How Does the Hydroxylated Carbon Chain Length in Polyol Electrolyte Additives Influence the Stability of Zn Anode?

Zinc (Zn) anode shows great potential for aqueous zinc-ion batteries yet faces persistent issues of dendritic growth and parasitic reactions at the interface. Here, six polyol additives with different hydroxylated carbon chain lengths are systematically studied under standardized conditions as interfacial regulators for optimizing Zn plating behavior. The calculations coupled with experimental analyses reveal a critical chain-length dependence: short-chain polyols prioritize Zn migration and desolvation but insufficiently protect the interface, whereas long-chain polyols lead to excessive kinetic barriers despite effective interfacial stabilization.

Characteristics of Japanese encephalitis virus infection in NCG-hSTAT2+/+ mice: a novel model for studying neurological symptoms and immune response.

Japanese encephalitis virus (JEV), a leading cause of viral encephalitis in Asia and the Western Pacific, is regulated by type I interferon (IFN) signaling pathway, in which STAT2 is critical. However, STAT2's exact role in JEV-mediated IFN evasion remains unclear. Existing murine models of JEV infection predominantly employ high viral titers to induce encephalitis and primarily use immunocompetent or IFN receptor-deficient mice, limiting their utility for studying JEV's IFN evasion mechanisms.

Psychological richness can enhance innovative behavior of Chinese college students: the chain mediating role of cognitive flexibility and creative self-efficacy.

To investigate the relationship between psychological richness and innovative behavior among Chinese college students, as well as the roles of cognitive flexibility and creative self-efficacy in this relationship, this study employed the Psychologically Rich Life Questionnaire, Cognitive Flexibility Scale, Creative Self-Efficacy Scale, and Innovative Behavior Scale to survey 669 Chinese college students. The results show that: (1) Psychological richness positively predicts innovative behavior; (2) Cognitive flexibility and creative self-efficacy, respectively, play a partial mediating role between psychological richness and innovative behavior; (3) Cognitive flexibility and creative self-efficacy play a chain mediating role between psychological richness and innovative behavior. The findings enrich the research results in the field of innovative behavior among Chinese college students and provide enlightenment for the cultivation of innovative talents in Chinese higher education.

Organic materials input promotes the soil aggregate sequestration through changing soil aggregates structure and stability.

The strategic application of organic amendments presents a transformative approach for enhancing agroecosystem sustainability by modulating soil hydrostructural dynamics and carbon sequestration. However, changes in soil moisture, nutrients, aggregate stability, and SOC sequestration under different organic materials type input in farmland of arid northwest China remain uncertain. In this study, an experiment with five treatments (CK: control, LB: smashed leaves and branches, CS: smashed corn stalks, HV: green fertilizer, MS: waste mushroom bran) input applied into the soil.

Propofol-related infusion syndrome happened in a non-critically ill perioperative young patient: A case report.

Propofol is a commonly used sedative for the induction of clinical anesthesia and sedation maintenance in intensive care unit patients. However, in a minority of patients, prolonged infusion of propofol may cause metabolic acidosis, electrocardiographic abnormalities, arrhythmias, and rhabdomyolysis, a condition known as propofol-related infusion syndrome. If not promptly identified and managed, propofol-related infusion syndrome can be fatal.

Chinese herbal formula Huoxiang Zhengqi Qral liquid for atopic dermatitis: The CHARM randomized controlled trial.

Background: There is an unmet treatment need and a lack of efficacy evidence for Huoxiang Zhengqi (HXZQ) oral liquid for atopic dermatitis (AD).

Objectives: To assess the therapeutic efficacy and safety profile of HXZQ therapy in adult Chinese patients with AD or eczema.

Methods: In the CHARM study (a multi-center, double-blind, randomized controlled trial), randomized participants with mild AD or eczema received HXZQ or a placebo for 4 weeks randomly.

Current status of detection strategies for pathogenic Escherichia coli: a brief review and summary.

Pathogenic E. coli, a significant concern for researchers and health organizations worldwide, has caused numerous large-scale bacterial infection deaths worldwide. Low-dose infection and high pathogenicity underscore the need for rapid and accurate detection of E.

Risk Prediction of Severe Complications Caused by Hymenoptera Insect Stings: Development and Validation of a Nomogram Mode.

Background: Hymenopteran stings (Apidae/Vespidae) represent critical emergencies frequently encountered during summer and autumn seasons. These incidents can trigger localized inflammatory responses and severe systemic complications-including anaphylactic shock, acute organ injury, and multi-organ dysfunction-potentially leading to death, especially in resource-limited areas. While honeybee and wasp venom components (melittin/hyaluronidase vs kinins/phospholipase) and effects differ, potentially causing distinct complications, this study develops a universal early risk prediction tool without differentiating bee species.

Evaluation of soil quality and analysis of drivers of different vegetation patterns in the loess region of Northern Shaanxi.

Evaluating the effects of different vegetation patterns on soil quality and clarifying the soil quality drivers in the loess area of northern Shaanxi are highly important for the future land use and vegetation optimization in this area. In this work, eight typical vegetation patterns in the loess area of northern Shaanxi were used as research objects, and the main soil physicochemical indicators were screened out using principal component analysis, the soil quality evaluation model was established using fuzzy comprehensive evaluation method, and the soil quality (SQ) was comprehensively evaluated. Finally, structural equation modeling (SEM) was used to explore the key factors affecting soil quality.

Effect of warmed ropivacaine versus room temperature ropivacaine administered spinal anesthesia on recovery of lower limb muscle strength following total knee or hip replacement: a prospective, double-blind, randomized controlled study.

Background: With the aging of the population, the number of hip and knee replacements worldwide continues to increase. Postoperative enhanced recovery has become a clinical focus, and an increasing number of hip and knee replacement surgeries are completed on an outpatient basis. Spinal anesthesia is the most widely used anesthetic method in clinical practice, but its disadvantages, such as slow recovery of lower limb muscle strength after operation, have hindered the rapid recovery of such patients.

RBM15 enhances paclitaxel resistance in triple-negative breast cancer by targeting mA methylation of TNFSF9 and inducing polarization of tumor-associated macrophages to M2 phenotype.

Background: Triple-negative breast cancer (TNBC) is one of the breast cancer subtypes with a poor prognosis, and the current main treatment modalities include surgical resection and adjuvant chemotherapy. However, the development of drug resistance in tumor cells to chemotherapeutic agents poses great challenges to anticancer treatment.

Methods: Bioinformatics analysis was used to screen the up-regulated genes in paclitaxel (PTX)-resistant TNBC cells.

Cost-Effectiveness and Cost-Utility Analysis of Tongxinluo Capsules Compared With Conventional Therapy for the Treatment of Acute Myocardial Infarction.

Aim: Tongxinluo (TXL) capsule, a traditional Chinese medicine compound, has proven effective in acute myocardial infarction (AMI), but its cost-effectiveness is unclear.

Methods: This economic evaluation utilized individual data from clinical trials to compare major adverse cardiac and cerebrovascular events (MACCEs) at 30 days and quality-adjusted life years (QALYs) at 1 year between an intervention group (TXL combined with conventional therapy) and the control group (placebo plus conventional therapy), from a healthcare perspective. A lifetime cost-utility analysis (CUA) was conducted using a Markov model, and sensitivity analyses were performed to evaluate the robustness of the results.

The Role of Endoplasmic Reticulum Stress in Polycystic Ovary Syndrome and Exploration of Potential Therapeutic Targets.

Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women. In recent years, endoplasmic reticulum (ER) stress has gained increasing attention in the pathogenesis of PCOS. This study aims to explore the potential role of ER stress in PCOS by constructing a predictive model based on ER stress-related genes, and further evaluate the characteristics of immune infiltration and screen potential drugs.

GSDME-dependent astrocyte pyroptosis promotes the progression of neuroinflammation in experimental cerebral malaria.

Cerebral malaria (CM), a life-threatening neurological complication of Plasmodium falciparum infection, is characterized by severe neuroinflammation and long-term neurological sequelae. Central nervous system inflammation, driven by brain-infiltrated CD8 T cells, represents a hallmark pathological feature of CM. In this study, we demonstrate that astrocytes, a critical component of the blood-brain barrier and neurovascular unit, exhibit a robust interferon-γ response during CM, facilitating CD8 T cell recruitment into the brain parenchyma and antigen presentation to these immune cells.

Involvement of mediodorsal thalamus and its related neural circuit in pain regulation in mice.

The mediodorsal thalamus (MD) constitutes an integral component of the medial nociceptive transmission system, although its precise role and related neural pathway in pain processing remains incompletely elucidated. While anatomical studies have confirm reciprocal projections between the MD and anterior cingulate cortex (ACC), the functional contribution of ACC-MD neural circuitry to nociceptive regulation has not yet been systematically investigated. In this study, we used immunohistochemistry, pharmacogenetic manipulations, and multidimensional behavioral assessments to investigate the role of the MD and ACC-MD pathway in pain modulation.

IGF2BP3 as a Novel Prognostic Biomarker and Therapeutic Target in Lung Adenocarcinoma.

RNA-binding proteins (RBPs), particularly IGF2BP3, play critical but underexplored roles in lung adenocarcinoma (LUAD). This study investigated IGF2BP3's clinical and functional significance using single-cell/RNA sequencing, validated by qPCR, Western blot, and immunohistochemistry. The results show IGF2BP3 was significantly upregulated in LUAD tissues and associated with advanced-stage, larger tumors, lymph node metastasis, and poor prognosis.

Development and validation of machine learning models to predict vertebral artery injury by C2 pedicle screws.

Purpose: Cervical 2 pedicle screw (C2PS) fixation is widely used in posterior cervical surgery but carries risks of vertebral artery injury (VAI), a rare yet severe complication. This study aimed to identify risk factors for VAI during C2PS placement and develop a machine learning (ML)-based predictive model to enhance preoperative risk assessment.

Methods: Clinical and radiological data from 280 patients undergoing head and neck CT angiography were retrospectively analyzed.

Predictors of infarction and outcomes in capsular warning syndrome: a retrospective observational study.

Background: Capsular warning syndrome (CWS), a rare subtype of transient ischemic attack, is associated with a high risk of progression to acute cerebral infarction. However, predictive factors for infarction and determinants of functional outcome remain inadequately defined.

Methods: In this retrospective study, we analyzed 89 CWS patients admitted between January 2021 and December 2024.

Transrectal Ultrasound-Guided Prostate Biopsy With and Without PSMA PET-Targeted Prostate Biopsy for Prostate Cancer Diagnosis.

Purpose: Transrectal ultrasound-guided prostate biopsy (TRUS-GB) is associated with the underdiagnosis of prostate cancer (PCa), and PSMA-PET-targeted prostate biopsy (PSMA-TB) may reduce the misclassification of PCa. The primary outcome was the accuracy of the two methods in identifying clinically significant prostate cancer (csPCa). The secondary outcomes included accuracy in identifying clinically insignificant PCa (insignPCa; GG1) and GG3 or greater tumors, cancer detection stratified by the previous biopsy status, and the detection rate of csPCa using the combination of PSMA-TB and TRUS-GB.

Association of 24-h Blood Pressure Pattern With Mortality in ICU Patients: A Multicenter Retrospective Study.

Blood pressure (BP) is a crucial component of the APACHE II scoring system for assessing the severity of illness in ICU patients, and it plays a pivotal role in predicting patient mortality. Based on fluctuations, the 24-h BP patterns of ICU patients can be categorized into dippers (10% ≤ the fall < 20%), extreme-dippers (fall ≥ 20%), non-dippers (0% ≤ the fall < 10%), and reverse-dippers (fall < 0%). This study aims to investigate whether there are statistically significant differences in ICU mortality, in-hospital mortality, 28-day mortality, and 1-year mortality among the dipper, non-dipper, extreme-dipper, and reverse-dipper groups.

[Holmium laser ω-shaped pre-transection of prostate apex with preservation of the bladder neck improves urinary continence and sexual function in BPH patients after HoLEP].

Objective: To investigate the effect of holmium laser ω-shaped pre-transection of the prostate apex (PTPA) with preservation of the bladder neck on the urinary continence and sexual function of the patients with BPH after transurethral holmium laser enucleation of the prostate (HoLEP).

Methods: This retrospective study included 165 cases of BPH undergoing holmium laser ω-shaped PTPA with preservation of the bladder neck following HoLEP from January 2018 to January 2023. We recorded and compared the baseline, perioperative and 12-month follow-up data on the patients, and evaluated their urination function using IPSS, maximum urinary flow rate (Qmax), postvoid residual urine volume (PVR), and quality of life (QOL) scores.

Attitudes of medical students towards abortion and their willingness to perform abortion: meta-analysis.

Background And Objectives: This study evaluates the opinion of medical students about abortion and their willingness to perform the abortion.

Methods: After a systematic review, meta-analyses of proportions were performed to achieve percent estimates of medical students' opinions about abortion and willingness to perform the abortion.

Results: 15 studies appraising 6341 medical students were included.

miR-365a-3p Alleviates Isoflurane-Induced Neuroinflammation and Cognitive Impairment by Targeting MyD88 to Inhibit NF-κB Signaling.

Isoflurane (ISO) exposure is associated with neuroinflammation and postoperative cognitive dysfunction (POCD) in aged populations, although the underlying mechanisms remain unclear. This study aimed to determine whether ISO-induced cognitive decline involves miR-365a-3p and its downstream signaling targets. Aged rats were exposed to ISO to establish a POCD model.