Acrodermatitis continua of Hallopeau: a review and update on biological and small molecule targeted immunomodulatory therapies.

Acrodermatitis continua of Hallopeau (ACH) is a rare aseptic pustular dermatosis for which clinical guidelines are lacking and treatment is largely based on case reports. Biologically targeted therapies offer new therapeutic ideas, with TNF antagonists such as adalimumab showing promising efficacy in both adults and children.The IL-17 and IL-23 axes play a key role in the pathogenesis of ACH, and anti-IL-17A and anti-IL-23 antibodies have shown therapeutic efficacy.

Effect of respiratory filter resistance on respiratory mechanics and human-machine synchrony during invasive jet atomization: a prospective self-controlled study.

Background: To reduce the contamination of the breathing circuit, respiratory filters are used in patients receiving mechanical ventilation. However, their use increases the resistance and dead space volume of the breathing circuit, which potentially leads to asynchrony events, especially when patients are receiving jet nebulization. However, the impact of respiratory filter resistance on respiratory mechanics and human-machine synchronization during invasive ventilation with jet nebulization is not clear.

Palmoplantar Pustulosis during Pregnancy Was Successfully Treated with Tofacitinib: A Case Report.

Introduction: Palmoplantar pustulosis (PPP) is a common chronic recurrent skin disease characterized by sterile pustules on the palms and soles of the feet. Most patients with PPP have a rash that improves during pregnancy due to the influence of estrogen and progesterone, but relatively few have an exacerbation of the rash during pregnancy.

Case Introduction: Here, we show a female patient diagnosed with PPP, whose rash worsened during pregnancy and gestation.

Percutaneous ethanol and calcitriol injection therapy for hyperparathyroidism - a single-centre experience.

Background: The purpose of this study is to evaluate the use of percutaneous ethanol and calcitriol injection therapy for hyperparathyroidism (HPT), while taking into account the efficacy, safety and feasibility as an ambulatory procedure alternative to surgical parathyroidectomy.

Methods: We included nine patients who underwent percutaneous injection therapy for HPT from January 2018 to December 2021 in our institution. They were followed up from date of first percutaneous injection until death or October 2022 (mean duration of 9.

Machine learning based differential diagnosis of SAPHO syndrome and secondary bone tumors using whole body bone scintigraphy.

SAPHO syndrome is an inflammatory disorder with bone and cutaneous manifestations, for which whole-body bone scintigraphy (WBBS) is frequently used in diagnosis. The WBBS findings of SAPHO syndromes and secondary bone tumors (SBT) have overlapping features, posing diagnostic challenges. In this multicenter study, we aim to identify different bone and joint involvement patterns between the two disease entities through multiple methods to build machine-learning models and explore interpretable variables.

Self-Healing Polymeric Puerarin Hydrogel Dressing Promotes Diabetic Wound Healing Through Synergistic Immunomodulation and Tissue-Regenerative Remodeling.

Chronic wound healing is a significant challenge in diabetes. Puerarin is an active compound extracted from the traditional Chinese medicine . Puerarin has been used in the treatment of diabetes and derives benefits from its antioxidant, anti-inflammatory, antibacterial, and pro-angiogenesis properties, but its efficacy is hampered by poor water solubility and bioavailability.

Risk analysis of the association between red blood cell distribution width-to-peripheral oxygen saturation ratio and poor prognosis in critical patients with obstructive sleep apnea.

Background: Obstructive sleep apnea (OSA) is prevalent among critically ill patients and associated with increased mortality. This study investigates the red blood cell distribution width (RDW)-to-peripheral oxygen saturation ratio (RSR) as a predictor of all-cause mortality in critically ill OSA patients using the MIMIC-IV database.

Methods: We extracted clinical data from 3237 critically ill OSA patients in MIMIC-IV (version 3.

Short-Term Relief with Upadacitinib: A Case Report of Palmoplantar Pustulosis in a Pediatric Patient.

Palmoplantar pustulosis (PPP) is a chronic inflammatory skin disease with recurrent erythema, scales, and sterile pustules on the palms and soles. Treating PPP in children is difficult due to limited effective therapies, especially as there's a lack of data on upadacitinib use in children under 12.This article reports a pediatric PPP case.

Acrodermatitis Continua of Hallopeau and Generalised Pustular Psoriasis: Case Reports of Two Different Manifestations of IL36RN Mutation in Siblings.

In our manuscript, we present a case study of siblings with Generalized Pustular Psoriasis (GPP) and Acrodermatitis Continua of Hallopeau (ACH), both harboring IL36RN gene mutations. The 3-year-old proband exhibited systemic pustules leading to a GPP diagnosis, while his 6-year-old sister developed nail ulcers and subungual pustules characteristic of ACH. Despite standard treatments, their conditions were refractory.

History of primary hypertrophic osteoarthropathy.

Primary hypertrophic osteoarthropathy (PHO) is a rare systemic disorder characterized. by periosteal new bone formation, clubbing of fingers and toes, and thickening of the. skin, particularly on the forehead and face.

Crystal structure modulation enabling fast charging and stable layered sodium oxide cathodes.

Layered oxide cathodes show great promise for commercial applications due to their low cost, high specific capacity, and energy density. However, their rapid capacity decay and slow kinetics primarily caused by harmful phase transitions and a high energy barrier for Na diffusion result in inferior battery performance. Herein, we modulate the crystal structure of layered oxide cathodes by replacing the Fe site with Al, which strengthens the transition metal layers and enlarges the Na translation layer owing to the smaller ion radius of Al and the stronger bonding energy of Al-O.

Clinical and imaging characteristics of 135 cases of infectious sacroiliitis: a retrospective cohort study in China.

To study the clinical, imaging, and computed tomography (CT)-guided biopsy pathology of patients with infectious sacroiliitis (ISI). We retrospectively analysed 135 patients diagnosed with ISI between 2008 and 2020, comprehensively evaluating clinical characteristics, laboratory test outcomes, pathological examination results, and magnetic resonance images (MRI). Among the 135 patients with ISI, 90 (66.

Mizagliflozin ameliorates diabetes induced kidney injury by inhibitor inhibit inflammation and oxidative stress.

Background: Mizagliflozin (MIZ) is a specific inhibitor of sodium-glucose cotransport protein 1 (SGLT1) originally developed as a medication for diabetes.

Aim: To explore the impact of MIZ on diabetic nephropathy (DN).

Methods: Diabetic mice were created using db/db mice.

Case Report: A Ticking Time Bomb: Femoral Artery Aneurysm as a Complication of Behcet's Disease in Adolescents.

Behcet's disease is a rare, chronic inflammatory disorder that can affect various organs, with large vessel involvement being particularly uncommon. This case report discusses a 17-year-old male with Behcet's disease who presented with a rapidly enlarging, painful mass in the right groin region, later diagnosed as a femoral artery aneurysm. The patient underwent successful surgical intervention and was subsequently managed with immunosuppressive therapy to prevent relapse.

Early screening to identify and diagnose primary nasal tuberculosis in patients with tumor necrosis factor inhibitors.

In this editorial, we comment on the article by Liu . Based on our analysis of a case report, we consider that early screening and recognition of primary nasal tuberculosis are crucial for patients undergoing treatment with tumor necrosis factor inhibitor (TNFi). While TNFi therapy increases the risk of reactivating latent tuberculosis, primary nasal tuberculosis remains rare due to the protective mechanisms of the nasal mucosa.

Evaluating the impact of electrode planes on regional lung function assessment.

Objective: The aim of the study was to explore the influence of the measurement plane on regional lung function assessed via electrical impedance tomography (EIT).

Methods: The forced vital capacity (FVC) maneuver was prospectively performed in 30 healthy male volunteers. Simultaneously, EIT measurements were conducted at the 3rd, 4th, and 5th intercostal spaces (ICS).

Medical dilemma: Programmed death 1 blockade (sintilimab) therapy in patients suffering from tumours combined with psoriasis.

Tumour immunotherapy represented by immune checkpoint inhibitors (ICIs) has greatly improved the overall prognosis of patients with malignant tumours, and is regarded as an important breakthrough in the field of medicine in recent years. ICIs have gradually become the core of tumour therapy and are increasingly used in the clinic. In order to achieve early clinical prediction and management of immune-related adverse events (irAEs), it is still necessary to perform further research on the mechanisms, risk factors, and predictors of irAE occurrence in the future.