Clinicopathological features of dermal clear cell sarcoma: A series of 13 cases.

Background: Dermal clear cell sarcoma (DCCS) is a rare malignant mesenchymal neoplasm. Owing to the overlaps in its morphological and immunophenotypic profiles with a broad spectrum of tumors exhibiting melanocytic differentiation, it is frequently misdiagnosed as other tumor entities in clinical practice. By systematically analyzing the clinicopathological characteristics, immunophenotypic features, and molecular biological properties of DCCS, this study intends to further enhance pathologists' understanding of this disease and provide a valuable reference for its accurate diagnosis.

Visualizing NEK9 in action: aptamer-based fluorescent probes for real-time live-cell imaging.

Live-cell imaging of intracellular proteins enables real-time observation of protein dynamics under near-physiological conditions, providing pivotal insights for both fundamental life science research and medical applications. However, due to limitations such as poor probe permeability and cytotoxicity associated with conventional antibody-based or genetically encoded labeling techniques, live-cell imaging remains a significant challenging. To address these limitations, here in this study, we developed and rigorously validated a novel aptamer-based fluorescent probe for real-time imaging of NEK9 kinase in living cells.

The manipulator behind "Scissors": γ -secretase and its modulators in Alzheimer's disease.

The intramembrane aspartic protease, γ-secretase, is a heterotetrameric protein complex composed of four integral membrane proteins: presenilin (PSEN), nicastrin (NCT), Anterior pharynx defective-1 (APH-1), and presenilin enhancer 2 (PEN-2). These components are sequentially assembled into a functional complex. γ-secretase is ubiquitously expressed in all cells and tissues and exhibits enzymatic activity akin to "molecular scissors" by cleaving various type I transmembrane proteins.

YOLOv10-kiwi: a YOLOv10-based lightweight kiwifruit detection model in trellised orchards.

To address the challenge of real-time kiwifruit detection in trellised orchards, this paper proposes YOLOv10-Kiwi, a lightweight detection model optimized for resource-constrained devices. First, a more compact network is developed by adjusting the scaling factors of the YOLOv10n architecture. Second, to further reduce model complexity, a novel C2fDualHet module is proposed by integrating two consecutive Heterogeneous Kernel Convolution (HetConv) layers as a replacement for the traditional Bottleneck structure.

Targeting mitochondrial dysfunction to intervene in liver cancer.

The occurrence and progression of liver cancer are closely associated with mitochondrial dysfunction. Mitochondria exhibit characteristics, such as decreased oxidative phosphorylation efficiency, abnormal accumulation of reactive oxygen species in liver cancer and promoting tumor proliferation and drug resistance through the Warburg effect, as the core of energy metabolism and apoptosis regulation. Mutations in mitochondrial DNA (mtDNA) and dysregulation of mitochondrial autophagy (mitophagy) further enhance the invasive and metastatic capabilities of liver cancer.

Rapid and sensitive acute leukemia classification and diagnosis platform using deep learning-assisted SERS detection.

Rapid identification and accurate diagnosis are critical for individuals with acute leukemia (AL). Here, we propose a combined deep learning and surface-enhanced Raman scattering (DL-SERS) classification strategy to achieve rapid and sensitive identification of AL with various subtypes and genetic abnormalities. More than 390 of cerebrospinal fluid (CSF) samples are collected as targets, encompassing healthy control, AL patients, and individuals with other diseases.

Gut Microbes and Inflammation: Their Role in Spinal Cord Injury Progression and Secondary Damage.

This review article describes recent research advances in the relationship between spinal cord injury (SCI) and the gut microbiota and each other's inflammatory response. SCI is a serious neurological disease that directly damages physiological function. Recent studies have shown that SCI significantly affected the composition and function of the gut microbiota, and even caused intestinal inflammation.

Recaticimab in adult heterozygous familial hypercholesterolemia (REMAIN-3): A multicentre, randomised, double-blind, placebo-controlled phase 3 study.

Aims: Heterozygous familial hypercholesterolemia (HeFH) is a genetic disorder, characterised by high plasma concentrations of low-density lipoprotein cholesterol (LDL-C) from birth. This study aimed to assess the efficacy and safety of recaticimab, a new humanised anti-PCSK9 antibody capable of reducing LDL-C levels in patients with poorly controlled HeFH.

Methods And Results: REMAIN-3 was a multicentre, randomised, double-blind, placebo-controlled phase 3 study done at 25 sites in China.

[Symptoms and treatment of benign prostatic hyperplasia patients with upper urinary tract calculi after ureteral stent implantation].

Objective： To analyze the symptoms, diagnosis and treatment of upper urinary tract calculi patients combined with mild and moderate benign prostatic hyperplasia (BPH) after ureteral stent implantation. Methods： One hundred and six BPH patients who were hospitalized for upper urinary tract calculi and had ureteral stents retained from January 2019 to December 2022 were selected and divided into 2 weeks group and 4 weeks group according to the time of removal of ureteral stents after surgery. Their general clinical data were analyzed and compared.

The role of USP36 in ribosome biogenesis and other pathophysiological processes.

Ubiquitination and deubiquitination are common forms of protein post-translational modifications that play crucial roles in the regulation of intracellular homeostasis. As a member of deubiquitination enzyme USP family, USP36 maintains the stability of substrate proteins by mediating their deubiquitination, thereby playing a significant role in various pathophysiological processes. Here we focus on discussing how USP36 participates in regulating ribosome biosynthesis and responds to ribotoxic stress response.

Blood pressure in the first 6 hours for older adults with stroke after endovascular therapy: a pooled analysis of the DEVT and RESCUE BT randomized clinical trials.

Optimal systolic blood pressure (SBP) targets after endovascular therapy (EVT) for stroke in older adults (≥ 65 years) remain undefined. This study assessed age-stratified associations between early post-EVT SBP (first 6 h) and outcomes. Post hoc analysis of two trials.

Mitochondrial dysfunction reveals HS-mediated synaptic sulfhydration as a potential mechanism for autism-associated social defects.

Clinical studies have identified multiple mitochondrial disturbances in the peripheral tissues of patients with autism. However, how neuronal metabolism contributes to the autism-associated phenotype remains unclear. In this study, we focused on the anterior cingulate cortex (ACC) and reported hydrogen sulfide (HS) elevation as a common outcome to mitochondrial dysfunction in Shank3b and Fmr1 neurons.

Bidirectional carrier channels boost photocatalytic hydrogen evolution over NiO/CdMnS/TiCT ternary heterojunction.

Hydrogen evolution reaction (HER) driven by solar energy has attracted considerable attention due to its outstanding efficiency, environmental compatibility, and sustainability. Regrettably, the sluggish progress of the HER and the limitations in charge separation efficiency impede its practical photocatalysis. Herein, a two-step electrostatic self-assembly approach is adopted to construct NiO/CdMnS/TiCT (NO/CMS/TCT) ternary heterojunction with bidirectional carrier channels for boost photogenerated separation and oriented carrier accumulation.

From gut microbial ecology to lipid homeostasis: Decoding the role of gut microbiota in dyslipidemia pathogenesis and intervention.

Dyslipidemia, a complex disorder characterized by systemic lipid profile abnormalities, affects more than half of adults globally and constitutes a major modifiable risk factor for atherosclerotic cardiovascular disease. Mounting evidence has established the gut microbiota (GM) as a pivotal metabolic modulator that is correlated with atherogenic lipid profiles through dietary biotransformation, immunometabolic regulation, and bioactive metabolite signaling. However, the host-microbe interactions that drive dyslipidemia pathogenesis involve complex gene-environment crosstalk spanning epigenetic modifications to circadian entrainment.

Faster, more accurate? A feasibility study on replacing human judges with artificial intelligence in video review for the Paris Olympics Taekwondo competition.

Introduction: This study explores the potential of artificial intelligence (AI) to enhance the accuracy and efficiency of video review systems in Taekwondo, addressing limitations in current human-based judgment processes during competitions.

Methods: A total of 241 video review cases from the 2024 Paris Olympic Taekwondo competition were analyzed. AI-based judgments were generated using ChatGPT-4.

Rescuing a "hopeless" tooth with severe internal resorption during orthodontic therapy: a case report.

Root resorption is one of the leading complications that follows orthodontic treatment. It's an inflammatory process involving ischemic necrosis. Therefore, it is called orthodontically induced inflammatory root resorption (OIIRR).

Cell Function Experiments and Bioinformatics Analysis Jointly Revealed the Antineoplastic Effect of Lumican on Hepatocellular Carcinoma.

Unlabelled: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and immune checkpoint inhibitor (ICI)-based therapies are now an integral part of systemic treatment. In this study, we identify potential biomarker for HCC and further investigate its functional significance using both bioinformatic and experimental methods. Differential analysis and weighted gene co-expression network analysis (WGCNA) were conducted, identifying () as the target gene.

Correction: Characteristics and correlations of sleep disorders in patients with relapsing-remitting multiple sclerosis in China: a cross-sectional study.

[This corrects the article DOI: 10.3389/fneur.2025.

Sm/Cd-CPs with Dual-Core Clusters as High-Performance Multifunctional Fluorescence Sensors for Real-Time Detection of Fe, CrO, Nitrobenzene in Water.

In light of the escalating water pollution problem, there is an urgent need to construct novel sensing materials capable of swift and real-time detection of pollutants. Coordination polymers (CPs) are widely used in the field of fluorescence sensing due to their special and novel structural characteristics. Here, the ligands 5-[(4-pyridyl)methoxy]isophthalic acid (HPLIA) and 4,4-bis(imidazolyl)biphenyl (BIBP) with high symmetry are employed as precursors to synthesize luminescent CPs [Sm(PLIA)(HO)] (CP1) and [Cd(PLIA)(BIBP)(HO)] (CP2) under solvothermal conditions.

Best practices for home nutritional management in postoperative gastric cancer patients: an evidence summary.

Objective: To review and summarize the most compelling evidence on home nutritional management for postoperative gastric cancer patients, with the aim of providing a reference to improve patients' nutritional status at home.

Methods: A comprehensive search was conducted across both Chinese and English-language databases according to the '6S' evidence resource model to identify relevant literature on home nutritional management for postoperative gastric cancer patients. The selected studies were screened, evaluated, and synthesized to extract high-quality evidence.

FDA-DETR: A frequency-aware DETR with dynamic query and adaptive multi-task optimization for oriented small object detection.

Oriented small object detection remains a challenging problem in computer vision, largely due to the weak feature representation and high computational cost of existing detection Transformer (DETR)-based detectors. To address these issues, this work presents Frequency Domain Awareness Detection Transformer (FDA-DETR), an end-to-end framework that enhances both accuracy and efficiency for oriented small object detection. The core of FDA-DETR lies in its multi-scale frequency domain enhancement, which amplifies high-frequency details crucial for small object discrimination.

IDHP Mitigates LPS-Induced Cardiomyocyte Injury via the GAS6/Axl-AMPK Axis: A Multi-Target Strategy Counteracting Inflammation, Oxidative Stress, and Apoptosis.

Sepsis-induced myocardial injury (SIMI) significantly contributes to sepsis-related mortality, yet effective therapies remain limited. This study investigated the cardioprotective potential of isopropyl 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate (IDHP), a bioactive metabolite from , focusing on its mechanism via the GAS6/Axl signaling axis in lipopolysaccharide (LPS)-induced myocardial injury. Using an in vitro HL-1 cardiomyocyte model, IDHP's cytotoxicity was assessed (0-20 μM).

Functions of (L.) Gaertn Extracts: Investigating the Mechanism of Gastroparesis Amelioration from the Perspective of the Gut Microbiota and Its Metabolites.

The functional exploration of natural foods, coupled with the increasing prevalence of gastrointestinal motility disorders and the associated therapeutic challenges, has generated significant interest in this field. This study aims to investigate the ameliorative effects of the extract from (L.) Gaertn (EAEPC), a traditional edible vegetable in northwest China's desert region, on atropine-induced gastroparesis in mice, as well as to elucidate its mechanism in terms of the gut microbiota and major metabolites.

Genome-Wide Identification of the Dirigent Gene Family and Expression Pattern Analysis Under Drought and Salt Stresses of (L.).

The () gene family is pivotal for lignin polymerization and stress adaptation in plants, yet its systematic characterization in (), a critical bioenergy crop, remains underexplored. Leveraging the genome database, we conducted a genome-wide identification, phylogenetic classification, and expression profiling of the gene family. Evolutionary dynamics, gene structure variations, promoter cis-regulatory elements, and spatiotemporal transcriptome patterns were analyzed using bioinformatics and experimental validation (RT-qPCR).

How Does the Hydroxylated Carbon Chain Length in Polyol Electrolyte Additives Influence the Stability of Zn Anode?

Zinc (Zn) anode shows great potential for aqueous zinc-ion batteries yet faces persistent issues of dendritic growth and parasitic reactions at the interface. Here, six polyol additives with different hydroxylated carbon chain lengths are systematically studied under standardized conditions as interfacial regulators for optimizing Zn plating behavior. The calculations coupled with experimental analyses reveal a critical chain-length dependence: short-chain polyols prioritize Zn migration and desolvation but insufficiently protect the interface, whereas long-chain polyols lead to excessive kinetic barriers despite effective interfacial stabilization.