Exploring Targeted Delivery Systems for Boron Neutron Capture Therapy and Its Potential as a Promising Therapeutic Modality for Hepatocellular Carcinoma.

Boron neutron capture therapy (BNCT) is a precision binary radiotherapy. In this modality, thermal neutrons combine with 10B to induce a nuclear reaction that kills tumor cells. Its therapeutic efficacy depends on the targeted accumulation of boron delivery agents.

Effect of cognitive reserve on cognitive function and cognitive deterioration in Parkinson's disease: a longitudinal cohort study.

Background: Previous cross-sectional work has suggested that higher cognitive reserve (CR) is associated with better cognitive performance and slower cognitive decline in Parkinson's disease (PD); however, these findings need confirmation in prospective longitudinal designs. The current study therefore examined how CR influences both cognitive function and the rate of cognitive deterioration in a longitudinal PD cohort.

Methods: This study utilized a prospective, longitudinal design and recruited participants from Tianjin Huanhu Hospital between September 2017-September 2019.

Sensitive micro UAV detection based on a high-repetition-rate single-photon LiDAR.

High sensitivity detection of micro unmanned aerial vehicles (UAVs) is a key technology for defending against UAV threats. This paper proposes a single-photon light detection and ranging (SPL) that multiplexes wavelength and repetition rate, and incorporates parallel line scanning to achieve an efficient and uniform distribution of 8.1 million laser pulses emitted per second, thereby enhancing the SPL's detection capability for small targets.

Pharmacokinetic, biodistribution, safety and efficacy studies of borophenylalanine (BPA) in BNCT in hepatocellular carcinoma cells and tumor-bearing mouse model.

Boron neutron capture therapy (BNCT), using boronophenylalanine (BPA) as the main boron carrier, is a dual-targeted particle radiotherapy at the cellular level. Although BPA shows clinical promise in liver cancer, there is relatively little basic research on its effect on hepatocellular carcinoma. Therefore, we systematically evaluated the uptake, safety, pharmacokinetics, and therapeutic efficacy of BPA.

Interfacial kinetics regulation and electrochemical optimization in ultrasonic-induced sponge cadmium nucleation.

The cementation method has become the dominant method for recovering cadmium from copper-cadmium slag leach solution due to its low cost and safety features. However, the conventional method has several limitations, including low zinc powder utilization, low sponge cadmium purity, and an extended production cycle. These limitations primarily stem from zinc powder agglomeration and the subsequent coverage of zinc particles by the product layer.

Comparative efficacy and safety of acupuncture for adolescent depression: protocol for a systematic review and Bayesian network meta-analysis.

Background: Adolescents are in a critical stage of development and represent a high-risk population for depression. Various studies have demonstrated the efficacy of acupuncture therapies in the treatment of adolescent depression. However, trials directly comparing the efficacy and safety of different acupuncture therapies for adolescent depression are still lacking.

Integrative multiomics analysis reveals the subtypes and key mechanisms of platinum resistance in gastric cancer: identification of KLF9 as a promising therapeutic target.

Background: Gastric cancer (GC) is characterized by significant intertumoral heterogeneity, which often leads to the development of resistance to platinum-based chemotherapy. Combining platinum drugs with other therapeutic strategies may improve treatment efficacy; however, the mechanisms underlying platinum resistance in GC remain unclear.

Methods: Key genes related to platinum resistance in GC were selected from the platinum resistance gene database and GC resistance datasets.

Activation of a nongenetic AHR-ELMSAN1 axis optimizes BET-targeting therapy and suppresses leukemia stem cells in preclinical models.

Developing strategies to enhance the response to bromodomain and extraterminal domain (BET) inhibitors and effectively eradicate cancer stem cells would represent a major cancer treatment advance against leukemia. Through a functional CRISPR screen, we identified the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor, as a critical regulator of MYC expression and BET inhibitor sensitivity in human acute myeloid leukemia (AML). Constitutive or pharmacological activation of AHR repressed MYC and synergized with BET inhibitors to inhibit MYC transcription and suppress leukemia growth across diverse AML models.

Serum metabolomics in pulmonary sarcoidosis: metabolic signatures across prognoses.

Background: Sarcoidosis is a systemic inflammatory disease, primarily affecting the lungs, with a prognosis that varies widely among patients. While some patients recover spontaneously after diagnosis, others experience disease progression. Currently, the metabolomic profile associated with pulmonary sarcoidosis and its different clinical outcomes remains poorly understood.

Why do bootlickers get empowered more than boat-rockers? The effects of voice and helping on empowering leadership through threat and goal congruence perceptions.

As empowering leadership becomes increasingly needed in today's complex organizations, so does the need to understand what motivates leaders to give more (or less) empowering leadership to followers. We draw on threat rigidity theory to examine how followers' challenging and supportive voice differentially impact the extent to which leaders empower their followers. We argue that leaders perceive followers' challenging voice as more threatening and tend to empower them less, whereas leaders perceive followers' supportive voice as reflective of their goal congruence with followers, which motivates leaders to give them more empowering leadership.

Thymosin alpha 1 alleviates inflammation and prevents infection in patients with severe acute pancreatitis through immune regulation: a systematic review and meta-analysis.

Background: Immune and inflammatory disorders are part of the complex pathophysiological processes that exacerbate severe acute pancreatitis (SAP) and subsequent infection. Thymosin alpha 1 (Tα1) is an important immunomodulatory agent in clinical practice, but there is a lack evidence to prove its effectiveness in improving the condition of SAP patients. In this study, we aimed to evaluate the efficacy in meta-analysis.

Integrated Phylogenomics and Expression Profiling of the Gene Family in Reveals Their Role in Development and Stress Tolerance.

The () gene family plays a crucial role in multiple biological processes, including microtubule organization, cell division regulation, fruit morphogenesis, stress adaptation, and growth and development. To delve deeper into the potential functions of in , this study employed bioinformatics methods to systematically identify and analyze the family genes in (Westar). Using the model plant as a reference and based on six conserved motifs, 100 members were first identified in .

On-Chip Light-Scattering Enhancement Enabled by a Microlens Array for High-Performance Single-Particle Tracking under Conventional Bright-Field Microscopy.

Scattering-based single-particle tracking (S-SPT) has revolutionized the label-free detection and characterization of nanoscopic objects, offering immense potential for diverse analytical applications. However, the high technical demands placed on optical systems have long impeded its widespread adoption. To address this, an on-chip microlens-based approach that significantly enhances light scattering, thereby reducing the requirements on back-end optical systems, is introduced.

Efficacy and safety of therapeutic means for postoperative ileus: an umbrella review of meta-analyses.

Background & Aims: Postoperative ileus is treated using a large number of methods with variable efficacy. This study further clarifies the advantages and disadvantages of existing treatments through umbrella evaluation.

Method: This study conducted a systematic search of databases to select and include meta-analyses discussing the treatment of postoperative ileus.

Nasal-to-brain delivery of CCR5 antagonist for reshaping the dysregulated microglia-neuron axis and enhancing post-traumatic cognitive function.

The dysregulation of the microglia-neuron axis plays a pivotal role in the pathogenesis of cognitive dysfunction following traumatic brain injury (TBI). The C-C chemokine receptor 5 (CCR5), markedly upregulated on both microglia and neurons post-injury, serves as a crucial mediator in the neuroinflammatory response and consequent neurological deficits. However, the therapeutic application of CCR5 antagonists in TBI is impeded by the delivery barriers presented by the blood-brain barrier (BBB) and their limited neuron-targeting efficacy.

O-GalNAc Glycosylation Activates MBL-Mediated Complement and Coagulation Cascades to Drive Organotropic Metastasis.

Liver metastasis is prevalent among patients with neuroendocrine prostate cancer (NEPC) and other types of neuroendocrine (NE) cancers, featuring with an aggressive clinical course and a dismal prognosis. However, the cellular and molecular mechanisms underlying liver-specific metastatic tropism in NE cancers remain poorly understood. Intriguingly, it is found that NEPC liver metastatic foci are frequently associated with thrombi.

Engineering of Two-Dimensional Heterostructures for Enhanced Photocatalytic Decontamination of Methyl Orange.

Two-dimensional (2D)/2D heterostructured catalysts have garnered significant attention in photocatalytic environmental remediation due to their relevance in optoelectronic, as well as solar energy conversion systems. However, fast photocarrier separation of 2D/2D heterojunctions, made from the stacking of different layered materials through strong chemical bonds rather than weak van der Waals interactions, remains an unmet challenge. To address this, herein, a generation of 2D/2D p-n heterojunction photocatalysts, composed of BiOCl and HMo Nb O nanosheets, was fabricated via chemical absorption and hydrolysis strategies.

esMPRA: an easy-to-use systematic pipeline for MPRA experiment quality control and data analysis.

Motivation: Massively Parallel Reporter Assays (MPRAs) have emerged as pivotal tools for systematically profiling cis-regulatory element activity, playing critical roles in deciphering gene regulation mechanisms and synthetic regulatory element engineering. However, MPRA experiments involve multi-step library processing procedures coupled with high-throughput sequencing. Operational errors during these complex workflows can lead to substantial resource depletion and experimental delays.

Advanced performance and operational strategies of partitioned anaerobic membrane bioreactor combined with ferromagnetic biochar for pesticide wastewater treatment at low-temperature and insufficient hydraulic load.

Accompanied by high energy consumption and the difficulty in maintaining process stability, the treatment of pesticide wastewater in cold climates remain a significant challenge due to its low biodegradability and complex composition. Therefore, this study developed a hybrid anaerobic membrane bioreactor (HAnMBR) that incorporates ferromagnetic biochar and a partitioned upflow anaerobic sludge blanket structure. Its performance was evaluated and compared to that of a conventional anaerobic membrane bioreactor (CAnMBR) under varying organic loading rate (OLR) and hydraulic loading rate (HLR) at 10 °C.

PD-L1 in plasmacytoid dendritic cells promote HBV persistence through disrupting humoral immune response.

Objective: To investigate the efficacy of PD-L1 blockade in restoring humoral immune response against HBV.

Methods: HBV-persistent C57BL/6J mice were established through hydrodynamic tail vein injection of 10 µg pAAV-HBV1.2 plasmid.

Strong and Tough Porous Silicon Carbide Ceramics.

Porous silicon carbide (SiC) ceramics are considered promising materials for structural applications under severe conditions. However, the inadequate mechanical strength and fracture toughness restrict their further applications. Here, we report the development of strong and tough porous SiC ceramics with highly cross-linked SiC nanowire networks as reinforcements.

When voice takes destructive rather than constructive forms in manager-employee dyads: A power-dependence perspective.

We offer a relational perspective on how power shapes voice in the employee-manager dyad. We argue that to properly understand the impact of employees' power on voice, it must be analyzed alongside the power held by their managers. We propose that although voice increases when employees hold high power, its form-whether constructive or destructive-depends on their managers' power.

Preparation of a 1,4-Diazabicyclo[2.2.2]octane sulfonate betaine zwitterionic stationary phase and comparative evaluation of its separation performance in hydrophilic interaction chromatography.

Background: Hydrophilic interaction liquid chromatography (HILIC) offers an alternative approach for efficient separation of polar molecules on polar stationary phases. The development of hydrophilic stationary phases with novel zwitterionic structures represents a promising approach to improving the efficiency of separations and accommodating the analysis of polar compounds in complex samples.

Results: This work details the preparation and thorough evaluation of the novel zwitterionic stationary phase, Sil-DBO-PS, composed of a 1,4-diazabicyclo[2.

Preliminary Study on the Functions of Peptides Obtained from White Mullet ( var. Kimnra) Meat.

To explore the functions of peptides obtained from white mullet ( var. Kimnra) meat, the meat was hydrolyzed via simulated digestion in vitro, and the functions (milk secretion ability, antioxidant activity, angiotensin-converting enzyme (ACE) inhibitory activity, and Fe chelation) of the obtained peptide were evaluated. The results indicated that both low-dose and high-dose peptide promoted milk secretion in lactating rats in vivo; the peptides had scavenging effects on free radicals of 1,1-diphenyl-2-trinitrophenylhydrazine (DPPH), 2,2'-azino-bis (3-ethylbenzo-thiazoline-6-sulfonic acid) diammonium salt (ABTS), OH, and O, and the EC concentrations were 55.

Vanadium-enhanced Mg-Ni alloys: Advancing zero pollution and zero emission hydrogen storage for a circular economy.

This study investigates the effect of varying vanadium (V) content on the hydrogen absorption/desorption kinetics of (MgNi)V (x = 1, 3, 5) alloys prepared via high-energy ball milling. The results demonstrate that the addition of V enhances the hydrogenation reaction rate, activates the alloy, and accelerates hydrogen diffusion, with the (MgNi)V alloy exhibiting the best hydrogen absorption performance at an optimal V content of 1. During hydrogen absorption, the alloys quickly reach hydrogen saturation in the rapid absorption stage, but the hydrogen absorption capacity decreases as V content increases.