Exercise workload: a key determinant of immune health - a narrative review.

The total exercise workload is an important factor influencing immune health. Appropriately prescribed physical activity can mitigate the detrimental effects of chronic inflammation, bolster the body's defenses against both infectious and non-infectious diseases, and decelerate the immunosenescence process. Physiological and immune system responses to moderate and strenuous exercise workloads vary markedly.

Building gene regulatory networks to uncover tolerance mechanisms to salt and drought in Tamarix hispida.

Salt and drought stress significantly impact plant survival. The gene regulatory network (GRN) is crucial for elucidating stress tolerance mechanisms and identifying key transcription factors (TFs) involved in stress regulation. This study developed a three-layered GRN in Tamarix hispida for both salt and drought stress, identifying regulatory relationships among genes using a partial correlation coefficient algorithm.

Comparative analysis of indwelling time and complications of mid-line catheters in different punctured veins of neonates.

Objective: We aims to evaluate the effects and complications associated with mid-line catheters inserted via different puncture veins in neonates, ultimately providing a foundation for selecting the most suitable puncture site for catheterization in clinical neonatal practice.

Methods: A retrospective data analysis was conducted, involving 244 neonates with indwelling mid-line catheters who were admitted to a Class III Grade A general hospital in Anhui Province between August 2020 and December 2023. The study compared catheter indwelling duration, the incidence of catheter-related complications, and the first puncture success among neonates with catheterization through various veins.

Wheat miRNA TaMIR5062-5A Targets Calmodulin TaCML31 That Cooperates With MYB Member TaMYB77 to Modulate Drought and Salt Responses.

MicroRNAs (miRNAs) are key regulators of plant growth, development, and abiotic stress tolerance, acting via posttranscriptional control of target genes. In this study, we identified and characterized TaMIR5062-5A, a miRNA member in Triticum aestivum, focusing on its role in mediating drought and salt stress responses. TaMIR5062-5A showed downregulated expression upon exposure to drought and salt stress conditions, whereas its target gene TaCML31, a calmodulin-encoding gene verified by dual luciferase (LUC) assay, displayed the opposite expression trend under the above stress conditions.

Nanozyme colorimetric sensor array-based Au as an electron bank facilitated surface charge redistribution of CeO for on-site detection and discrimination of sulfur-containing metal salts.

Developing a highly efficient array-based sensing platform for sulfur-containing metal salt (SCM) analysis is imperious due to its potential to harm the environment and human health. Herein, we fabricated a ternary channel colorimetric sensor array technique to monitor multiple SCMs simultaneously, depending on the Au nanoparticle-loaded CeO nanobelt (Au/CeO) heterostructure with excellent peroxidase-like (POD-like) activity. The results of XPS and DFT calculations revealed that Au NPs as an electron bank can promote the charge redistribution on the surface of CeO.

Residual Inflammatory Risk and Intracranial Atherosclerosis Plaque Vulnerability: Insights From High-Resolution Magnetic Resonance Imaging.

Background And Purpose: This study aimed to investigate the association between residual inflammatory risk (RIR) and vulnerable plaques using high-resolution magnetic resonance imaging (HRMRI) in symptomatic intracranial atherosclerotic stenosis (ICAS).

Methods: This retrospective study included 70%-99% symptomatic ICAS patients hospitalized from January 2016 to December 2022. Patients were classified into four groups based on high-sensitivity C-reactive protein (hs-CRP) and low-density lipoprotein cholesterol (LDL-C): residual cholesterol inflammatory risk (RCIR, hs-CRP ≥3 mg/L and LDL-C ≥2.

Laminated Au-TiO/C Nanozyme for Ultrasensitive Detection of Cholesterol and Enhanced Bactericides.

Cholesterol, the primary component of cell membranes, plays a critical role in wound healing and antibacterial defense. Recently, various reactive oxygen species-mediated strategies have been developed for disinfecting drug-resistant microorganisms. However, development of low-cost cholesterol consumption-based enzyme-mimicking platforms with high antibacterial efficacy remains a significant challenge.

Mitochondria-derived vesicles: A promising and potential target for tumour therapy.

Mitochondria-derived vesicles (MDVs) participate in early cellular defence mechanisms initiated in response to mitochondrial damage. They maintain mitochondrial quality control (MQC) by clearing damaged mitochondrial components, thereby ensuring the normal functioning of cellular processes. This process is crucial for cell survival and health, as mitochondria are the energy factories of cells, and their damage can cause cellular dysfunction and even death.

Self-alleviation of continuous-cropping obstacles in potato via root-exudate-driven recruitment of growth-promoting bacteria.

Continuous-cropping (CC) obstacles are among the primary factors limiting the development of global agriculture. Although most plants are negatively affected by barriers that develop with CC, they may also overcome such obstacles by altering the soil biological and chemical environment to favor plant growth. In this study, we investigated the mechanism by which plants recruit beneficial microorganisms using root exudates to alleviate obstacles in a 10-year CC potato system.

Proteomic signatures and predictive modeling of cadmium-associated anxiety in middle-aged and elderly populations: an environmental exposure association study.

Background: Emerging evidence implicates environmental contaminants such as cadmium (Cd) as modifiable risk factors for anxiety. Despite growing recognition of heavy metal toxicity in neuropsychiatric disorders, the molecular mechanisms linking environmental exposure to anxiety pathogenesis remain poorly understood.

Methods: Based on the established cohort of individuals with cognitive impairment in cadmium-contaminated areas, this cross-sectional association study enrolled 50 middle-aged and elderly hospitalized patients from these regions, adhering to the STROBE guidelines.

Epiphytic bacterial consortia drive growth regulation in potato under methyl jasmonate elicitation: A leaf surface multi-omics perspective.

Methyl jasmonate (MeJA), a lipid-derived signaling molecule widely reported as a plant growth regulator, was revealed in this study to coordinate oxidative stress adaptation and delay senescence in potato through metabolite-microbe interactions, ultimately improving yield. MeJA triggered leaf oxidative stress while integrating rapid enzymatic scavenging, sustained osmoprotectant accumulation, and membrane stabilization, effectively delaying senescence initiation. Metabolic reprogramming under MeJA suppressed endogenous jasmonic acid synthesis while promoting saturated fatty acid biosynthesis, altering leaf surface lipid composition.

Cinnamaldehyde mitigates acute myocardial infarction by regulating ferroptosis through the PI3K-AKT signaling pathway.

Objective: This investigation sought to elucidate the protective efficacy of Cinnamaldehyde (CA) against acute myocardial infarction (AMI) while investigating its therapeutic mechanisms through the integration of network pharmacology technology as well as in vitro and in vivo experiments.

Methods: An AMI rat model was constructed via left anterior descending coronary artery ligation after the experimental rats were subjected to continuous intragastric administration of CA over a 14-day period. In parallel, an AMI cell model was established by subjecting neonatal primary rat cardiomyocytes to glucose/oxygen deprivation (OGD).

Wheat Tae-MIR1118 Constitutes a Functional Module With Calmodulin TaCaM2-1 and MYB Member TaMYB44 to Modulate Plant Low-N Stress Response.

Distinct target genes are modulated by microRNA members and affect various biological processes associated with abiotic stress responses in plants. In this study, we characterized a functional module comprising miRNA/target and a downstream MYB transcription factor partner, Tae-MIR1118/TaCaM2/TaMYB44, in Triticum aestivum to mediate the plant low-nitrogen (N) stress response. Dual luciferase (LUC) assay and expression analysis indicated that TaCaM2 is regulated by Tae-MIR1118 through a posttranscriptional cleavage mechanism.

Mitochondrial dysfunction is a key link involved in the pathogenesis of sick sinus syndrome: a review.

Sick sinus syndrome (SSS) is a grave medical condition that can precipitate sudden death. The pathogenesis of SSS remains incompletely understood. Existing research postulates that the fundamental mechanism involves increased fibrosis of the sinoatrial node and its surrounding tissues, as well as disturbances in the coupled-clock system, comprising the membrane clock and the Ca clock.

Wheat TaPYL9-involved signalling pathway impacts plant drought response through regulating distinct osmotic stress-associated physiological indices.

The abscisic acid (ABA) signalling pathway plays a crucial role in plants' response to drought stress. In this study, we aimed to characterize the impact of an ABA signalling module, which consisted of TaPYL9 and its downstream partners in Triticum aestivum, on plant drought adaptation. Our results showed that TaPYL9 protein contains conserved motifs and targets plasma membrane and nucleus after being sorted by the endoplasmic reticulum.

TaCDPK1-5A positively regulates drought response through modulating osmotic stress responsive-associated processes in wheat (Triticum aestivum).

Wheat TaCDPK1-5A plays critical roles in mediating drought tolerance through regulating osmotic stress-associated physiological processes. Calcium (Ca) acts as an essential second messenger in plant signaling pathways and impacts plant abiotic stress responses. This study reported the function of TaCDPK1-5A, a calcium-dependent protein kinase (CDPK) gene in T.

Stereo imaging inspired by bionic optics.

Stereo imaging has been a focal point in fields such as robotics and autonomous driving. This Letter discusses the imaging mechanisms of jumping spiders and human eyes from a biomimetic perspective and proposes a monocular stereo imaging solution with low computational cost and high stability. The stereo imaging mechanism of jumping spiders enables monocular imaging without relying on multiple viewpoints, thus avoiding complex large-scale feature point matching and significantly conserving computational resources.

Hydrogen generated by electrochemical water splitting as electron donor for nitrate removal from micro-polluted reservoir water.

Extremely limited organic carbon sources and aerobic environment in micro-polluted reservoir water make conventional denitrification exceptionally challenging. As a result, total nitrogen (TN) concentration in most reservoir waters exceeds standard value year-round. In this study, for the first time, we constructed a mini water-lifting and aeration system (mini-WLAS) to remove nitrate in actual reservoir water.

Coding smell patterns of crude oil by the electronic nose: A soil pollution case.

In our study, we leveraged an electronic nose to detect the patterns of crude oils and their mixtures, sourced from the oil fields from neighboring regions in pursuit of the task of environmental impact evaluation. The temporal dynamics of oil-related patterns acquired by an electronic nose was tracked to identify the influence of high or low emissions of volatiles that depend on the oil composition. Analyzing the oils by Fourier-transform IR-spectroscopy and GC×GC-MS, we confirmed the correlation between sensor responses and the oil compositions, significantly dependent on the ratio of aromatic compounds/alkanes.

Mediating effect of coping strategy and psychological status between illness perception and quality of life among patients with atrial fibrillation: a cross-sectional study.

Background: This study investigated the mediating effects of coping strategies and psychological status on the relationship between illness perception and health-related quality of life (HRQoL) among patients with atrial fibrillation (AF).

Methods: This cross-sectional study enrolled 178 patients with AF who were admitted to a tertiary hospital in Beijing City in mainland from March 2020 and June 2022. Assessments were made for HRQoL using the Short Form Health Survey depressive symptoms using the Patient Health Questionnaire-9, anxiety using the Generalized Anxiety Disorder-7 (GAD-7), illness perception using the Brief Illness Perception Questionnaire (BIPQ), AF symptoms using the Atrial Fibrillation Severity Scale (AFSS), and coping strategies using the Brief-COPE Scale.

Effects of Artificial Sugar Supplementation on the Composition and Nutritional Potency of Honey from .

In the global apiculture industry, reward feeding and supplementary feeding are essential for maintaining bee colonies. Beekeepers provide artificial supplements to their colonies, typically in the form of either a honey-water solution or sugar syrup. Owing to cost considerations associated with beekeeping, most beekeepers opt for sugar syrup.

Tandem gene duplication selected by activation of horizontally transferred gene in bacteria.

Horizontal gene transfer occurs frequently in bacteria, but the mechanism driving activation and optimization of the expression of horizontally transferred genes (HTGs) in new recipient strains is not clear. Our previous study found that spontaneous tandem DNA duplication resulted in rapid activation of HTGs. Here, we took advantage of this finding to develop a novel technique for tandem gene duplication, named tandem gene duplication selected by activation of horizontally transferred gene in bacteria (TDAH), in which tandem duplication was selected by the activation of horizontally transferred selectable marker gene.