Medicinal Fungi and Soil: Interactions, Plant Interactions, and Ecological Restoration for Sustainable Use: A Review.

Medicinal fungi are widely used in Chinese traditional medicine for their various medicinal effects. Soil has an irreplaceable effect on most medicinal fungi. The purpose of this study is to sum up the relationship between medicinal fungi and soil.

Biomechanical effect of cage size in single-level anterior cervical discectomy and fusion: a finite element analysis.

Background: Anterior cervical discectomy and fusion (ACDF) is a common surgical procedure for treating cervical spine diseases, but its anterior approach can lead to complications such as dysphagia and carotid artery injury due to the large incision. However, performing ACDF under a percutaneous endoscopic approach can effectively mitigate these issues. Considering the need for smaller-sized cages in endoscopic procedures, this study explores the feasibility of using small-sized cages for percutaneous endoscopic ACDF surgery.

Genome-wide identification of SWEET gene family and functional analysis of BcSWEET1-2 associated with flowering in flowering Chinese cabbage (Brassica campestris).

Background: The bolting and flowering processes are crucial for the yield of stem vegetables and require sugar support. Sugar is synthesized through photosynthesis in the leaves and transported to the stems via transmembrane transport. Brassica campestris (flowering Chinese cabbage) is a unique vegetable that does not require vernalization for flowering and has a distinct flowering regulation mechanism.

Diagnosing malignant transformation potential in oral submucous fibrosis with leukoplakia: an approach utilizing deoxyribonucleic acid image cytometry.

Oral submucous fibrosis (OSF) is a chronic oral condition with a potential for malignant transformation. This study aims to investigate the correlation between DNA aneuploidy and dysproliferative lesions in OSF using DNA image cytometry to provide insights into cancer risk assessment. The study included patients diagnosed with OSF, OSF combined with oral leukoplakia (OLK), OSF that progressed to oral squamous cell carcinoma (OSCC), and healthy controls.

Prognostic factors of invasive fungal infections in pediatric intensive care units and changes in treatment outcomes before and after the COVID-19 pandemic: a multicenter retrospective study.

Objective: To investigate the prognostic factors influencing the outcomes of children with invasive fungal infection in pediatric intensive care unit (PICU) and explore the effects of changes in clinical characteristics before and after the COVID-19 pandemic on treatment outcomes.

Methods: In total, 665 children with invasive fungal infections from the PICUs of four hospitals in China were retrospectively enrolled from January 2017 to December 2021. These children were categorized into an effective treatment group (336 cases) and a failure group (329 cases, including treatment abandonment and death) based on prognosis.

Penicipyrrolidines A-N, pyrrolidine derivatives with inhibitory effects on EMT and fibroblast activation from the mangrove-derived fungus sp. DM27.

Unlabelled: An investigation of the mangrove-derived fungus sp. DM27 led to the isolation of 19 new compounds, including three pairs of piperidinone enantiomers ( ±)-, ( ±)-, and ( ±)-, two pairs of pyrrolidinone enantiomers ( ±)- and ( ±)-, and nine pyrrolidine derivatives -. The structures of - were elucidated through NMR and HRESIMS analysis, coupled with experimental and calculated ECD spectroscopy and the modified Mosher method.

Geriatric Nutritional Risk Index as a Predictor of Delirium and Pressure Injuries in Critically Ill Older Patients With Ischaemic Stroke: An Observational Cohort Study.

Background: Malnutrition is a prevalent phenomenon among patients with ischaemic stroke, and it is associated with a multitude of adverse health outcomes.

Aim: To evaluate the Geriatric Nutritional Risk Index (GNRI) as a predictor of both delirium and pressure injuries in critically ill older adults with ischaemic stroke.

Study Design: An observational cohort study of 969 patients with ischaemic stroke conducted at a tertiary academic medical centre in the United States, divided into two groups based on GNRI scores: at risk of malnutrition (GNRI ≤ 98) and not at risk (GNRI > 98).

Real-world pathogen diagnosis in critically ill infected children: A retrospective study using metagenomic next-generation sequencing with different enrichment strategies.

Background: Study on the clinical pathogen diagnosis in large cohort of critically ill children using metagenomic next-generation sequencing (mNGS) with different enrichment strategies has been limited.

Methods: 763 samples were enrolled and we summarized the clinical pathogen diagnosis and compared the performance between mNGS and clinical microbial tests (CMTs) in different sample types, as well as between shotgun-based (S-mNGS) and hybrid capture-based mNGS (C-mNGS).

Results: A total of 93 clinical diagnosed pathogens were identified from763 samples with suspected infections, with a positive rate of 60.

The experience and need of patients with cauda equina syndrome caused by lumbar disc herniation: a phenomenological qualitative study.

Objective: Cauda equina syndrome (CES) is an emergency disease that can lead to serious sequelae. The purpose of this study was to deeply understand the experience and need of patients with CES caused by lumbar disc herniation (LDH).

Methods: Sixteen patients diagnosed as CES caused by LDH were enrolled.

MIZU-KUSSEI 1 regulates root hydrotropism and cytokinin signal transduction by interacting with cytokinin receptors.

Roots exhibit hydrotropism in response to moisture gradients to avoid drought stress. Several proteins have been reported to regulate this process, with MIZU-KUSSEI 1 (MIZ1) being identified as a pivotal regulator. Although most studies on the regulatory mechanisms of root hydrotropism have focused on MIZ1, the molecular mechanisms of MIZ1 are poorly understood.

Application of Narrative Medicine in Undergraduate Orthodontics Education.

Objective: The objective of this study is to incorporate narrative medicine (NM) into undergraduate orthodontics educational courses, evaluate its impact on the empathy levels and professional skills of students, and examine student feedback on the curriculum.

Methods: A cohort of 120 fifth-year undergraduate orthodontics students enrolled between June 2023 and June 2024 were selected as participants in the study and randomly assigned to the experimental and control groups. Students in the control group received training through traditional teaching methods that combined textbook content with clinical cases.

Glycemic variability and its association with short and long term clinical outcomes in critically ill patients with cerebral hemorrhage.

Cerebral hemorrhage is a major cause of mortality and disability. This study investigates the association between glycemic variability (GV) and short- and long-term clinical outcomes such as poor outcomes at discharge, mortality at 90 days and 1 year and intensive care unit (ICU) /hospital length of stay (LOS) in ICU patients with critically ill cerebral hemorrhage. This retrospective analysis examined 732 ICU patients with non-traumatic cerebral hemorrhage from the Medical Information Mart for Intensive Care (MIMIC)-IV database.

Structurally diverse tetrahydroxanthone analogues from Paraconiothyrium sp. AC31 with pyroptosis induction through targeted inhibition of PARP1 in hepatocellular carcinoma cells.

This study reports the isolation and characterization of six novel tetrahydroxanthone derivatives, paraconixanthones A - F (1-6), a new diphenyl ether (7), and thirteen known compounds (8-20) from the endophytic fungus Paraconiothyrium sp. AC31. The chemical structures were elucidated using NMR, MS, X-ray diffraction, and ECD analyses.

Cinnamaldehyde mitigates acute myocardial infarction by regulating ferroptosis through the PI3K-AKT signaling pathway.

Objective: This investigation sought to elucidate the protective efficacy of Cinnamaldehyde (CA) against acute myocardial infarction (AMI) while investigating its therapeutic mechanisms through the integration of network pharmacology technology as well as in vitro and in vivo experiments.

Methods: An AMI rat model was constructed via left anterior descending coronary artery ligation after the experimental rats were subjected to continuous intragastric administration of CA over a 14-day period. In parallel, an AMI cell model was established by subjecting neonatal primary rat cardiomyocytes to glucose/oxygen deprivation (OGD).

Human inborn errors of immunity underlying infections: a multicenter, retrospective cohort study.

Introduction: () infections in children can occur secondary to inborn errors of immunity (IEIs). We aimed to investigate the clinical and genetic features of infection in Chinese pediatric patients.

Materials And Methods: We retrospectively reviewed 18 pediatric patients with IEIs who were diagnosed with infections at five public hospitals in China from January 2015 to January 2023.

Mitochondrial dysfunction is a key link involved in the pathogenesis of sick sinus syndrome: a review.

Sick sinus syndrome (SSS) is a grave medical condition that can precipitate sudden death. The pathogenesis of SSS remains incompletely understood. Existing research postulates that the fundamental mechanism involves increased fibrosis of the sinoatrial node and its surrounding tissues, as well as disturbances in the coupled-clock system, comprising the membrane clock and the Ca clock.

Intradermal Delivery of Cell Vaccine via Ice Microneedles for Cancer Treatment.

The living tumor cell vaccine (TCV) holds a promise for cancer immunotherapy. Microneedle arrays provide a tool to improve the immune response of vaccines by the intradermal administration in a painless manner. However, it remains challenges for microneedle arrays to deliver the living TCV intradermally.

Development of a diagnostic model based on glycolysis-related genes and immune infiltration in intervertebral disc degeneration.

Background: The glycolytic pathway and immune response play pivotal roles in the intervertebral disc degeneration (IDD) progression. This study aimed to develop a glycolysis-related diagnostic model and analyze its relationship with the immune response to IDD.

Methods: GSE70362, GSE23130, and GSE15227 datasets were collected and merged from the Gene Expression Omnibus, and differential expression analysis was performed.

Penicipyrrolizidinones A-C, three pyrrolizidinone alkaloids with unprecedented skeletons from the mangrove-derived fungus Penicillium sp. DM27.

Three previously undescribed pyrrolizidinone alkaloids, penicipyrrolizidinones A and B (1 and 2), possessing an unprecedented 2-methyl-2-(oct-6-enoyl)pyrrolizidin-3-one skeleton, and penicipyrrolizidinone C (3), featuring a rare 1-alkenyl-2-methyl-pyrrolizidin-3,7-dione skeleton, together with four known pyrrolidine derivatives (4-7) were isolated from the mangrove-derived fungus Penicillium sp. DM27. Their structures were elucidated through comprehensive spectroscopic analysis, theoretical calculations of ECD spectra, and the modified Mosher's method.

Smart delivery vehicles for cancer: categories, unique roles and therapeutic strategies.

Chemotherapy and surgery remain the primary treatment modalities for cancers; however, these techniques have drawbacks, such as cancer recurrence and toxic side effects, necessitating more efficient cancer treatment strategies. Recent advancements in research and medical technology have provided novel insights and expanded our understanding of cancer development; consequently, scholars have investigated several delivery vehicles for cancer therapy to improve the efficiency of cancer treatment and patient outcomes. Herein, we summarize several types of smart therapeutic carriers and elaborate on the mechanism underlying drug delivery.

Co-Doped Porous Carbon/Carbon Nanotube Heterostructures Derived from ZIF-L@ZIF-67 for Efficient Microwave Absorption.

Carbon-based magnetic metal composites derived from metal-organic frameworks (MOFs) are promising materials for the preparation of broadband microwave absorbers. In this work, the leaf-like co-doped porous carbon/carbon nanotube heterostructure was obtained using ZIF-L@ZIF-67 as precursor. The number of carbon nanotubes can be controlled by varying the amount of ZIF-67, thus regulating the dielectric constant of the sample.

Unrevealing the coupling coordination degree between atmospheric CO concentration and human activities from geospatial and temporal perspectives.

Anthropogenic activities exhibit intricate and significant relationships with atmospheric CO concentration. Dissecting the spatiotemporal patterns and potential drivers of their coupling coordination relationships from geospatial and temporal perspectives contributes to the benign coordinating development between the two. The coupling coordination degree (D) and types, and their potential influencing factors in China were explored using a coupling coordination model, emerging hotspot analysis, and Multiscale Geographically Weighted Regression model.

Sulfated peptides and their receptors: Key regulators of plant development and stress adaptation.

Four distinct types of sulfated peptides have been identified in Arabidopsis thaliana. These peptides play crucial roles in regulating plant development and stress adaptation. Recent studies have revealed that Xanthomonas and Meloidogyne can secrete plant-like sulfated peptides, exploiting the plant sulfated peptide signaling pathway to suppress plant immunity.

Developing Chinese herbal-based functional biomaterials for tissue engineering.

The role of traditional Chinese medicine (TCM) in treating diseases is receiving increasing attention. Chinese herbal medicine is an important part of TCM with various applications and the active ingredients extracted from Chinese herbal medicines have physiological and pathological effects. Tissue engineering combines cell biology and materials science to construct tissues or organs or .