ACDF).

Material And Methods: Eighteen human cadaveric spines (C2-T1) were evaluated under displacement-input protocol.

Coupled motion of cervical spine in three level hybrid constructs.

To compare the biomechanical characters of three-level anterior cervical fusion and hybrid constructs by measuring coupled motion changes of the cervical spine, Eighteen adult human cadaveric cervical spines were biomechanically investigated under eccentric displacement control in lateral bending and axial rotation by measuring vertebral motion (X, Y, Z -axis).The 3DPD condition displayed similar coupled motion compared to the intact condition both in lateral bending and in axial rotation, while the 3PDP condition was similar only in lateral bending. However, the coupled motion of the cervical spine under 3P conditions markedly changed in both lateral bending and axial rotation.