In vitro Activity of Eravacycline and Risk Factors for Carbapenem-Resistant Acinetobacter Baumannii Infections in Patients with Respiratory Diseases: A Retrospective Cohort Study.

Background: Carbapenem-resistant Acinetobacter baumannii (CRAB) infections, particularly among respiratory patients, are associated with high mortality rates and substantial healthcare costs, exceeding $1.2 billion annually. Current the medications are recommended therapies, including Colistin and Tigecycline, face significant limitations, such as nephrotoxicity and inadequate lung tissue penetration.

Comprehensive review of Bayesian network applications in gastrointestinal cancers.

Gastrointestinal cancers, including esophageal, gastric, colorectal, liver, gallbladder, cholangiocarcinoma, and pancreatic cancers, pose a significant global health challenge due to their high mortality rates and poor prognosis, particularly when diagnosed at advanced stages. These malignancies, characterized by diverse clinical presentations and etiologies, require innovative approaches for improved management. Bayesian networks (BN) have emerged as a powerful tool in this field, offering the ability to manage uncertainty, integrate heterogeneous data sources, and support clinical decision-making.

Deciphering the multifaceted role of circular RNA in aging: from molecular mechanisms to therapeutic potentials.

Aging is an inevitable physiological process that occurs in living organisms and has significant implications for health and disease. As the human lifespan extends, the functionality of organs gradually diminishes, leading to the emergence of various aging-related symptoms. While it is not feasible to completely halt the aging process, investigating key molecules involved in aging can help devise valid strategies to delay its progression.

Simultaneous determination of nine compounds from the roots of , and and their anti-tumor activities.

Langdu is generally considered as the roots of , and . However, whether these three plants can substitute for one another has always been a concern. This article aims to clarify the differences among the three Langdu species in chemical constituents and anti-tumor effects.

FusionEncoder: identification of intrinsically disordered regions based on multi-feature fusion.

Motivation: Intrinsic disorder regions (IDRs) play a significant role in diverse biological processes and are widely distributed in proteins. Thus, accurately predicting these regions is essential for analyzing protein structure and function. Amino acid feature extraction servers as a foundational process in the development of computational predictive models.

The epidemiological trends of inflammatory bowel disease among women of reproductive age: a global analysis from 1990 to 2021.

This study aimed to evaluate the global burden of inflammatory bowel disease (IBD) among women of reproductive age (15-49 years) from 1990 to 2021, analyze its association with socio-demographic index (SDI), and identify age-period-cohort (APC) effects to inform region-specific public health strategies. Using data from the Global Burden of Disease (GBD) 2021 study, we assessed age-standardized incidence (ASIR), prevalence (ASPR), mortality (ASMR), and disability-adjusted life years (ASDR) across 204 countries. Statistical analyses included Pearson correlation to evaluate SDI associations, decomposition analysis to quantify burden drivers, and APC modeling to disentangle age, period, and cohort effects.

A study on the status of myopia and pre-myopia among primary school students in different regions of Shaanxi Province, China.

Objective: This cross-sectional study aimed to investigate the geographic disparities in myopia and pre-myopia prevalence among elementary school students across three distinct regions of Shaanxi Province (southern Hanzhong, Guanzhong, and northern Yulin) to inform region-specific myopia control strategies.

Methods: From March to May 2024, we employed multistage cluster sampling to recruit 8,207 eligible students (2,724 southern Shaanxi, 2,761 Guanzhong, 2,722 northern Shaanxi) from 12 randomly selected primary schools. Comprehensive ophthalmic examinations including uncorrected visual acuity and non-cycloplegic autorefraction were conducted.

Statistical Difference Representation-Based Transformer for Heterogeneous Change Detection.

Heterogeneous change detection refers to using image data from different sensors or modalities to detect change information in the same region by comparing images of the same region at different time periods. In recent years, methods based on deep learning and domain adaptation have become mainstream, which can effectively improve the accuracy and robustness of heterogeneous image change detection through feature alignment and multimodal data fusion. However, a lack of credible labels has stopped most current learning-based heterogeneous change detection methods from being put into application.

Isolation and Identification of YJ-2 from the Rhizosphere Soil of to Explore Its Potential as a Biocontrol Agent Against Plant Fungal Diseases.

Plant fungal diseases remain a major threat to global agricultural production, necessitating eco-friendly and sustainable strategies. Conventional chemical fungicides often lead to the development of resistant pathogen strains and cause environmental contamination. Therefore, the development of biocontrol agents is particularly important.

Expert Consensus on Subxiphoid and Subcostal Arch Thoracoscopic Resection for the Treatment of Thymoma.

Surgery is the primary treatment for thymoma. Although subxiphoid and subcostal arch thoracoscopic thymoma surgery is widely used, there is currently a lack of consensus regarding its use, nor have standards been established. Based on the surgical experience of many domestic thoracic surgery centers, the Department of Thoracic Surgery of Tangdu Hospital of Air Force Medical University has formulated this expert consensus regarding key clinical issues related to thoracoscopic thymoma surgery, including preoperative evaluation, surgical indications, preoperative preparation, surgical details, perioperative management, postoperative treatment, and follow-up.

Beyond Bone Loss: A Biology Perspective on Osteoporosis Pathogenesis, Multi-Omics Approaches, and Interconnected Mechanisms.

Osteoporosis is a systemic bone disorder characterized by decreased bone mass and deteriorated microarchitecture, leading to an increased risk of fractures. Recent studies have revealed that its pathogenesis involves complex biological processes beyond bone remodeling, including oxidative stress, chronic inflammation, cellular senescence, osteoimmunology, gut microbiota alterations, and epigenetic modifications. Oxidative stress disrupts bone homeostasis by promoting excessive free radical production and osteoclast activity.

TGF-β1 regulates pannexin1 channels and evokes apoptotic response in osteoblasts.

Objective: Extracellular ATP is suggested to be involved in cell-cell interactions and TGF-β1 stimulates ATP release through pannexin1 channels. However, the role of TGF-β1 in regulating of pannexin1 channels and cell apoptosis remains unclear. In the present study, the aim was to clarify the role of TGF-β1 in relation to pannexin1 channels and cell apoptosis in osteoblasts.

Spatial Distribution Characteristics and Driving Factors of Formicidae in Small Watersheds of Loess Hilly Regions.

This study takes the Jinfoping Small Watershed in the Loess Hilly Region as the research area. Through field investigation and laboratory analysis, combined with methods such as spatial autocorrelation analysis, the ordinary least squares method (OLS), and the geographically weighted regression model (GWR), it deeply explores the spatial distribution characteristics and driving factors of Formicidae in the study area. The research results are as follows: (1) Spatial autocorrelation analysis indicates that the distribution of Formicidae is significantly regulated by spatial dependence and has significant spatial autocorrelation (global Moran's I = 0.

Efficacy and Safety of Daridorexant in Chinese Patients with Insomnia Disorder: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase III Clinical Trial.

Study Objectives: To evaluate the efficacy and safety of daridorexant in Chinese patients with insomnia disorder.

Methods: This was a multicenter, randomized, double-blind, parallel-group, placebo-controlled Phase III clinical trial in China. Adults aged 18-75 years meeting the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5®) criteria for insomnia disorder, with a baseline Insomnia Severity Index (ISI) ≥15, were randomly assigned in a 1:1 ratio to receive daridorexant 50 mg or placebo once every evening for 1 month.

Targeting the ferroptosis pathway for rheumatoid arthritis: molecular mechanisms and prospects for inhibitor development.

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease with severe complications. Ferroptosis, an iron-dependent form of apoptosis, encompasses mechanisms including iron overload, lipid peroxidation, redox homeostasis, and reactive oxygen species accumulation, all of which are closely related to RA pathogenesis. This study focused on the mechanism of ferroptosis and RA, detailing their relationship and outlining the reported roles of ferroptosis inhibitors in RA treatment to provide a useful research basis in drug discovery and development and for clinicians.

Analyzing the influence of TikTok on sustainable choices: the moderating role of environmental consciousness.

The influence of TikTok on consumer purchase intentions and sustainable choices is a burgeoning area of research that holds significant implications for marketing and consumer behavior. This study explores the moderated mediation effect of TikTok influence on sustainable purchase intentions, emphasizing the roles of sustainable attitudes and environmental consciousness. Grounded in social cognitive theory and environmental psychology, data were collected through a cross-sectional approach from active TikTok users.

Efficacy and safety of ongericimab in Chinese statin-intolerant patients with primary hypercholesterolemia or mixed dyslipidemia: a randomized, placebo-controlled phase 3 trial.

Background And Aims: Several protein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have been shown to significantly reduce low-density lipoprotein cholesterol (LDL-C) levels in statin-intolerant patients, but none have been verified in Chinese patients. This study aimed to evaluate the efficacy and safety of ongericimab, a novel PCSK9 monoclonal antibody, in Chinese statin-intolerant patients with primary hypercholesterolemia or mixed dyslipidemia.

Methods: This was a randomized, multicenter, double-blind, placebo-controlled phase 3 study designed to enroll 120 statin-intolerant adult patients.

Exercise training promotes nerve cell repair and regeneration after spinal cord injury.

Spinal cord injury is a severe neurological condition characterized by the permanent loss of nerve cell function and a failure in neural circuit reconstruction-key factors contributing to disability. Therefore, exploring effective strategies to promote the repair and regeneration of nerve cells after spinal cord injury is crucial for optimizing patient prognosis. The purpose of this paper is to conduct an in-depth review of the pathological changes in nerve cells after spinal cord injury and to present the state of research on the role of exercise training in promoting the repair and regeneration of nerve cells after spinal cord injury.

Seasonal climate change characteristics of the Mu Us Sandy Land based on long time scale.

The study of seasonal-scale climate-vegetation coupling mechanisms is important for coordinating desertification control and climate adaptation. Taking the Mu Us Sandy Land (MUSL) as a case study, we gathered meteorological data from 1959 to 2019 (including maximum temperature, minimum temperature, and precipitation) for seasonal analysis. We conducted M-K significance and mutation analysis, Morlet wavelet periodicity analysis and correlation analysis and investigated the effects of various seasonal and annual climate factors on NDVI using NDVI values collected from 1999 to 2019.

The diagnostic and therapeutic process of invasive encapsulated follicular variant of papillary thyroid carcinoma with lung metastasis: a case report.

The invasive encapsulated follicular variant of papillary thyroid carcinoma (IEFVPTC) is a subtype of papillary thyroid carcinoma (PTC) that is often clinically misdiagnosed as a benign lesion. This case report describes a case of IEFVPTC with lung metastasis, highlighting its pathological features and treatment process to enhance understanding of this disease. A female patient discovered to have a thyroid nodule during a routine physical examination sought evaluation and treatment at our hospital.

Research Progress of PROTAC-Degraded CDKs in the Treatment of Breast Cancer.

Breast cancer (BC) is the most common type of cancer among women worldwide. A large number of studies have found that the high expression or dysregulation of cyclin-dependent protein kinases (CDKs) is closely associated with breast cancer. For example, the CDK4/6-Rb axis is involved in the G1/S phase transition of the cell cycle and plays an important role in BC; CDK1 and its associated cyclin are commonly involved in mitotic progression, and increased expression of CDK1-associated cyclin has been observed in BC; loss of CDK12 significantly ameliorates triple-negative breast cancer.

Encapsulating Ionophores in Zeolite Imidazolate Framework-8 for Long-Term Monitoring of Ion Fluctuations in Living Rat Brain.

Various ions in the brain (e.g., H, K, and Ca) play essential roles in neural information transmission and physiopathological processes.