Integrated Analysis of Slow Transit Constipation and Colorectal Cancer Reveals the Co-Pathogenic Targets and Their Potential Clinical Value.

Background: Slow transit constipation (STC) is a potential risk of the onset of colorectal cancer (CRC). Thus, the purpose of this work is to focus on the co-pathogenic targets between STC and CRC, meanwhile evaluating their prognostic value for CRC.

Methods: The miRNA and mRNA data of STC and CRC were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus databases.

Osmoregulatory evolution of gills promoted salinity adaptation following the sea-land transition of crustaceans.

Unlabelled: The sea-land transition is one of the most dramatic evolutionary changes and requires an adaptive genetic response to salinity changes and osmotic stress. Here, we used multi-species genomes and multi-tissue transcriptomes of the talitrid crustaceans, a living sea-land transition model, to investigate the adaptive genetic changes and osmoregulatory organs that facilitated their salinity adaptation. Genomic analyses detected numerous osmoregulatory genes in terrestrial talitrids undergoing gene family expansions and positive selection.

Landscape structure evolution and ecological risk evaluation of oasis desert cities: A case study of Tiemenguan city.

The rapid development of oasis desert cities adversely affects fragile ecosystems, preventing regional sustainable development. This study investigates the spatiotemporal evolution characteristics and potential quantitative relationship between oasis landscape structure (OLS) and the ecological risk index (ERI) and the trend in different development scenarios in Tiemenguan City, a typical oasis city in an arid zone in northwestern China, from 1990 to 2020. We calculated the ERI thresholds for different landscape types, classified ecological risk levels, and examined the factors influencing ecological risk.

Applying bio-organic fertilizer improved saline alkaline soil properties and cotton yield in Xinjiang.

Bio-organic fertilizers have demonstrated significant potential in enhancing saline-alkali soil properties, boosting crop yield, and reducing chemical fertilizer dependency. However, the extent of improvement and optimal application rates for varying saline-alkali soil conditions remain unclear. We conducted a 2-year field experiment (2022-2023) to evaluate the effects of different bio-organic fertilizer application rates on soil properties, nutrient availability, and cotton yield across three saline-alkali cotton fields with varying salinity levels 4.

Industrial water consumption efficiency and driving factors based on the super-efficient SBM and Tobit approach.

Water scarcity in arid regions is a significant factor constraining industrial development globally. Xinjiang, which has a huge potential for economic development, is constrained for its local industry development owing to the scarcity of water resources. Enhancing the efficiency of industrial water consumption is thus crucial to alleviate the conflict between water resource constrain and economic development.

Aqueous Zinc-Ion Batteries with Boosted Stability and Kinetics under a Wide Temperature Range.

Sustainable aqueous zinc ion batteries (AZIBs) necessitate a wide operational temperature range to ensure practicability, yet achieving this often compromises either reaction kinetics at low temperatures or cycling stability at high temperatures. Here we present an electrolyte design that balances this trade-off, enhancing the stability and kinetics of AZIBs across -60 to 60 °C. Our approach incorporates silk fibroin as a multifunctional additive into ZnCl-based "water-in-salt" electrolyte, which modifies both electrolyte structure and electrode interphase.

Machine Learning-Driven Mass Discovery and High-Throughput Screening of Fluoroether-Based Electrolytes for High-Stability Lithium Metal Batteries.

Developing novel fluoroether electrolytes with high-voltage stability is an effective strategy to improve the performance of lithium metal batteries (LMB). However, the vast chemical space of fluoroether is underexplored due to the absence of effective tools to evaluate the potential used in high-voltage LMB. Herein, a framework was developed in combination of Voting ensemble algorithms and graph convolution neural network (GCNN), allowing the fast assessment of oxidative stability of non-aqueous liquid electrolytes, synthesizability of solvents as well as the solvation ability of them to dissolve lithium salts.

Assessing the impact of residual film on agriculture: A meta-analysis of soil moisture, salinity, and crop yield.

Residual films (RFs) disrupt the normal migration and distribution of water, salts and nutrients in soil, posing a significant threat to the sustainable development of agriculture and food security. The effect complexity of RF on soil water-salt distribution and crop growth result in conflicting findings in previous studies. Systematic and quantitative exploration of RF thresholds is of great significanse.

Simulating water and salt changes in the root zone of salt-alkali fragrant pear and the selection of the optimal surface drip irrigation mode.

Faced with the increasingly serious problem of water scarcity, developing precise irrigation strategies for crops in saline alkali land can effectively reduce the negative effects of low water resource utilization. Using a model to simulate the dynamic changes in soil water and salt environment in the root zone of fragrant pear trees in saline alkali land, and verifying them from a production practice perspective with comprehensive benefits as the goal, can optimize the irrigation amount and irrigation technology elements of saline alkali fruit trees, broaden the comprehensive evaluation perspective of decision-makers, and have important significance for improving the yield and production efficiency of forestry and fruit industry in arid and semi-arid areas worldwide. In this study, a two-year field experiment based on three irrigation levels (3000, 3750, and 4500 m·ha) and four emitter discharge rates (1, 2, 3, and 4 L·h) was conducted in Xinjiang, China.

Study of the mechanism by which Bacillus subtilis improves the soil bacterial community environment in severely saline-alkali cotton fields.

Soil salinization severely damages the soil bacterial community environment. Bacillus subtilis can improve bacterial communities and enhance crop nutrient absorption. However, the mechanism by which B.

Modular synthesis of triphenylphosphine-derived cage ligands for rhodium-catalyzed hydroformylation applications.

Four new triphenylphosphine-derived cage ligands were modularly synthesized dynamic imine chemistry (DIC), and their absolute structures were characterized by single crystal X-ray diffraction (SXRD), nuclear magnetic resonance (NMR) and high resolution mass spectroscopy (HRMS). In contrast to small-molecule analogues, cage ligands demonstrate superior activity and selectivity. The Rh/Cage-L2 catalyst exhibits remarkable performance with an aldehyde selectivity of 89%, accompanied by a TOF value of 2665 h and an / ratio of 2.

Fatigue and damage evolution in wood T-shaped mortise and tenon joints.

Mortise and tenon joint is a key connecting component in timber-framed architecture. Accurately assessing the damage to joints is crucial for the structural design of wooden buildings. This study conducted fatigue tests at three stress levels (70%, 100%, and 130%) based on the maximum stress from static bending tests to analyze the impact of different stress levels on the fatigue performance of mortise and tenon joints.

Impact of task-oriented training based on acupuncture rehabilitation on upper extremity function and quality of life of patients with early stroke.

Background: Eighty percent of stroke patients develop upper limb dysfunction, especially hand dysfunction, which has a very slow recovery, resulting in economic burden to families and society.

Aim: To investigate the impact of task-oriented training based on acupuncture therapy on upper extremity function in patients with early stroke.

Methods: Patients with early stroke hemiplegia who visited our hospital between January 2021 and October 2022 were divided into a control group and an observation group, each with 50 cases.

Ozone decomposition on transition-metal-atom anchored graphdiyne: Insights from computation and experiment.

Transition-metal-atom anchored graphdiynes (TM@GDY, TM = Mn, Fe, Co, Ni and Cu) have already been synthesized and found applications in hydrogen evolution, nitrogen fixation and etc. By means of first-principle predictions and test experiments, we propose here that Fe@GDY and Co@GDY are efficient catalysts for the sustainable conversion of O to O. These two catalysts can spontaneously chemisorb O with zero reaction barrier and have low O conversion barriers (0.

Risk Prediction of Diabetes Progression Using Big Data Mining with Multifarious Physical Examination Indicators.

Purpose: The purpose of this study is to explore the independent-influencing factors from normal people to prediabetes and from prediabetes to diabetes and use different prediction models to build diabetes prediction models.

Methods: The original data in this retrospective study are collected from the participants who took physical examinations in the Health Management Center of Peking University Shenzhen Hospital. Regression analysis is individually applied between the populations of normal and prediabetes, as well as the populations of prediabetes and diabetes, for feature selection.

Effects of water-nitrogen coupling on water and salt environment and root distribution in Suaeda salsa.

Understanding the spatial distribution of crop roots is crucial for effectively managing crop water and fertilizer. We investigate the effects of water-nitrogen coupling on the water-salt environment and root distribution in the root zone of . Three irrigation levels were established, calculated according to 0.

Exploring a Substitution Strategy to Ethylene Oxide for CO Sequestration and Catalytic Conversion: A Theoretical Study.

We show here that attaching -NH, -NHCH, or -N(CH) to ethylene oxide can dramatically reduce the CO cycloaddition barrier, from 69.5 kcal/mol (R = -H) down to 22.1 kcal/mol [R = -N(CH)], which may enable CO fixation under milder conditions without the help of catalysts.

Mine pressure behavior law of isolated island working face under extremely close goaf in shallow coal seam.

In order to study the mining pressure characteristics of the shallow buried coal seam with the same silo working face under the very close mining void zone and the overlying coal rock body, the theoretical analysis is used to determine whether the open-cutting eye bearing layer belongs to the mining under the very close mining void zone or not, based on the numerical simulation of FLAC3D and on-site measurement of the working resistance at the end of the cycle of the working face's hydraulic bracket, It is proposed to divide the mining stress of the working face based on the advancing length of the working face, that is, the high-pressure zone, the transition zone and the low-pressure zone. The results of the study show that: FLAC software was used to analyze the stress intensity of the "C" island working face when it was mined back to 50 m, 100 m, 150 m, and 180 m (one time "square"), and the simulation results were imported into the Origin software, which was used to analyze the stress intensity of the working face. The simulation results were imported into Origin software, and the influence range of mining stress was divided into four areas: high-stress area, stress transition area, low-stress area, and "square" stress concentration area.

Electric-Field Effects on the Internal Charge Reorganization Energies of Crystalline Organic Semiconductors.

The synergistic effects of molecular packing and external electric fields (EEFs, including axial and nonaxial fields) on the internal charge reorganization energies (λ) of typical p-type SMOS have been investigated. Combined quantum and molecular mechanics calculations show that, for all-ring-fused rigid molecules single-molecule approximation and neglect of EEFs are adequate for computing λ, while for nonrigid molecules with inter-ring carbon-carbon (IRCC) linkers, the above simplifications may cause a significant deviation from the actual λ. For nonrigid molecules, solid-state packing can prevent "bad" EEFs ( and ) from enhancing λ (adverse to charge transfer), while it allows λ to be greatly reduced (in favor of charge transfer) if "good" EEFs (, , and ) are imposed.

A Reversible Six-Electron Transfer Cathode for Advanced Aqueous Zinc Batteries.

The electrochemical reactions for the storage of Zn while embracing more electron transfer is a foundation of the future high-energy aqueous zinc batteries. Herein, we report a six-electron transfer electrochemistry of nano-sized TeO /C (n-TeO /C) cathode by facilitating the reversible conversion of TeO ↔Te and Te↔ZnTe. Benefitting from the integrated conductive nanostructure and the proton-rich environment in providing optimized electrochemical kinetics (facilitated Zn uptake and high electronic conductivity) and feasible thermodynamic process (low Gibbs free energy change), the as-prepared n-TeO /C with stable cycling performance exhibits a superior reversible capacity of over 800 mAh g at 0.

Research on Output Characteristics of Microscale BST Laminate Structure Based on Mixed Finite Element Method.

The flexoelectric effect, which is sensitive to size, refers to the phenomenon of coupling between the strain gradient and electrical polarization and involves higher-order derivatives of physical quantities such as displacement, and the analytical process is complicated and difficult. Therefore, in this paper, a mixed finite element method is developed considering the effects of size effect and flexoelectric effect on the electromechanical coupling behavior of microscale flexoelectric materials. Based on the theoretical model of enthalpy density and the modified couple stress theory, the theoretical model and finite element model of microscale flexoelectric effect are established, and the Lagrange multiplier is used to coordinate the higher-order derivative relationship between the displacement field and its gradient, and the C continuous quadrilateral 8-node (displacement and potential) and 4-node (displacement gradient and Lagrange multipliers) flexoelectric mixed element.

Engineering Isomeric AIEgens Containing Tetraphenylpyrazine for Dual Memory Storage.

Tetraphenylpyrazine (TPP) is a promising heterocycle-based aggregation-induced emission luminogen (AIEgen) which has sparked multiple applications in organic light-emitting diodes, sensors, and biotherapy. However, the utility of it in developing information storage materials is relatively rare. Moreover, TPP is mostly employed as an electronic acceptor in molecular design, while the consideration of it as an electronic donor is attractive in studies which may provide a full understanding of its property to tailor the materials.