Prediction of favorable outcomes of acute basilar artery occlusion using machine learning.

Background: This study aims to develop an interpretable machine learning model using SHapley Additive exPlanations (SHAP) to predict favorable outcomes based on clinical, imaging, and angiographic data.

Methods: This study analyzed data from 184 patients with acute basilar artery occlusion (BAO) who underwent endovascular treatment (EVT) and completed a 90-day follow-up at Shanxi Provincial People's Hospital. A total of 68 medical variables were collected to develop predictive models using three machine learning algorithms: logistic regression (LR), support vector machine (SVM), and Light Gradient Boosting Machine (LightGBM).

Persistent burden and health inequalities of disease in women of childbearing age attributable to Intimate Partner Violence, 1990-2021.

Aims: Intimate Partner Violence (IPV) presents a significant global public health issue, particularly affecting women of childbearing age (WBCA). The COVID-19 pandemic has exacerbated the IPV globally. This study aimed to assess the global burden and health inequalities attributable to IPV among WBCA from 1990 to 2021.

Smart microenvironment-activatable silybin nano-prodrug for precise NIR-II fluorescence monitoring and on-demand therapy of acute liver injury.

Acute liver injury (ALI) is a serious disease characterized by liver function impairment caused by multiple causes in a short period of time. Due to lack of precise diagnosis and timely intervention, many patients with ALI rapidly progress to liver dysfunction and liver failure. Here, a multifunctional silybin nano-prodrug, PTS@IR, was developed that integrated microenvironment-activatable second near-infrared (NIR-II) fluorescence (FL) imaging for precise diagnosis and timely therapy of ALI.

Network toxicological insights into DEHP exposure and thyroid cancer development and progression.

This study aimed to identify markers of di-2-ethylhexyl phthalate (DEHP) exposure associated with thyroid cancer occurrence and prognosis by integrating network toxicology and molecular docking. Expression profiles and clinical information were obtained from TCGA-THCA and five GEO datasets (GSE3467, GSE3678, GSE33630, GSE53157, and GSE60542). Venn diagram analysis revealed six overlapping genes (CYP1B1, ABCC3, KRT19, CUX2, GABRB2, and TNFSF15) between the combined dataset and DEHP's target genes.

Exploration of the distribution of intestinal bacteria in mice under normal and intestinal leakage (IBD) conditions.

The distribution of micro-organisms in healthy organisms remains a subject of debate. Emerging evidence revealed the colonization of microbial communities in multiple anatomical sites previously considered sterile under homeostatic conditions. However, the mechanistic relationship between compromised intestinal epithelial barrier integrity and subsequent translocation of gut-resident bacteria into systemic circulation has yet to be comprehensively elucidated.

Near-infrared laser-activated PLGA-PDA core-shell nanohybrids for synergistic photothermal antibacterial therapy and sustained ion release in orthodontic white spot lesions prevention.

Objective: To develop near-infrared (NIR) laser-activated PLGA-PDA core-shell nanohybrids encapsulating Ag/CuO nanoparticles for simultaneous photothermal antibacterial therapy and sustained Ag/Cu release, and to evaluate their bactericidal efficacy against Streptococcus mutans and preventive potential in orthodontic white spot lesions.

Methods: Ag/CuO nanoparticles were encapsulated in PLGA/PDA nanospheres via a double-emulsion and self-polymerization approach. The resulting core-shell particles were fully characterized for composition, size distribution, zeta potential, morphology, photothermal performance, release kinetics, and cytocompatibility.

Experimental investigation of retinal injury following endocryocoagulation in a rabbit model.

The aim of this study is to evaluate the effects of varying endocryocoagulation parameters on retinal function and histological integrity in a rabbit model and to assess the feasibility of intraocular foreign body (IOFB) removal using a 20G cryoprobe. Twenty-seven adult New Zealand white rabbits were randomly assigned to three experimental groups (n = 9 per group). Endocryocoagulation was administered with a 20G cryoprobe under different conditions: Group An underwent vitreous cavity freezing for 5 s; Group B underwent retinal surface freezing for 5 s; and Group C underwent vitreous cavity freezing for 10 s.

Resin Infiltration for Dental Fluorosis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials on Esthetic Masking Efficacy.

Objective: This systematic review and meta-analysis aimed to evaluate the color masking efficacy of resin infiltration (RI) in the management of dental fluorosis.

Materials And Methods: A comprehensive literature search was conducted to identify eligible randomized controlled trials (RCTs) comparing RI to other minimally invasive techniques, including bleaching, microabrasion, remineralization (PROSPERO Registration: CRD42025635311). Primary outcomes were improvement in stain coverage (SC) and esthetic improvement (EI), both evaluated using the Visual Assessment Scale (VAS), as well as color differences (ΔE) measured by colorimetry.

Mitochondria-immobilized fluorescent probes for viscosity and cellular imaging.

A mitochondria-immobilized fluorescent probe Mito-CDM was designed and synthesized for viscosity sensing via the twisted intramolecular charge transfer (TICT) mechanism. The N,N-diethylaminophenyl group is the viscosity-sensitive unit in the prepared Mito-CDM molecular structure, while the pyridinium cation is the mitochondria-targeting group that is responsible for monitoring mitochondrial viscosity. As the viscosity increased from 0.

Post-marketing safety monitoring of RSV vaccines: A real-world study based on the Vaccine Adverse Event Reporting System (VAERS).

Two protein subunit vaccines - RSVPreF3 (Arexvy, GSK) and RSVpreF (Abrysvo, Pfizer) - and one mRNA RSV vaccine, mRNA-1345 (mRESVIA, Moderna), have been approved. Post-marketing surveillance is crucial for evaluating the safety of RSV vaccines. We reviewed VAERS reports on RSV vaccines, using the Reporting Odds Ratio (ROR) and Bayesian Confidence Propagation Neural Network (BCPNN) to identify safety signals.

Perceived prevalence, risk factors, and reported management of delirium in critically ill emergency patients: a survey of physicians in China.

Purpose: To investigate Chinese emergency physicians' perceptions of prevalence, associated risk factors, and reported management practices for delirium in critically ill emergency department (ED) patients.

Methods: A cross-sectional survey of 402 physicians from EDs across 18 Chinese provinces.

Results: Physician-estimated delirium prevalence varied widely (median: 15%; interquartile range: 10%-30%), with most perceiving higher incidence during night shifts.

Irisin improves acute kidney injury induced by ischemia-reperfusion through targeting energy metabolism reprogramming.

The kidney possesses a highly complex reabsorption function, with tubular epithelial cells (TECs) being the primary functional units. The TECs mainly rely on fatty acid oxidation (FAO) for energy supply. FAO is hindered during ischemia-reperfusion (I/R)-induced acute kidney injury (AKI), leading to impairments in oxidative phosphorylation.

Natural History and Outcomes of Deep-seated Brain Arteriovenous Malformations: a Propensity Score Matched Analysis Using Nationwide Multicenter Prospective Registry Data.

Objectives: This study aims to evaluate the natural history of deep-seated brain arteriovenous malformation (AVMs), as well as the risk-benefit outcomes of interventional treatment versus conservative management.

Materials & Methods: Patients with deep-seated AVMs were selected from a nationwide prospective multicenter registry study in China (the MATCH study), and univariate and multivariate analyses were conducted to identify factors associated with AVM rupture. In the analysis of outcomes, propensity score matching (PSM) was performed between the interventional and conservative treatment groups, adjusting for baseline differences.

Predicting acupuncture efficacy for neck pain based on functional connectivity features: a machine learning study.

Objective: To explore the mechanisms of acupuncture-induced neck pain relief and identify appropriate candidates using neuroimaging and machine learning techniques.

Methods: Eighty neck pain patients were included, with clinical data and functional magnetic resonance imaging scans collected pre- and post-treatment. A support vector machine (SVM) model was built using pre-treatment brain functional connectivity to predict acupuncture responsiveness, identifying key features as potential biomarkers for effectiveness.

Endovascular Therapy Versus Medical Management for Large Ischemic Infarct: 1-Year Outcomes of the ANGEL-ASPECT Trial.

Background: Several trials have shown the benefit and safety of endovascular therapy (EVT) compared with medical management (MM) of patients with a large ischemic core in the 90-day follow-up. However, the 1-year outcome comparison between EVT and MM in Asian patients with a large ischemic core has not been investigated. Our aim was to evaluate the 1-year outcomes of patients in the ANGEL-ASPECT trial (Endovascular Therapy in Acute Anterior Circulation Large Vessel Occlusive Patients with a Large Infarct Core).

MiR-145-5p arrests the cell cycle by modulating SMAD5/cyclin D1 to inhibit gastric cancer progression.

Purpose: This study aimed to explore the dysregulation of miR-145-5p in gastric cancer (GC) and its effects on the proliferation and cell cycle of GC cells, exploring the potential regulatory mechanism of miR-145-5p in GC.

Methods: In this study, the TCGA database combined with Microarray was used to detect differentially expressed microRNA (miRNA) in GC tissues and cells. Quantitative real-time (qRT)-PCR was used to further verify the expression of miR-145-5p in GC cells and the 41 pairs of GC tissues and adjacent tissues.

Evolution of polycystic ovary syndrome and related infertility in women of child-bearing age: A global burden of disease study 2021 analysis.

Background: Understanding the epidemiological trends of polycystic ovary syndrome (PCOS) and related-infertility among women of childbearing age (WCBA) is crucial for developing effective public health strategies. This study aims to analyze epidemiological trends of PCOS and related infertility among WCBA using Global Burden of Disease (GBD) study 2021.

Methods: Using GBD Study 2021, this study examined trends of PCOS and related infertility among WCBA across global, age, regional, national, and socio-demographic index (SDI) levels from 1990 to 2021, and projected the prevalence to 2050.

Association between creatinine-to-albumin ratio and mortality in intracerebral hemorrhage: a superior predictive indicator.

Background: Intracerebral hemorrhage is a severe and devastating condition with a high mortality rate worldwide. While creatinine and albumin levels have been studied individually, the prognostic value of the creatinine-to-albumin ratio in predicting mortality in intracerebral hemorrhage patients remains underexplored.

Methods: We performed a retrospective cohort study of intracerebral hemorrhage patients from West China Hospital of Sichuan University (December 2010-July 2019) and The First People's Hospital of Longquanyi District, Chengdu (January 2017-October 2020).

MACC1 drives metastasis in colorectal cancer by coordinating YKT6-dependent exosome biogenesis and c-Met cargo selection.

Colorectal cancer metastasis remains a major cause of cancer-related mortality, with the Metastasis-Associated in Colon Cancer 1 (MACC1) protein emerging as a critical regulator of tumor progression. Although exosomes are recognized mediators of oncogenic communication, the interplay between MACC1 and exosome biology is yet to be fully explored. This study unveils a dual mechanism through which MACC1 coordinates exosome biogenesis and oncogenic cargo delivery to drive metastatic progression.

Macrophage Zc3h12c Limits Tissue Inflammation and Injury via Alternative Splicing of Pre-mRNA.

RNA-binding proteins regulate post-transcriptional gene translation, but the macrophage-specific role of Zc3h12c remains poorly characterized. Here, the role of Zc3h12c in macrophages is characterized using Tnfrsf11a-Zc3h12c mice. Both Tnfrsf11a and Zc3h12c are highly expressed in the kidney tissue from patients with chronic kidney disease and showed a positive association with an interstitial fibrosis score.

Machine learning-based construction of Immunogenic cell death-related score for improving prognosis and personalized treatment in glioma.

Immunogenic cell death (ICD) is capable of activating both innate and adaptive immune responses. In this study, we aimed to develop an ICD-related signature in glioma patients and facilitate the assessment of their prognosis and drug sensitivity. Consensus clustering and non-negative matrix factorization (NMF) were performed to classify patients into subgroups.

Expression of GSDMs in glioma and its influence on prognosis.

Despite extensive research on therapeutic targets for glioma, progress has been limited by ineffective treatments. Our aim was to analyze gasdermin (GSDM) family expression, mutations, and clinical relevance in glioma to support clinical decision-making and risk assessment. Glioma specimens were procured from The Cancer Genome Atlas for the purpose of conducting gene expression profile interaction analysis and human protein mapping using various bioinformatics tools, including gene expression profiling interactive analysis, Human Protein Atlas, Kaplan-Meier plotters, cBioPorta, LinkedOmics, database for annotation, visualization and integrated discovery, and R Software.

Effects of BPAF exposure on endometrial remodeling: A focus on the homeostasis of the extracellular matrix and the immune status.

Bisphenol AF (BPAF), a substitute for bisphenol A (BPA), is frequently found in the environment and daily necessities and has garnered significant attention due to its endocrine-disrupting effects. Uterus is a potential target of BPA while more evidences about BPAF are needed, especially at human-relevant levels. The aim of this study was to determine the effects of BPAF exposure with realistic human exposure pathway and dosage on the uterus, as well as to explore its molecular mechanisms through transcriptome sequencing (RNA-seq) and alternative splicing (AS) analysis.

Contrast-enhanced CT-based deep learning model assists in preoperative risk classification of thymic epithelial tumors.

Background: This study aimed to develop and evaluate a deep learning (DL) model utilizing contrast-enhanced computed tomography (CT) to assist radiologists in accurately stratifying the risk of thymic epithelial tumors (TETs) based on the World Health Organization (WHO) classification.

Methods: Involved retrospectively enrolling clinical data from 266 patients with histopathologically confirmed TETs from two centers: Center 1 (training set, n=205) and Center 2 (external testing set, n=61). Six DL models (DenseNet 121, ResNet 101, Inception V3, VGG 11, MobileNet V2, and ShuffleNet V2) were developed and evaluated using venous-phase CT images, alongside a traditional radiomic model using a support vector machine (SVM) for comparison.

Neuroactive network tissue based on dual-factor neuroregenerative bioactive coating scaffolds and neural stem cells for spinal cord injury repair.

Spinal cord injury (SCI) results in sensory and motor dysfunction, with neuronal death, circuit disruption, and the inhibitory microenvironment serving as key limitations to effective treatment. In this study, we developed a neuroactive network tissue for SCI repair by immobilizing dual recombinant growth factors based on biomimetic mussel adhesive units onto an oriented electrospun nanofiber scaffold, and seeding neural stem cells (NSCs) onto the scaffold. This dual-factor system continuously stimulates and enhances the paracrine function of NSCs, promoting repair of the injury site.