Stable Ultrabroad-Absorbing Radical Achieves Efficient NIR-II Photothermal Conversion via Facile Synthesis.

Inspired by the electron-withdrawing ability of nitroxide radicals, a novel open-shell material, EDOT-TPAO is reported, synthesized via one-step demethylation and oxidation of its closed-shell precursor, EDOT-TPAOMe. Time-dependent density functional theory calculations confirm an acceptor-donor-acceptor configuration of EDOT-TPAO where radical termini act as electron acceptors. This structural transformation narrows the optical bandgap from 2.

Revealing the Relationship between Interfacial Morphology Degradation and Unsatisfied Stability in Phenethylamine-Treated Perovskite Solar Cell.

The surface passivation with phenethylammonium halides has proven effective in reducing defect density and trap-assisted recombination, enabling outstanding efficiency in perovskite solar cells. Despite its promise, it is ambiguous whether this strategy can improve the stability of devices under rigorous conditions, such as light soaking and thermal aging. A critical issue is whether the interface is robust in structure and morphology under light illumination.

A copper-based single-atom material effectively controls plant diseases with nearly zero soil residue and low phytotoxicity.

A growing population necessitates the development of sustainable agriculture, which requires achieving atom economy in pesticide delivery, fertilization, and so on. To this end, we focus on single-atom materials (SAMs) to enhance atom utilization within agricultural systems. In this study, we report a novel pesticide for plants, a single-atom copper (Cu) formulation, by employing a precipitation-equilibrium-driven (K-driven) method to anchor Cu onto a calcium carbonate (CaCO) carrier.

Ultraviolet photodissociation of methanethiol (CHSH): revealing an S(D) atom elimination channel.

We report time-sliced velocity map imaging studies of the methyl (CH) and electronically excited sulfur (S(D)) fragments formed following the photoexcitation of jet-cooled CHSH molecules in the 2A'' ← X̃ A' absorption band (. at wavelengths in the range 190 ≤ ≤ 210 nm). Analyses of images of CH fragments in their = 0, 1 and 2 vibrational levels confirm the perpendicular parent transition dipole moment and prompt bond fission and show that the ground state SH(X) partners are formed with an inverted vibrational population distribution, peaking at = 2 at the shortest excitation wavelengths investigated.

Ouabain alleviates -triggered inflammatory responses through dual regulation of NLRP3 inflammasome activity and M1 macrophage polarization.

Introduction: () is a highly drug-resistant pathogen responsible for chronic pulmonary inflammation in humans. The cardiac glycoside ouabain exhibits broad anti-inflammatory effects in various disease models, but its therapeutic potential against -induced pneumonia remains unexplored.

Methods: We investigated the role of ouabain in -induced inflammation using and  models.

Effects of vitamin D supplementation combined with exercise on glucolipid metabolism in adults: A meta-analysis.

Evidence on vitamin D supplementation combined with exercise for glucolipid metabolism in adults remains inconclusive. This review synthesizes meta-analyses to evaluate their effects. Three databases were searched up to 1 May 2025.

Mechanistic insights into the T6SS of multi-drug-resistant and its role in competition and pathogenesis.

, an opportunistic pathogen, often encodes Type VI Secretion System (T6SS) genes. However, the specific functions of T6SS, particularly in the context of clinical strains, remain poorly understood. In this study, we characterize a multi-drug-resistant strain, AH54, which possesses a complete and functional T6SS, composed of a structural cluster and two homologous auxiliary clusters (Aux1 and Aux2).

In-situ-formed TCM-inspired dual-function nanocomposite hydrogel for intraoperative hemostasis and postoperative recurrence prevention in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, with high postoperative recurrence rates due to occult micrometastases or minimal residual disease, markedly worsening the prognosis for HCC patients. Current therapies lack effective strategies to prevent recurrence, while traditional Chinese medicine (TCM) shows potential in delaying HCC progression. Combining a hemostatic hydrogel with nanoparticle-based delivery of active TCM components provides a strategy to enhance tumor recurrence prevention.

Rational Design of an Organotellurium Chalcogen Bonding Catalyst for Azetidine Activation.

The application of chalcogen bonding catalysis has been largely confined to benchmark reactions due to the limited structural diversity and activating ability of the catalysts, especially those derived from tellurium. Herein, we present a group of rationally designed bis-telluronium catalysts and realize the first application of chalcogen bonding donor in catalyzing the [4 + 2] cycloaddition reaction between azetidines and non-activated alkenes or alkynes. This chemistry demonstrates excellent functional group tolerance and offers an efficient avenue to access the piperidine and tetrahydropyridine architectures in generally moderate-to-good efficiency.

Wireless Electrotactile System with Hydrogel-Based Electrodes for Conformal Tactile Interaction.

A wireless epidermal electrotactile interface is demonstrated through integration of skin-conformal electrodes and flexible circuitry, addressing existing limitations in haptic technology caused by mechanical mismatch and system-level integration challenges. This electrotactile system achieves low stimulation thresholds (<20 V) through optimized electrode-skin modulus matching and improved electrochemical interfaces, enabling pain-free tactile sensation generation across finger pads. The millimeter-scale architecture incorporates multiplexed stimulation channels that spatially map to ISO-standard Braille configurations, demonstrating 91.

Perfluorodecanoic Acid (PFDA) Disrupts Immune Regulation via the Toll-like Receptor Signaling Pathway in Zebrafish.

As there are a growing number of per- and polyfluoroalkyl substances (PFAS) alternative substitutes applied globally, it remains paramount to characterize their potential health risks. Perfluorodecanoic acid (PFDA) is the most common alternative PFAS detected in the environment; however, its toxic effects and underlying mechanism of action to aquatic biota remains unclear. In this study, we present evidence of PFDA-induced immunotoxicity and gain insight into underlying molecular mechanisms.

AEBP1 drives fibroblast-mediated T cell dysfunction in tumors.

T cell dysfunction enables tumor immune evasion, understanding its mechanism is crucial for improving immunotherapy. Here we show, by RNA-sequencing analysis of human colon adenocarcinoma and triple-negative breast cancer tissues, that expression of Adipocyte Enhancer-Binding Protein 1 (AEBP1) positively correlates with T cell dysfunction and indicative of unfavorable patient outcomes. Subsequent single-cell RNA sequencing identifies cancer-associated fibroblasts (CAF) as the primary AEBP1 source.

Ciprofloxacin Enhances RSL3-Induced Ferroptosis by Promoting Mitochondrial Zn Accumulation via the STING1-CAV2 Pathway.

Ciprofloxacin (CFX) is a broad-spectrum antibiotic belonging to the fluoroquinolone class, widely used to treat bacterial infections by inhibiting bacterial DNA replication. Ferroptosis, a form of regulated cell death, is characterized by lipid peroxidation on cellular and organelle membranes. Our previous studies demonstrated that ciprofloxacin inhibits erastin-induced ferroptosis by enhancing glutathione peroxidase 4 (GPX4) protein stability.

One-step solid phase reaction-induced hydroxyapatite/magnesian whitlockite bioceramics for enhanced bone regeneration.

Regenerative bioceramics for bone repair require an optimal balance of mechanical properties and osteogenic activity. Achieving this dual enhancement remains a significant challenge, particularly regarding the intrinsic properties of the ceramic. This study introduces a one-step solid-phase reaction strategy to generate new phase and nanostructure to enhance the performance of hydroxyapatite (HA) ceramic for bone repair.

Multi-omics reveals changes in astrocyte fatty acid metabolism during early stages of Alzheimer's disease.

Background: Although astrocytes are known to contribute to Alzheimer's disease (AD) progression, their dynamic molecular alterations remain poorly characterized, particularly in early stages of the disease.

Methods: We performed multi-omics profiling (transcriptomics, proteomics, spatial metabolomics) of astrocytes from APP/PS1 and WT mice to characterize dynamic changes during AD progression. To assess similar changes in early human AD, we analyzed single-nucleus RNA sequencing data from human samples.

Dynamic control of halide perovskite structures for tailored ferroelectric and second-order nonlinear optical functionalities.

Metal halide perovskites (MHPs) are rapidly developing as a class of versatile materials combining the exceptional optoelectronic characteristics with tunable ferroelectricity and nonlinear optical responses. Spanning across the three-dimensional, two-dimensional, and one-dimensional architectures, these materials have demonstrated exceptional structural diversity, providing immense opportunities for tailored property design. We start by referencing the classic oxide perovskites, sharing differences and similarities of these material systems.

An activator regulates the DNA damage response and anti-phage defense networks in Moraxellaceae.

DNA-damage chemicals, including many antibiotics, often induce prophage induction and phage outbreaks within microbial communities, posing a significant threat to bacterial survival. Moraxellaceae strains are clinically relevant due to their remarkable resistance to antibiotics and radiation. However, the cellular-level regulation mechanisms that underlie their DNA damage response and anti-phage defense remain extensively unexplored.

Development of a high-efficiency N-acetylneuraminic acid production platform through multi-pathway synergistic engineering.

The growing demand for N-acetylneuraminic acid (NeuAc) has driven the need for efficient and environmentally sustainable biomanufacturing processes. Microbial fermentation offers a promising route, yet optimizing cell factories with excellent phenotypes remains challenging. Here, we engineered Escherichia coli to enable high-efficiency co-utilization of glucose and glycerol.

A Pseudomonas aeruginosa endolytic muramidase targets cell-wall peptidoglycan in bacterial competition.

Pseudomonas aeruginosa is an opportunistic pathogen that frequently resides in multispecies communities. During chronic infections, P. aeruginosa employs a diverse arsenal of antibacterial weapons to complete with other bacteria for resources and space.

Mechanistic insights into Nipah virus 5' UTR functionality reveal an antiviral target.

The highly pathogenic Nipah virus (NiV), a World Health Organization priority pathogen with pandemic potential, remains a critical public health threat due to its capacity to cause fatal encephalitis and respiratory disease. Despite its 1998 emergence, no approved therapeutics exist against NiV infection, underscoring the urgent need to identify genomic regulatory elements as antiviral targets. Our study focuses on the extended 5' UTRs characteristic of NiV transcripts, a distinctive genomic feature whose functional significance remained enigmatic.

Distinct amyloid fibril structures formed by ALS-causing SOD1 mutants G93A and D101N.

Two hundred eight genetic mutations in SOD1 have been linked to amyotrophic lateral sclerosis (ALS). Of these, the G93A and D101N variants maintain much of their physiological function, closely resembling that of wild-type SOD1, and the SOD1-G93A transgenic mouse is the most extensively used mouse line in the study of ALS. In this study, we report two cryo-EM structures of amyloid fibrils formed by G93A and D101N mutants of SOD1 protein.

Probiotics derived sodium benzoate improves social behavior of offspring exposed in the maternal immune activation through regulation of histone lysine benzoylation in astrocytes.

Autism Spectrum Disorder (ASD) is a neurodevelopmental condition increasingly linked to microbiota-gut-brain axis dysregulation, yet the causal microbial mediators and molecular mechanisms remain elusive. Based on our previously published ASD cohort, we discovered that depletion of Lactobacillus species in children with ASD correlates with exacerbated gastrointestinal symptoms and social deficits. Maternal immune activation (MIA) during pregnancy has been established as a critical environmental risk factor for ASD.

Impact of Reactive Chlorine on Atmospheric Oxidative Capacity in a Snowy Polluted Environment.

Reactive chlorine species can significantly influence the formation of secondary air pollutants. Due to limited observational data, their contribution to haze formation in cold environments remains poorly constrained. In this study, we conducted field measurements of reactive chlorine species in snowy Northeast China, a region frequently affected by wintertime haze events.