Correction: Qiu et al. P53 Deficiency Accelerates Esophageal Epithelium Intestinal Metaplasia Malignancy. 2023, , 882.

In the original publication [...

Human herpesvirus type 4 combined with Brucella abortus meningitis case report.

Objective: To observe and analyse the clinical characteristics, diagnosis and treatment of Human herpesvirus type 4 combined with Brucella abortus meningitis, in order to improve clinicians' understanding of this disease.

Methods: The clinical data of a patient withHuman herpesvirus type 4 combined with Brucella abortus meningitis diagnosed on 8 January 2024 in Baotou People's Hospital were analysed. Results The case was a middle-aged female patient with the main symptoms of dizziness and numbness and weakness of the limbs.

Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes.

Epigenetic clocks in blood have shown promise as tools to quantify biological age, displaying robust associations with morbidity and all-cause mortality. Whilst the effect of cell-type heterogeneity on epigenetic clock estimates has been explored, such studies have been limited to studying heterogeneity within the adaptive immune system. Much less is known about whether heterogeneity within the innate immune system can impact epigenetic clock estimates and their associations with health outcomes.

Structural and mechanistic insights into the transcriptional regulation of chromosomal T6SS by large conjugative plasmid-encoded TetRs in Acinetobacter baumannii.

The type VI secretion system (T6SS) is a highly sophisticated nanomachine widely used by bacteria to achieve competitive advantage, important for survival and pathogenicity. In Acinetobacter baumannii, the large conjugative plasmid pAB3 encodes two TetR-family transcriptional regulators, TetR1 and TetR2, that play crucial roles in restricting T6SS function and promoting recipient survival after conjugation. Using X-ray crystallography, we demonstrate that the plasmid-encoded TetRs are structurally homologous but distinct in DNA sequence binding preferences, which we have also mapped out using chromatin immunoprecipitation and validated with electrophoretic mobility shift assay and isothermal titration calorimetry.

Adipocyte RNA-binding protein CELF1 promotes beiging of white fat through stabilizing Dio2 mRNA.

RNA-binding proteins (RBPs) regulate diverse post-transcriptional processes and play roles in adipocyte development; however, their role in white fat beiging remains unclear. Here we identify CUG-BP Elav-like family member 1 (CELF1) as a key RBP promoting beiging of inguinal white adipose tissue in response to cold. Adipocyte-specific Celf1 deficiency impairs cold-induced thermogenic gene expression and reduces energy expenditure.

Perceptions on financial exploitation and technology-based solutions among older adults.

Financial exploitation of older adults is rising significantly, necessitating effective interventions. This qualitative study examined perceptions and experiences of technology use among 40 adults over age 60 through rural and urban focus groups. Three primary themes emerged: technology knowledge gaps, trust and privacy concerns dependent on source credibility, and reactive rather than proactive approaches to combating financial exploitation.

Clinical and radiological course of asymptomatic and hemodynamically stable moyamoya disease: a systematic review and meta-analysis.

Background: Moyamoya disease (MMD) is an idiopathic, chronic intracranial vascular stenosis and occlusion disease. However, there is currently a lack of comprehensive analysis on the clinical and radiological course of asymptomatic MMD (AMMD) and hemodynamically stable MMD (HSMMD).

Data Source: We conducted a comprehensive literature search using major bibliographic indexing databases, including Embase, Medline, PubMed, Web of Science, and Cochrane Library.

BRAF p.V600E-negative low-grade adenocarcinoma of the mandible with features of sialadenopapillary ductal tumor and prominent mucinous differentiation: report of a unique case.

Cutaneous tubular adenoma (TA), also known as tubulopapillary hidradenoma, is a rare benign sweat gland tumor. In the oral cavity, 2 groups of glandular neoplasms morphologically similar to cutaneous TA have been previously described, under the names tubulopapillary hidradenoma-like tumor of the mandible (TPHLTM) and sialadenoma papilliferum-like intraductal papillary tumor (SP-IPT), respectively. Recent evidence suggests that sialadenoma papilliferum, SP-IPT, and TPHLTM may form a biological continuum, and a unifying term, sialadenopapillary ductal tumor (SDT), has been proposed for these lesions.

PepBERT: Lightweight language models for bioactive peptide representation.

Protein language models (pLMs) have been widely adopted for various protein and peptide-related downstream tasks and demonstrated promising performance. However, short peptides are significantly underrepresented in commonly used pLM training datasets. For example, only 2.

An unsupervised cluster analysis of multimorbidity patterns in older adults in Shenzhen, China.

Background: Population aging challenges health care systems due to the high prevalence and impact of multimorbidity in older adults. Studies on multimorbidity in Shenzhen have primarily focused on the quantity of multimorbidity, lacking in-depth exploration of multimorbidity patterns.

Methods: Based on baseline data from the Shenzhen aging-related disease cohort, this study analyzed information from 8,911 people aged 60 and above after excluding missing and abnormal values from interview results.

Research progress in intracranial artery dissections over past 25 years: a review and bibliometric analysis.

Background: A bibliometric and visual analysis of articles related to intracranial artery dissection (IAD) was performed to reveal the academic developments in this research field, to better assist researchers in reviewing previous research results, exploring current scientific research hotspots and cutting-edge trends, and obtaining a global perspective on IAD research.

Methods: Articles on IAD published from January 1, 2000 to March 15, 2025 were searched, screened, and downloaded using the Web of Science Core Collection (WoSCC). All literature included in the study was analyzed using VOSviewer, CiteSpace and Microsoft Excel.

Unified high-resolution immune cell fraction estimation in blood tissue from birth to old age.

Variations in immune-cell fractions can confound or hamper interpretation of DNAm-based biomarkers in blood. Although cell-type deconvolution can address this challenge for cord and adult blood, currently there is no method applicable to blood from other age groups, including infants and children. Here we construct and extensively validate a DNAm reference panel, called UniLIFE, for 19 immune cell-types, applicable to blood tissue of any age.

Metabolic Engineering of for High-Yield -Butanol Production by Increasing Intracellular Reducing Equivalent with NADPH-Dependent 3-Hydroxybutyryl-CoA Dehydrogenase.

was engineered to overexpress E2 encoding the aldehyde/alcohol dehydrogenase and an exogenous NADPH-dependent 3-hydroxybutyryl-CoA dehydrogenase from (Ck) for -butanol production. In general, large amounts of butyrate, acetate, and ethanol are also produced from glucose when butanol biosynthesis is hindered by limited intracellular NADH pools. flux balance analysis showed that coupling NADP/NADPH turnover with butanol production increased the reducing equivalent supply and butanol selectivity over ethanol and acids, thus increasing butanol production from glucose.

ESG and corporate performance: The moderating role of government subsidies and mediating effect of analyst coverage in Chinese A-share listed companies.

In recent years, the heightened emphasis on sustainable and high-quality economic development has garnered substantial investor interest in corporate ESG performance, significantly influencing the long-term operational stability of firms. This study, based on data from A-share listed companies from 2015 to 2022, explores the relationship between corporate ESG performance and corporate financial performance. This research employed regression analysis to examine this relationship and found that improved ESG performance significantly enhances financial performance, especially in state-owned enterprises and the manufacturing sector.

Dissolved organic matter mediates the interactions between bacterial community and heavy metal fractionation in contaminated coal mine soils.

Heavy metal (HM) contamination in coal mine soils disrupts local bacterial networks, leading to prolonged soil deterioration. Dissolved organic matter (DOM), a crucial soil component, actively modulates both bacterial metabolism and HM mobilization. Despite its significance, our understanding of the complex interactions among bacterial communities, soil chemical and DOM properties, and HM fractionation remains limited.

Membrane Selectivity Mechanisms of the Antimicrobial Peptide Snakin-Z Against Prokaryotic and Eukaryotic Membrane Models.

Snakin-Z, a novel cationic antimicrobial peptide (AMP) derived from fruits, exhibits broad-spectrum antimicrobial activity against bacteria and fungi. Importantly, it displays minimal hemolytic activity toward human red blood cells (RBCs). Elucidating the molecular basis of membrane selectivity of Snakin-Z is essential for its development as a novel antimicrobial agent.

Systems Metabolic Engineering of Clostridium tyrobutyricum for 1,3-Propanediol Production From Crude Glycerol.

Clostridium tyrobutyricum has emerged as a non-pathogenic microbial cell factory capable of anaerobic production of various value-added products, such as butyrate, butanol, and butyl butyrate. This study reports the first systematic engineering of C. tyrobutyricum for the heterologous production of 1,3-propanediol (1,3-PDO) from industrial by-product crude glycerol.

Extrachromosomal circular DNA as a novel biomarker for the progression of colorectal cancer.

Background: Extrachromosomal circular DNA (eccDNA) has potential in tumor diagnosis, particularly for improving diagnostic accuracy and early cancer detection; however, many challenges remain in its application to clinical practice.

Methods: We conducted a Circle-Seq analysis on clinical samples at different stages of colorectal cancer progression to examine the dynamic changes of eccDNA during the progression of colorectal cancer. We used breakpoint-specific PCR to verify candidate eccDNAs identified by Circle-Seq.

FusionESP: Improved Enzyme-Substrate Pair Prediction by Fusing Protein and Chemical Knowledge.

To reduce the cost of the experimental characterization of the potential substrates for enzymes, machine learning prediction models offer an alternative solution. Pretrained language models, as powerful approaches for protein and molecule representation, have been employed in the development of enzyme-substrate prediction models, achieving promising performance. In addition to continuing improvements in language models, effectively fusing encoders to handle multimodal prediction tasks is critical for further enhancing model performance by using available representation methods.

The protective role of muscone in the development of COPD.

Background: Muscone, a key component of musk, exhibits anti-inflammatory properties. However, its therapeutic potential in inflammatory lung diseases, such as chronic obstructive pulmonary disease (COPD), remains largely unexplored. This study aimed to investigate whether Muscone could exert a protective effect in a mouse model of COPD .

Pore-Forming Protein LIN-24 Enhances Starvation Resilience in by Modulating Lipid Metabolism and Mitochondrial Dynamics.

The ability to survive starvation is a critical evolutionary adaptation, yet the molecular mechanisms underlying this capability remain incompletely understood. Pore-forming proteins (PFPs) are typically associated with immune defense, where they disturb the membranes of target cells. However, the role of PFPs in non-immune functions, particularly in metabolic and structural adaptations to starvation, is less explored.

Chemokine family significance and prognostic value in colorectal cancer.

Background: Colorectal cancer (CRC) poses a substantial global health concern, exhibits inconspicuous early symptoms, and is typically diagnosed at advanced stages leading to unfavorable outcomes. The intricate tumor microenvironment plays a crucial role in CRC development and progression, where chemokines contribute significantly. These chemokines exhibit widespread expression within tumor cells, facilitating immune cell infiltration, angiogenesis, and the establishment of distant metastases.