Resin Infiltration for Dental Fluorosis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials on Esthetic Masking Efficacy.

Objective: This systematic review and meta-analysis aimed to evaluate the color masking efficacy of resin infiltration (RI) in the management of dental fluorosis.

Materials And Methods: A comprehensive literature search was conducted to identify eligible randomized controlled trials (RCTs) comparing RI to other minimally invasive techniques, including bleaching, microabrasion, remineralization (PROSPERO Registration: CRD42025635311). Primary outcomes were improvement in stain coverage (SC) and esthetic improvement (EI), both evaluated using the Visual Assessment Scale (VAS), as well as color differences (ΔE) measured by colorimetry.

Recent trends and future perspectives of emergent analytical techniques for methamphetamine sensing.

Methamphetamine (METH) is one of the most widely abused illicit synthetic drugs globally, necessitating the development of rapid detection technologies. Conventional instrumental analytical methods are costly and cumbersome to perform. Sensors have emerged as a research hotspot, and METH detection sensors can be categorized into six types based on the signal energy form, recognition mode, and detection principles: colorimetric sensors, fluorescent sensors, surface-enhanced Raman sensors, surface plasmon resonance sensors, electrochemical sensors, and electrochemiluminescent sensors.

Identification and expression analysis of cinnamyl CoA reductase gene family and function of in potato ( L.).

Cinnamoyl-CoA reductase (CCR), a key rate-limiting enzyme in plant lignin biosynthesis, critically regulates plant growth, development, and abiotic stress responses. As one of the world's four major staple crops, potato ( L.) is extensively cultivated due to its nutritional value and versatile applications, underscoring the importance of investigating the gene family and its expression patterns under abiotic stress.

Exploring the incidence rate and imaging differential diagnosis of anterior mediastinal lesions: an 11-year retrospective study based on 2,626 cases.

Background: There are many complex types of anterior mediastinal lesions, and preoperative differential diagnosis is difficult in clinical practice. This study aimed to explore the incidence of different anterior mediastinal lesions and their differential diagnosis based on clinical and imaging features.

Methods: We examined the local incidence of anterior mediastinal lesions and their different types in 2,626 patients with anterior mediastinal lesions.

Development and validation of growth prediction models for multiple pulmonary ground-glass nodules based on CT features, radiomics, and deep learning.

Background: The development of growth prediction models for multiple pulmonary ground-glass nodules (GGNs) could help predict their growth patterns and facilitate more precise identification of nodules that require close monitoring or early intervention. Previous studies have demonstrated the indolent growth pattern of GGNs and developed growth prediction models; however, these investigations predominantly focused on solitary GGN. This study aimed to investigate the natural history of multiple pulmonary GGNs and develop and validate growth prediction models based on computed tomography (CT) features, radiomics, and deep learning (DL) as well as compare their predictive performances.

The expansin-like gene StEXLB1 plays a role in potato defence against bacterial wilt.

Potato is an important food crop worldwide with high nutritional value. However, infections caused by pathogenic bacteria can significantly reduce yield and tuber quality. Improving the resistance of potato itself is an effective solution.

Combining transcriptomics and metabolomics to analyse the mechanism of allelopathy in Cyclachaena xanthiifolia.

As a vicious invasive plant, Cyclachaena xanthiifolia has caused severe ecological disruption and significant reductions in crop yield, necessitating urgent control measures. However, the underlying mechanisms of its allelopathic invasion remain unclear, representing the primary bottleneck in current management strategies. In this study, we used metabolomic and transcriptomic analyses to evaluate the differences in allelopathy and related physiological and biochemical indices among different extract fractions of C.

SYNTAXIN OF PLANTS132 Regulates Root Meristem Activity and Stem Cell Niche Maintenance via RGF-PLT Pathways.

Root growth and development are contingent upon continuous cell division and differentiation in root tips. In this study, we found that the knockdown of the syntaxin gene () in resulted in a significant reduction in root meristem activity and disruption of root stem cell niche (SCN) identity. The knockdown mutant exhibits a compromised SCN characterized by an increased number of quiescent center (QC) cells, abnormal columella stem cells (CSCs), reduced meristem size, and subsequent inhibition of root growth.

Extracellular Vesicles From Dental Pulp Cells Promote Osteogenic Differentiation in Periodontal Ligament Cells.

Aim: Periodontal osseous defects are mainly caused by periodontitis, which seriously affects the quality of patient life. Dental pulp cells (DpCs)-derived extracellular vesicles (EVs) can effectively promote tissue regeneration. Homeobox A9 (HOXA9) mRNA is abundant in EVs derived from DSCs, which may be related to promoting alveolar bone regeneration, but the specific mechanism is unclear.

Pulmonary Subsolid Nodules: Upfront Surgery or Watchful Waiting?

Background: Patients with pulmonary subsolid nodules (SSNs) of ≤ 2 cm in diameter and a consolidation to tumor ratio (CTR) of ≤ 0.25 have good postoperative prognoses, but their management remains controversial.

Research Question: Does upfront surgical intervention lead to higher survival than watchful waiting in patients with SSNs with diameter of ≤ 2 cm and CTR of ≤ 0.

Immunomodulation with M2 macrophage-derived extracellular vesicles for enhanced titanium implant osseointegration under diabetic conditions.

M2 macrophage-derived extracellular vesicles (M2-EVs) demonstrate the capacity to reduce pro-inflammatory M1 macrophage formation, thereby restoring the M1-M2 macrophage balance and promoting immunoregulation. However, the efficacy of M2-EVs in regulating macrophage polarization and subsequently enhancing osseointegration around titanium (Ti) implants in patients with diabetes mellitus (DM) remains to be elucidated. In this study, Ti implants were coated with polydopamine to facilitate M2-EVs adherence.

Development and validation of a questionnaire to assess knowledge, attitudes, and practices regarding the addictive and detrimental effects of novel psychoactive substances among university students.

Background: The misuse of novel psychoactive substances (NPSs) is highly prevalent among university students, leading to significant public health and social safety concerns. To improve our drug education efforts related to NPSs, we developed a knowledge, attitudes and practices (KAP)-based questionnaire for university students.

Methods: We developed a KAP-based questionnaire after performing a comprehensive literature review and consulting experts.

Nitrogen and Sulfur Co-doped Carbon Dots for Ratiometric Fluorometric Determination of Mercury Ions.

Nitrogen and sulfur co-doped carbon dots (N, S-CDs) were prepared for dual-channel ratiometric fluorescence determination of mercury ions (Hg). The dual-emission N, S-CDs were synthesized using a simple one-pot hydrothermal treatment. When excited with visible light, N,S-CDs exhibited two emission peaks at 390 and 500 nm.

Optimal fermentation of Shuanghuanglian and its effects on production performance of laying hens.

Background: Shuanghuanglian is a Chinese medicine composed of , , and . It has various effects, including anti-inflammatory, antibacterial, antiviral, and immunomodulatory effects. The fermented product of Shuanghuanglian can be used as an antibiotic alternative, as it has similar efficacy, which may improve the immunity, feed intake and utilization efficiency of laying hens, thus improving their production performance.

Differential allelopathic effects of mangrove plants Kandelia obovata and Aegiceras corniculatum on harmful algal species: Potential applications in algal bloom control.

This study examined effects of mangrove plants Kandelia obovata and Aegiceras corniculatum on harmful algal species. While A. corniculatum leaf extract had no inhibitory effect, K.

A prediction model based on computed tomography characteristics for identifying malignant from benign sub-centimeter solid pulmonary nodules.

Background: Distinguishing benign from malignant sub-centimeter solid pulmonary nodules (SSPNs) continues to be challenging in clinical practice. Earlier diagnosis is crucial for improving patient survival and prognosis. This study aimed to investigate the risk factors of malignant SSPNs and establish and validate a prediction model based on computed tomography (CT) characteristics to assist in their early diagnosis.

Case studies of the load-bearing performance of shield tunnel segment with misaligned defects.

The segment misalignment is a common defect in the segment installation of a shield tunnel construction, due to the complexity and uncertainty of its construction conditions. This raises a concerning about the safety of the segment lining for the shield tunnel. In this paper, the integrated numerical models with surrounding rock, peastone grouting and segment lining were built using three-dimensional finite element method, by introducing two kinds of misaligned defects of segments.

A Study on the Functional Identification of Overexpressing Winter Wheat Expansin Gene in Rice under Salt Stress.

Expansin is a cell wall relaxant protein that is common in plants and directly or indirectly participates in the whole process of plant root growth, development and morphogenesis. A well-developed root system helps plants to better absorb water and nutrients from the soil while effectively assisting them in resisting osmotic stress, such as salt stress. In this study, we observed and quantified the morphology of the roots of overexpressing the gene obtained by the research group in the early stage of development.

Overexpression of Wild Soybean Expansin Gene Enhanced the Tolerance of Transgenic Soybean Hairy Roots to Salt and Drought Stresses.

As a type of cell-wall-relaxing protein that is widely present in plants, expansins have been shown to actively participate in the regulation of plant growth and responses to environmental stress. Wild soybeans have long existed in the wild environment and possess abundant resistance gene resources, which hold significant value for the improvement of cultivated soybean germplasm. In our previous study, we found that the wild soybean expansin gene is specifically transcribed in roots, and its transcription level significantly increases under salt and drought stress.

Predicting epidermal growth factor receptor mutations in non-small cell lung cancer through dual-layer spectral CT: a prospective study.

Objective: To determine whether quantitative parameters of detector-derived dual-layer spectral computed tomography (DLCT) can reliably identify epidermal growth factor receptor (EGFR) mutation status in patients with non-small cell lung cancer (NSCLC).

Methods: Patients with NSCLC who underwent arterial phase (AP) and venous phase (VP) DLCT between December 2021 and November 2022 were subdivided into the mutated and wild-type EGFR groups following EGFR mutation testing. Their baseline clinical data, conventional CT images, and spectral images were obtained.

Radiological and clinical features of large consolidative-type pulmonary invasive mucinous adenocarcinoma.

Background: This study aimed to investigate the radiological, pathological, and prognostic characteristics of large consolidative-type pulmonary invasive mucinous adenocarcinomas (IMA).

Methods: We retrospectively reviewed 738 patients who confirmed IMA between January 2010 and August 2022, and two radiologists reviewed imaging data to determine subtypes. We included 41 patients with pathologically large consolidative-type IMA.

Correlation between different points on the face and the width of maxillary anterior teeth.

Statement Of Problem: There is currently no consensus on the relationship between maxillary anterior teeth and different facial anthropometric measurements. Additionally, whether these relationships vary by age and sex remains unreported.

Purpose: This clinical study aimed to investigate the relationship between the intercanine distance (ICaD) and intercanthal distance (ICD), interpupillary distance (IPD), interalar width (IAW), and intercommissural width (ICW), and to compare whether these relationships differ between different age and sex populations.