Case Report: Concurrent retinal vasculitis and optic neuritis in systemic lupus erythematosus.

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that can affect the ocular system, with retinal vasculitis and optic neuritis being rare but serious manifestations. We present a case of a 26-year-old female with newly diagnosed SLE who developed both retinal vasculitis and optic neuritis, leading to progressive visual impairment. She was successfully treated with methylprednisolone and rituximab, achieving significant visual recovery.

Eco-friendly fabrication of hydrophobic and breathable nanofibrous membranes molecularly engineered WPU/PAM composites.

As demands increase for multifunctional textiles and breathable coatings in high-humidity and high-mobility environments, the development of membranes that combine waterproofing, breathability, and mechanical durability has become a critical challenge. This study presents a novel, organic solvent-free electrospinning approach to fabricate waterborne polyurethane (WPU)-based nanofiber membranes, enhanced by polyacrylamide (PAM) as a dual-functional additive. By leveraging hydrogen bonding interactions between the -COO, -NHCOO- groups in WPU and the -CONH groups in PAM, the resulting composite achieved stable electrospinning, improved fiber morphology, and a significantly higher water contact angle (86.

What Drives "Group Roaming"? A Study on the Pathway of "Digital Persuasion" in Media-Constructed Landscapes Behind Chinese Conformist Travel.

In the era of digital intelligence, digital media landscapes increasingly influence cultural tourism consumption. Consumerism capitalizes on tourists' superficial aesthetic commonalities, constructing a homogenized media imagination that leads to collective convergence in travel decisions, which obscures aspects of local culture, poses safety risks, and results in fleeting local tourism booms. In this study, semistructured interviews were conducted with 36 tourists, and NVivo12.

Case Report: Bilateral adrenal hemorrhage in a patient with systemic lupus erythematosus and antiphospholipid syndrome.

This case report describes a rare and life-threatening complication of bilateral adrenal hemorrhage (AH) in a 15-year-old female with overlapping systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). The patient presented with prolonged abdominal pain, low-grade fever, and lower limb pain. Imaging revealed bilateral adrenal hemorrhages, while laboratory investigations confirmed triple-positive antiphospholipid antibodies (ACA-IgG, ACA-IgM, anti-β2 glycoprotein I) and SLE-related serological markers.

Disitamab vedotin combined with toripalimab and radiotherapy for multimodal organ-sparing treatment of muscle invasive bladder cancer: a proof-of-concept study.

Purpose: Although trimodal therapy is currently the standard organ-sparing approach for muscle-invasive bladder cancer (MIBC), its clinical benefit is limited, and noninvasive biomarkers to guide dynamic decision-making are lacking. Here, we present a proof-of-concept study evaluating disitamab vedotin (RC48, a HER2-targeted antibody-drug conjugate) combined with toripalimab (JS001, anti-PD-1) and radiotherapy for bladder preservation in localized HER2-positive MIBC.

Patients And Methods: In the first-stage of an open-label phase II clinical trial (ClinicalTrials.

Successful use of belumosudil in a patient with chronic ocular GVHD: A case report.

Background: Belumosudil is a selective ROCK2 inhibitor approved by the U.S. Food and Drug Administration (FDA) for the treatment of patients who have failed at least two prior systemic therapies.

Forensic wound age estimation (2003-2024): evolving perspectives on tissue viability and molecular pathology.

Determining the precise timing of injuries remains a longstanding and complex challenge in forensic pathology. Within the domain of injury time extrapolation, our research emphasizes the use of immunohistochemical techniques to detect wound viability markers, offering a promising approach to infer the temporal dynamics of tissue injury. Despite growing interest in this area, comprehensive bibliometric analyses remain scarce.

The epidemiology of chronic postsurgical pain after video-assisted thoracic surgery (VATS-CPSP) in China: a multicentre prospective study.

Background: Chronic postsurgical pain (CPSP) after video-assisted thoracic surgery (VATS) has been a focus for research and clinical improvement for decades. However, large-scale epidemiological reports from prospective studies are still lacking. The goal of this study was to present the CPSP profiles after VATS from a nationwide survey.

Gender-specific association of oxidative balance score with sarcopenia in American adults: NHANES 2011-2018.

Background & Aims: Nutritional status and levels of oxidative stress may be modifiable risk factors for the development of sarcopenia. The Oxidative Balance Score (OBS) is a comprehensive measure of oxidative balance in diet and life exposures. We conducted a cross-sectional study to investigate the association between OBS and sarcopenia in US adults.

Predicting single-cell protein production from food-processing wastewater in sequencing batch reactors using ensemble learning.

Producing single-cell protein (SCP) from food-processing wastewater offers a sustainable approach to resource recovery, animal feed production, and wastewater treatment. Decision-makers need accurate system performance data under variable influent conditions to select operational parameters for efficiency. However, predicting system performance under variable conditions is challenging due to the complexity of unsteady-state bioreactions.

Development and Validation of the UriMee Model: A Methylation-based Diagnostic Tool for Early Diagnosis of Urothelial Carcinoma.

Background And Objective: Urothelial carcinoma (UC) is a common malignancy that imposes a significant health care burden. Current diagnostic methods are limited by their invasiveness and low sensitivity, particularly for detecting low-grade tumors. Noninvasive, accurate, and reliable diagnostic tests for an early diagnosis of UC are urgently needed.

Thickness- and Wavelength-Dependent Nonlinear Optical Absorption in 2D Layered MXene Films.

As a rapidly expanding family of 2D materials, MXenes have recently gained considerable attention. Herein, by developing a coating method that enables transfer-free and layer-by-layer film coating, the nonlinear optical absorption (NOA) of TiCT MXene films is investigated. Using the -scan technique, the NOA of the MXene films is characterized at ≈800 nm.

Predictive models of epidermal growth factor receptor mutation in lung adenocarcinoma using PET/CT-based radiomics features.

Background: Lung adenocarcinoma (LAC) comprises a substantial subset of non-small cell lung cancer (NSCLC) diagnoses, where epidermal growth factor receptor (EGFR) mutations play a pivotal role as indicators for therapeutic intervention with targeted agents. The emerging field of radiomics, which involves the extraction of numerous quantitative attributes from medical imaging, when coupled with positron emission tomography/ computed tomography (PET/CT) technology, has demonstrated promise in the prognostication of EGFR mutation status. The objective of this investigation is to construct and validate predictive models for EGFR mutations in LAC by leveraging PET/CT-derived radiomics features, thereby refining diagnostic precision and facilitating tailored treatment strategies.

Case Report: Nutcracker Syndrome Triggered by Rapid Weight Loss in a Patient With Systemic Lupus Erythematosus.

Nutcracker syndrome (NCS) is a rare vascular disorder characterized by compression of the left renal vein, typically causing hematuria, proteinuria, and flank pain. Although NCS is often linked with weight loss and anatomical variations, no previous reports have connected it to systemic lupus erythematosus (SLE). We describe a 44-year-old male with SLE who developed NCS after rapid weight loss, presenting with abdominal pain, hematuria, and proteinuria.

Enhanced electrochemical performance of N-doped carbon coated NaFePOF cathode materials for sodium-ion batteries: achieving high capacity and cycle stability.

Iron-based phosphates, known for their abundance, cost-effectiveness, and eco-friendliness, have garnered significant attention as viable cathode materials for sodium-ion batteries. However, synthesizing pure phase, high-capacity cathodes remains a substantial challenge. This research focuses on NaFePOF and achieves a significant enhancement in its electrochemical properties through a refined preparation process, leading to the development of NaFePOF@C.

Enhancement of Dendrite-Free Lithium Metal Anode Performance through LiF-Rich Protective Layer for Lithium Metal Batteries.

Lithium metal batteries represent a cutting-edge class of energy storage devices, yet the high surface diffusion energy barrier of lithium metal prompts preferential Li accumulation and deposition, fostering the growth of lithium dendrites. To address this challenge, a straightforward solvent-based approach is employed to create a LiF-rich protective layer on the lithium anode. The uniform LiF interface facilitates the transport of Li and effectively induces the uniform plating and stripping of lithium while inhibiting the formation of dendrites.

[Ginsenoside-Rg5 Synergizes with Imatinib to Enhances the Anti-Chronic Myeloid Leukemia K562 Cell Activity through PI3K/AKT/mTOR Pathway].

Objective: To investigate the synergistic effect and its mechanism of ginsenoside-Rg5 in combination with imatinib in inhibiting proliferation of chronic myeloid leukemia K562 cells.

Methods: K562 cells were treated with ginsenoside-Rg5 and imatinib. Cell survival was detected by CCK-8 assay, and IC were calculated separately for each drug.

Combined with the semantic features of CT and selected clinical variables, a machine learning model for accurately predicting the prognosis of Omicron was established.

Objectives: To efficiently use medical resources and offer optimal personalized treatment for individuals with Omicron infection, it is vital to predict the disease's outcome early on. This research developed three machine learning models to foresee the results for Omicron-infected patients.

Methods: Data from 253 Omicron-infected patients, including their CT scans, clinical details, and relevant laboratory values, were studied.

The non-monotonic effect of sucrose on interactions between lipid-bearing surfaces.

The extremely low sliding friction of articular cartilage in synovial joints has been attributed to phospholipid boundary layers, lubricating via the hydration lubrication mechanism at their exposed, highly hydrated polar-head-groups, in a medium - the synovial fluid - where osmolytes, which may modify the hydration layer, are ubiquitous. Here, using a surface force balance (SFB), we carried out a systematic study to elucidate the effect of sucrose, a known osmotic regulator solute, with concentrations c, ranging from 5 to 20 wt%, on the normal and shear forces between interacting phosphatidylcholine (PC) bilayers, both in the gel (1,2-dipalmitoyl-sn-glycero-3-phosphocholine, DPPC) and liquid (1,2-dimyristoyl-sn-glycero-3-phosphocholine, DMPC) phases, supported on atomically-smooth mica substrates. Several additional approaches including cryo-transmission electron microscope, atomic force microscopy, small- and wide-angle X-ray scattering, differential scanning calorimetry, dynamic light scattering and zeta potential measurements are exploited to get additional insight into the nature of the sucrose-dependent interactions.

Morphology and Electrical Properties of AC Electric-Field-Assisted Low-Density Polyethylene.

The direct current (DC) electrical properties of insulating polymers (e.g., low-density polyethylene, LDPE) are very important for the development of high-voltage direct current (HVDC) cables.

Characteristics of ocular findings of patients with coronavirus disease 2019 in China.

Purpose: This study aimed to report the ocular manifestations in individuals with coronavirus disease 2019 (COVID-19) and investigate any correlation between the occurrence of ocular symptoms and systemic symptoms.

Methods: A retrospective electronic survey was conducted among the general public in northern China from December 2022 through February 2023. Inclusion criteria for COVID-19 was confirmed testing positive via a polymerase chain reaction (PCR) test or testing positive for COVID-19 via an antigen kit.