Global research trend and foci of oral lichen planus: A bibliometric analysis from 2014 to 2023.

Background: Oral lichen planus (OLP) is a common oral disease. Currently, there are many controversies surrounding OLP, including etiopathogenesis, diagnostic criteria, and malignant transformation. We employed a bibliometric analysis to delineate the current status, evolving hotspots, and emerging frontiers in OLP research.

Magnolol Ameliorates Depression Through Modulating the TREM2-DOK3-ERK Pathway.

Depression is a mental disorder with a high incidence and high clinical cure rate but a low treatment acceptance rate and a high recurrence rate. Depression is often accompanied by neuroinflammation. Magnolol (MA), a pharmacologically active compound in Magnolia officinalis, has an antidepressant effect.

Preclinical and phase I randomized study of a potent inhalable nanobody targeting TSLP for the treatment of airway inflammation.

Background: TSLP, a cytokine derived from epithelial cells at barrier surfaces, has been extensively studied as a pivotal regulator of type 2 and non-type-2 immune responses, implicated in inflammatory airway diseases. Although mAb therapy targeting TSLP has shown significant therapeutic effects, there is still no approved TSLP-targeting inhaled formulation.

Objectives: Leveraging the distinct advantages of nanobodies (Nbs) in maintaining efficacy during storage and administration, our objective is to develop a novel inhalable TSLP Nb for effectively treating airway inflammation.

KDM4B enhances immune surveillance via demethylating cGAS.

Cyclic GMP-AMP synthase (cGAS) serves as a crucial sentinel in innate immunity by sensing cytosolic DNA, yet the molecular mechanisms governing its activation remain incompletely understood. Here, we identify lysine demethylase 4B (KDM4B) as the specific demethylase that erases cGAS K350 methylation, facilitating its chromatin release and subsequent activation. Genetic ablation of Kdm4b compromised both antiviral immunity against HSV-1 infection and antitumor responses, while also diminishing the efficacy of anti-PD-1 immunotherapy.

Retrospective Analysis of Prognostic Factors and Pregnancy Outcomes in Patients with Moderate-to-Severe Intrauterine Adhesions Following Hysteroscopic Adhesiolysis and Modified Intrauterine Stent Intervention.

Objective: To assess the clinical prognosis and reproductive outcomes in individuals presenting with moderate-to-severe intrauterine adhesion (IUA) following the administration of hysteroscopic adhesiolysis (HA) in conjunction with modified intrauterine stents.

Methods: A cohort comprising 156 individuals diagnosed with IUA (105 with moderate severity and 51 with severe severity) was enrolled. Subsequent to hysteroscopic intervention, all participants received intrauterine stent placement during the immediate postoperative phase.

Engineering Electronic Structure of Sulfur-Bridged Atomically Dispersed Asymmetric Dual-site Catalysts for Enhancing Oxygen Bifunctional Activity.

The top-level design of oxygen reduction and evolution reaction (ORR/OER) bifunctional electrocatalyst materials with intrinsic activity and high site exposure is considered to be the most promising strategy to solve the problems of sluggish kinetics and unsatisfactory cycling durability faced by clean and renewable energy conversion systems. Herein, a directional strategy of bonding-strengthening to obtain a flexurally stable Fe-S-Ni bridge bond with high intrinsic activity by axial bonding of sulfur atoms introducing into hexa-coordinating FeNi dual sites (Fe-S-Ni-NC) at the atom design level to further enhance the asymmetry of the site and boost reversible ORR/OER bifunctional activity in pH-universal electrolytes with a lower potential gap of 0.66 V and higher turnover frequency, which is superior to the benchmark catalyst (Pt/C for ORR and RuO for OER).

Emotional factor matters in language learning? A meta-analysis of emotional intelligence on language achievement.

Emotional intelligence (EI) has garnered sustained theoretical and empirical attention over recent decades. Within the domain of linguistics, a growing body of research has investigated the relationship between EI and language achievement. Publication trends in this area reveal two distinct phases: a period of lukewarm attention (2009-2017), followed by a phase of rapid growth (2018-present).

BioMeta: modular reprogrammable metasurface for noninvasive human respiration monitoring.

Human vital-sign sensing using electromagnetic wave has emerged as a promising technology for the noninvasive monitoring of individuals' health status. Here, a modular reprogrammable metasurface system is presented to suppress noise in noninvasive human respiration sensing. The proposed reprogrammable Biological Metasurface () provides three-dimensional dynamic control over wavefront shaping and thus can reduce interference from human limb motions.

The promise and limitations of artificial intelligence in CTPA-based pulmonary embolism detection.

Computed tomography pulmonary angiography (CTPA) is an essential diagnostic tool for identifying pulmonary embolism (PE). The integration of AI has significantly advanced CTPA-based PE detection, enhancing diagnostic accuracy and efficiency. This review investigates the growing role of AI in the diagnosis of pulmonary embolism using CTPA imaging.

Investigation on the reactive transport characteristic of uranium-bearing sandstone during the in-situ leaching mining uranium.

The multi-phase flow in dynamic pore-fracture is crucial to the safety and efficient uranium mining using the in-situ leaching method. In this study, the pore-fracture evolution and multi-phase flow morphology was investigated using the online low-field nuclear magnetic resonance (NMR) system, and the relationship of pore structure, permeability transformation and chemical reaction was analyzed. The results show that the adsorption pore (0.

Mid-urethral sling with proper sling tension is an effective treatment for stress urinary incontinence in women after pelvic radiotherapy: a pilot study of case series.

Background: At present, consensus on the management of female stress urinary incontinence (SUI) after pelvic radiotherapy is lacking. We aim to assess the clinical effects of mid-urethral sling (MUS) for the treatment of SUI after pelvic radiotherapy in women.

Methods: We conducted a retrospective review of the clinical database of female with SUI after pelvic radiotherapy from June 2015 to February 2022.

Brassinosteroid Enhances Cucumber Stress Tolerance to NaHCO by Modulating Nitrogen Metabolism, Ionic Balance and Phytohormonal Response.

Under NaHCO stress, exogenous 24-epibrassinolide (EBR) markedly alleviated Na accumulation in cucumber plants, thereby decreasing the Na/K, Na/Mg, and Na/Ca ratios. This mitigation was accompanied by elevated concentrations of K, Ca, and Mg, as well as enhanced expression of the and genes. In addition, the activities of plasma membrane H-ATPase, vesicular membrane H-ATPase, and vesicular membrane H-PPase were significantly increased, contributing to the maintenance of ionic balance in cucumber plants.

Gut microbial-derived phenylacetylglutamine accelerates host cellular senescence.

Gut microbiota plays a crucial role in the host health in the aging process. However, the mechanisms for how gut microbiota triggers cellular senescence and the consequent impact on human aging remain enigmatic. Here we show that phenylacetylglutamine (PAGln), a metabolite linked to gut microbiota, drives host cellular senescence.

Research on Deep Learning Detection Model for Pedestrian Objects in Complex Scenes Based on Improved YOLOv7.

Objective: Pedestrian detection is very important for the environment perception and safety action of intelligent robots and autonomous driving, and is the key to ensuring the safe action of intelligent robots and auto assisted driving.

Methods: In response to the characteristics of pedestrian objects occupying a small image area, diverse poses, complex scenes and severe occlusion, this paper proposes an improved pedestrian object detection method based on the YOLOv7 model, which adopts the Convolutional Block Attention Module (CBAM) attention mechanism and Deformable ConvNets v2 (DCNv2) in the two Efficient Layer Aggregation Network (ELAN) modules of the backbone feature extraction network. In addition, the detection head is replaced with a Dynamic Head (DyHead) detector head with an attention mechanism; unnecessary background information around the pedestrian object is also effectively excluded, making the model learn more concentrated feature representations.

Degradation of Rhodamine B by Visible Light Driven MoO@TiO Core-Shell Photocatalyst.

In this study, a MoO@TiO composite core-shell material was developed to remove Rhodamine B (RhB) dye through synergistic adsorption and photocatalytic degradation. n-n heterostructures were formed by coupling n-type semiconductors to enhance the efficiency of photocarrier separation and photocatalytic performance. MoO, which possesses strong adsorption capacity, was primarily used as a dye adsorbent.

Mixed-level designs with orthogonality and relatively optimal run order.

Orthogonality and optimality of run order are two important and worthy to be considered criteria in design of experiment. For the mixed-level designs commonly used in the case of unequal levels of factors in the experiment, both orthogonality and optimality of run order are taken into account at the same time in this paper. The construction methods of mixed-level designs with orthogonality and relatively minimum or maximum level changes are respectively proposed.

Preparation and Luminescence Properties of Broadband Orange-Emitting Persistent ScBaZnGaO:Bi Phosphor.

This article describes a new kind of afterglow material, ScBaZnGaO:Bi, which was synthesized through a high-temperature solid-phase method. Its crystal structure, photoluminescent characteristics, and afterglow characteristics were studied and analyzed. Upon excitation at 344 nm, ScBaZnGaO:Bi exhibits broadband emission with a central wavelength located at 571 nm (fwhm = 172.

SS-31 mitigates oxidative stress and restores mitochondrial function in cigarette smoke-damaged oral epithelial cells via PINK1-mediated mitophagy.

Smoking is a well-established risk factor for several oral diseases, including oral cancer, oral leukoplakia and periodontitis, primarily related to reactive oxygen species (ROS). SS-31, a mitochondria-targeting tetrapeptide, has exhibited demonstrable efficacy in medical conditions by attenuating mitochondrial ROS production. However, its potential in the treatment of oral diseases remains underexplored.

[Medium to long-term efficacy of tension-free vaginal tape procedure in the treatment of female recurrent stress urinary incontinence].

Objective: To investigate the effectiveness and clinical efficacy of tension-free vaginal tape (TVT) surgery in treating female recurrent stress urinary incontinence (rSUI).

Methods: A retrospective analysis was conducted on 24 patients who experienced recurrence of mid-urethral sling failure and were treated with TVT surgery at Beijing Chao-Yang Hospital from January 2016 to June 2020. Basic patient information was collected.

The impact of gender differences on the clinical characteristics of critically ill patients with venous thromboembolism: A retrospective, observational study.

The aim of this study is to describe the general information, disease and treatment of venous thromboembolism (VTE) in critically ill patients, to explore the characteristics of severe patients with deep venous VTE and provide clinical reference data for the prevention and treatment of VTE in critically ill patients. This study carried out a retrospective study on the medical records of patients who were treated in the intensive care unit of Affiliated Hospital of Jining Medical College from 2020 to 2022. The general data, general conditions, drug use, past history, VTE prevention measures, post-VTE conditions, and Padua risk score of 297 patients with VTE during the period of hospitalization in intensive care unit (ICU) were classified and statistically analyzed.

A novel inhalable nanobody targeting IL-4Rα for the treatment of asthma.

Background: Inhalable biologics represent a promising approach to improve the efficacy and safety of asthma treatment. Although several mAbs targeting IL-4 receptor α chain (IL-4Rα) have been approved or are undergoing clinical trials, the development of inhalable mAbs targeting IL-4Rα presents significant challenges.

Objective: Capitalizing on the distinctive advantages of nanobodies (Nbs) in maintaining efficacy during storage and administration, we sought to develop a novel inhalable IL-4Rα Nb for effectively treating asthma.

Efficacy of Mid-Urethral Sling and Urethral Dilation for Stress Urinary Incontinence Combined with Urethral Stricture in Women.

Objective: To investigate the potential clinical benefits of mid-urethral sling (MUS) and urethral dilatation (UD) operations for the treatment of stress urinary incontinence (SUI) combined with urethral stricture.

Study Design: Descriptive study. Place and Duration of the Study: Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China, from January 2017 to 2022.

Kisspeptin expression during menstruation in PCOS patients undergoing ovulation induction and the correlation with early pregnancy.

Purpose: To examine the pattern of kisspeptin expression throughout the menstrual cycle in polycystic ovary syndrome (PCOS) patients under the ovulation induction and identify any possible associations with early pregnancy.

Materials And Methods: A prospective cohort of 80 PCOS women who expressed the desire for fertility was enrolled in this study. All of them received the ovulation induction by using letrozole.