The association between the uric acid to high-density lipoprotein cholesterol ratio (UHR) index and obesity in postmenopausal women: a cross-sectional analysis based on the NHANES.

Background: Obesity has emerged as a critical global public health challenge. Postmenopausal women experience significantly elevated risks of metabolic disorders and a marked increase in obesity prevalence due to declining estrogen levels. The uric acid to high-density lipoprotein cholesterol ratio (UHR), an emerging biomarker for metabolic syndrome, is gaining clinical recognition.

Research Progress on Histone Lactylation Modification in Ischemic Stroke: Mechanisms and Therapeutic Potential.

Ischemic stroke (IS) is a leading cause of death and disability worldwide, with a complex pathogenesis involving neuroinflammation, oxidative stress, and disruption of the blood-brain barrier. Recent research has brought histone lactylation into focus as a novel epigenetic modification that plays a crucial role in IS. Under cerebral ischemia and hypoxia, lactate levels rise, providing an alternative energy source to support ischemic brain regions.

A Shape-Recovery Polycationic Fibroin for Hemostasis-Regeneration Transition by Recapitulating Natural Coagulation Networks.

Large-scale and deep trauma restricts the effective hemostasis and tissue regeneration management, even causing death. The formation of the fibrin network is the initial stage of wound control. Inspired by Fn's characteristics during coagulation, an artificial polycationic fibroin (pCSF/β) is designed to achieve hemostasis-regeneration transition.

Efficacy and safety of reduning injection for severe pneumonia: a systematic review and meta-analysis.

Objectives: Reduning (RDN) injection is a traditional Chinese medicine (TCM) extract injection commonly used as an adjunct therapy for severe pneumonia (SP) in clinical practice in China; however, further validation is required. This study aims to systematically assess the efficacy and safety of RDN injection in treating SP.

Methods: The study was conducted using the data from CNKI, WanFang, VIP, SinoMed, PubMed, Embase, Cochrane Library, and Web of Science databases from their inception to 6 April 2024.

NETs accelerate aortic valve calcification by promoting M1 macrophage polarization through the TLR9 signaling pathway.

Neutrophil extracellular traps (NETs) are positively correlated with the severity of calcific aortic valve disease (CAVD). This study aims to elucidate the mechanism by which NETs contribute to CAVD. The CAVD mice model was established by calcification-promoting diets, and NETs formation was modulated via intraperitoneal injection of Cl-amidine.

Electroacupuncture stimulation improves pulmonary fibrosis by modulating ferroptosis in rats: multiscale analysis of transcriptome and proteome.

Background: Idiopathic Pulmonary fibrosis (IPF) is a progressive lung disease with poor survival. Electroacupuncture has been proven to improve dyspnea in IPF patients, but the mechanism remains unclear.

Methods: The IPF rat model was established by intratracheal instillation of bleomycin.

Efficacy and Safety of Firsekibart Compared to Etoricoxib for Gout Flares: A Phase 2, Multicenter, Open-label, Active-controlled, Randomized Non-inferiority Trial.

Introduction: Firsekibart, an anti-interleukin (IL)-1β monoclonal antibody, has demonstrated more sustained control of gout flares compared with compound betamethasone in previous clinical studies. This study evaluated the efficacy and safety of firsekibart versus etoricoxib for the treatment of frequent gout flares.

Methods: In this phase 2, randomized, open-label, active-controlled, multicenter study (NCT05936268), adults with gout according to American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR) 2015 criteria experiencing frequent flares (≥ 2 flares within 12 months pre-screening) were randomized (1:1) to receive either a single subcutaneous injection of firsekibart 200 mg, or once-daily oral etoricoxib 120 mg administered until pain remission or treatment intolerance for up to 8 days.

Inhaling Eugenol Inhibits NAFLD by Activating the Hepatic Ectopic Olfactory Receptor Olfr544 and Modulating the Gut Microbiota.

Non-alcoholic fatty liver disease (NAFLD) is a major public health threat with currently limited therapeutic options. Inhalation therapy shows promise for treating metabolic disorders due to rapid absorption and high patient adherence, though relevant medications remain scarce. Eugenol (EUG), the primary component of Syzygium aromaticum volatile oil, emerges as a promising NAFLD inhibitor from lipid-lowering aromatic Chinese medicine screening.

Clinical Characteristics and Prognosis of Acute Heart Failure in Patients with Chronic Obstructive Pulmonary Disease.

This study describes clinical profiles of acute heart failure (AHF) patients from the Heart Failure Registry of Patient Outcomes (HERO) study and evaluates the prognostic impact of chronic obstructive pulmonary disease (COPD). HERO enrolled 5,620 hospitalized AHF patients (November 2017 to 2018); 4,428 were followed. Primary endpoint: composite all-cause death or heart failure (HF) readmission.

Efficacy and safety of Suhuang Zhike capsule for cough variant asthma: a multicenter, single-arm, open-label phase IV real-world clinical trial.

Objective: To summarize the clinical efficacy characteristics of Suhuang Zhike capsule and evaluate the incidence of adverse reactions in its broad clinical application.

Methods: This was a multicenter, prospective, single-arm, open-label phase IV clinical trial. A total of 1100 patients diagnosed with cough variant asthma (CVA) and the Traditional Chinese Medicine (TCM) syndrome of wind evil invading the lung and lung failing to propagate were planned for recruitment.

Electroacupuncture Protects Against Post-stroke Cognitive Impairment by Promoting an IL-33/ST2 Axis-Mediated Microglia M2 Polarization.

Post-stroke cognitive impairment (PSCI) is a common and debilitating complication of stroke that significantly hinders rehabilitation. Electroacupuncture (EA), which integrates traditional acupuncture with electrical stimulation, has been widely applied in clinical practice and shown remarkable efficacy in treating PSCI. However, its underlying mechanisms remain largely unexplored.

FEAOF: A transferable framework applied to prediction of hERG-related cardiotoxicity.

Inhibition of the hERG (human ether-a-go-go-related gene) channel by drug molecules can lead to severe cardiac toxicity, resulting in the withdrawal of many approved drugs from the market or halting their development in later stages. These findings highlight the pressing need to evaluate hERG blockade during drug development. We propose a novel framework for feature extraction and aggregation optimization (FEAOF), which primarily consists of a feature extraction module and an aggregation optimization module.

Exploring the biological basis for the identification of different syndromes in ischemic heart failure based on joint multi-omics analysis.

Background: IHF is a major chronic disease that seriously threatens human health. Qi deficiency and blood stasis syndrome (QDBS), Yang deficiency with blood stasis syndrome (YDBS) and Yang deficiency and blood stasis with fluid retention syndrome (YDBSFR) are the basic syndromes of IHF in Chinese medicine. This study aims to explore the biological basis of the three IHF syndromes through integrated multi-omics research.

Development and validation of a conventional MRI-based model to predict cerebral palsy in infants (aged 6-24 months) with periventricular white matter injury: a multicentre, retrospective cohort study.

Background: Periventricular white matter injury (PVWMI) is the most common form of brain injury and the leading cause of cerebral palsy (CP). Early prediction of CP within the first 2 years of life is crucial for timely and effective intervention. Early CP prediction tools for infants with PVWMI are lacking.

Cornus officinalis Sieb.: An updated review on the ethnopharmacology, phytochemistry, pharmacology, toxicology, and pharmacokinetics.

Ethnopharmacological Relevance: Cornus officinalis Sieb. et Zucc., belonging to the family Cornaceae, has a history of nearly two thousand years of use in Traditional Chinese Medicine (TCM) and has also been widely applied in traditional medicine across East Asia.

[Effect and safety of electroacupuncture in the treatment of chronic prostatitis / chronic pelvic pain syndrome: A systematic review and meta-analysis of 17 randomized controlled trials].

Objective: To systematically evaluate the effect and safety of electroacupuncture in the treatment of chronic prostatitis / chronic pelvic pain syndrome (CP/CPPS).

Methods: We searched the major Chinese and English databases of CNKI, Wanfang Data, VIP, CBM, PubMed, Cochrane Library, Web of Science and Embase for randomized controlled trials (RCT) on electroacupuncture or combination therapy in the treatment of CP/CPPS published from the establishment of the databases to August 2024. The dichotomous data and continuous data were represented by risk ratio (RR) and mean difference (MD) respectively, both with 95% confidence interval (CI).

Association Between Intracranial Plaque Characteristics and Stroke Recurrence Risk Stratified by Stenosis Severity.

Rationale And Objectives: This study aims to analyze the association between plaque characteristics and stroke recurrence across different degrees of stenosis, and to evaluate the predictive value of combining culprit plaque characteristics with the modified Essen score for stroke recurrence.

Materials And Methods: This retrospective analysis included 368 intracranial atherosclerotic stenosis (ICAS) patients from two centers, categorized into mild-to-moderate stenosis (<70%, n = 155) and severe stenosis (≥70%, n = 213) groups. High-resolution vessel wall images and clinical data were analyzed.

Exosomal microRNA biomarkers in Alzheimer's disease: Systematic review and meta-analysis.

Background: Recent studies have suggested an association between exosomal microRNAs (miRNAs) and Alzheimer's disease (AD). However, their effectiveness as clinical biomarkers has yet to be definitively established. This study aims to assess the diagnostic value of exosomal miRNAs in AD through a meta-analysis.

[Factors for low libido in male patients with sexual dysfunction].

Objective: To analyze the factors for low libido in male patients with sexual dysfunction and provide some evidence for the clinical diagnosis and treatment of the condition.

Methods: We retrospectively analyzed the clinical data on 111 cases of sexual dysfunction (including disorders in erection, ejaculation or libido) treated in the Zhengzhou University First Hospital from June to September 2023. According to the patients' complaints of low libido or accompanied symptoms, we divided them into a normal libido group (n = 68) and a low libido (n = 43), obtained their scores on IIEF-5, Premature Ejaculation Diagnostic Tool (PEDT), 13-Item Self-Rating Libido Scale for Males (SRLS-M), Patients' Health Questionnaire-9 (PHQ-9) and General Anxiety Disorder-7 (GAD-7), examined the levels of the sexual hormones FSH, LH, PRL, T, free testosterone (fT), E2,?insulin-like growth factor 1 (IGF-1) and growth hormone (GH), compared the basic parameters between the two groups, and analyzed their correlation with the libido values.

Effect of Acupuncture on Functional Connectivity of the Limbic Network in Patients with Knee Osteoarthritis: A Resting State Functional Magnetic Resonance Imaging Study.

Background: Knee osteoarthritis (KOA) is a prevalent degenerative joint disorder. Acupuncture therapy demonstrates significant efficacy in alleviating KOA symptoms. However, the central neuroimaging mechanisms underlying acupuncture's therapeutic effects remain incompletely elucidated.

Risk prediction models for mortality in patients with severe pneumonia: a systematic review and meta-analysis.

Background: The number of risk prediction models for mortality in patients with severe pneumonia (SP) is increasing, while the quality and clinical applicability of these models remain unclear. This study aimed to systematically review published research on risk prediction models for mortality in patients with SP.

Methods: PubMed, Embase, Cochrane Library, and Web of Science were searched from inception to August 31, 2024.

Striking effectiveness of siltuximab-based treatment in refractory idiopathic multicentric Castleman disease resembling IgG4-related disease.

Castleman disease (CD) and immunoglobulin G4-related disease (IgG4-RD) are rare systemic immune-mediated disorders that share similar clinical manifestations and overlapping pathological features. We present a case of insidious idiopathic multicentric CD (iMCD) with elevated serum IgG4 levels, characterized by a persistent dry cough and widespread lymphadenopathy. A 38-year-old male patient exhibited persistent dry cough, generalized lymphadenopathy, and fatigue.

Latent profile analysis and influencing factors of post-traumatic stress disorder symptoms in young and middle-aged spinal cord injury patients.

Background: Post-traumatic stress disorder (PTSD) has a profound impact on the physiological, psychological, social functioning, and occupational development of young and middle-aged spinal cord injury (SCI) patients, with a multitude of factors influencing its manifestation. However, the majority of current studies treat all spinal cord injury patients as a homogeneous group, thereby ignoring the intrinsic characteristics of patients and the inter-individual heterogeneity that exists. The aim of this study was to identify distinct subgroups of young and middle-aged SCI patients according to their PTSD symptom severity and to explore the factors affecting different subgroups.

Dupilumab for the treatment of COPD: protocol for a systematic review and meta-analysis.

Introduction: Chronic obstructive pulmonary disease (COPD) is a significant global public health issue, with a high incidence and mortality burdening patients heavily. Although existing treatment methods have made certain progress, their effectiveness in intervention during acute exacerbations and long-term management remains suboptimal for some patients. In recent years, biologic agents have provided new directions for COPD treatment.

A multi-algorithm prognostic model combining inflammatory indices and surgical features in distal cholangiocarcinoma.

Background: Derived neutrophil-to-lymphocyte ratio (dNLR) is an emerging blood-based inflammatory biomarker previously reported to have prognostic value in various malignancies. This study aimed to investigate the prognostic significance of dNLR in patients with distal cholangiocarcinoma (dCCA) after curative resection.

Methods: Clinicopathological data of patients with dCCA in our hospital from Jan.