Reconstruction of Provenance and Paleo-Sedimentary Environment of the Saihan Formation in the Manglai Uranium Deposit, Central-Eastern Erlian Basin, China.

The Manglai uranium deposit is located in the Tabei Sag within the Manit Depression, centrally positioned in the eastern Erlian Basin at the core of an ancient valley uranium metallogenic belt. This study analyzed the geochemical properties of 22 clastic and mudstone samples from the Lower Cretaceous Saihan Formation in the Manglai deposit to assess its tectonic setting, provenance direction, redox conditions, and paleoclimatic environment. Key findings reveal that (1) The primary sediment source of the Saihan Formation in the Manglai deposit consists of felsic igneous rocks, situated mainly in a passive continental margin setting.

2, 2', 4, 4'-tetrabromodiphenyl ether induces thyroid toxicity by targeting BRAF-mediated MEK-ERK-NIS pathway in human thyroid follicular epithelial cells.

2, 2', 4, 4'-tetrabromodiphenyl ether (BDE-47), one of the most abundant and toxic congeners of polybrominated diphenyl ethers (PBDEs), has been implicated in thyroid disorders, but its thyroid toxicity in human thyroid cells and underlying mechanisms remain unclear. Given the pivotal role of the V-Raf murine sarcoma viral oncogene homolog B (BRAF) and the downstream mitogen-activated protein kinase kinase (MEK)- signal-regulated kinase (ERK) pathway in cell proliferation, differentiation, cell cycle and thyroid functions, in this study, we constructed BRAF knockout (BRAF-KO) and overexpression (BRAF-OE) cell models using Nthy-ori 3-1 cells, to evaluate the effect of BDE-47 on human thyroid cells and explore the potential mechanisms. Our results showed that exposure to BDE-47 resulted in reduced cell viability, Gap 2 (G2)/mitosis (M) phase cell cycle arrest, enhanced cell migration, and decreased cell invasion.

Advancements in AI-driven drug sensitivity testing research.

Antimicrobial resistance (AMR) constitutes a significant global public health challenge, posing a serious threat to human health. In clinical practice, physicians frequently resort to empirical antibiotic therapy without timely Antimicrobial Susceptibility Testing (AST) results. This practice, however, may induce resistance mutations in pathogens due to genetic pressure, thereby complicating infection control efforts.

Nonlinear relationship between triglyceride-glucose index and cardiovascular mortality with competing risk analysis on populations aged 18-80 years.

Background: The existing evidence regarding the relationship between the triglyceride-glucose index (TyG index) and cardiovascular mortality risk remains relatively limited and controversial, particularly within the context of competing risk scenarios. This study seeks to investigate this relationship, while further incorporating the impact of non-cardiovascular mortality as a competing risk event to this association.

Methods: Data of eligible participants were extracted from National Health and Nutrition Examination Surveys (NHANES) 1999-2018.

Emergence of a clinical Salmonella enterica serovar 1,4,[5], 12: i:-isolate, ST3606, in China with susceptibility decrease to ceftazidime-avibactam carrying a novel bla variant and a bla.

Purpose: The detection rate of Salmonella enterica serovar 1,4,[5], 12: i: - (S. 1,4,[5], 12: i: -) has increased as the most common serotype globally. A S.

A High-Resolution Linkage Map Construction and QTL Analysis for Morphological Traits in Anthurium ( Linden).

Linden is a prominent ornamental plant belonging to the family Araceae and is cultivated worldwide. The morphology characteristics are crucial because they significantly impact ornamental values, commercial properties, and the efficiency of space utilization in production. However, only a few related investigations have been conducted in anthurium to date.

SV channel VfTPC1 is a hyperexcitable variant of plant vacuole Two Pore Channels.

To fire action-potential-like electrical signals, the vacuole membrane requires the two-pore channel TPC1, formerly called SV channel. The TPC1/SV channel functions as a depolarization-stimulated, non-selective cation channel that is inhibited by luminal Ca. In our search for species-dependent functional TPC1 channel variants with different luminal Ca sensitivity, we found in total three acidic residues present in Ca sensor sites 2 and 3 of the Ca-sensitive AtTPC1 channel from that were neutral in its ortholog and also in those of many other Fabaceae.

Association of triglyceride-glucose index and neutrophil-to-lymphocyte ratio with coronary artery disease.

Objective: The present study aimed to investigate the association of triglyceride-glucose (TyG) index and neutrophil-to-lymphocyte ratio (NLR) with coronary artery disease (CAD), and evaluate the cumulative value of TyG index and NLR in identifying CAD, as well as the severity of CAD.

Methods: This retrospective study enrolled 2867 patients who underwent coronary angiography (CAG) for the first time between January 2013 and June 2022 in Zhongnan Hospital of Wuhan University. There were 2109 patients with CAD and 758 patients without CAD.

Diagnostic value of aldo‑keto reductase family 1 member B10 in human nasopharyngeal carcinoma.

Aldo-keto reductase family 1 member B10 (AKR1B10) is a potential marker of several types of cancer; however, the role of AKR1B10 in nasopharyngeal carcinoma (NPC) remains unclear. In the present study, AKR1B10 RNA-seq data and clinical information were obtained from The Cancer Genome Atlas head and neck squamous cell carcinoma (HNSCC) database to evaluate the role of AKR1B10 in HNSCC. There was no statistically significant difference in the expression of AKR1B10 between HNSCC tissues and adjacent normal tissues, and high AKR1B10 expression was not associated with poor overall survival according to the public database.

MIB-derived odor management based upon hydraulic regulation in small drinking water reservoirs: Principle and application.

The musty odorant (2-methylisoborneol, MIB) is prevalent in source water reservoirs and has become one of the major challenges for drinking water quality. This study proposes an approach to control the growth of MIB-producing cyanobacteria in a small reservoir based on hydraulic regulation, according to the results of long-term field investigations, laboratory culture experiments, model construction, and field application. Field investigations found that longer hydraulic retention time (HRT) is a factor that triggers MIB episodes.

Driving forces for the growth of MIB-producing Planktothricoides raciborskii in a low-latitude reservoir.

In comparison with the middle- and high-latitude regions, the low-latitude regions are less associated with the occurrence of 2-methylisoborneol (MIB) episodes, since most of the previously identified MIB producers favor moderate/low light/temperature conditions. Here, we report a serious MIB outbreak over the period from Jul. 2018 to Jun.

Molecular basis of multistep voltage activation in plant two-pore channel 1.

Voltage-gated ion channels confer excitability to biological membranes, initiating and propagating electrical signals across large distances on short timescales. Membrane excitation requires channels that respond to changes in electric field and couple the transmembrane voltage to gating of a central pore. To address the mechanism of this process in a voltage-gated ion channel, we determined structures of the plant two-pore channel 1 at different stages along its activation coordinate.

Evaluation of the MIB-producing potential based on real-time qPCR in drinking water reservoirs.

Cyanobacteria release 2-methylisoborneol (MIB) as a secondary metabolite. Here, we propose a reverse transcription quantitative real-time PCR (RT-qPCR) based method to evaluate the MIB-producing potential in source water by detecting the MIB-synthesis gene (mic). A MIBQSF/R primer set was designed based on 35 mic gene sequences obtained from 12 pure-cultured MIB-producing strains and 23 sequences from the NCBI database.

Ecological niche and in-situ control of MIB producers in source water.

Odor problems in source water caused by 2-methylisoborneol (MIB) have been a common issue in China recently, posing a high risk to drinking water safety. The earthy-musty odorant MIB has an extremely low odor threshold (4-16 ng/L) and is hard to remove via conventional processes in drinking water plants (DWP), and therefore could easily provoke complaints from consumers. This compound is produced by a group of filamentous cyanobacteria, mainly belonging to Oscillatoriales.

Diabetes Mellitus and COVID-19: Associations and Possible Mechanisms.

Coronavirus disease 2019 (COVID-19) is a recently emerged disease with formidable infectivity and high mortality. Emerging data suggest that diabetes is one of the most prevalent comorbidities in patients with COVID-19. Although their causal relationship has not yet been investigated, preexisting diabetes can be considered as a risk factor for the adverse outcomes of COVID-19.

Retraction of "MICAL2 Mediates p53 Ubiquitin Degradation through Oxidating p53 Methionine 40 and 160 and Promotes Colorectal Cancer Malignance".

[This retracts the article DOI: 10.7150/thno.28228.

Investigation and Analysis of 108 Cases of Home Isolated Patients With Mild COVID-19.

Background: Coronavirus disease 2019 (COVID-19) began to spread across Wuhan, China, by the end of 2019, and patients were unable to be hospitalized because medical resources were limited.

Methods: A questionnaire survey was conducted among 108 participants with mild COVID-19 who have isolated at home under the guidance of doctors. The results of the questionnaire and outpatient data were integrated to evaluate participants' compliance with various epidemic prevention measures.

Voltage-dependent gating of SV channel TPC1 confers vacuole excitability.

In contrast to the plasma membrane, the vacuole membrane has not yet been associated with electrical excitation of plants. Here, we show that mesophyll vacuoles from Arabidopsis sense and control the membrane potential essentially via the K-permeable TPC1 and TPK channels. Electrical stimuli elicit transient depolarization of the vacuole membrane that can last for seconds.

Nuclear factor-erythroid 2-related factor 3 (NRF3) is low expressed in colorectal cancer and its down-regulation promotes colorectal cancer malignance through activating EGFR and p38/MAPK.

Nuclear factor-erythroid 2-related factor 3 (NRF3), a nuclear transcription factor, has been implicated in various cellular processes including carcinogenesis. However, mechanisms underlying its regulation in carcinogenesis are unclear. Herein, we found that NRF3 is lowly expressed in colorectal cancer (CRC) tissues and cells, and NRF3 low-expressions in CRC tissue samples are associated with CRC carcinogenesis and poor patient outcomes.

MICAL2 Mediates p53 Ubiquitin Degradation through Oxidating p53 Methionine 40 and 160 and Promotes Colorectal Cancer Malignance.

Molecule interacting with CasL2 (MICAL2), a microtubule-associated monooxygenase, is highly expressed in various cancers and is involved in cancer pathogenesis, but the mechanisms underlying its regulation in carcinogenesis are unclear. In this study, we aim to clarify the mechanism by which MICAL2 participates in colorectal cancer (CRC) and identify novel markers for predicting prognosis of CRC patients. Methods: The value of MICAL2 in CRC prognosis was determined by immunohistochemical analysis of a CRC biopsy array.

MNAT1 is overexpressed in colorectal cancer and mediates p53 ubiquitin-degradation to promote colorectal cancer malignance.

Background: MNAT1 (menage a trois 1, MAT1), a cyclin-dependent kinase-activating kinase (CAK) complex, high expresses in various cancers and is involved in cancer pathogenesis. However, mechanisms underlying its regulation in carcinogenesis are unclear.

Methods: The tissue microarray of colorectal cancer (CRC) was used to evaluate MNAT1 expressions in CRC tissues using immunohistochemistry, CRC cell lines were also detected MNAT1 expression using Western-blotting.

Dinitrosopiperazine-decreased PKP3 through upregulating miR-149 participates in nasopharyngeal carcinoma metastasis.

Nasopharyngeal carcinoma (NPC) has a high metastatic clinicopathological feature. As a carcinogen factor, N,N'-dinitrosopiperazine (DNP) is involved in NPC metastasis, but its precise mechanism has not been fully elucidated. Herein, we showed that DNP promotes NPC metastasis through upregulating miR-149.