Analysis of differentially expressed genes and biological information between rheumatoid arthritis and osteoarthritis based on the GEO database.

In the present study, we investigated the relationship between rheumatoid arthritis (RA) and knee osteoarthritis (OA) using bioinformatics, aiming to identify the differentially expressed genes (DEGs) of RA and explore the possible mechanism of RA. The GSE55584 and GSE153015 microarray datasets for RA and OA gene expression profiles were acquired from the Gene Expression Omnibus (GEO) database. The DEGs of the two datasets were obtained by R language processing and analysis.

Target recycling amplification (TRA) combined with multiple strand displacement amplification (SDA) for sensitive detection of Epstein-Barr virus microRNA.

Objectives: Epstein-Barr virus (EBV) infection is strongly associated with the development of nasopharyngeal carcinoma. However, existing diagnostic methods based on EBV antibodies and plasma DNA exhibit insufficient sensitivity and specificity for early detection. This study aimed to overcome this limitation by developing a highly sensitive and specific method for detecting the EBV-encoded biomarker microRNA miR-BART6-3p.

Innovative Development of Low Carbon Cementitious Materials Based on Magnesium Smelting Slag by the Response Surface Method: Chemical Activation, Hydration Characteristics and Application.

The swift expansion of the worldwide magnesium industry has resulted in substantial accumulation of magnesium slag (MS) as a byproduct of the magnesium metal smelting process, presenting a growing environmental hazard. To effectively address the issue of MS resource usage, the synergistic activation impact among MS, fly ash (FA), and desulfurized gypsum (DG) was examined utilizing response surface methodology (RSM). This study calculated the appropriate ratio of cementitious materials and investigated the hydration characteristics of magnesium-slag-based low-carbon cementitious materials (MSLCM).

Raspberry ketone alleviates radiation-induced lung injury through the STAT2-P2X7r/NLRP3 signaling pathway.

Background: Radiation-induced lung injury (RILI) is a frequent side effect in patients with breast cancer receiving radiotherapy. Currently, there is no optimal radioprotective agent that is widely utilized for RILI treatment. Raspberry ketone (RK) is a natural aromatic compound found in raspberries (Rubus idaeus L.

A Review of Preparation of Low-Carbon Cementitious Materials from Chemically Activated Red Mud: Synergy, Hydration Mechanism, Rheological Properties and Applications.

Red mud, a byproduct of the alumina refining process, is generated at a rate of 1-2.5 tonnes per tonne of alumina produced. In 2022, China's alumina production totaled 77.

Differential Expression of LHR and FSHR in Canine Mammary Tumors: Correlation with Malignancy and Spay Status.

Canine mammary tumors (CMTs) constitute one of the most prevalent malignancies in female canines, whereas the functional involvement of gonadotropin receptors-luteinizing hormone receptor (LHR) and follicle-stimulating hormone receptor (FSHR)-in these neoplasms remains uncharacterized. This study investigated LHR and FSHR expression in 79 CMTs and 14 normal mammary tissues collected from 59 female dogs (ethical approval AW82903202-2-3), using immunohistochemistry (IHC) and quantitative real-time PCR, specifically examining their association with tumor malignancy and spay status. Relative to normal mammary tissue, CMTs exhibited statistically significant downregulation of both LHR and FSHR transcripts and corresponding proteins ( < 0.

Effects of cold plasma and sodium bicarbonate on the rheological, foaming, digestibility, and gelation properties of duck myofibrillar protein.

This study investigated the effects of sodium bicarbonate (SB) on the rheological properties, foaming ability, digestibility, and gelation behavior of duck myofibrillar protein (MP) during cold plasma (CP) treatment. Duck MP solutions containing 0 %, 0.2 %, 0.

Identification and functional characterization of hub genes CLTA, EDIL3, HAPLN1, and HIP1 as diagnostic biomarkers and therapeutic targets in thyroid cancer and Hashimoto's thyroiditis.

In this study, we sought to identify key molecular players in both thyroid cancer (TC) and Hashimoto's thyroiditis (HT) by analyzing differentially expressed genes (DEGs) and their potential as biomarkers. We utilized datasets from the Gene Expression Omnibus (GEO) database and identified CLTA, EDIL3, HAPLN1, and HIP1 as hub genes common to both TC and HT. These genes were significantly upregulated in TC cell lines compared to normal controls, with high diagnostic accuracy as indicated by Receiver Operating Characteristic (ROC) curve analysis.

Mechanistic study of ultrasound synergy with soybean 11S globulin to improve myofibrillar protein gel properties in low-salt lamb: molecular conformation and water migration.

The quality deterioration of low-salt meat products poses a significant technical challenge in the development of innovative meat products. This study, investigated the impact of co-sonication with soybean 11S globulin on the conformation and gel properties of myofibrillar proteins (MPs) derived from low-salt lamb. The findings revealed that ultrasound treatment for 30 min combined with 4 % soybean 11S globulin markedly improved the solubility, surface hydrophobicity, reactive sulfhydryl group content, and energy storage modulus (G') of low-salt MPs, while substantially reducing the particle size and turbidity.

Antimicrobial Resistance and Risk Factors of Canine Bacterial Skin Infections.

Bacterial skin infections are common in dogs and often secondary to underlying conditions like allergies or ectoparasite infestations. Untreated primary causes can lead to recurrent infections and an increased risk of antimicrobial resistance, including methicillin-resistant (MRSP), posing a substantial clinical challenge. Here, we analyzed 896 canine bacterial skin infection samples collected from the China Agricultural University Veterinary Teaching Hospital between 2018 and 2022.

Molecular mechanisms of pyroptosis in non-alcoholic steatohepatitis and feasible diagnosis and treatment strategies.

Pyroptosis is a distinct form of cell death that plays a critical role in intensifying inflammatory responses. It primarily occurs via the classical pathway, non-classical pathway, caspase-3/6/7/8/9-mediated pathways, and granzyme-mediated pathways. Key effector proteins involved in the pyroptosis process include gasdermin family proteins and pannexin-1 protein.

Layered Potassium Vanadate KVO as a Robust Cathode Material for Aqueous Zinc-Ion Batteries.

Layered vanadates are promising cathode materials for aqueous zinc-ion batteries (AZIBs). Herein, a layered potassium vanadate KVO is reported as a promising cathode material for AZIBs. It provides a high reversible capacity of 471.

Eliminating the myth of individual penalties in environmental law: Individual penalties and pollution emission reduction before and after the revision of China's environmental protection act.

Developing countries, including China, have long focused on punishing individuals through environmental laws. This focus stems from the fact that individual penalties are increasing and pollution emissions are decreasing. However, the over-emphasis on individual punishment in environmental laws is actually a false superstition.

Targeted drug delivery systems for atherosclerosis.

Atherosclerosis is a complex cardiovascular disease driven by multiple factors, including aging, inflammation, oxidative stress, and plaque rupture. The progression of this disease is often covert, emphasizing the need for early biomarkers and effective intervention measures. In recent years, advancements in therapeutic strategies have highlighted the potential of targeting specific processes in atherosclerosis, such as plaque localization, macrophage activity, and key enzymes.

CLIC1 and IFITM2 expression in brain tissue correlates with cognitive impairment via immune dysregulation in sepsis and Alzheimer's disease.

Background: Sepsis, a life-threatening condition driven by dysregulated host responses to infection, is associated with long-term cognitive impairments resembling Alzheimer's disease (AD). However, the molecular mechanisms linking sepsis-induced cognitive dysfunction and AD remain unclear. We hypothesized that shared genetic pathways underlie cognitive deficits in both conditions.

CD47-amyloid-β-CD74 signaling triggers adaptive immunosuppression in sepsis.

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. However, how this dysregulation occurs remains to be elucidated. In this study, we use single-cell RNA sequencing (scRNA-seq) and conventional RNA-seq to analyze the immune landscape of sepsis and observe that adaptive immunity is acutely and strongly suppressed.

PRMT1-mediated modification of H4R3me2a promotes liver cancer progression by enhancing the transcriptional activity of SOX18.

Background: HCC is one of the most prevalent and deadliest malignancies worldwide, with a poor prognosis. Altered histone modifications have been shown to play a significant role in HCC. However, the biological roles and clinical relevance of specific histone modifications, such as the asymmetric dimethylation on arginine 3 of histone H4 (H4R3me2a), remain poorly understood in HCC.

Embelin improves alcoholic steatohepatitis in alcohol-associated liver disease via ATF6-mediated P2X7r-NLRP3 signaling pathway.

Background: Alcohol-associated liver disease (ALD) manifests with impaired lipid metabolism and inflammation within the liver. Embelin (EB), a natural para-benzoquinone compound derived from the Embelia ribes Burm.f.

Preparation of Ion Composite Photosensitive Resin and Its Application in 3D-Printing Highly Sensitive Pressure Sensor.

Flexible pressure sensors play an extremely important role in the fields of intelligent medical treatment, humanoid robots, and so on. However, the low sensitivity and the small initial capacitance still limit its application and development. At present, the method of constructing the microstructure of the dielectric layer is commonly used to improve the sensitivity of the sensor, but there are some problems, such as the complex process and inaccurate control of the microstructure.

m6A-modified LINC02418 induces transcriptional and post-transcriptional modification of CTNNB1 via interacting with YBX1 and IGF2BP1 in colorectal cancer.

Colorectal cancer (CRC) represents a significant menace to human health, but its molecular pathogenesis remains unclear. Herein, we explored the functional role of LINC02418 in CRC progression. The function of LINC02418 in CRC was determined through vitro and in vivo experiments.

The anatomical basis and molecular mechanism of Arachis hypogaea nyctinastic movement.

Nyctinastic movement of plants refers to the circadian rhythms of the leaves or leaflets of some plants that open during the daytime and close at night. It is the turgor movement that induces the reversible change of the volume of pulvinus motor cells. The accomplishment of this movement demands the accurate control of water and ion flux by membrane proteins and the regulation of light signals and biological clocks.

Identification of intratumoral microbiome-driven immune modulation and therapeutic implications in diffuse large B-cell lymphoma.

Objective: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma, with significant clinical heterogeneity. Recent studies suggest that the intratumoral microbiome may influence the tumor microenvironment, affecting patient prognosis and therapeutic responses. This study aims to identify microbiome-related subtypes in DLBCL and assess their impact on prognosis, immune infiltration, and therapeutic sensitivity.

Pan-cancer analysis of Methyltransferase-like 16 (METTL16) and validated in colorectal cancer.

Human Methyltransferase-like 16(METTL16) is an independent N6-methyladenosine (m6A) methyltransferase. Previous studies have proven METTL16 been linked with some types of cancers. However, comparative studies of the relevance of METTL16 across diverse tumors remain sparse.

Yolk-shell SnSe@NC nanocubes: synergistic interior void and spatial confinement for superior sodium-ion battery anodes.

Rationally designed nanostructured electrode materials, especially yolk-shell metal selenide@void@C architectures, are gaining prominence as potential anode candidates for sodium-ion batteries (SIBs) due to their exceptional sodium-ion storage capabilities. In this work, we propose a template-assisted carbon coating route to fabricate nitrogen-doped carbon nanocubes encapsulating SnSe nanoparticles, forming a yolk-shell structure with an internal void space (SnSe@NC), resulting in a high-performance anode for SIBs. The yolk-shell architecture, with SnSe nanoparticles embedded within a nitrogen-doped carbon shell, significantly boosts structural integrity and sodium storage performance.