Neonicotinoid Residues in Tea Products from China: Contamination Patterns and Implications for Human Exposure.

Neonicotinoids (NEOs) are a class of systemic insecticides widely used in agriculture owing to their high efficacy and selectivity. As one of the most globally consumed beverages, tea may represent a potential dietary source of pesticide residues. However, limited research has examined NEO contamination in tea and its implications for human exposure, highlighting the need for further investigation.

[Study of school influenza epidemic prediction based on Bayesian Structural Time Series model and multi-source data integration].

To analyze the spatiotemporal correlation between the surveillance data of influenza in students reported by medical institutions and school absenteeism due to illness, and evaluate the application of Bayesian Structural Time Series model (BSTS) in the prediction of school influenza epidemic. A total of 13 schools in Dapeng new district of Shenzhen were selected. The incidence data of influenza in schools in Shenzhen from January 1, 2015 to December 31, 2019 were collected from China Disease Control and Prevention Information System and the illness related school absentence data during this period were collected from Shenzhen Student Health Surveillance System, and the spatiotemporal correlation between the data from two systems was analyzed and compared.

Clinical features of a fatal case of acute encephalitis associated with a novel influenza H3N2 recombinant virus possessing human-origin H7N9 internal genes: a descriptive study.

Newly emerging or "re-emerging" influenza viruses have been regarded as a huge global threat to human public health. However, there are few reports of human deaths caused by newly emerging influenza viruses derived from pigs and poultry. Here, we described the clinical and virological features of a fatal encephalitis caused by a novel H3N2 reassortant virus generated from swine H3N2 and human H7N9 viruses.

Capsaicin Inhibits Ferroptosis through Facilitating SYVN1-Mediated Ubiquitination and Degradation of ACSL4.

As the primary active component of chili peppers, capsaicin (CAP) remains controversial regarding its potential carcinogenic effects. This study aimed to elucidate the role of capsaicin in tumor progression and its underlying molecular mechanisms. Cellular proliferation was assessed using MTT assay and soft-agar colony formation assay.

UMPlex™: a targeted next-generation sequencing primer design workflow.

We have developed a tailored next-generation sequencing (tNGS) panel, employing our innovative UMPlex™ primer design workflow, to enhance pathogen identification in clinical diagnostics. Through iterative experimentation and rigorous validation, we refined the primer design by excluding those with insufficient specificity or efficiency. To mitigate amplification challenges arising from pathogenic mutations, we implemented a strategy of using a minimum of two primer pairs per pathogen, ensuring redundancy and robust detection.

Genetic diversity of norovirus in Shenzhen Based on continuous surveillance from 2016 to 2022.

Introduction: Norovirus is a key pathogen of acute gastroenteritis and poses a significant burden on both the economy and public health. This study focuses on continuous monitoring of norovirus in Shenzhen, China, from 2016 to 2022, aiming to analyze the epidemic characteristics and genetic diversity of norovirus in the context of global sequence data.

Methods: The study was based on data collected from local sentinel hospitals.

2, 2', 4, 4'-tetrabromodiphenyl ether induces thyroid toxicity by targeting BRAF-mediated MEK-ERK-NIS pathway in human thyroid follicular epithelial cells.

2, 2', 4, 4'-tetrabromodiphenyl ether (BDE-47), one of the most abundant and toxic congeners of polybrominated diphenyl ethers (PBDEs), has been implicated in thyroid disorders, but its thyroid toxicity in human thyroid cells and underlying mechanisms remain unclear. Given the pivotal role of the V-Raf murine sarcoma viral oncogene homolog B (BRAF) and the downstream mitogen-activated protein kinase kinase (MEK)- signal-regulated kinase (ERK) pathway in cell proliferation, differentiation, cell cycle and thyroid functions, in this study, we constructed BRAF knockout (BRAF-KO) and overexpression (BRAF-OE) cell models using Nthy-ori 3-1 cells, to evaluate the effect of BDE-47 on human thyroid cells and explore the potential mechanisms. Our results showed that exposure to BDE-47 resulted in reduced cell viability, Gap 2 (G2)/mitosis (M) phase cell cycle arrest, enhanced cell migration, and decreased cell invasion.

Analysis of Epidemiological and Evolutionary Characteristics of Seasonal Influenza Viruses in Shenzhen City from 2018 to 2024.

The SARS-CoV-2 pandemic and the implementation of associated non-pharmaceutical interventions (NPIs) profoundly altered the epidemiology of seasonal influenza viruses. To investigate these changes, we analyzed influenza-like illness samples in Shenzhen, China, across six influenza seasons spanning 2018 to 2024. Influenza activity declined markedly during the SARS-CoV-2 pandemic compared with the pre-pandemic period but returned to or even exceeded pre-pandemic levels in the post-pandemic era.

An unsupervised cluster analysis of multimorbidity patterns in older adults in Shenzhen, China.

Background: Population aging challenges health care systems due to the high prevalence and impact of multimorbidity in older adults. Studies on multimorbidity in Shenzhen have primarily focused on the quantity of multimorbidity, lacking in-depth exploration of multimorbidity patterns.

Methods: Based on baseline data from the Shenzhen aging-related disease cohort, this study analyzed information from 8,911 people aged 60 and above after excluding missing and abnormal values from interview results.

AdipoRon attenuates steatosis, inflammation and fibrosis in murine diet-induced NASH via inhibiting ER stress.

Aim: The rising global prevalence of obesity has accelerated the incidence of metabolic dysfunction-associated steatotic liver disease (MASLD), with nonalcoholic steatohepatitis (NASH) representing its progressive and life-threatening phenotype. Despite its clinical urgency, no pharmacotherapy is currently approved for NASH. AdipoRon, an orally active adiponectin receptor agonist, exhibits dual regulatory effects on glucose/lipid homeostasis alongside anti-inflammatory and antioxidant properties.

Cumulative handgrip strength and longitudinal changes in cognitive function and daily functioning among people aged 50 years and older: evidence from two longitudinal cohort studies.

Background And Purpose: Our study assesses the association between cumulative handgrip strength and longitudinal changes in cognitive function and daily functioning.

Methods: Two comparative cohort studies were used, including the English Longitudinal Study of Ageing (ELSA) and the Survey of Health, Ageing and Retirement in Europe (SHARE). Cumulative handgrip strength was calculated using three repeated measurements of handgrip strength.

Decorative cosmetics and skin care products contribute significantly to short-chain perfluoroalkyl carboxylates exposure.

Research on dermal exposure of per- and polyfluoroalkyl substances (PFAS) in personal care products is limited. Here, we investigated the permeation of 14 PFAS using in vitro 3D-human skin equivalents (3D-HSE). Results revealed that perfluorobutanoic acid (PFBA) exhibited the highest cumulative permeation, while perfluorotetradecanoic acid (PFTeDA) showed the lowest.

Organ-specific lithium accumulation and its toxic effects on female reproduction.

Li exposure is becoming a new prominent major issue in energy-environment-health field. However, its reproductive health risk has been less explored. In this study, we find that exposure to 28-fold REED (really environmental exposure dose) of Li is enough to induce mouse miscarriage by altering the structures and functions of placenta.

Exploring monkeypox virus antibody levels: insights from human immunological research.

Monkeypox(mpox) is a zoonotic disease caused by the monkeypox virus (MPXV), which was previously endemic to West and Central Africa. However, it has recently appeared in several non-endemic countries beyond Africa. On July 23, 202 WHO declared mpox outbreak a public health emergency of international concern, a declaration reaffirmed on August 14, 2024.

Inhibition of Cathepsin B Ameliorates Murine Cognitive Dysfunction and Neuronal Damage in Ischemic Stroke by Inhibiting Mitochondrial Apoptosis and Drp1-Mediated Mitochondrial Fission.

The surviving brain tissue undergoes secondary degeneration long after an ischemic stroke. Cathepsin B plays dual roles as both a scavenger and an executor. Using a mouse model of ischemic stroke, we specifically investigated the mechanism by which inhibiting Cathepsin B with CA074 methyl ester (CA-074Me) during the chronic phase of stroke exerts a protective effect.

Chronic BPAF exposure differentially enhances fat deposition in mice fed normal or high-fat diets via lipid metabolism dysregulation.

Background: Bisphenol AF (BPAF), an alternative to Bisphenol A (BPA), is increasingly utilized in various industrial applications, yet its toxicological profile remains incompletely understood. This study aims to investigate the impact of BPAF exposure on obesity and lipid metabolism in male mice subjected to either a normal chow diet (ND) or a high-fat diet (HFD).

Methods: Mice were exposed to BPAF at a concentration of 100 μg/kg every other day for five months under different dietary conditions, and body weight, rectal temperature, and food intake were monitored regularly.

The significance of assessing the weight-adjusted-waist index (WWI) in patients with depression: a systematic review and meta-analysis.

Background: Obesity is recognized as a potential risk factor for depression, a prevalent psychiatric disorder that adversely impacts the health of adults globally. Based on this premise, the current study systematically examined the weight-adjusted-waist index (WWI), a more comprehensive measure of obesity, in individuals diagnosed with depression.

Method: Following PRISMA guidelines, a thorough search was conducted across five online databases: PubMed, Scopus, Embase, ScienceDirect, and Web of Science.

N-methyl-D-aspartate receptors (NMDARs): a glutamate-activated cation channel with biased signaling and therapeutic potential in brain disorders.

N-methyl-D-aspartate receptors (NMDARs) are a class of calcium-permeable ion channel that are extensively distributed throughout the body, composed of various subunits. The presence of diverse ligands and subcellular localizations of the receptors confers biased signaling and distinct functional roles. Activation of the NMDARs induces calcium influx, which plays a pivotal role in neurotransmitter release, synaptic plasticity, and intracellular signaling.

Path analysis of trace elements and physiological and biochemical indices associated to mild cognitive impairment in elderly Chinese.

The intricate relationships between cognitive function and a broad spectrum of trace elements and physiological and biochemical indices remain unclear. This study aimed to employ a path analysis model to investigate the effects of multiple trace elements and physiological and biochemical factors on mild cognitive impairment (MCI) among elderly Chinese. A total of 5768 residents aged 60 years and older were recruited in Shenzhen, China.

Asparagine endopeptidase cleaves apolipoprotein A1 and accelerates pathogenesis of atherosclerosis.

Atherosclerosis is a slowly progressing inflammatory disease characterized with cholesterol disorder and intimal plaques. Asparagine endopeptidase (AEP) is an endolysosomal protease that is activated under acidic conditions and is elevated substantially in both plasma and plaques of patients with atherosclerosis. However, how AEP accelerates atherosclerosis development remains incompletely understood, especially from the view of cholesterol metabolism.

Luteolin: A potential therapeutic agent for respiratory diseases.

Acute lung injury, COVID-19, lung cancer, and asthma are a few of the respiratory conditions that are the main causes of morbidity and mortality worldwide. The increasing incidence and mortality rates have attracted significant attention to the prevention and treatment of these conditions. In recent years, there has been a renewed interest in utilizing naturally derived compounds as therapeutic agents for respiratory diseases.

Associations between seminal plasma metal mixture and semen quality: A metabolome-mediated case-control study.

Metal exposure constitutes a global public health concern associated with male infertility. This matched case-control study advances mechanistic understanding of how environmental pollutants interact with biological systems to impair human reproduction by investigating multi-metal exposure and seminal plasma metabolic responses. Based on this matched case-control study among 522 males, we assessed the role of untargeted metabolomic profiling of 265 seminal plasma metabolites in the relationship between seminal metals and abnormal semen quality (ASQ).

Dietary inflammatory index and Alzheimer's disease mortality in a prospective cohort.

Objective: This study examined the relationship between the Dietary Inflammatory Index (DII) and Alzheimer's disease (AD) mortality in US adults.

Methods: Data from 45,093 participants in the 1988-2014 National Health and Nutrition Examination Survey (NHANES) were analyzed, with mortality follow-up through December 2019. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) for AD mortality.