pH-triggered Schottky heterojunctions for NIR-II-activated and tumor-specific pyroelectrodynamic and photothermal therapy.

Pyroelectrodynamic therapy (PEDT) of tumors faces challenges due to its low electrocatalytic efficiency at mild temperature and the potential for off-target toxicity to healthy tissue. To overcome these issues, we have engineered pyroelectric nanoparticles (NPs) that feature a pH-triggered heterojunction structure and tumor-selective reactive oxidative species (ROS) production, faclitating synergistic PEDT and mild photothermal therapy (PTT). Herein, molybdenum trioxide (MoO) was deposited in-situ on the surface of tetragonal BaTiO (tBT) to create tBT@MO.

Ultrasound-actuated platelet mimetic nanomotors enable targeted piezocatalytic ROS storm for precision thrombolysis.

Thrombotic diseases pose life-threatening risks, yet current thrombolytic therapies face limitations including poor targeting and bleeding risks. To address this, ultrasound-activatable nanomotors (hBT-Pt@Pm) were developed through the integration of hollow BaTiO₃/Pt Schottky heterojunctions with platelet membrane (Pm) coatings. The hollow structure enhances piezocatalytic efficiency by shortening charge migration distances, while Pt deposition improves carrier separation, collectively boosting reactive oxygen species (ROS) generation under ultrasound.

Unraveling the Abnormal Positive Effect from Halogen Ion Adsorption on Pd-Catalyzed Electro-hydrogenation of Benzaldehyde.

The adsorption of halogen ions on the catalyst surface is generally believed to poison the catalyst surface, thus reducing the efficiency of the electrocatalytic reaction. In this work, we demonstrate that the strong adsorption of halogen ions on the surface of Pd nanowires can effectively promote the electrocatalytic hydrogenation of benzaldehyde and enhance the faradaic efficiency (FE) of the reaction. The unexpected promotional behavior correlates directly with the strength of halogen ion adsorption on the Pd surface, as revealed by systematic electrochemical and electrical transport spectroscopy (ETS) investigations.

Disordered Ru-O Octahedrons for Efficient and Selective Electro-oxidation of Sulfide to Sulfoxide via Boosted Surface Oxygen Kinetics.

Sulfoxides are essential intermediates for the production of various chemicals and pharmaceuticals, typically synthesized via direct sulfide oxidation. While current methods generally require harsh conditions and/or hazardous oxidants, electrochemical conversion from sulfide to sulfoxide promises ideal selectivity, sustainability, and energy efficiency while uniquely utilizing water as the green oxygen source. However, achieving efficient electro-organic conversion has been challenging due to sluggish surface oxygenating kinetics under nonaqueous conditions.

Nanodrug Delivery Systems for Direct Clearance or Neutralization of LPS.

Lipopolysaccharide (LPS) is a unique component of the outer wall of gram-negative bacteria and is a complex composed of lipids and polysaccharides. Normally, liver sinusoidal endothelial cells (LSECs) systemically clear LPS via unknown mechanisms. However, under pathological conditions, LPS causes lethal endotoxemia if it cannot be rapidly cleared from the blood circulation.

Unlocking a Nano-Aluminum Oxide Lewis Acid Layer as the Electrocatalyst for Hydrogenation of Thiophene and Other Arenes.

Owing to the ready formation of an insulating oxide layer, there is an intrinsic obstacle to the use of aluminum material as the cathode in the electrocatalytic reaction. In this report, a new Al-based material with a surface aluminum oxide/chloride nanolayer (nAlClO@Al) is prepared. Via the quantum tunneling effect, this material realizes conductivity through the nano-Al-O layer.

Compact all-polarization-maintaining dual femtosecond fiber laser system with large repetition rate tuning ranges based on self-made fiber actuators.

We present a dual fiber laser system that comprises two compact all-polarization-maintaining fiber lasers. The main feature of this laser system is that, facilitated by self-made fiber actuators, the repetition rates of the sub lasers can be tuned across wide ranges and phase-locked with high stability and low phase noise. The fiber actuator consists of a PZT coupled with an annular displacement amplifier.

Investigation of Nutritional Status by GLIM Criteria in Outpatients with GIST.

Nutritional management has proven to be significant in the treatment of cancer. Nonetheless, studies have rarely conducted on outpatients with gastrointestinal stromal tumor (GIST) currently. Data of outpatients with GIST at our hospital from June 1, 2020, to August 1, 2022, were retrospectively analyzed.

Dose-response relationship between different physical activity types and depressive symptoms in middle-aged and elderly people: a study of Chinese urban-rural differences.

Background: Evidence on the dose-response connection involving depressive symptoms and various types of physical activity in urban and rural populations is scarce. This study compares the dose-response connection across depressive symptoms and different types of activity in populations living in rural and urban areas.

Methods: The study is based on a cross-sectional weighted sample from the 2020 China Health and Retirement Longitudinal Study (CHARLS).

Impulsivity and social support as intervening and interactive variables in the link between childhood socioeconomic status and mental health among first-year college students.

Background: Significant attention has been given to the mental health of college students, especially first-year college students, with childhood socioeconomic status (SES) identified as a key factor. This study investigated the correlation of impulsivity and social support in the relationship between childhood SES and current mental health, with a focus on depressive and anxiety symptoms, in first-year college students.

Methods: A cross-sectional study was designed, surveying 6,378 first-year students (mean age = 20.

Biomimetic multifunctional nanoparticles for improved radiotherapy and immunotherapy in cancer treatment.

Radiotherapy represents a conventional approach in clinical cancer treatment, but suffers from insufficient DNA damage and limited tumor selectivity. Herein, bismuth oxyiodide quantum dots loaded hollow manganese dioxide (MB) nanoparticles was fabricated and subsequently wrapped with bacterial membrane vesicles (MVs) to create MB@MV nanoparticles. This biomimetic radiosensitizer is designed to enhance the efficacy of radiotherapy through a combined approach of tumor immunotherapy and oxygen delivery strategy.

Takeaway food consumption and depressive symptoms in Chinese university students: mediating effects of physical activity.

Background: The consumption of takeaways is becoming increasingly prevalent. Despite this, the relationship between takeaway food consumption and depressive symptoms in Chinese populations has not been clarified. Furthermore, the factors that mediate the association between takeaway frequency and depressive symptoms are unknown.

Homotypic membrane-camouflaged camptothecin nanorods combining photothermal and chemotherapy for synergistic antitumor therapy.

Chemotherapy hardly achieves satisfactory therapeutic efficacy owing to the widely occurred adverse effects and drug tolerance, and the extensively investigated delivery systems suffer from complicated synthesis, low drug loading and less efficient tumor accumulation. Herein, we developed rod-shape nanocrystals to address challenges in the circulation stability, tumor targeting and therapeutic efficacy of camptothecin (CPT), a mainstay of treatments for various cancers. CPT nanorods (CNR) were coated with polydopamine (PDA) to achieve combinational chemo- and photothermal therapies (PTT) and then wrapped with cell membrane (CM) from homotypic tumor cells to obtain CNR@PDA-CM.

Parameterization and quantification of two key operando physio-chemical descriptors for water-assisted electro-catalytic organic oxidation.

Electro-selective-oxidation using water as a green oxygen source demonstrates promising potential towards efficient and sustainable chemical upgrading. However, surface micro-kinetics regarding co-adsorption and reaction between organic and oxygen intermediates remain unclear. Here we systematically study the electro-oxidation of aldehydes, alcohols, and amines on Co/Ni-oxyhydroxides with multiple characterizations.

Interface-Engineered CuO@BiMoO Heterojunctions to Inhibit Piezoelectric Screening Effect and Promote Double-Nanozyme Catalysis for Antibacterial Treatment.

Sonodynamic therapy is confronted with the low acoustic efficiency of sonosensitizers, and nanozymes are accompanied by intrinsic low catalytic activity. Herein, to increase the piezopotential of N-type piezoelectric semiconductors, the P-N heterojunction is designed to inhibit the piezoelectric screening effect (PSE) and increase electron utilization efficiency to enhance nanozyme activity. P-type CuO nanoparticles are in situ grown on N-type piezoelectric BiMoO (BMO) nanoflakes (NFs) to construct heterostructured CuO@BMO by interface engineering.

Universal high-efficiency electrocatalytic olefin epoxidation via a surface-confined radical promotion.

Production of epoxides via selective oxidation of olefins affords a fundamental source of key intermediates for the industrial manufacture of diverse chemical stocks and materials. Current oxidation strategy generally works under harsh conditions including high temperature, high pressure, and/or request for potentially hazardous oxidants, leading to substantial challenges in sustainability and energy efficiency. To this end, direct electrocatalytic epoxidation poses as a promising solution to these issues, yet their industrial applications are limited by the low selectivity, low yield, and poor stability of the electrocatalysts.

Correction: Ran et al. Nomogram for Predicting Recurrence-Free Survival of Primary Localized Gastrointestinal Stromal Tumor. 2023, , 498.

In the original publication [...

Liraglutide alleviates sepsis-induced acute lung injury by regulating pulmonary surfactant through inhibiting autophagy.

Background: Pulmonary surfactant (PS) plays an important role in the treatment of sepsis-induced acute lung injury (ALI). Liraglutide, a glucagon-like peptide-1 (GLP-1) analog, improves the secretion and function of PS in ALI, but the underlying mechanism remains unknown. This study aimed to investigate how liraglutide regulates PS secretion in ALI.

On-demand bactericidal and self-adaptive antifouling hydrogels for self-healing and lubricant coatings of catheters.

Catheter-related infections are one of the most common nosocomial infections with increasing morbidity and mortality, and robust antibacterial or antifouling catheter coatings remain great challenges for long-term implantation. Herein, multifunctional hydrogel coatings were developed to provide persistent and self-adaptive antifouling and antibacterial effects with self-healing and lubricant capabilities. Polyvinyl alcohol (PVA) with β-cyclodextrin (β-CD) grafts (PVA-Cd) and 4-arm polyethylene glycol (PEG) with adamantane and quaternary ammonium compound (QAC) terminals (QA-PEG-Ad) were crosslinked through host-guest recognitions between adamantane and β-CD moieties to acquire PVEQ coatings.

Bacterial lipase-responsive polydopamine nanoparticles for detection and synergistic therapy of wound biofilms infection.

Wound biofilms represent an elusive conundrum in contemporary treatment and diagnostic options, accredited to their escalating antibiotic resistance and interference in chronic wound healing processes. Here, we developed mesoporous polydopamine (mPDA) nanoparticles, and grafted with rhodamine B (Rb) as biofilm lipase responsive detection probe, followed by π - π stacking mediated ciprofloxacin (CIP) loading to create mP-Rb@CIP nanoparticles. mPDA NPs with a melanin structure could quench fluorescence emissions of Rb.

Regulating molecular brush structure on cotton textiles for efficient antibacterial properties.

The molecular brush structures have been developed on cotton textiles for long-term and efficient broad-spectrum antimicrobial performances through the cooperation of alkyl-chain and quaternary ammonium sites. Results show that efficient antibacterial performances can be achieved by the regulation of the alkyl chain length and quaternary ammonium sites. The antibacterial efficiency of the optimized molecular brush structure of [3-(N,N-Dimethylamino)propyl]trimethoxysilane with cetyl modification on cotton textiles (CT-DM-16) can reach more than 99 % against both E.

Advanced gastrointestinal stromal tumor: reliable classification of imatinib plasma trough concentration via machine learning.

Aim: Patients with advanced gastrointestinal stromal tumors (GISTs) exhibiting an imatinib plasma trough concentration (IM C) under 1100 ng/ml may show a reduced drug response rate, leading to the suggestion of monitoring for IM C. Consequently, the objective of this research was to create a customized IM C classification model for patients with advanced GISTs from China.

Methods: Initial data and laboratory indicators from patients with advanced GISTs were gathered, and the above information was segmented into a training set, validation set, and testing set in a 6:2:2 ratio.

Biofilm Microenvironment-Sensitive Piezoelectric Nanomotors for Enhanced Penetration and ROS/NO Synergistic Bacterial Elimination.

Sonodynamic therapy offers a highly accurate treatment for bacterial infections; however, its antibacterial efficacy is hindered by bacterial biofilms that limit the penetration of sonosensitizers. Herein, a nitric oxide (NO)-driven mushroom-like Janus nanomotor (BT@PDA-La) based on the unilateral coating of polydopamine (PDA) on piezoelectric tetragonal barium titanate (BT) and further modified with l-arginine (l-Arg) on the PDA side is fabricated. In the infected microenvironment with high levels of HO, NO is produced unilaterally from BT@PDA-La, thus leading to its self-propelled movement and facilitating its permeability in the biofilm.

Apolipoprotein E (ApoE) orchestrates adipose tissue inflammation and metabolic disorders through NLRP3 inflammasome.

Obesity is a metabolic disorder characterized by the hypertrophy expansion of adipose tissue, resulting in dysregulated energy metabolism, and accompanied by chronic low-grade inflammation. Adipose tissue macrophages (ATMs), a principal component of inflammation, respond to microenvironment signals and modulate adipose tissue remodeling and metabolic processes situation-specific. However, the mechanisms governing how the organism maintains equilibrium between its chronic inflammation and metabolism still need to be understood.

Ultrasound-Chargeable Persistent Luminescence Nanoparticles to Generate Self-Propelled Motion and Photothermal/NO Therapy for Synergistic Tumor Treatment.

Cancer phototherapy indicates advantages in ease of manipulation, negligible drug resistance, and spatiotemporal control but is confronted with challenges in tumor cell accessibility and intermittent light excitation. Herein, we propose a strategy with persistent luminescence (PL)-excited photothermal therapy (PTT), concurrent thermophoresis-propelled motion, and PL-triggered NO release, where PL emission is chargeable by ultrasonication for readily applicable to deep tumors. Mechanoluminescent (ML) nanodots of SrAlO:Eu (SAOE) and PL nanodots of ZnGaO:Cr (ZGC) were deposited on mesoporous silicates to obtain mSZ nanoparticles (NPs), followed by partially coating with polydopamine (PDA) caps and loading NO donors to prepare Janus mSZ@PDA-NO NPs.